1.Progress in irisin and its upstream and downstream antidepressants
Jiala SANG ; Shanshan LI ; Xin CUI ; Qingqing REN ; Ruiling HOU ; Xingfang PAN ; Shenjun WANG ; Meidan ZHAO
Chinese Journal of Comparative Medicine 2024;34(1):130-138
Depression is a major cause of disability and has adverse effects.Despite the many types of anti-depressants,clinical treatments of depression remain poor.Therefore,novel anti-depressant mechanisms need to be explored.The beneficial effects of irisin on the nervous system are gradually being elucidated,and studies have found that irisin has an anti-depressant effect,which may become a new treatment for depression.This study explored the mechanism of irisin and its upstream and downstream anti-depressants by reviewing the existing studies explaining the link between irisin and depression,and proposes that SIRT1/PGC-1α may mediate FNDC5/irisin to regulate BDNF to promote neurogenesis and improve depression,which provides a new idea to study irisin and its upstream and downstream anti-depressants.
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