[Summary] In this case report , a 44-year-old female patient complained of three years of tightness and chest pain , and was hospitalized in January 2016.The thymus and tumor were completely resected under video-assisted thoracoscopic surgery (VATS). Postoperative pathological examination presented a thymic mucoepidermoid carcinoma .The patient received 30 times of chemotherapy after operation and were followed up for 2 months.Postoperative recovery was smooth without symptoms .The CT scanning showed negative result .We consider that VATS was feasible and safe for the treatment of thymic carcinoma .