Objective To investigate the changes and significance of risk factors (blood lipid ,UA ,visfatin ,HCY and hs CRP) for cardiovascular diseases in patients with subclinical hypothyroidism(SCH) .Methods One hundred patients with SCH were divided into observation group A (5 mIU/L≤TSH<10 mIU/L ,n=60) and observation group B (TSH≥10 mIU/L ,n=40) in accordance with thyroid stimulating hormone (TSH ) level .The control group included one hundred healthy individuals .We measured the factors of cardiovascular diseases such as TSH ,total cholesterol (TC) ,triglyceride (TG) ,high density lipoprotein cholesterol (HDL‐C) ,low density lipoprotein cholesterol (LDL‐C) ,serum uric acid (UA) ,visfatin ,homocysteine (HCY) and high sensitive C‐reactive protein (hs‐CRP) and visfatin level .Results The levels of TG and visfatin of observation groups were signifi‐cantly higher than control group (P<0 .05) .In group B ,levels of TG ,visfatin ,LDL‐C ,UA ,HCY and hs‐CRP were much more sig‐nificantly higher than control group(P<0 .05) ,and TG and visfatin had the most significant increase (P<0 .01) ,and there were no significant different in HDL‐C in group A and B(P>0 .05) .Conclusion In Subclinical hypothyroidism patients ,lipid disorders and hyperuricemia are the risk factors of thyroid nodules and coronary heart disease .HCY ,hs‐CRP and visfatin should be used as the indicators to evaluate the cardiovascular risk .