1. Analysis of new occupational diseases in Hengyang from 2006 to 2017
Bin LI ; Guanxiang ZOU ; Jiajia KUANG ; Yong CHEN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2019;37(3):194-197
Objective:
To analyze the situation of new occupational diseases in Hengyang City from 2006 to 2017, and put forward prevention and control strategies.
Methods:
The data of the new occupational disease report of Hengyang city in the Occupational Disease and Occupational Health Information Monitoring System from January 1, 2006 to December 31, 2017 was collected, and the age, working years, and the region and industry of the new occupational disease patients were analyzed.
Results:
From 2006 to 2017, there were 7 categories, 30 kinds and 2 110 cases of new occupational diseases in Hengyang City, including 1 117 cases of pneumoconiosis, 951 cases of chronic occupational poisoning, 15 cases of acute occupational poisoning, 12 cases of occupational otolaryngological and stomatological diseases, 7 cases of occupational skin diseases, 6 cases of occupational diseases caused by physical factors, and 1 case of occupational eye diseases(cataracts), 1 case of occupational tumor (lung cancer and skin cancer caused by arsenic and its compounds). New occupational diseases were mainly concentrated in Changning and Leiyang County-level city (87.82%, 1 853/2110), among which occupational poisoning had the most incidence in Changning County-level city (97.83%, 945/966), and pneumoconiosis had the most incidence in Leiyang County-level city (67.05%, 749/1 117). New occupational diseases were mainly concentrated in the manufacturing and mining industries (95.59%, 2 017/2 110). Pneumoconiosis (63.74%, 712/1 117) and acute occupational poisoning (60.00%, 9/15) were mainly caused by small businesses. Chronic occupational poisoning (61.62%, 586/951) and occupational otolaryngological and stomatological diseases (75.00%, 9/12) were mainly caused by large enterprises.
Conclusion
The new occupational diseases in Hengyang city are mostly pneumoconiosis and chronic occupational poisoning, and we should focus on strengthening the prevention and control of occupational diseases in the mining industry and manufacturing industry.
2.Correlation of polymorphism of glial high-affinity glutamate transporter (SLC1A3) gene and non-suicidal self-injury in adolescents
Ming AI ; Jiajia JIN ; Liuyi RAN ; Su HONG ; Suya WANG ; Qi ZHANG ; Jianmei CHEN ; Li KUANG
Chinese Journal of Behavioral Medicine and Brain Science 2018;27(3):222-225
Objective To explore the correlation between polymorphisms (SNPs) of locus rs2269272 of glial high-affinity glutamate transporter (SLC1A3) gene and suicide attempt among Chinese adolescents.Methods iMLDRTM genotyping technology was used to detect the polymorphism of rs2269272 SLC1A3 gene loci in 55 suicide attempters and 112 healthy controls,and survival analysis was applied to analyze the relationship between allele (T) and the age of suicide attempt.Results The differences of rs2269272 locus allele distribution between two groups were statistically significant(x2=4.208,P=0.040),but genotype distribution of two groups had no significantly differences(x2 =4.011,P=0.135).Non-suicidal self-injury adolescents with locus rs2269272 (15.6 ± 0.4) were younger than adolescents without locus rs2269272(16.4±0.7),but the difference was not statistically significant.Conclusion Preliminary findings suggest that rs2269272 SLC1 A3 may be relevant to non-suicidal self-injury acts,and rs2269272 locus allele is not related to earlier suicide attempt.
3.Spatial Distribution of Parvalbumin-Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson's Disease.
Changgeng SONG ; Yan ZHAO ; Jiajia ZHANG ; Ziyi DONG ; Xin KANG ; Yuqi PAN ; Jinle DU ; Yiting GAO ; Haifeng ZHANG ; Ye XI ; Hui DING ; Fang KUANG ; Wenting WANG ; Ceng LUO ; Zhengping ZHANG ; Qinpeng ZHAO ; Jiazhou YANG ; Wen JIANG ; Shengxi WU ; Fang GAO
Neuroscience Bulletin 2023;39(11):1683-1702
Parvalbumin interneurons belong to the major types of GABAergic interneurons. Although the distribution and pathological alterations of parvalbumin interneuron somata have been widely studied, the distribution and vulnerability of the neurites and fibers extending from parvalbumin interneurons have not been detailly interrogated. Through the Cre recombinase-reporter system, we visualized parvalbumin-positive fibers and thoroughly investigated their spatial distribution in the mouse brain. We found that parvalbumin fibers are widely distributed in the brain with specific morphological characteristics in different regions, among which the cortex and thalamus exhibited the most intense parvalbumin signals. In regions such as the striatum and optic tract, even long-range thick parvalbumin projections were detected. Furthermore, in mouse models of temporal lobe epilepsy and Parkinson's disease, parvalbumin fibers suffered both massive and subtle morphological alterations. Our study provides an overview of parvalbumin fibers in the brain and emphasizes the potential pathological implications of parvalbumin fiber alterations.
Mice
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Animals
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Epilepsy, Temporal Lobe/pathology*
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Parvalbumins/metabolism*
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Parkinson Disease/pathology*
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Neurons/metabolism*
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Interneurons/physiology*
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Disease Models, Animal
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Brain/pathology*
4.Correction: Spatial Distribution of Parvalbumin-Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson's Disease.
Changgeng SONG ; Yan ZHAO ; Jiajia ZHANG ; Ziyi DONG ; Xin KANG ; Yuqi PAN ; Jinle DU ; Yiting GAO ; Haifeng ZHANG ; Ye XI ; Hui DING ; Fang KUANG ; Wenting WANG ; Ceng LUO ; Zhengping ZHANG ; Qinpeng ZHAO ; Jiazhou YANG ; Wen JIANG ; Shengxi WU ; Fang GAO
Neuroscience Bulletin 2023;39(11):1747-1748