Continnous theoretical and technological progress in the face of increasing expectations for quality of health care and progress in medical technology has transformed the surgical paradigm.Based on the historical trends and technique advances,a novel paradigm ofPrecision Surgery has been proposed,which is featuring certainty-based practice to ensure the best results for each patient with multi-objective optimization of therapeutic effectiveness,surgical safety and minimal invasiveness.The main characteristics of precision surgery may be summarized as determinacy,predictability,controllability,integration,standardization and individualization.The strategy of precision hepatic surgery is to seek a balance of maximizing the removal of the target lesions,while maximizing the functional remnant liver and minimizing surgical invasiveness.The concept of precision surgery should be considered for wider application in liver surgery and other fields as a step toward the ultimate goal of perfect surgery.

The concept of minimally invasive surgery is adopted in the diagnosis and treatment of biliary diseases,while during the process,the biological function of the sphincter of Oddi is ignored,and blind expansion of indications of endoscopic sphincterotomy (EST) severely affected the function of the sphincter of Oddi.In this condition,protection of the sphincter of Oddi should be attached great importance.Proper selection of diagnosis method,strictly control of the indications of EST,timely repair the injured sphincter of Oddi are important for a better prognosis of patients with biliary diseases with preservation of the function of the sphincter of Oddi.

The principles of “precise liver surgery”include to absolutely clearing target lesions,ensuring structural　integrity of residual liver,maximizing the volume of remnant　liver,controlling bleed as well as minimizing hepatic parenchymal damage and surgical invasiveness.This theory serves the　whole procedure of liver surgery for the optimal recovery of　patients.The major strategies consist of accurate preoperative　evaluation:rigorous surgical planning,refined surgical operation　and meticulous perioperative care.The construction of “recise　liver surgery” system requires the combination of modern technology and traditional surgery,and the breakthrough in the core　theory and key techniques of liver surgery.

Esophageal variceal hemorrhage is a severe complication of portal hypertension.Non selective-blockers and endoscopic variceal ligation have been utilized to prevent variceal hemorrhage as the first line therapeutic measures.The role of surgical approaches in the treatment of portal hypertension is still controversy.The selective shunt operation,devascularization operation,transjugular intrahepatic portosystemic shunt and liver transplantation have their own indications and limitations.Based on the precision surgical therapy,individualized selection of suitable surgical management on portal hypertension should be advocated to minimize invasiveness and cost-effect ration,maximize organ saving and outcome.For patients with extrahepatic portal hypertension,Meso-Rex bypass operation could be the preventive treatment method,surgical treatment could be applied to patients with regional portal hypertension.

With inheritance of scientific spirit of Huang Zhiqiang,depending on the modern science and technology of evidence-based medicine methods,digital surgical technique,molecular imaging technique,minimally invasive technology,genomics and proteomics technology and Big Data analytics,giving full play to the characteristics of precision surgery,which include evidence-base,quantification,visualization and controllability,a new era of biliary surgery in China is inaugurated.

With the progress in muhimodality therapy, the management of hepatocellular carcinoma (HCC) comes to an era of diversification. Dudng the last 2 decades, the increased understanding of biological behaviors of HCC and innovations of various treatment modalities has led to dramatic changes in concepts and strategies of treatment for HCC. The changes include the shifts from experience-based medicine to evidence-based medicine, from rough treatment to precise treatment and from single therapy to integrated therapy. The implementation of these concepts and therapies will further improve the chance of survival and the quality of life for HCC patients.

Continuous progress of medicine and related areas are initiating and motivating a paradigm transformation of traditional surgery to precise surgery,which is characterized by precision in decision making and surgical intervention.The strategy of precise surgery is to seek a balance of maximized lesion removal,maximized organ sparing and minimal surgical invasiveness.Due to the special location and biological characteristics,the therapy of hilar cholangiocarcinoma is still challenging.To meet the demand of precise surgery,the knowledge of anatomy,biological characteristics and liver functional reserve is needed and the technical aspects of pre-surgical intervention,liver resection and reconstruction of vessels are also very important.

Anatomic segmental hepatectomy,as an important part ofprecision surgery,has been accepted and widely applied as the promotion of precision hepatectomy.Anatomic segmental hepatectomy is superior to non-anatomical hepatectomy in clinical efficacy,application scope and operation techniques.There are many operation techniques developed by surgeons to accomplish segmental hepatectomy,and it is worthy for spreading in clinical practice.

Hilar cholangiocarcinoma always presents with a mass, thickness of the bile duct wall or nodules in the bile duct. Computed tomography (CT) can demonstrate the above findings with high partial resolution as well as dilation of the intrahepatic bile duct. CT can show the field and the involvement of adjacent vessels on 3D reconstruction images for hilar cholangiocarcinoma spreading along the lumen of the bile duct. CT images can also demonstrate vessel involvement when evaluating the resectability. When combined with 3D reconstruc-tion, the sensitivity and specificity of CT imaging can reach 90.5% and 91.7% , respectively, for detecting vessel involve-ment.

From ancient to present,liver has always been a mystery and magical organ.As the largest glandular organ of the body,liver has many vital functions.Its regenerative capabilities and functional reservation allow major resection of up to 80%of its volume.Many diseases,such as liver cancer,cirrhosis and hepatolithiasis Can affect liver,and the mainstay of curative treatment is liver resection.Technological advances play an important role in modern surgery,and a new surgical paradigm characterized by precision has evolved.Recently,we haveadvocated the concept of"precise hepatectomy"on the basis of modem anatomy,physiology,oncology,imaging and surgical techniques,which is characterized by minimal invasion,liversaving and maximally restoration of liver function.Related subjects,including computer sciences,imaging and information are needed to be combined to create a new alliance of treatment.Although,there are still many theoretical and technical problems about liver resection and liver function preservation.With the development of science and technology,precise hepatectomy will further improve the outcomes of liver surgery.