ObjectiveTo observe the clinical effect of Tianma Goutengyin combined with acupuncture on adult patients with tic disorder of ascendant liver-yang hyperactivity. MethodThe 64 adult patients with tic disorder of ascendant liver-yang hyperactivity who were treated in the outpatients and inpatients of the 989^th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army from January 2019 to December 2020 were selected and classified into the control group （32 cases） and the treatment group （32 cases） with the random number table method. The control group took oral western medicine Duloxetine Hydrochloride Enteric Capsules， and the treatment group was treated by Tianma Goutengyin and acupuncture. The treatment lasted 8 weeks for both groups and the efficacy was observed. ResultThe traditional Chinese medicine （TCM） syndrome score， Yale Global Tic Severity Scale （YGTSS） score， total bile acid （TBA）， triglyceride （TG）， and partial pressure of carbon dioxide （PaCO₂） were significantly lower， and the Na⁺ concentration and partial pressure of oxygen （PaO₂） were significantly higher than those before treatment in both groups （P<0.05）. After treatment， the TCM syndrome score， YGTSS score， and TBA were significantly lower， and and the Na⁺ concentration and PaO₂ were significantly higher than in the treatment group than in the control group （P<0.05）. The efficacy on TG and PaCO₂ was similar in the two groups. The total clinical effective rate of the treatment group was 90.6% （29/32）， as compared with the 64.5% （20/31） of the control group （χ²=6.210， P<0.05）. The incidence of clinical adverse reactions in the treatment group was 12.5% （4/32） in comparison with the 35.5% （11/31） in the control group （χ²=4.585， P<0.05）. The recurrence rate in the treatment group （9.4%， 3/32） was lower than that （32.3%， 10/31） in the control group （χ²=5.035， P<0.05）. ConclusionThe combination of Tianma Goutengyin and acupuncture can remarkably alleviate the clinical symptoms of adult tic disorder patients with ascendant hyperactivity of liver yang， reduce TBA， TG and PaCO₂， and increase the concentration of Na⁺ and PaO₂. Patients treated with the combination show small adverse reactions and low recurrence rate.