Transforming growth factor-?(TGF-?) is a multifunctional growth factor. It plays a very important role in the growth, dif ferentiation, migration, apoptosis of cells and production of extracellular matr ix throughout many signaling pathways. MAPK cascade is one of those signaling pa thways. TGF-? can activate MAPKs and fulfill its multiple regulation on a varie ty of cells.

Objective: To observe the effect of the combination of acupuncture and medication on orthostatic hypotension after incomplete cervical spinal cord injury. Methods: Ninety-two patients with orthostatic hypotension after incomplete cervical spinal cord injury were divided into two groups according to the random number table method, with 46 cases in each group. The control group was treated with oral midodrine hydrochloride on the basis of conventional treatment, and the observation group was treated with acupuncture in addition to the intervention used in the control group. Both groups were treated for 4 weeks. The changes in supine and orthostatic blood pressures, motor and sensory scores, quadriplegic function index score, clinical efficacy, and safety evaluation were observed. Results: During the treatment, 2 cases dropped out in the observation group, and 3 cases dropped out in the control group. After 4 weeks of treatment, the clinical efficacy of the observation group was better than that of the control group (P<0.05). After treatment, the supine systolic blood pressure and diastolic blood pressure in the two groups had no significant changes (P>0.05), while the orthostatic systolic blood pressure and diastolic blood pressure, the motor and sensory scores, and the quadriplegic function index score were significantly higher than those before treatment (P<0.05), and the scores in the observation group were higher than those in the control group (P<0.05). Adverse reactions were mild in both groups. Conclusion: The combination of acupuncture and medication can significantly improve the orthostatic blood pressure, motor and sensory function and daily living ability of patients with orthostatic hypotension after incomplete cervical spinal cord injury, and it is safe and reliable.

Based on the idea that the pathogenic-etiologic mechanism is the " blockadeof liver channels, blood stasis and Qi stagnation resulting in malnutrition of liver due to iack of blood supply", the treating principle of " e-liminating stasis and supporting body resistance" was established with the combined use of extracts from peach -kernel plus cordicep hypha. 6 cases were thus treated. All of them received laparoscopy , and liver biopsy before and after the treatment. The gross appearance, histology and ultra. - microscopic structure and irnmuno - histo - chemistry were examined. Results showed that most of the activatedfat - storage cells after treatment were silent the I, III types of collagen depo - sited among the spaces of peri - sinusoid and liver cells and FN, LM weredecreased in part of the patient, resulting in less intrahepatic fibrosis, degradation of collagen fibres deposited in inter hepatic cellular spaces, inhibition and reversion of capillariza-tion oi liver sinusoid, hence, improvement of degener-ation of liver cells in most cases. The texture of the liver were turning normal with amelioration of portal hypertension and decrease of varicose mesenteric ves-seis. The liver turned red, swelling of falciform lig(?)-ment disappeared, and ascitis subsided.

Montreal cognitive assessment(MoCA, Beijing Version) was chosen as cognition assessment implement. 63 patients suffering from type 2 diabetes mellitus with mild cognitive impairment (MCI) were chosen to form a research group, and 27 patients with type 2 diabetes mellitus and normal cognitive function served as a control group. It was found that atherosclerosis played an important role in the pathogenesis of MCI in type 2diabetes, therefore, early prevention and management of atherosclerosis may help to improve the cognitive function.

Antiviral Agents ; therapeutic use ; Hepatitis B, Chronic ; drug therapy ; Humans ; Lamivudine ; therapeutic use ; Liver Cirrhosis ; drug therapy