ObjectiveTo observe the effects of salmeterol fluticasone on the glucose metabolism and bone density of the elderly patients with chronic obstructive pulmonary disease (COPD) combined with type 2 diabetes mellitus (T2DM).MethodsThirty-one patients with COPD combined with T2DM were divided into 2 groups by random digits table,14 cases in control group were given conventional therapy,17 cases in experimental group were given conventional therapy and fluticasone propionate 50/500 μg,twice a day,for 3 months.The fasting blood glucose,postprandial 2 hours glucose,glycosylated hemoglobin,plasma cortisol and bone density respectively before and after treatment were detected.ResultsIn experimental group,the fasting blood glucose,postprandial 2 hours glucose,glycosylated hemoglobin and bone density before treatment was (5.25 ± 0.21 ) mmol/L,(7.14 ± 0.33 ) mmol/L,(5.58 ± 0.26 )％,( 1.96 ± 0.11 ) g/cm2,and after treatment was(5.31 ± 0.27 ) mmol/L,(7.22 ± 0.29 ) mmol/L,(5.67 ± 0.23 )％,(2.03 ± 0.15 ) g/cm2,there was no significant difference (P ＞ 0.05).In control groups,the fasting blood glucose,postprandial 2 hours glucose,glycosylated hemoglobin and bone density before treatment was (5.33 ± 0.35) mmol/L,( 7.26 ± 0.29 ) mmol/L,( 5.62 ± 0.19 )％,( 1.88 ± 0.20 ) g/cm2,and after treatment was ( 5.36 ± 0.31 ) mmol/L,(7.30 ± 0.35 ) mmol/L,( 5.69 ± 0.26 )％,( 1.98 ± 0.17 ) g/cm2,there was no significant difference (P ＞ 0.05 ).There was no significant difference in plasma cortisol before and after treatment in two groups (P ＞0.05).ConclusionInhaling salmeterol fluticasone for elderly patients with COPD combined with T2DM is safe.

Objective:To explore the application value of preoperative high-resolution magnetic resonance imaging(MRI)enhanced examination in the preoperative diagnosis of tumor node metastases(TNM)staging of rectal tumor.Methods:A total of 80 patients with rectal tumor admitted to Guang'an People's Hospital from June 2021 to September 2022 were selected.All patients underwent high-resolution MRI enhanced examinations before surgery and they were confirmed by postoperative pathological examination.The consistency of MRI T staging,N staging and postoperatively pathological staging results was analyzed.Results:The postoperative pathological staging results showed that 14 cases were at T1 stage,and 29 cases were at T2 stage,and 25 cases were at T3 stage,and 12 cases were at T4 stage,and 28 cases were at N0 stage,and 33 cases were at N1 stage and 19 were at N2 stage in the 80 patients.The diagnostic accuracies of T staging and N staging of high-resolution MRI routine and enhanced examinations were respectively 86.25%(69/80)and 90.00%(72/80)(Kappa=0.806,0.847,P<0.05).The consistency rate between preoperative high-resolution MRI detection and postoperative pathology for metastatic lymph nodes of 80 patients was 88.75%(71/80).The analysis found that metastatic lymph nodes mostly concentrated in the diameter range of 0.8-1.0 cm,accounting for 66.41%.With the increasing of N staging and T staging,the volume transfer constant(Ktrans)of the region of interest(ROI)of tumor increased successively.The Ktrans value of metastatic lymph nodes was significantly higher than that of non-metastatic lymph nodes,and the difference was statistically significant(t=14.890,P<0.05).Conclusion:Preoperative high-resolution MRI routine and enhanced examination has highly consistency with postoperative pathological TN staging of rectal tumor.The improvement of high-resolution MRI enhanced examination is helpful to assess the progression of patients'tumors and to determine treatment plans for them.

Endoplasmic reticulum (ER) stress, as an emerging hallmark feature of cancer, has a considerable impact on cell proliferation, metastasis, invasion, and chemotherapy resistance. Ovarian cancer (OvCa) is one of the leading causes of cancer-related mortality across the world due to the late stage of disease at diagnosis. Studies have explored the influence of ER stress on OvCa in recent years, while the predictive role of ER stress-related genes in OvCa prognosis remains unexplored. Here, we enrolled 552 cases of ER stress-related genes involved in OvCa from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) cohorts for the screening of prognosis-related genes. The least absolute shrinkage and selection operator (LASSO) regression was applied to establish an ER stress-related risk signature based on the TCGA cohort. A seven-gene signature revealed a favorable predictive efficacy for the TCGA, International Cancer Genome Consortium (ICGC), and another GEO cohort (P<0.001, P<0.001, and P=0.04, respectively). Moreover, functional annotation indicated that this signature was enriched in cellular response and senescence, cytokines interaction, as well as multiple immune-associated terms. The immune infiltration profiles further delineated an immunologic unresponsive status in the high-risk group. In conclusion, ER stress-related genes are vital factors predicting the prognosis of OvCa, and possess great application potential in the clinic.
Humans ; Female ; Ovarian Neoplasms/genetics* ; Cell Proliferation ; Cytokines ; Endoplasmic Reticulum Stress/genetics*