Objective To study the curative efficacy of different doses of atorvastatin combined with fenofibrate in treatment of mixed type hyperlipidemia and its effects on blood lipid and prognosis.Methods 120 patients of mixed type hyperlipidemia who received therapy were selected as research subjects.According to random number table,the patients were divided into A group (n=60) and B group (n=60).The two groups were treated with atorvastatin and fenofibrate,the dose of atorvastatin in A group was 10mg,which in B group was 20mg,fenofibrate dose was 200mg.After 4 weeks of treatment,the therapeutic effect was compared.Results After treatment,the blood lipids of the two groups were improved(P<0.05),but total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C) in A group were better than those in B group[(5.20±0.31)mmol/L vs.(5.87±0.46)mmol/L,(2.61±0.29)mmol/L vs.(3.85±0.34)mmol/L,(1.12±0.17)mmol/L vs.(0.93±0.13)mmol/L,(3.03±0.32)mmol/L vs.(3.48±0.41)mmol/L](t=9.355,21.493,6.877,6.702,all P<0.05).There was no significant difference in the total effective rate between the two groups[96.67%(58/60) vs.91.67%(55/60)](x2=1.365,P>0.05).The incidence rate of adverse reactions in A group was lower than that in B group[96.67%(58/60) vs.76.67%(46/60)](x2=6.171,P<0.05).Conclusion Low dose (10 mg) of atorvastatin combined with fenofibrate for mixed type hyperlipidemia has good lipid regulating effect,and adverse reaction is low,has little effect on the liver function of patients,which can effectively improve the prognosis,it is worthy of application and promotion.