Objective To summarize and analyze the clinical features,diagnosis,surgical approaches and treatment outcomes of patients with primary nasal sinus osteoma.Methods A retrospective review of 48 cases with primary nasal sinus osteoma treated from January 2007 to December 2013 was performed.All patients underwent preoperative CT scan and postoperative histopathologic examination.The surgical approaches included lateral rhinotomy in 14 cases,nasal endoscopic resection in 12 cases,coronal surgical incision craniotomy in 13 cases,combined craniofacial approach in 4 cases,and Caldwell-Luc approach in 5 cases.Results The postoperative pathological diagnosis consisted of 3 variants,including 20 for compact type and 15 for cancellous type,and 13 for mixed type.Six cases were lost to follow-up and 42 cases were followed up for 6-60 months,5 cases recurred.The post-operative complications included sinus mucous cyst in 4 cases,cerebrospinal fluid leak in 3 cases.Conclusions Nasal sinus osteoma are common.CT or MRI is helpful to evaluate the osteoma size,location and possible sources,and to make operation scheme.Surgery is the first choice for sinus osteoma.Lateral rhinotomy and nasal endoscopic resection can be applied to most sinus osteoma.The prognosis of sinus osteoma is good,with fewer recurrence.

Objective To investigate the impact of Sca-1 bone marrow derived stem cells on apoptosis in murine cardiac fibroblasts and the molecular mechanisms of young(Y)Sca-1 bone marrow stem cell(BMSC)on old(O)cardiac fibroblast cell(CFC)apoptosis.Methods The apoptosis and survival of Y and O CFC were assessed under hypoxic conditions.Co-cultures of Y and O Sca-1 bone marrow-derived mesenchymal stem cells(BMSC)with O CFC were established to investigate the impact of Sca-1 BMSC on the apoptotic response and viability of O CFC,employing TUNEL staining,qRT-PCR,Western Blot,and CCK8 assays.Furthermore,differential secretion profiles of growth factors by Y and O Sca-1 BMSC were compared using qRT-PCR and ELISA analysis.Results Compared to Y CFC,O CFC exhibited an increased rate of apoptosis and a decreased rate of cell survival.However,when compared to O cells,Y Sca-1 BMC significantly reduced apoptosis in O CFC and enhanced cell survival.Moreover,Y Sca-1 BMSC demonstrated a higher secretion of GDF5(Growth Differentiation Factor 5)than O cells(P<0.05).Importantly,the protective effects of Y Sca-1 BMSC on apoptosis and survival in O CFC were abolished upon neutral-ization of GDF5 expression.Conclusion Y Sca-1 BMSC decreases O CFC apoptosis through GDF5.