1.The impact of score and weight of regular grade on the total mark in medical microbiology
Jiezhong DENG ; Linxin PAN ; Jiacheng YANG ; Qiwen HU
Chinese Journal of Medical Education Research 2016;15(5):441-445
Objective To explore the influence of the scores and weights of the regular grade on the evaluation of students' learning effect.Method To compare the impact of the regular grade before and after adjustment on the total mark,analyze the problems exposed during scoring and search for the solutions according to Medical Microbiology results of four grades including Grade 2010 to 2013.SPSS 13.0 software was used for statistical analysis and Pearson method was used for correlation analysis and theory achievement scores.Results The regular grade of four grades scored highly,with the average (95.00 ± 3.80),(96.00 ± 4.55),(95.00 ± 2.84) and (95.00 ±-2.82) respectively.What was more,it had randomness.The correlation coefficient between regular grade and total mark were 0.069,0.149,0.984 and 0.285 respectively.The regular grade of Grade 2010 was the same as Grade 2013 and the theoretical score of Grade 2013 was 4 points lower than Grade 2010(71 vs.75),however the total mark of Grade 2013 was 1 point higher than Grade 2010 (80 vs.79),which showed the more the regular grade weights,the greater it impacted on the total mark.Conclusion The appropriate score and weight of the regular grade is important to evaluate the students' learning effect objectively.
2.MR influence of different magnetic field and different scanner with same magnetic field on apparent diffusion coefficient of abdominal organs in healthy volunteers
Jiayin GAO ; Jiacheng ZHANG ; Zhenghan YANG ; Jinning LI ; Min CHEN ; Cheng ZHOU
Chinese Journal of Radiology 2013;(2):142-146
Objective To evaluate the reproducibility of ADC measurements at 1.5 vs 3.0 T and at 1.5 T of different scanners in liver,spleen and pancreas of healthy volunteers.Methods Abdominal DWI were performed on 33 healthy volunteers by using GE 1.5 T,Siemens 1.5 T and Philips 3.0 T MR scanners.The mean ADC values of liver,spleen,pancreatic head,body,and tail were calculated.The ADC data were analyzed by using paired-sample t tests.Results The mean ADC of liver at GE 1.5 T,Siemens 1.5T and Philips 3.0 T were (1.56 ±0.10) ×10-3,(1.67 ±0.15) ×10-3 and(1.35 ±0.12) ×10-3 mm2/s,spleen were (0.96±0.10) × 10 3,(0.98 ±0.11) ×10-3and(0.81 ±0.14) × 10-3 mm2/s,pancreatic head were (2.09 ± 0.27) × 10-3,(2.20 ± 0.21) × 10-3 and (2.05 ± 0.27) × 10-3 mm2/s,pancreatic body were (2.03 ± 0.27) × 10-3,(2.09 ± 0.30) × 10-3 and (1.76 ± 0.25) × 10-3 mm2/s,pancreatic tail were (1.88 ± 0.28) × 10-3,(1.88 ± 0.27) × 10-3 and (1.56 ± 0.27) × 10-3 mm2/s,respectively.From the aspect of different field strength MR scanners,there were significant differences in mean ADC of liver (t =11.073,P <0.01 in GE 1.5 T vs Philips 3.0 T; t =12.795,P <0.01 in Siemens 1.5 T vs Philips 3.0 T),spleen (t =4.143,P < 0.01 in GE 1.5 T vs Philips 3.0 T; t =5.376,P < 0.01 in Siemens 1.5 T vs Philips 3.0 T),pancreatic body (t =4.677,P < 0.01 in GE 1.5 T vs Philips 3.0 T; t =5.174,P <0.01 in Siemens 1.5 T vs Philips 3.0 T) and tail (t =5.356,P <0.01 in GE 1.5 T vs Philips 3.0 T; t =4.648,P <0.01 in Siemens 1.5 T vs Philips 3.0 T),but there were no significant differences in mean ADC of pancreatic head (t =0.340,P > 0.05 in GE 1.5 T vs Philips 3.0 T; t =1.349,P > 0.05 in Siemens 1.5 T vs Philips3.0 T).From the aspect of different 1.5 T MR scanners,there were significant differences in mean ADC of liver (t =-4.563,P < 0.01),but there were no significant differences in mean ADC of spleen (t =-0.732,P > 0.05),pancreatic head (t =-0.879,P > 0.05),body (t =-1.020,P >0.05) and tail (t =0.054,P > 0.05).Conclusion Between 1.5 T and 3.0 T MR scanners,there were significant differences in mean ADC of liver,spleen,pancreatic body and tail,but there were no significant differences in mean ADC of pancreatic head.At different 1.5 T MR scanners,there were significant differences in mean ADC of liver,but there were no significant differences in mean ADC of spleen,pancreatic head,body and tail.
3.Practical experience about the compatibility of PDF converter in ECG information system.
Gang YANG ; Weishi LU ; Jiacheng ZHOU
Chinese Journal of Medical Instrumentation 2009;33(6):455-457
OBJECTIVETo find a way to view ECG from different manufacturers in electrocardiogram information system.
METHODSDifferent format ECG data were transmitted to ECG center by different ways. Corresponding analysis software was used to make the diagnosis reports in the center. Then we use PDF convert to change all ECG reports into PDF format. The electrocardiogram information system manage these PDF format ECG data for clinic user.
RESULTSThe ECG reports form several major ECG manufacturers were transformed to PDF format successfully. In the electrocardiogram information system it is freely to view the ECG figure.
CONCLUSIONSPDF format ECG report is a practicable way to solve the compatibility problem in electrocardiogram information system.
Electrocardiography ; standards ; Hospital Information Systems ; Image Processing, Computer-Assisted ; methods ; Software
4.The correlation and dose-response relationship of pulse pressure and pulse pressure index with metabolic syndrome in the elderly
Minrui XU ; Deren QIANG ; Suyi SHI ; Jing ZONG ; Jiacheng YANG ; Yuan TAO
Chinese Journal of Geriatrics 2021;40(1):57-61
Objective:To investigate the correlation and dose-response relationship of pulse pressure and pulse pressure index with metabolic syndrome in the elderly population.Methods:This was a cross-sectional study.A total of 114 212 subjects aged 65 years and over in Wujin District receiving health examination in 2019 were enrolled, including 40 388(35.4%)patients with metabolic syndrome.The survey contents included a questionnaire, physical examination and laboratory tests.Logistic regression and restricted cubic splines were used to analyze the correlation and dose-response relationship of pulse pressure and pulse pressure index with metabolic syndrome.Results:With increases in pulse pressure levels and pulse pressure index, the prevalence of metabolic syndrome and its components increased accordingly( P<0.01). After adjusting for confounding factors, the ORvalue of metabolic syndrome gradually increased along with increases in pulse pressure and pulse pressure index.Compared with the first quartile, pulse pressure and pulse pressure index in the second, third and fourth quartiles were correlated with metabolic syndrome(pulse pressure: OR=1.52, 95% CI: 1.47~1.58, OR=1.89, 95% CI: 1.82~1.96 and OR=2.15, 95% CI: 2.07~2.23, respectively; pulse pressure index: OR=1.22, 95% CI: 1.18~1.26, OR=1.36, 95% CI: 1.31~1.41 and OR=1.47, 95% CI: 1.42~1.53, respectively). Restricted cubic spline analysis showed that pulse pressure and pulse pressure index had non-linear dose-response relationships with metabolic syndrome( χ2=309.23 and 57.14, P<0.01). Conclusions:Pulse pressure and pulse pressure index are correlated and show non-linear dose-response relationships with metabolic syndrome and its components in the elderly.
5.Preliminary application of MR diffusion weighted imaging in the diagnosing and evaluating therapeutic effect of autoimmune pancreatitis
Jiacheng ZHANG ; Chen ZHANG ; Zhenghan YANG ; Weilin TANG ; Jinzhou FANG ; Zhongfei XU ; Ye TAN ; Jie ZHU ; Min CHEN ; Cheng ZHOU
Chinese Journal of Radiology 2014;(6):484-488
Objective To investigate the role of DWI in differentiating autoimmune pancreatitis ( AIP) from pancreatic cancer ( PC) , and in the therapeutic effect evaluation of AIP.Methods DWI data of 26 cases with AIP , 29 cases with PC and 30 cases with normal pancreas ( NP ) were analyzed retrospectively.The distribution type and signal feature of lesions in cases with AIP or PC were evaluated by Chi-squared test.ADC values were measured and compared among 3 groups by Kruskal-Wallis test.ADC values of AIP and PC were analyzed by using ROC curve to determine the optimal threshold and diagnostic efficiency.ADC values were compared in AIP ( n=15 ) before and after steroid therapy by paired t test.Results Diffuse lesions were detected in 21 cases with AIP and 3 cases with PC, while focal lesions in 5 cases with AIP and 26 cases with PC (χ2 =27.64, P<0.01).On DWI, most of AIP (n=19) and PC (n=24) showed hyper-intense signal, while a few of AIP (n=7) and PC (n =5) showed iso-intense signal (χ2 =0.75, P>0.05).The median ADC values of AIP, PC and NP were 1.15 ×10 -3,1.35 × 10 -3 ,1.59 ×10-3 mm2/s, respectively; and the difference was statistically significant ( H=45.60, P <0.01).ROC analysis yielded an optimal ADC cutoff value of 1.255 ×10 -3 mm2/s (80.8% sensitivity, 79.3%specificity and 0.871 area under curve for the diagnosis of AIP ).ADC values of AIP ( n=15) were markedly increased from the baseline (1.10 ±0.19) ×10 -3 to (1.57 ±0.12) ×10 -3 mm2/s after steroid therapy (t=-10.14, P<0.01).Conclusions DWI may be useful for diagnosing and evaluating the effect of steroid therapy in AIP.ADC values of AIP were significantly lower than those of pancreatic cancer and normal pancreas.After steroid therapy , ADC values were markedly increased in AIP.
6.Application value of pancreaticojejunostomy with double-layer continuous suture in total laparoscopic pancreaticoduodenectomy
Jiacheng WU ; Xuewen ZHANG ; Yongsheng YANG ; Yu WANG ; He FANG ; Ruixin LIN
Chinese Journal of Digestive Surgery 2018;17(7):746-751
Objective To investigate the application value of pancreaticojejunostomy with double-layer continuous suture in total laparoscopic pancreaticoduodenectomy (TLPD).Methods The retrospective crosssectional study was conducted.The clinicopathological data of 21 patients who underwent TLPD with pancreaticojejunostomy using double-layer continuous suture in the Second Hospital of Jilin University between January and December 2017 were collected.The anastomosis used Child method,and pancreaticojejunostomy,choledochojejunostomy and gastroenteric anastomosis in turn were done.Observation indicators:(1) surgical and postoperative recovery;(2) postoperative pathological examination;(3) follow-up and survival situations.Follow-up using outpatient examination and telephone interview was performed to detect postoperative survival and tumor recurrence or metastasis up to February 2018.Measurement data with normal distribution were represented as x±s.Measurement data with skewed distribution were described as M (P25,P75).Results (1) Surgical and postoperative recovery:21 patients underwent successful TLPD with pancreaticojejunostomy with double-layer continuous suture.The operation time,time of pancreaticojejunostomy and volume of intraoperative blood loss were respectively (352±25)minutes,(46±8)minutes and (168±34) mL.There was no intraoperative blood transfusion.The time of postoperative abdominal drainage-tube removal was (10.1±4.4)days.Of 21 patients,12 were complicated with biochemical fistula,and 3 with grading B of pancreatic fistula (pancreatic duct in type Ⅱ),and they were improved by inhibiting pancreatic secretion and drainage patency.There was no occurrence of biliary fistula,chylous fistula,postoperative bleeding,abdominal infection and delayed gastric emptying.The duration of postoperative hospital stay of 21 patients was (11.3± 2.0) days.(2) Postoperative pathological examination:surgical margins of 21 patients were negative.The pathological type:8,6,4,2 and 1 patients were diagnosed as distal bile duct cancer,ampulla cancer,duodenal papilla and duodenal cancer,pancreatic head cancer and neuroendocrine cancer of ampulla,respectively.(3) Follow-up and survival situations:21 patients were followed up for 3-12 months,with a median time of 7 months.During the follow-up,all the patients survived,and there was no tumor recurrence and metastasis.Conclusion Pancreaticojejunostomy with double-layer continuous suture is safe and feasible for TLPD,with advantages of exact anastomosis effect and good application value.
7.Treatment of Merkel cell carcinoma
Aimin YANG ; Jiangwei CHENG ; Jiacheng HUANG ; Ying CEN ; Junjie CHEN
Chinese Journal of Dermatology 2024;57(7):665-667
Surgical resection and radiotherapy have been commonly applied to the treatment of early- and intermediate-stage Merkel cell carcinoma. In recent years, immunotherapy based on immunogenic characteristics of Merkel cell carcinoma has been proved to be effective in the treatment of advanced Merkel cell carcinoma. This review focuses on advances in the treatment of Merkel cell carcinoma, and provides a reference for its clinical diagnosis and treatment.
8.Effect of underdilated stent on the occurrence of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt creation
Chaoyang WANG ; Bin XIONG ; Jiacheng LIU ; Chongtu YANG ; Shuguang JU ; Yaowei BAI ; Wei YAO ; Yingliang WANG
Chinese Journal of Internal Medicine 2022;61(5):537-542
Objective:To evaluate whether underdilated stent could reduce the occurrence of hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS) creation.Methods:A total of 197 patients with decompensated liver cirrhosis, who had underwent TIPS creation at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, were analyzed retrospectively, including 110 males and 87 females with age 25-79 (54±11) years old. Uncovered and covered stents with 8 mm diameter were implanted in all subjects, and then dilated by balloon catheters with 6 mm or 8 mm diameter. The patients were divided into two groups, including underdilated group (6 mm, n=105) and control group (8 mm, n=92).Kaplan-Meier curves were used to illustrate cumulative rate of HE, and the differences were assessed with the log-rank test. Multivariate analyses with a Cox regression model were conducted to explore the risk factors for HE. Results:During a median follow-up period of 29 (12-54) months, 16 (15.2%) patients developed HE in the underdilated group and 27 (29.3%) patients in the control group. There was a significant difference in the cumulative rate of HE ( P=0.014), but no statistical differences were found in terms of variceal rebleeding, shunt dysfunction and survival between the two groups ( P=0.608, P=0.659, P=0.968). In multivariated analysis, group assignment (underdilated vs. control, HR=0.291, 95% CI 0.125-0.674, P=0.004) was identified as an independent risk factor for HE after TIPS creation. Conclusion:Underdilated TIPS could reduced the risk of HE compared with completely dilated TIPS, with comparable risk of variceal rebleeding, shunt dysfunction and mortality. And it is worthy of applying this technique to a large sample of patients in clinical practice.
9.Bioinformatics analysis of potential biomarkers for primary osteoporosis
Jiacheng ZHAO ; Shiqi REN ; Qin ZHU ; Jiajia LIU ; Xiang ZHU ; Yang YANG
Chinese Journal of Tissue Engineering Research 2025;29(8):1741-1750
BACKGROUND:Primary osteoporosis has a high incidence,but the pathogenesis is not fully understood.Currently,there is a lack of effective early screening indicators and treatment programs. OBJECTIVE:To further explore the mechanism of primary osteoporosis through comprehensive bioinformatics analysis. METHODS:The primary osteoporosis data were obtained from the gene expression omnibus(GEO)database,and the differentially expressed genes were screened for Gene Ontology(GO)function and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis.In addition,the differentially expressed genes were subjected to protein-protein interaction network to determine the core genes related to primary osteoporosis,and the least absolute shrinkage and selection operator algorithm was used to identify and verify the primary osteoporosis-related biomarkers.Immune cell correlation analysis,gene enrichment analysis and drug target network analysis were performed.Finally,the biomarkers were validated using qPCR assay. RESULTS AND CONCLUSION:A total of 126 differentially expressed genes and 5 biomarkers including prostaglandins,epidermal growth factor receptor,mitogen-activated protein kinase 3,transforming growth factor B1,and retinoblastoma gene 1 were obtained in this study.GO analysis showed that differentially expressed genes were mainly concentrated in the cellular response to oxidative stress and the regulation of autophagy.KEGG analysis showed that autophagy and senescence pathways were mainly involved.Immunoassay of biomarkers showed that prostaglandins,retinoblastoma gene 1,and mitogen-activated protein kinase 3 were closely related to immune cells.Gene enrichment analysis showed that biomarkers were associated with immune-related pathways.Drug target network analysis showed that the five biomarkers were associated with primary osteoporosis drugs.The results of qPCR showed that the expression of prostaglandins,epidermal growth factor receptor,mitogen-activated protein kinase 3,and transforming growth factor B1 in the primary osteoporosis sample was significantly increased compared with the control sample(P<0.001),while the expression of retinoblastoma gene 1 in the primary osteoporosis sample was significantly decreased compared with the control sample(P<0.001).Overall,the study screened and validated five potential biomarkers of primary osteoporosis,providing a reference basis for further in-depth investigation of the pathogenesis,early screening and diagnosis,and targeted treatment of primary osteoporosis.
10.Total hip arthroplasty in treating elderly femoral neck fracture with hemiplegia
Jiacheng ZANG ; 300211 天津市天津医院创伤骨科 ; Yumin WANG ; Jingbo WANG ; Xin LI ; Shuang YANG ; Xinlong MA
Chinese Journal of Orthopaedics 2017;37(23):1466-1473
Objective To investigate the clinical effects of high restrictive anti-dislocation prosthesis total hip arthroplasty(THA)in treating elderly femoral neck fracture patients with hemiplegia.Methods From June 2015 to January 2017,Fortythree elderly femoral neck fracture patients with hemiplegia were treated with CombiCup THA system.There were 15 males and 28 females with an average age of 71.5±5.6 years (60-84 years).The left side was involved in 20 cases,while the right side in 23 cases.There were 15 cases with Garden Ⅲ type and 28 cases with type Ⅳ.Lower limb muscle strength grade were 20 cases in grade 3,19 cases in grade 4,and 5 cases in grade 5.Sixteen cases walked independently before injury,while 27 of them walked with the aid of crutches.The duration between injuries to operation ranged from 2 days to 5 days.The size of the prosthesis and offset distance were recorded by template technique pre-operation.The appropriate type of prosthesis was selected to restore the offset and to reconstruct the abductor muscle arm,according to the actual measurement in the operation and the preoperative plan.Based on the bone mineral density and medullary cavity morphology,biological or cemented femoral stem prosthesis was selected.The quality of the implant and the length of both lower limbs were evaluated by pelvic X-ray immediately after operation.The patients were followed-up at 2 weeks,1 months,2 months,3 months,6 months,1 and 2 years.Functional exercise guidance and complications were recorded at the follow-up duration.At the last follow-up,the hip function and limb function were evaluated according to the Harris score and Fugl-Meyer motor function assessment respectively.Results Based on pelvic X-ray evaluation after operation,all prosthesis position were favorable with the average angle of acetabular abduction 45.1±2.3 degrees and the length difference of both limbs less than 5 mm (average 2.2±0.8 mm).The follow-up duration ranged from 6 to 24 months with an average of 11.2±3.5 months.There was no complication such as prosthesis dislocation and infection.Deep venous thrombosis in calf occurred in 3 patients at 2 days after operation,who underwent recanalization after thrombolysis.At the last follow-up,the average score of Harris hip function and Fugl-Meyer were 90.2±3.8 (77 to 96) and 97.1±2.5 (83 to 100),respectively.No dislocation,infection,loosening,subsidence and osteolysis phenomenon was found during the follow-up.Conclusion The elderly patients with Garden type Ⅲ or Ⅳ femoral neck fractures accompanied with hemiplegia can be treated with anti-dislocation prosthesis THA.It does have the advantages of low dislocation rate and imoroved hemiolegic limb function.