1.Down-regulation of FTO in human gastric cancer and its effect on cell line MGC-803 function
Jingnan PI ; Jie ZHANG ; Xuepeng WANG ; Jiachao XIONG ; Jia YU
Basic & Clinical Medicine 2017;37(7):907-911
Objective To investigate the expression of FTO in gastric cancer tissues and the functional significance of FTO in MGC-803 cell line.Methods The FTO mRNA was detected by RT-qPCR in 54 cases of gastric cancer samples and their paired adjacent normal control tissues.The effect of FTO overexpression in MGC-803 on cell proliferation,cell migration and invasion were detected by CCK-8,wound heal and ranswell assays,respectively.Results The expression of FTO mRNA was significantly lower than that of adjacent tissues(P<O.05).Furthermore,overexpression of FTO in MGC-803 cells inhibited cell proliferation,cell migration and invasion.Conclusions FTO is low expressed in gastric cancer tissues and inhibits gastric cancer cell line MGC-803 proliferation,migration and invasion.FTO is closely associated with the development of gastric cancer.
2. Research progress of adipose-derived stem cells on refractory wounds
Chinese Journal of Reparative and Reconstructive Surgery 2018;32(4):457-461
Objective: To summarize the recent advances in the research of adipose-derived stem cells (ADSCs) for the treatment of refractory wounds.