1.Research of the development strategy of a children's hospital in Shanghai
Guoying HUANG ; Di XUE ; Lianhua CAO ; Xiayan HUANG ; Xiaohu WU ; Jiabao FU
Chinese Journal of Hospital Administration 2009;25(7):453-456
This paper introduced the background, contents, methods and main results, as well as its strategic goals for the next decade and strategic development planning for the next five years. The authors believed that inherent logic, supports from the governments and other authorities as well as the executive power of the hospital in question were the basic factors for the success of its strategic planning and implementation. The authors also held that a package of actions would be conducive to correctly positioning tertiary hospitals and that medical services pricing ought to be rational for the costs, technology and policy guidelines of medical care.
2.Research progress on the mechanism of ferroptosis in septic cardiomyopathy
Jiayu SONG ; Yiming HE ; Kaixuan ZHOU ; Jiabao XUE ; Xue ZI ; Lijing LI
Chinese Critical Care Medicine 2022;34(10):1107-1111
Sepsis is a serious complication of infection, and its further development may lead to multi-organ dysfunction syndrome. Sepsis cardiomyopathy is a common complication of sepsis and has been directly linked to high mortality. Although the pathogenesis of septic cardiomyopathy is not fully understood, in-depth study of the pathogenesis of septic cardiomyopathy and the identification of its potential therapeutic targets may reduce mortality in patients with sepsis. Ferroptosis is an iron-dependent mode of cell death that has been shown to be involved in the pathophysiological mechanisms of many diseases. Some related studies have reported that ferroptosis may be a potential mechanism of septic cardiomyopathy. This review provides new insights into the mechanisms of mitochondrial dysfunction, lipid peroxidation, xc-system, glutathione peroxidase 4 (GPX4), iron metabolism and the role of ferroptosiswith septic cardiomyopathy for further research and treatment of septic cardiomyopathy.