1.Topo II alpha in breast cancer: an update.
Jia WEI ; Fang-fang LIU ; Li FU
Chinese Journal of Pathology 2008;37(2):132-135
2.Updates on genes related to breast cancer metastasis.
Bing-bing LIU ; Jia WEI ; Li FU
Chinese Journal of Pathology 2008;37(4):266-269
Acetyltransferases
;
genetics
;
Breast Neoplasms
;
genetics
;
Female
;
GPI-Linked Proteins
;
Gene Expression Regulation, Neoplastic
;
genetics
;
Humans
;
Membrane Glycoproteins
;
genetics
;
Neoplasm Metastasis
;
genetics
;
physiopathology
;
S100 Proteins
;
genetics
;
Transcription Factors
;
genetics
3.Effect of CXCL12 in tumor microenvironment.
Fang-Fang LIU ; Jia WEI ; Li FU
Chinese Journal of Pathology 2008;37(3):193-196
4.The applied value of 256 spiral CT dynamic volume scanning in the diagnosis of moyamoya disease
Huijuan JIA ; Li WEI ; Yucun FU
Chinese Journal of Postgraduates of Medicine 2014;37(18):12-14
Objective To discuss the value of 256 spiral CT dynamic volume scanning in the diagnosis of moyamoya disease.Methods Twenty-three patients with moyamoya disease undergoing 256 spiral CT dynamic volume scanning (moyamoya group) were selected,and 18 patients having cerebrovascular disease symptoms,but the brain artery without stenosis (control group) were also selected.The volume reconstruction (VR),maximum intensity projection (MIP) and cerebral CT perfusion imaging was displayed.The cerebral CT perfusion imaging parameters of anterior,middle,posterior cerebral artery were measured and analyzed.Results VR,MIP could well reproduce lesion location,degree of stenosis and skull base abnormal vascular network change.Compared with control group,the cerebral blood volume (CBV) was increased [(8.46 ±0.91) ml/100 g vs.(2.92 ±0.72) ml/100 g],time to peak (TTP) was increased [(30.27 ±5.02) s vs.(24.83 ±4.07) s] in anterior cerebral artery,and there was significant difference (P < 0.01),but there was no significant difference in the cerebral blood flow (CBF),the mean transit time (MTT)(P > 0.05).Compared with control group,CBV was increased [(8.06 ± 1.05) ml/100 g vs.(6.08 ± 0.56) ml/100 g],MTT,TTP was increased [(6.34 ± 1.01) s vs.(3.83 ± 0.83) s,(32.06 ± 2.55) s vs.(25.83 ± 2.34) s] in middle cerebral artery,and there was significant difference (P< 0.01),but there was no significant difference in CBF (P > 0.05).Compared with control group,there was no significant difference in the cerebral CT perfusion imaging parameters of posterior cerebral artery (P >0.05).Conclusion 256 spiral CT dynamic volume scanning can be combined with morphology and function imagings,and has important guiding significance for diagnosis of moyamoya disease.
6.Clinical observation of neutrophil adhesion molecules expression during coronary artery surgery under cardiopulmonary bypass
Wei ZHAO ; Chenghui LI ; Naiguang JIA
Chinese Journal of Thoracic and Cardiovascular Surgery 1995;0(05):-
Objective To investigate the changes of CD11b on neutrophils during myocardial ischemia-reperfusion injury. Methods 12 patients undergoing coronary bypass grafts under CPB were studied. Blood samples were obtained from the coronary (coronary sinus) and systemic circulation (central venous and CPB machine), respectively. Samples obtained from coronary and systemic circulation were taken before the beginning of CPB, during CPB and after cardiac reperfusion. Neutrophil CD11b expression and serum cTnI concentration were measured. Results (1)Expression of CD11b increased gradually in systemic circulation during CPB and after reperfusion (P
7.Detection of Extended-spectrum Beta-lactamases and Analysis of Antibiotics Resistance of Clinical Isolates from Pneumonia Patients
Chinese Journal of Nosocomiology 2006;0(08):-
0.05).Except imipenem and ampicillin,there was significant difference between the resistance of non-ESBLs-producing strains from CAP and from HAP to other eleven kinds of antibiotics(?2 test,P
8.Extended-spectrum ?-Lactamases and Resistance in Escherichia coli Isolated from Biliary Tract and Abdominal Cavity
Yunsong LI ; Jia WEI ; Zizhong XIONG
Chinese Journal of Nosocomiology 2006;0(05):-
OBJECTIVE To investigate the prevalence of extended-spectrum ?-lactamases(ESBLs) and the resistance in Escherichia coli isolates from biliary tract and abdominal cavity.METHODS ESBLs-producers were detected by CLSI Phenotypic Confirmatory Test and susceptibilities were tested by agar dilution method.RESULTS 50.1% Of isolates were ESBLs producers in those isolates.ESBLs producers were highly resistant to ampicillin,cefazolin,cefuroxime,fluoroquinolones,and cefotaxime.The resistant rate to ceftazidime,cefepime,cefoperazone-sulbactam,amikacin,and cefmetazole was less than 40%.None was resistant to meropenem in ESBLs producers.In non-ESBLs producers the resistant rate to ampicillin,cefazolin,cefuroxime,fluoroquinolones was more than 40% and most were susceptible to other antimicrobial agents.The resistant rate to ampicillin,cefazolin,cefuroxime,and ciprofloxacin was significantly higher in ESBLs producers than non-ESBLs producers.CONCLUSIONS With resistance to most of antimicrobial agents,ESBLs-producers were highly prevalent in E.coli isolates from biliary tract and abdominal cavity,so more attention should be paid to survey and detect those strains.
9.The value of blood lipid and CA125 in identification diagnosis between lung cancer and pulmonary tuberculosis
Hui LI ; Tingting WANG ; Jia WEI
International Journal of Laboratory Medicine 2016;37(19):2677-2679
Objective To explore the value of blood lipid and CA125 in identification diagnosis between lung cancer and pulmo‐nary tuberculosis .Methods The blood lipid and serum CA125 levels in 131 patients with lung cancer( Ⅰ - Ⅳ stage) ,53 patients with pulmonary tuberculosis and 60 normal controls were determined by biochemstry ,immunoturbidimetry and electrochemilumi‐nescence immunoassay and was done compared study .Results The serum TC and HDL‐C level in 131 patients with lung cancer were decreased with severity and were lower than in those of in 53 patients with pulmonary tuberculosis(TC :P< 0 .05 ,< 0 .05 ,<0 .01 and < 0 .001 respectively ;HDL‐C :P< 0 .05 ,< 0 .05 ,< 0 .01 and < 0 .01 respectively) .The serum LDL‐C level was no differ‐ences between lung cancer( Ⅰ - Ⅲ stage) and in 53 patients with pulmonary tuberculosis(P> 0 .05) only the lung cancer( Ⅳ stage) was a little increased(P< 0 .05) .The serum TG and ApoB/ApoA1 ratio levels in 131 patients with lung cancer( Ⅰ - Ⅳ stage) were increased with severity and were significantly higher than in those of 53 patients with pulmonary tuberculosis (TG :P < 0 .05 ,< 0 .05 ,< 0 .01 and < 0 .01 respectively ;ApoB/ApoA1 :P< 0 .05 ,< 0 .05 ,< 0 .01 and < 0 .01 respectively) .The level of CA125 in 131 patients with lung cancer was significantly higher than in those 53 patients with pulmonary tuberculosis(P< 0 .001) .Conclusion The serum TC and HDL‐C ,TG ,ApoB/ApoA1 ratio and CA125 levels may be the indexs of identification diagnosis between lung cancer and pulmonary tuberculosis .
10.Research frontiers in foreign medical informatics
Li WEI ; Yunqiu ZHANG ; Jia FENG
Chinese Journal of Medical Library and Information Science 2015;(11):27-31
The research frontiers in foreign medical informatics were analyzed according to the co-occurrence net-work map, hotspots density map and cluster tree map that were plotted for the PubMed-covered scientific papers on medical informatics from 2010 to 2014 , which showed that the research frontiers in foreign medical informatics were the natural language processing and data mining of electronic health records, medical decision-making assistant system, computer-aided drug therapy, clinical decision-making support, health service attitude, health service quality, health service model, medical records system and its linkage, information system and its integration.