This paper reviewed the award of the title for senior professional post from four aspects: changing process of the technical post title enforcement efficiency, characteristic and problem, in Tianjin Medical University General Hospital in recent eight years. It was indicated that the new evaluation of high ranking professional title played a rule in inspiring and leading effect on the teaching and research of the hos-pital.

The core problem of the brain-computer interface (BCI) based on neural signal is estimating neural firing rate from a spike train and then using neural population decoding algorithm to decode movement trajectory.In this artical, we review the theoretical basis of both classic and current firing rate estimations and compare the advantages and drawbacks of these methods. At the same time we also review the decoding algorithm which using neural firing rate to decode movement trajectory in brain- computer interface: population vector algorithm, linear filter and kalman filter. At last, some results applying these estimators of firing rate to decode arm movement in BCI are introduced. The results show apparently different performance of the different firing rate estimators, while minimal differences are observed in the actual application of BCI.

Objective To study the expression of intercellular adhesion molecule-1 (ICAM-1), interleukin-1? (IL-1?) and ultrastructure changes in capillaries and to explore whether capillaries may play a role in the pathogenesis of polymyositis (PM). Methods Ten cases of patients with PM were collected. Control group 1 consists of 6 patients with other myopathies,Control group 2 consists of 2 muscle specimens without clinical and histological evidence of a neuromuscular disorder. An immunohistochemical technique was applied to indentify the expression of ICAM-1 and IL-1? in capillaries in the PM group, Control group 1 and Control group 2. The first analysis was a qualitative assessment. For the second analysis, the number of positive mononuclear cells and capillaries of the whole tissue section from each patient and control was estimated for all the immunologic markers investigated. 10 PM patients were also examined by electron microscopy in order to observe capillary changes in muscles. Results We found that the capillaries in tissues from PM (median (64?20)/mm~2 of tissue, ranging 44—106/mm~2) were significantly less than those from controls (median (157?46)/mm~2 of tissue, ranging 93—213/mm~2) (t=-4.523, P=0.003). A significantly higher number of capillaries expressed IL-1? in the PM group than in the Control group 1(median 15/mm~2 of tissue (ranging 6—46/mm~2) vs 3/mm~2 of tissue (ranging 0—16/mm~2)) (t=3.721, P=0.003). There was no significant difference between PM group and Control group 1 in the number of capillaries expressing ICAM-1 (t=0.529,P=0.617). However, ICAM-1 expressions in endothelial cells of capillaries were stronger in PM patients as IL-1?. Electronic microscopy found capillary changes in 6 PM patients, showing as thickening and duplication of basement membrane, swelling of endothelial cells, stenosis or occlusion of vessels.Conclusion Our findings indicate that capillary changes might take a role in the pathogenesis of PM.

The problem that the medical information work is specific expression of hospital comprehensive efficiency is pointed out. By giving medical information personnel is the key of the information construction, the emphasizing important effect of it and aiming directly at "patient-centered" to produce the construction level on the function of information center and medical information personnel. The hospital development combines with reality of medical information to prefer culti- vation suggestion of the medical information personnel.

OBJECTIVETo observe the effect of Yijing Recipe (YR) on the apoptosis of testis spermatogenic cells and the protein expression of Bcl-2/Bax in rats with adenine induced infertility.

METHODSTotally 75 Wistar rats were randomly divided into 5 groups, i.e., the blank control group, the model group, the high dose YR group, the middle dose YR group, and the low dose YR group, 15 in each group. Except those in the blank control group, rats in the rest groups were intragastrically administered with adenine for 10 successive days. From the 11th day, rats in the blank control group and the model group were fed with equal volume of normal saline. Rats in the YR groups were intragastrically administered with YR at different doses (3.38 g/100 g; 1.69 g/100 g; 0.85 g/100 g), once daily for 20 consecutive days. All rats were killed by the end of the experiment and their testes extracted. The apoptosis of spermatogenic cells and the expression of Bcl-2/Bax proteins were detected by terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling (TUNEL) and SABC method.

RESULTSCompared with the blank control group, the Bcl-2 protein expression decreased, the Bax protein expression increased, and the apoptosis index increased in the model group, showing statistical difference (P <0.01). Compared with the model group, the Bcl-2 protein expression increased in the three YR treated groups (P <0.01, P <0.05). The Bax protein expression level decreased in the high and middle dose YR groups (P <0. 01, P <0. 05). The apoptosis index decreased in the middle dose YR group (P <0.01).

CONCLUSIONYR could inhibit the apoptosis of spermatogenic cells through regulating the expression of Bcl-2 and Bax protein in the testis.

Animals ; Apoptosis ; drug effects ; Drugs, Chinese Herbal ; pharmacology ; Infertility ; metabolism ; Male ; Rats ; Spermatogenesis ; drug effects ; Testis ; metabolism ; bcl-2-Associated X Protein ; metabolism

30%-50% patients with non-small cell lung cancer (NSCLC)will occur cerebral metastasis in the course of their illnesses.NSCLC with brain metastases is one of the difficulties in cancer treatment. Treatment measures include surgery,radiotherapy,chemotherapy,biological targeted therapy and so on.The new prognostic scoring system is recommended to predict the prognosis of patients.Individualized treatment methods should be chosen according to prognostic score.

Sperm ultrastructural abnormalities are often associated with sperm motility, the integrity of genetic material, and the fertilization potential. The investigation of sperm ultrastructural abnormalities is based on the evolution of microscopy techniques. In his paper, we review the improvement of the microscopy techniques and the ultrastructure of several specific morphological defects and he apoptotic spermatogenic cells in order to expound the significance of sperm ultrastructural observation in clinical practice. We deem it necessary to analyze the sperm ultrastructure before exploring the pathology and adopting assisted reproductive technology for some special patients with teratozoospermia.
Humans ; Male ; Microscopy ; Spermatozoa ; abnormalities ; ultrastructure

The paper is to systematically evaluate the efficacy and safety of Deng Zhan Xi Xin injection ( DZXXI) as an adjuvant treatment for patients with angina pectoris. The Cochrane Library, Medline, EMbase, CBM, CNKI, VIP, and Wan fang Data base were searched. Randomized controlled trials (RCTs) of DZXXI combined with western medicine routine treatment versus western medicine routine treatment alone for angina pectoris patients were all included. All trials were assessed according to the Cochrane Reviewer' s Handbook 5.1 for Systematic Reviews of Intervention and Meta analyses were performed by RevMan 5. 2 Software. A total of 30RCTs (3 086 patients including 1 572 patients of treatment group and 1 514 patients of control group) were included. Meta-analysis of treatment group compared with control group showed superior effect over reducing cardiovascular events ( OR = 0.33; 95% CI: [0.16, 0.67], P = 0.002, improving effective rate of DZXXI as adjuvant treatment for angina pectoris patients (OR = 3.97; 95% CI: [3.15, 5.02]; P < 0.000 010 and electrocardiogram curative effect (OR = 2.21; 95% CI; [1.83, 2.68]; P < 0.000 010. Funnel figure seemed that there was publication bias. The current limited evidence showed that when compared with the control group, treatment group was superior in improving patients with angina pectoris. But based on the limitations of the study, rigorous design with long follow up clinical trials are necessary for further evidence.
Adjuvants, Pharmaceutic ; Adult ; Aged ; Angina Pectoris ; drug therapy ; physiopathology ; Drugs, Chinese Herbal ; administration & dosage ; Electrocardiography ; Female ; Heart ; physiopathology ; Humans ; Injections ; Male ; Middle Aged ; Randomized Controlled Trials as Topic

Electroencephalogram (EEG) classification for brain-computer interface (BCI) is a new way of realizing human-computer interreaction. In this paper the application of semi-supervised sparse representation classifier algorithms based on help training to EEG classification for BCI is reported. Firstly, the correlation information of the unlabeled data is obtained by sparse representation classifier and some data with high correlation selected. Secondly, the boundary information of the selected data is produced by discriminative classifier, which is the Fisher linear classifier. The final unlabeled data with high confidence are selected by a criterion containing the information of distance and direction. We applied this novel method to the three benchmark datasets, which were BCI I, BCI II_IV and USPS. The classification rate were 97%, 82% and 84.7%, respectively. Moreover the fastest arithmetic rate was just about 0. 2 s. The classification rate and efficiency results of the novel method are both better than those of S3VM and SVM, proving that the proposed method is effective.
Algorithms ; Brain-Computer Interfaces ; Electroencephalography ; classification ; Humans

Aiming at local field potential, the present paper introduces a method of estimating lag of neuron activities between brain areas based on windowed Harmonic wavelet transform (WHWT). Firstly, the WHWT of signals of two brain areas are calculated. Secondly, the instantaneous amplitude of the signals is calculated and finally, these amplitudes are cross-correlated and the lag at which the cross-correlation peak occurs is determined as the lag of neurons activities. Comparing with amplitude cross-correlation based on Gabor wavelet transform (GWT) or Hilbert transform (HT), this method is more precise and efficient in estimating the directionality and lag.
Brain ; physiology ; Humans ; Neurons ; physiology ; Wavelet Analysis