Angiotensin II Type 1 Receptor Blockers ; therapeutic use ; Antiviral Agents ; therapeutic use ; Biomarkers ; blood ; Biopsy ; Elasticity Imaging Techniques ; Humans ; Liver Cirrhosis ; diagnosis ; etiology ; therapy

OBJECTIVE:To provide reference for clinical rational drug use. METHODS:The drug sales amount,DDDs, DDC and major pharmaceutical enterprises in 273 sample hospitals of Yangtze River basin in 2014 were statistically analyzed. RE-SULTS:The growth of consumption sum slowed down gradually. The anti-infective drugs,cardiovascular drugs and nervous sys-tem drugs occupied the medical mainstream market. Top 3 drugs in the list of consumption sum in consecutive 4 quarters were monosialotetrahexosylganglioside,thymic peptide and lansoprazole. Nearly half of top 15 drugs were auxiliary drugs;Chinese pat-ent medicines grew increasingly and appeared in the list. The sales enterprises were mainly domestic enterprises,which concentrat-ed in Sichuan,Chongqing,Jiangsu province,and other places. CONCLUSIONS:The structure of drug use in sample hospitals is basically consistent with the spectrum of disease in China. However,there is deviation between auxiliary drug use and international guide,and the rationality of clinical drug use needs to be improved.

Objective To analyze the physical examination data of 557 faculty and staff working in one uni-versity,in order to provide a basis for control and prevent chronic disease in the same group people .Methods Five physical examination items including blood pressure ,blood sugar,cholesterin,triglyceride and blood uric acid were chosen and analyzed .Results The abnormal rate of high blood pressure was 20.83%,and that in males was obviously higher than the females(χ2 =26.82,P<0.05).The abnormal rate of high blood sugar was 9.69%,and that in males was obviously higher than females (χ2 =19.76,P<0.05).The abnormal rate of high blood uric acid was 16.52%, and that in males was apparently higher than the females (χ2 =10.89,P <0.05).The abnormal rate of high triglyceride was 28.55%,and that in males was obviously higher than females (χ2 =53.92,P<0.05).The abnormal rate of high cholesterin was 42.55%,there was no significant difference in gender (χ2 =0.00,P>0.05).Conclusion The health situation of faculties and staff is not optimistical .It is urgent to strengthen health education in these people .

Asialogycoprotein receptor (ASGPR) is a specific receptor of mammalian hepatocytes,exclusively up-take the glycoprotein in the blood.The number of ASGPR correlates significantly with liver function,and the reduction of the number of ASGPR suggest liver dysfunction.Decreased ASGPR in patients with liver cirrhosis or portal hypertension or hepatocellar carcinoma,lead to varying degrees of liver dysfunction,which made it more susceptible to post operative complications.liver ASGPR scintigraphy with Technetium-99 m DTPA-galactosyl human serum albumin (99m Tc-GSA),combinating with single photon emission computed tomography (SPECT) technology can assess the functional reserve of remnant liver and predict incidence of postoperative complications,then assist to evaluate the use fulness for clinically surgical decisions.Current situation and progress of 99mTc-GSA SPECT imaging in hepatic surgery were reviewed in the paper.

Tumor metastasis and recurrence had become a key to curative effect and long-term survival,and it's hotspot of current clinical oncology research.Differential expression of proteomics between cancer and normal tissue can be used for discovering new tumor markers.Clinical detection of liver cancer-related protein molecules was useful to monitor and assess early diagnosis,recurrence and prognosis of hepatocellular carcinoma.Herein,this article reviewed the research progression of protein molecules in hepatocellular carcinoma.

To train health supervision talents , one of the scarce talent cultivation plans of National Health and Family Planning Commission, the undergraduate of health supervision was set up by Harbin Medical University and approved by the Ministry of education in 2012. According to the problems of personnel training, the competency model of health supervision was established through empirical research, which covered six aspects and 33 factors, and based on the model, the personnel training model was developed to cultivate the compound health supervision talents to meet the demand of health supervision, and the curriculum system covered medical, law, supervision and management courses. In order to realize the target of talent training, some viable measures were taken such as re-forming the traditional teaching methods, establishing comprehensive teachers, strengthening teacher training, and so on.

0.05). Significant difference in diffused carbon monoxide percentage and change of heart rates before and after stair climbing test was found in LPF group (P0.05).Conclusions Patients of lung cancer intolerable for lobectomy by static pulmonary function test can be screened by stair climbing test before surgical operation,which can make some of them regain opportunity of surgical operation.

Objective To promote teaching qualities of pediatrics,problem-based learning (PBL)and lecture-based learnin(gLBL)were contrasted,and effects of the new teaching method were evaluated.Methods 58 medical students of English class Grade 2004 were chosen and divided into two groups,namely,PBL group,LBL group,each taught through the corresponding method in the chapter Rickets of Vitamin D Deficiency.At the end of the course,an objective exam was taken and the scores,checkout rate and excellent rate were used to assess the teaching quality.Results The scores and checkout rate of case analysis of the students in the PBL group are higher than that in the LBL group.Conclusion The approach of PBL can elevate the students'clinical thinking capability.

Objective To explore the cardiac differentiation of human embryonic stem cells(ESCs)in coculturing with human fetal cardiomyocytes.Methods Fetal cardiomyocytes and fibroblasts were obtained from the aborted fetus,and human ESCs were from the inner cell mass(ICM)of the surplus embryos for tube babies,with the treated fibroblast as feeder layer.Human ESCs of passage 2 to 5 were cocultured with fetal cardiomyocytes at the ratio of 1∶2,and the XY chromosome types of these two kinds of human cells were different to each other in order to be marked.At the same time,human ESCs without coculture were used as negative control.The cocultured cells were harvested 5 days later and were double-stained with human XY chromosome probe and cardiac specific antibody(desmin or cardiac troponin I,cTnI).Results On coculture day 5,40%-50% human ESCs expressed cardiac specific antigens,and human ESCs without coculture did not express those antigens.Conclusion Human ESCs could be induced into cardiac differentiation by the coculture with fetal cardiomyocytes,and hopefully they will be the candidate for cell transplantation of heart.