The external medicine is an indispensable treatment of traditional Chinese medicine (TCM) surgery.The application of Hg is one of the characteristics of TCM surgery medicine for external use.This paper analyzes the present situation of clinical application of Hg and summarizes the common adverse reactions in the literature.The focus of the research on the development of new drugs containing Hg in traditional Chinese medicine is discussed.

Traditional Chinese medicine (TCM) for external use in the treatment of surgical disease has good clinical effect and security,even played a unique effect.At present,surgical department of TCM lack of external application drug.The hospital's own production of external use drug cannot meet the clinical needs,seriously restricting the development of surgical department of TCM.Under the background of attaching great importance to new drug innovation research and development in our country,in the caseof clinical demand of external application drug increases year by year,it is imperative to promote external application drug research and development.This article summarizes the clinical application situation of external application drug,sums up the opportunity and the challenge of new drug research and development,analyses the difficulties and problems in research and development,and the countermeasures were discussed.

Influenza (hereinafter referred to as "flu") guidelines is spe cifically defined to guide the clinical research for new drug of traditional Chinese medicine and the technical standards that the manager,applicant and researcher shall abide by.This article discusses the revision status of flue guidelines for a better understanding and aims to play a guiding role in the research for the new drug development of traditional Chinese medicine.

Traditional Chinese medicine (TCM) orthopedics formula is an important part of the prevention and treatment of orthopedics disease,which has curative effect and the advantages of the whole regulation,but it needs to strengthen its clinical development and reasonable application in clinical.In this paper,by reviewing the current clinical present situation and some problems of the research and development about the TCM orthopedics formula,research and development direction were put forward:the source of prescription,the change of disease spectrum,the clinical location,the apphcation of toxic drugs and animal materials,and the quality control of clinical trials should be paid attentions to,hoping to provide some thoughts for the research and development of TCM orthopedics formula.

Diabetic foot ulcer (DFU) is one of the serious complications of diabetes.With high disability,high amputation rate,serious harm to the physical and mental health of diabetes patients.Traditional Chinese medicine drugs for external use has a certain effect and advantages for treatment of DFU.In this paper analyzes the clinical characteristics of DFU and the status of external drug application,and the necessity of research and development of traditional Chinese medicine for DFU treatment.In the article pointed out the difficulties and of the concerns in process of clinical trials for the DFU traditional Chinese medicine research and development.The preliminary recommendations are given in this article.

Knee osteoarthritis (KOA) is a clinical common and frequent ly-occurring disease,traditional Chinese medicine (TCM) and Chinese medicine have certain advantages for patients in the treatment of early-middle period KOA.In this paper,by reviewingthe clinical feature,evaluation methods and present status of treatment of KOA,the evaluation of traditional Chinese medicine of KOA was proposed.the disease characteristics and clinical localization and clinical characteristics of TCM should be paid attention to,so as to select the evaluation method that can reflect the treatment of characteristics.

Knee osteoarthritis(KOA) is a clinical common and frequently -occurring disease,traditional Chinese medicine (TCM) and Chinese medicine has a certain advantage for patients in the treatment of early-middle period.In this paper,review the clinical feature,evaluation methods and present status of treatment of KOA,offer the evaluation of traditional Chinese medicine of KOA,should pay attention to the disease characteristics and clinical localization and clinical characteristics of TCM,select the evaluation method that it can reflect the treatment of characteristics.