Objective:To prepare loxoprofen sodium sustained release pellets, and investigate the in vitro drug release behavior. Methods:Loxoprofen sodium loaded pellets were prepared by extrusion-spheronization technology, and the sustained release pellets were prepared with Eudragit RL 30D and Eudragit RS 30D as the sustained release coating film materials. The drug release behavior of loxoprofen sodium sustained release pellets in vitro was studied. Results:Eudragit RL 30D and Eudragit RS 30D with the ratio of 20 ∶80 was used as the sustained release coating film materials, the coating weight was 20%, the plasticizer content was 10%, and the content of talc was 45%. The in vitro release of loxoprofen sodium from the sustained release pellets was steady and entire in 12 h. Conclusion:The release behavior of loxoprofen sodium sustained release pellets is quite satisfactory. And the preparation technology may be used in the industrial production.

This paper introduced the medical device classification in China and USA. Through the comparison between the two systems, several problems in Chinese classification system were exposed. To the end, some suggestions were proposed referred to the classification system of USA.
China ; Device Approval ; standards ; Equipment and Supplies ; classification ; United States

The chitinase gene of baculovirus is an unnecessary and high conservative gene Chitinase is expressed in the late phase virus replication in insect cells There are signal peptide in its N termini, chitinases active motifs in its central section and ER attaching motifs of chitinase in its C termini Baculoviral chitinase possesses both endo and exo chitinase activities, which can hydrolyze inherent chitin in insects body Chitinase is necessary for liquefaction of the virus infected host insect, and it may also serve as a molecular chaperone for pro V Cath Perhaps Baculoviral chitinase has same ancestors with bacteriums chitinase

AIM: To establish a high performance liquid chromatography (HPLC) method to determine the concentration of valsartan in human plasma. METHODS: Using lrbesartan as internal standard, valsartan in plasma samples was determined by HPLC with liquid-liquid extraction, achieved by the column of Agilent ZORBAXSB-C_ 18( 150 mm? 4.6 mm, 5 ?m) at room temperature. The mobile phase consisted of a mixture acetonitrile : water : phosphoric acid : triethylamine was the ratio of 4060 1.0 1.5 (v/v), pumped at a flow rate of 1.0 ml?min~ -1, the wavelengths of fluorimetric excitation and emission were set at 265 and 378 nm respectively. RESULTS: The drug-free plasma did not interfere with the determination of drugs and internal standard. There was good linear relationships (1/C~2 weighted) between peak area ratio of valsartan to internal standard and C (r= 0.9996) within the range of 25-2 500 ng?ml~ -1. The precision of within-day and between-day was good. The lower limit of quantification was 25 ng?ml~ -1. The analytes reconstituted in the mobile phase were also stable at ambient conditions for at least 24 h. Furthermore, valsartan was stable for at least three freeze thaw cycles. CONCLUSION: The HPLC method can be used to determine the concentration of valsartan in human plasma.

Type 1 diabetes, a complex genetic disease, is determined by both genetic and environmental factors. After excluding the five susceptibility loci discovered by genetic linkage studies and candidate-gene association studies, more than 30 new susceptibility loci have been found to be related with type 1 diabetes as a result of genome-wide association study.

Objective This study was performed to find the association of the severity of coronary artery disease with ordinary risk factors for CHD and left ventricle heart function in patients with CHD. Methods Selective coronary angiography were carried on 305 consecutive patients admitted to our hospital from December 2008 to April 2009. The severity of coronary disease was accessed by the Gensini scoring system. These patients were divided into two groups, patients with CHD group (251 cases) and control group (patients without CHD) (54 cases) , to compare the difference of ordinary risk factors for CHD between the two groups. Multiple linear regression analysis was used to analyze the association of the severity of coronary artery disease with ordinary risk factors for CHD. We also used linear correlation analysis to investigate the association of the severity of coronary artery disease with left ventricle ejection fraction in patients with CHD. Results The two groups had statistically difference on age, sex, smoking index, hypertension prevalence rate, serum glucose abnormal prevalence rate, diabetes prevalence rate, and metabolic syndrome prevalence rate( P < 0.05). We found that age (β_1 =0.251, P <0.01), sex (β_2 =0.235, P < 0.01), LDL-C concentration (β_3 = 0.241,P <0.01), duration of diabetes (β_4 =0.226, P <0.01) went into multiple linear regression model. We also found the severity of coronary artery disease had a negative correlation ( r = -0. 362, P <0.01) with left ventricle ejection fraction in patients with CHD. Conclusion When we decide to cany out coronary angiography on susceptible patients, we should consider their age, sex, smoking index, whether had hypertension, serum glucose abnormal, diabetes, metabolic syndrome or not. Age, sex, LDLC concentration, duration of diabetes affect severity of coronary artery stenosis independently. Left ventricle ejection function will decrease as coronary atherosclerosis continues.

Infectious mononucleosis(IM) was one of the clinical common diseases, caused by epstein-barr virus infection in more than 90%patients. Changes of the surface antigen of the B cells with EB virus infection caused strong immune response of T lymphocytes, besides, helper T lymphocyte, dendritic cells, NK cells also played an important role in the pathogenesis of IM. The incidence of IM was not only closely related with social environment in childhood, but also closely with the number of siblings, birth order, and sunshine factor. In addition to the typical clinical manifestations, IM also can cause a variety of complications, such as spleen rupture and necrotizing mediastinitis , and could be life-threatening. Auxiliary examination means such as state of peripheral blood lymphocyte apoptosis, plasma proteomics, cerebrospinal fluid analysis, load test of EB virus can help to diagnose. Application of antiviral drugs was wider, but hormone was still controversial. Vaccine research progress had been slow, but there were vaccines for human test, which will provide effective measures for the prevention of IM.

Objective To improve quality of wearable nurse call system producing the best possible results,and to provide safe,high quality nursing service.Methods The improvement plan was designed through team building,baseline assessment and defect analysis.Effective measures were formulated and implemented,and the outcomes were followed up.Results Average call response time was reduced from 49.23±5.71 s to 16.62±3.83s.Patient satisfaction of response time was increased from 75％ to 93.6％.No nursing defects or accidents such as patient falls occurred.Conclusion Quality improvement of wearable nurse call system can shorten nurse's response time and increase patient satisfaction.

OBJECTIVE:To discuss the role of hospital pharmacists in the clinical drug trial.METHODS:The role of hospital pharmacists in publicizing and training of Good Clinical Practice(GCP),in the formulation of each standard operating instruction and in each stage of clinical drug trial was analyzed.RESULTS&CONCLUSION:Hospital pharmacists played a key role in clinical drug trial.They can get to know the basic research methodology from participating in the clinical drug trial,meanwhile their consciousness on scientific research can be strengthened.

Biology-related disciplines in medical school of comprehensive university are cur-rently confronted with some difficulties, including unclear position and indistinguishable characteris-tics. In this paper, we proposed that biology-related disciplines in medical school of comprehensive university should center on disease research, emphasize medical feature and give full play to its tech-nical advantage thus to provide technical support for basic medicine and clinical medicine. Mean-while, sources of multiple disciplines should be effectively integrated by breaking through the limitation of discipline and administrative system. An interdisciplinary molecular medicine platform was built up for researching and teaching.