1.Progress in non-invasive diagnostic model of hepatic fibrosis.
Bao-En WANG ; Ji-Dong JIA ; Wen-Sheng ZHANG
Chinese Journal of Integrated Traditional and Western Medicine 2006;26(1):5-7
Biomarkers
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blood
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Biopsy, Needle
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utilization
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Hepatitis C
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complications
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Humans
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Liver
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pathology
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Liver Cirrhosis
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diagnosis
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pathology
2.Design, synthesis and anti-platelet aggregation activities of ligustrazine-tetrahydroisoquinoline derivatives.
Di XIE ; En-li ZHANG ; Jia-ming LI ; Jie WANG ; Guang-wei HE
Acta Pharmaceutica Sinica 2015;50(3):326-331
Abstract: Fifteen novel ligustrazine-tetrahydroisoquinoline derivatives were designed and synthesized according to the association principle of pharmaceutical chemistry. The structures were identified by IR, NMR and ESI-MS. The inhibitory activities of platelet aggregation induced by ADP and AA have been measured by Bron method. Preliminary pharmacological results showed that compounds 7g, 7h and 7n had potent inhibitory activity against platelet aggregation induced by AA, and the compound 7o showed significant inhibitory activity against platelet aggregation induced by ADP.
Drug Design
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Platelet Aggregation
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drug effects
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Platelet Aggregation Inhibitors
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chemical synthesis
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chemistry
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Pyrazines
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chemical synthesis
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chemistry
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Tetrahydroisoquinolines
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chemical synthesis
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chemistry
3.Effects of dl-3-butylphthalide soft capsules on treatment of acute ischemlC stroke: multi-center, randomized, double-blind, double-dummy and aspirin-control study
Liying CUI ; Shunwei LI ; Weiwei ZHANG ; Guoguang PENG ; Li HE ; Dongsheng FAN ; Yang SHEN ; Yongjun WANG ; Xuguang GAO ; Jianping JIA ; Jinsheng ZENG ; En XU ; Chengyan LI ; Jia HE
Chinese Journal of Neurology 2008;41(11):727-730
Objective To assess the efficacy and safety of dl-3-butylphthalide on the treatment of acute ischemic stroke. Methods A total of 197 patients who were in the period of 72 hours of first attack of ischemic stroke of internal carotid artery with NIHSS from 5 to 25 scores were enrolled in this multi-center, randomized, double-blind and aspirin-control study. Compound " Dan Shen" was used as a baseline therapy. Results Basical recovery plus significant improvement was seen in 74.7% of the patients in dl-3-butylphthalide group and 60.9% in aspirin group (CMH value 4.0,P=0.047);There was a significant improvement for dl-3-butylphthalide group regarding NIHSS total score, total score difference value and Barthel index on the day 11th and 21st after treatment compared with control group. The main adverse reaction of dl-3-butylphthalide was increased aminotransferase and mainly the slight increase of aspartate aminotransferase, by 4.34% and 0 respectively. Conclusion dl-3-butyiphthalide should be regarded as an effective and safe treatment for ischemic stroke and a treatment without severe side effects.
4.Development of prognostic models of liver diseases.
Jun-yong ZHANG ; Fu-kui ZHANG ; Ji-dong JIA ; Bao-en WANG
Chinese Journal of Hepatology 2005;13(11):876-877
6.Uniformity of Coptidis Rhizoma decoction pieces dispensing based on effective constituent equivalence.
Qin DONG ; Jia-bo WANG ; Ding-kun ZHANG ; Wu-wen FENG ; Cong-en ZHANG ; Ming NIU ; Xiao-ping DONG ; Xiao-he XIAO
China Journal of Chinese Materia Medica 2015;40(20):3981-3986
Traditional Chinese medicine (TCM) dispensing is the final step of TCM used for clinical treatment, the stability of TCM dispensing is the guarantee of good clinical effect. Establishment of effect-constituent equivalence for Chinese herbal pieces based on clinical efficacy, can not only guarantee the stability of TCM dispensing, but also relate to the precision of clinical effect. This study chose Coptidis Rhizoma as the model, established effect-constituent equivalence of Coptidis Rhizoma, based on the effect-constituent index already established by our research group, and taking into consideration of homogeneity of clinical dosage and compliance of decoction, the uniformity of dispensing for different specification of Coptidis Rhizoma decoction pieces was studied. This research model was then applied to guide the specification-optimization of Coptidis Rhizoma and its clinical dispensing. The result indicated, effective constituent equivalence could reflect the fluctuation of specification, dosage and decoction to the fluctuation of efficacy; Optimized Coptidis Rhizoma decoction pieces had the characteristic of high homogeneity as for clinical dispensing, good compliance as for decoction, and high effective constituent equivalence. In conclusion, effective constituent equivalence could improve relevance of methods of TCM dispensing control to clinical effect. Preparated Superior-standard Decoction Pieces based on effective constituent equivalence was featured by good quality and a good practice of adjustable dosage, which could promote the development of TCM decoction pieces toward precision medicine.
Chemistry, Pharmaceutical
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methods
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Coptis
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chemistry
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Drugs, Chinese Herbal
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chemistry
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Quality Control
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Rhizome
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chemistry
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Therapeutic Equivalency
7. Advances in the research of Fournier gangrene
Xiangli KONG ; Kai SHI ; Yan XUE ; Jia′ao YU ; Lei ZHANG ; Zhendong WU ; Xiuhang ZHANG
Chinese Journal of Burns 2020;36(1):70-76
Fournier gangrene is a relatively rare clinical critical disease, and its clinical symptoms are not specific and easily unrecognized by some clinicians. It has the features of acute onset, quick development, severe illness, and often accompanied by infection shock which is seriously life-threatening. It is difficult in treatment with high medical costs and long length of hospitalization, which increases pain for patients and relatives and brings heavy economic and psychological burden on patients, society, and medical workers. By reviewing the literature home and abroad and combined with clinical practice, I summarize the researches on concept, epidemiology, clinical manifestation, diagnosis and treatment of Fournier gangrene, in order to provide reference for vast number of clinical workers.
8.Serum sodium concentration profile for cirrhotic patients and its effect on the prognostic value of the MELD score.
Jun-Yong ZHANG ; Cheng-Yong QIN ; Ji-Dong JIA ; Bao-En WANG
Chinese Journal of Hepatology 2012;20(2):108-111
To analyze the characteristics of serum sodium in decompensated cirrhosis and evaluate the prognostic ability of the model for end-stage liver disease (MELD) in Na-containing models. Patients diagnosed with decompensated cirrhosis at our hospital were enrolled for study between June 2005 and October 2010. Patients were classified among three groups, according to serum sodium concentration: less than 125 mmol/L, 125 to 135 mmol/L, and more than 135 mmol/L. Mortality rates among the three groups were compared by Kaplan-Meier survival analysis. In addition, the different serum sodium concentrations were analyzed for correlations between Child-Pugh score and complication incidence rates of portal hypertension. The area under the receiver operating characteristic (ROC) curve (AUC) was used to compare the predictive abilities of MELD, MELD-Na, and the integrated (i) MELD scores for 3-month, 6-month and 1-year mortalities. A total of 467 patients were analyzed, and 50.54% had hyponatremia ( less than 135 mmol/L). Sodium concentration was correlated with mortality, and Kaplan-Meier survival analysis indicated that mortality was significantly higher in each subgroup with lower sodium concentration (all, P = 0.000). Likewise, sodium concentration decreased in conjunction with increased severity of decompensation, as classified by Child-Pugh scoring (sodium: A more than B more than C; mortality: A less than B less than C). With the exception of digestive tract bleeding, complication incidence rates of hepatic encephalopathy, ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome increased when sodium concentration decreased. For predicting 3-month mortality, the AUC scores of MELD were not significantly different from the MELD-Na and iMELD scores (P more than 0.05). For predicting 6-month and 1-year mortality, the AUC scores of MELD-Na and iMELD were significantly higher than those of MELD (P less than 0.05). Hyponatremia is correlated with mortality and complications in decompensated cirrhosis patients. Incorporation of Na into the MELD may enhance it's prognostic ability.
Adult
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Aged
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End Stage Liver Disease
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Female
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Humans
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Liver Cirrhosis
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blood
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Liver Failure
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diagnosis
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Male
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Middle Aged
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Predictive Value of Tests
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Prognosis
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Serum
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chemistry
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Severity of Illness Index
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Sodium
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blood
9.Diagnosis and treatment of mediastinal enterogenous cysts in children.
Ke-ren ZHANG ; Hui-min JIA ; En-yuan PAN ; Lian-ying WANG
Chinese Medical Sciences Journal 2006;21(3):201-203
OBJECTIVETo investigate the diagnosis and therapy of mediastinal enterogenous cysts in children.
METHODSClinical data of 17 cases with mediastinal enterogenous cysts within 19 years in our hospital were retrospectively analyzed.
RESULTSOne case was intramural esophageal cyst and 16 cases were enteric cysts, two among which were complicated with abdominal enteric duplications. Most cases presented with symptoms of respiratory distress. Twelve cases were complicated with vertebral anomalies. Ultrasound of 12 cases and magnetic resonance imaging of 4 cases were helpful in confirming the cystic nature of these lesions. Eight cases had technetium-99m pertechnetate scintigraphy of posterior mediastinum.
CONCLUSIONSMost patients present with symptoms of respiratory distress, complicated with vertebral anomalies. Ultrasonography and magnetic resonance imaging may be helpful in confirming the cystic nature of these lesions. Technetium-99m pertechnetate scintigraphy is the most effective method for differentiation of the disease from other mediastinal cysts.
Diagnosis, Differential ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Magnetic Resonance Imaging ; Male ; Mediastinal Cyst ; diagnosis ; diagnostic imaging ; surgery ; Retrospective Studies ; Sodium Pertechnetate Tc 99m ; Ultrasonography
10.Efficacy of adaptive servoventilation in patients with congestive heart failure and Cheyne-Stokes respiration.
Xi-long ZHANG ; Kai-sheng YIN ; Xin-li LI ; En-zhi JIA ; Mei SU
Chinese Medical Journal 2006;119(8):622-627
BACKGROUNDCongestive heart failure (CHF) is associated with Cheyne-Stokes respiration (CSR), which may hasten CHF. Adaptive servoventilation (ASV) is a novel method of ventilatory support designed for removal of CSF in CHF patients. This study compares the efficacy of ASV in patients with CHF and CSR with the efficacy of oxygen therapy.
METHODSFourteen patients with CHF and CSR were recruited. During sleep, nasal oxygen therapy and ASV treatment were each performed for two weeks. Comparison before and after each treatment was made for the following items: a) parameters of sleep respiration, sleep structure and quality; b) left ventricle ejection fraction (LVEF) and 6-minute walk distance.
RESULTSCompared with the baseline levels of apnoea hypopnoea index of 34.5 +/- 6.1 before treatment, the apnoea hypopnoea index significantly decreased following oxygen therapy to 27.8 +/- 8.2, P < 0.05 and further reduced following ASV treatment to 6.5 +/- 0.8, P < 0.01. The minimal pulse oxygen saturation markedly increased following oxygen therapy from a baseline of (84.3 +/- 2.6)% to (88.6 +/- 3.7)%, P < 0.05 and further increased following ASV treatment (92.1 +/- 4.9)%, P < 0.01. Stages I + II sleep as percentage of total sleep time decreased from (81.9 +/- 7.1)% to (78.4 +/- 6.7)% following oxygen therapy and further to (72.4 +/- 5.0)% following ASV treatment. Stages III + IV sleep as percentage of total sleep time decreased from (8.4 +/- 5.5)% to (6.0 +/- 3.0)% following oxygen therapy and but increased to (11.9 +/- 5.4)% following ASV treatment. The arousal index of 30.4 +/- 8.1 before treatment significantly decreased following oxygen therapy to 25.6 +/- 5.7, P < 0.05 and further declined following ASV treatment to 18.2 +/- 6.1, P < 0.01. No significant difference was shown in above percentages between day 14 of oxygen therapy and before treatment (P > 0.05). LVEF was significantly higher on day 14 of ASV treatment (37.2 +/- 4.1)% than on day 14 of oxygen therapy (33.2 +/- 5.1)% and before treatment (30.2 +/- 4.6)% (all P < 0.05). Six-minute walk distance was the shortest before treatment (226 +/- 28) m, longer on day 14 of oxygen therapy (289 +/- 26) m, and the longest on day 14 of ASV treatment (341 +/- 27) m (all P < 0.01).
CONCLUSIONASV treatment is of better efficacy and greater clinical significance in improvement of CHF by eliminating CSR than oxygen therapy.
Adult ; Cheyne-Stokes Respiration ; physiopathology ; therapy ; Female ; Heart Failure ; complications ; physiopathology ; Humans ; Male ; Middle Aged ; Oxygen Inhalation Therapy ; Positive-Pressure Respiration ; methods ; Sleep ; physiology ; Stroke Volume ; Ventricular Function, Left