1.The impact of alcohol consumption on hearing loss in male workers with a focus on alcohol flushing reaction: the Kangbuk Samsung Cohort Study
Jaehong LEE ; Youshik JEONG ; Jihoon KIM ; Seonghyeon KWON ; Eunhye SEO ; Jinsook JEONG ; Woncheol LEE
Annals of Occupational and Environmental Medicine 2024;36(1):e1-
Despite hearing loss being a prevalent chronic condition, estimated to nearly 20% of the global population by the World Health Organization, the specific association with individual lifestyle factors, particularly alcohol consumption, remains unclear. In South Korea, approximately 80% of the population engages in alcohol consumption, with a notably high prevalence among males, indicating a high-risk drinking pattern. Therefore, this study aimed to assess the correlation between alcohol consumption and hearing loss in male workers, as well as to analyze additional variables such as alcohol flushing reaction, with the intention of improving worker health. The study was conducted from January 2012 to December 2019, targeting 114,114 participants who visited Kangbuk Samsung Hospital Total Healthcare Centers. Data were collected through pure-tone audiometry tests and alcohol-related questionnaire, and statistical analysis was performed using Cox regression analysis. Based on previous studies indicating a potential protective effect of light drinking on hearing loss, this group was designated as the reference. Additionally, stratified analyses were conducted based on the presence of alcohol flushing reaction and different working hours. The hazard ratio (95% confidence interval) for hearing loss was higher in the heavy drinking group (1.23 [1.11–1.37]) compared to the moderate drinking group (1.09 [0.98–1.20]). Stratified analyses revealed a significantly elevated the hazard ratio of hearing loss in groups with alcohol flushing reaction compared to those without this factor. Our study demonstrated that moderate or heavy alcohol consumption in male workers can increase the risk of hearing loss, particularly in those with alcohol flushing reaction. These findings underscore the importance of addressing alcohol-related factors concerning hearing health among male workers.
2.The impact of alcohol consumption on hearing loss in male workers with a focus on alcohol flushing reaction: the Kangbuk Samsung Cohort Study
Jaehong LEE ; Youshik JEONG ; Jihoon KIM ; Seonghyeon KWON ; Eunhye SEO ; Jinsook JEONG ; Woncheol LEE
Annals of Occupational and Environmental Medicine 2024;36(1):e1-
Despite hearing loss being a prevalent chronic condition, estimated to nearly 20% of the global population by the World Health Organization, the specific association with individual lifestyle factors, particularly alcohol consumption, remains unclear. In South Korea, approximately 80% of the population engages in alcohol consumption, with a notably high prevalence among males, indicating a high-risk drinking pattern. Therefore, this study aimed to assess the correlation between alcohol consumption and hearing loss in male workers, as well as to analyze additional variables such as alcohol flushing reaction, with the intention of improving worker health. The study was conducted from January 2012 to December 2019, targeting 114,114 participants who visited Kangbuk Samsung Hospital Total Healthcare Centers. Data were collected through pure-tone audiometry tests and alcohol-related questionnaire, and statistical analysis was performed using Cox regression analysis. Based on previous studies indicating a potential protective effect of light drinking on hearing loss, this group was designated as the reference. Additionally, stratified analyses were conducted based on the presence of alcohol flushing reaction and different working hours. The hazard ratio (95% confidence interval) for hearing loss was higher in the heavy drinking group (1.23 [1.11–1.37]) compared to the moderate drinking group (1.09 [0.98–1.20]). Stratified analyses revealed a significantly elevated the hazard ratio of hearing loss in groups with alcohol flushing reaction compared to those without this factor. Our study demonstrated that moderate or heavy alcohol consumption in male workers can increase the risk of hearing loss, particularly in those with alcohol flushing reaction. These findings underscore the importance of addressing alcohol-related factors concerning hearing health among male workers.
3.The impact of alcohol consumption on hearing loss in male workers with a focus on alcohol flushing reaction: the Kangbuk Samsung Cohort Study
Jaehong LEE ; Youshik JEONG ; Jihoon KIM ; Seonghyeon KWON ; Eunhye SEO ; Jinsook JEONG ; Woncheol LEE
Annals of Occupational and Environmental Medicine 2024;36(1):e1-
Despite hearing loss being a prevalent chronic condition, estimated to nearly 20% of the global population by the World Health Organization, the specific association with individual lifestyle factors, particularly alcohol consumption, remains unclear. In South Korea, approximately 80% of the population engages in alcohol consumption, with a notably high prevalence among males, indicating a high-risk drinking pattern. Therefore, this study aimed to assess the correlation between alcohol consumption and hearing loss in male workers, as well as to analyze additional variables such as alcohol flushing reaction, with the intention of improving worker health. The study was conducted from January 2012 to December 2019, targeting 114,114 participants who visited Kangbuk Samsung Hospital Total Healthcare Centers. Data were collected through pure-tone audiometry tests and alcohol-related questionnaire, and statistical analysis was performed using Cox regression analysis. Based on previous studies indicating a potential protective effect of light drinking on hearing loss, this group was designated as the reference. Additionally, stratified analyses were conducted based on the presence of alcohol flushing reaction and different working hours. The hazard ratio (95% confidence interval) for hearing loss was higher in the heavy drinking group (1.23 [1.11–1.37]) compared to the moderate drinking group (1.09 [0.98–1.20]). Stratified analyses revealed a significantly elevated the hazard ratio of hearing loss in groups with alcohol flushing reaction compared to those without this factor. Our study demonstrated that moderate or heavy alcohol consumption in male workers can increase the risk of hearing loss, particularly in those with alcohol flushing reaction. These findings underscore the importance of addressing alcohol-related factors concerning hearing health among male workers.
4.Reliability in Using Routine Coronary CT Angiography with Retrospective Electrocardiographic Gating for the Comprehensive Functional Evaluation of the Left Ventricle
Eun Ju KANG ; Jihoon HONG ; Jongmin PARK ; Jongmin LEE
Journal of the Korean Radiological Society 2019;80(1):69-80
PURPOSE:
To evaluate the feasibility of comprehensive left ventricle (LV) functional parameters on routine coronary computed tomographic angiography (CCTA) based on two-dimensional echocardiography (2DE).
MATERIALS AND METHODS:
Ninety-nine patients who underwent CCTA accompanied by 2DE were included in the study. The volumetric LV systolic functional parameters were acquired from 10-phase reconstruction of CCTA data. By differentiating the time-LV volume curve by time domain and measuring mitral valvular orifice areas, transmitral time-velocity curves were drawn and the early (E) to late (A) mitral inflow peak velocities ratio (E/A ratio) was acquired. By measuring a longitudinal jerking velocity of the mitral valvular annulus on a four-chamber view, the mitral peak velocity of early filling (E) to early diastolic mitral annular velocity (E') ratio (E/E' ratio) was evaluated. All functional parameters were compared with the 2DE results.
RESULTS:
The LV end diastolic volume, LV end systolic volume, ejection fraction, stroke volume, cardiac output, and LV myocardial mass measured by CCTA and 2DE showed moderate to strong correlations (r = 0.732, 0.821, 0.416, 0.394, 0.328, and 0.764, respectively; p < 0.05). The E/A and E/E' ratios showed strong correlation between CCTA and echocardiography (r = 0.807 and 0.751, respectively; p < 0.05).
CONCLUSION
When CCTA is performed with retrospective electrocardiographic gating, additional information about the LV function can be acquired as reliably as with echocardiography.
5.Multiple Sclerosis-like Illness in a Patient With HIV Infection.
Jihoon KIM ; Kee Ook LEE ; Sang Jun NA
Journal of the Korean Neurological Association 2010;28(3):222-224
The spectrum of neurological complications that occurs in the setting of HIV-1 infection includes AIDS-dementia complex, progressive multifocal leukoencephalopathy, brain lymphoma, toxoplasma encephalitis, and cryptococcal meningitis. We present a 36-year-old man with subacute multifocal neurologic signs who had a 3-year history of HIV-1 infection and a year history of left optic neuritis. The clinical presentation, CSF findings, and neuroradiological features in our patient were compatible with multiple sclerosis (MS), and hence he represented a rare case of HIV-related MS-like illness.
Adult
;
Brain
;
Encephalitis
;
HIV
;
HIV Infections
;
HIV-1
;
Humans
;
Leukoencephalopathy, Progressive Multifocal
;
Lymphoma
;
Meningitis, Cryptococcal
;
Multiple Sclerosis
;
Neurologic Manifestations
;
Optic Neuritis
;
Toxoplasma
6.Lymphoepithelioma-like Carcinoma of the Skin in the Cheek with a Malignant Metastatic Cervical Lymph Node.
Jongho LEE ; Jihoon PARK ; Hak CHANG
Archives of Plastic Surgery 2015;42(5):668-671
No abstract available.
Cheek*
;
Lymph Nodes*
;
Skin*
7.Pediculosis Capitis Misdiagnosed as Seborrheic Dermatitis.
Jihoon KIM ; Haryeong RYU ; Chulhyun YUN ; Joonseok CHOI ; Jin Ok BAEK ; Joo Young ROH ; Jong Rok LEE
Korean Journal of Dermatology 2015;53(4):337-338
No abstract available.
Dermatitis, Seborrheic*
;
Lice Infestations*
8.Pediculosis Capitis Misdiagnosed as Seborrheic Dermatitis.
Jihoon KIM ; Haryeong RYU ; Chulhyun YUN ; Joonseok CHOI ; Jin Ok BAEK ; Joo Young ROH ; Jong Rok LEE
Korean Journal of Dermatology 2015;53(4):337-338
No abstract available.
Dermatitis, Seborrheic*
;
Lice Infestations*
9.Gastric Organoid, a Promising Modeling for Gastric Stem Cell Homeostasis and Therapeutic Application
Subin LEE ; Jang-Hyun CHOI ; So-Yeon PARK ; Jihoon KIM
International Journal of Stem Cells 2024;17(4):337-346
The elucidation of the pathophysiology underlying various diseases necessitates the development of research platforms that faithfully mimic in vivo conditions. Traditional model systems such as two-dimensional cell cultures and animal models have proven inadequate in capturing the complexities of human disease modeling. However, recent strides in organoid culture systems have opened up new avenues for comprehending gastric stem cell homeostasis and associated diseases, notably gastric cancer. Given the significance of gastric cancer, a thorough understanding of its pathophysiology and molecular underpinnings is imperative. To this end, the utilization of patient-derived organoid libraries emerges as a remarkable platform, as it faithfully mirrors patient-specific characteristics, including mutation profiles and drug sensitivities. Furthermore, genetic manipulation of gastric organoids facilitates the exploration of molecular mechanisms underlying gastric cancer development. This review provides a comprehensive overview of recent advancements in various adult stem cell-derived gastric organoid models and their diverse applications.
10.Gastric Organoid, a Promising Modeling for Gastric Stem Cell Homeostasis and Therapeutic Application
Subin LEE ; Jang-Hyun CHOI ; So-Yeon PARK ; Jihoon KIM
International Journal of Stem Cells 2024;17(4):337-346
The elucidation of the pathophysiology underlying various diseases necessitates the development of research platforms that faithfully mimic in vivo conditions. Traditional model systems such as two-dimensional cell cultures and animal models have proven inadequate in capturing the complexities of human disease modeling. However, recent strides in organoid culture systems have opened up new avenues for comprehending gastric stem cell homeostasis and associated diseases, notably gastric cancer. Given the significance of gastric cancer, a thorough understanding of its pathophysiology and molecular underpinnings is imperative. To this end, the utilization of patient-derived organoid libraries emerges as a remarkable platform, as it faithfully mirrors patient-specific characteristics, including mutation profiles and drug sensitivities. Furthermore, genetic manipulation of gastric organoids facilitates the exploration of molecular mechanisms underlying gastric cancer development. This review provides a comprehensive overview of recent advancements in various adult stem cell-derived gastric organoid models and their diverse applications.