Objective To evaluate the diagnostic value of double-balloon push enteroscopy in patients with obscure small bowel bleeding. Methods Thirty-four cases with suspected small bowel bleeding were received double-balloon push enleroscopy from April to November 2003. Results The lesions were detected in 30 of 34 cases; the total diagnostic yield was 88. 3% . The enteroscopy reached to middle jejunum, middle or low portion of ileum in 1 and 3 cases with negative findings. Among thirty positive cases, the diagnosis were angiodysplasia 7 cases (20.6% , 1 in jejunum, 3 in jejunal-ileum, 3 in ileum) , small bowel tumor 11 cases (32.4% ) , all cases were certified by operation and pathology. The tumor growth in duodenum, jejunum and ileum were 2, 5 and 4 cases respectively. Pathology of incised tumors included lipoma, leiomyoma hemangioma, pheochromoeytoma, Kaposiform hemangioendothelioma and adenoearcinoma, 4 cases with Crohn's disease (11. 8% ) , and 8 cases in others. Conclusion The most common causes of obscure small bowel bleeding were angiodysplasia, small bowel tumor and Crohn's disease. Double-balloon push enleroscopy was a safe, reliable and effective diagnostic modality with high clinical value for obscure small bowel bleeding.

Objective To evaluate safety, extensity and clinical efficacy and patient tolerance of double-balloon push enteroscopy in diagnosis of patients with small bowel diseases. Methods Thirty cases suspected of small bowel diseases with negative findings of various routine diagnostic modalities were performed double-balloon push enteroscopy from April to July, 2003. Among which 20 cases were patients with gastrointestinal bleeding of unknown origin, and numbers of patient with abdominal pain, chronic diarrhea and partial small intestine obstruction of unknown causes were 5, 3 and 2 cases, respectively. Results The enteroscopy reached to jejunal-ileum transitional area, middle or low portion of ileum and terminal ileum in 9, 17 and 4 cases, with mean examination time ( 40.5 ?12.3) min , ( 64.3 ?18.6) min and ( 78.8 ?11.5) min , respectively. Most of patients were fairly tolerated to the procedure. The lesion was detected in 25 of 30 cases, the total diagnostic yield was 83.3% , and positive diagnostic rates in obscure gastrointestinal bleeding, abdominal pain, chronic diarrhea and partial small bowel obstruction were 80.0% , 80.0% , 33.3% and 100.0% respectively. No procedure-related complications were observed in all cases. Conclusion Double-balloon push enteroscopy was a safe, reliable diagnostic modality of high clinical value for small bowel diseases.

Objective To assess the clinical characteristics of primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL) and its treatment and prognosis. Methods Twenty patients diagnosed with PGI-DLBCL were admitted to hospital between 2003 and 2007. The clinical characteristics and tumor molecular model of PGI-DLBCL as well as therapeutic methods were retrospectively studied. The factors that related to survival and prognosis were statistically analysed.Results The overall survival (OS) time of the patients were from 42 months to 52 months,while the progression-free survival (PFS) time were from 37months to 47 months. The International Prognostic Index (IPI) score (0～2 or ＞2) played a reminding role in prognosis of the disease. Tumor molecular model was no effect on prognosis [that was no significant difference between germinal center B-cell-like (GCB) type and non-GCB type]. The efficacy of Rituximab in combination with CHOP chemotherapy (R-CHOP) in treatment of PGI-DLBCL was similar to CHOP chemotherapy alone, whereas surgical intervention might prolong survival period. Conclusions The biological characteristics of PGI-DLBCL is so particular that the most therapeutic method, which need to be further studied, would be different from DLBCL in other position.

Urinary microquantitative albumin (UALb), immunoglobulin G (UIgG) ?2-microglo-bulin (U?2m), and Tamm-Horsfall protein (THP) were measured in 36 chronic B hepatitis (CHB) and 23 liver cirrhosis (LC) patients with radioimmunoassay. 109 healthy normal subjects served as controls. The results showed that the excretion of UALb was significantly increased in 17 patients. Out of 17 patients,the excretion of UIgG in 5 and U?2m in 16 were increased and the excretion of THP in 9 patients were decreased. Compared with normal controls there was a significant difference (P

The coronavirus disease 2019 (COVID-19) has been developing rapidly since the outbreak of Wuhan in December 2019. It has spread to many regions in the world in the short term, which has attracted wide attention at home and abroad. With the active intervention of traditional medicine, the epidemic situation has been effectively controlled, especially for the treatment of severe and critical patients, which shows its unique advantages. Since the outbreak of COVID-19, ethnic medical practitioners have made suggestions on the understanding and prevention measures of COVID-19 based on the theory of ethnic medicine. We should optimize the individual internal environment of patients with individualized traditional medicine prescription, combine the environmental factors such as the soil and space for the emergence and spread of the disease, and contribute our own strength to fighting against the epidemic as soon as possible and ensure the life and health of the minority people. It was suggested to set up a project to excavate, sort out, research and develop the preparations of medical institutions for the prevention and treatment of “pestilence” by national medicine, and make sufficient preparations for the prevention and treatment of “pestilence” caused by various viruses that may occur frequently, so as to protect human health.

Objective To study the effects of γ-IFN on the expression of HLA-G mRNA in primary cultured astrocytoma cells. Methods Different concentrations of γ-IFN were added to primary cultured cells, and HLA-G mRNA were detected by RT-PCR. Results After γ-IFN treatment, HLA-G mRNA can not be determined from HLA-G originally negative astrocytoma cells. The expression of HLA-G are up - regulated in all original HLA-G positive astrocytoma cells in a dose-dependent manner. Conclusion γ-IFN can increase the ex-pression of HLA-G gene in the primary cultured astrocytoma cells which HLA - G are originally positive.

OBJECTIVETo observe the regulatory effects of electroacupuncture with different acupoints combinations on blood lipid and atherosclerosis index (AI) in rats with hyperlipemia, so as to make a preliminary screening for the optimal acupoints combination for hyperlipemia.

METHODSOne hundred and five clean-grade SD male rats were randomly divided into 9 groups, including a normal group, a model group, a Quchi group, a Zhongwan group, a Fenglong group, a Quchi+Zhongwan group, a Quchi+Fenglong group, a Zhongwan+Fenglong group and a Quchi+Zhongwan+Fenglong group (three acupoints group), 17 rats in the normal group and 11 rats in the rest groups. The normal group was fed with normal diet, while the rest groups were fed with high-fat diet for 3 weeks to prepare the hyperlipemia model. All the rats were given unlimited water. After the establishment of model, the normal group was fed freely without any treatment; the model group was bundled and immobilized everyday; the rest groups were bundled, immobilized and treated with electroacupuncture at corresponding acupoints with disperse-dense wave, 20 min per time, once a day. After 4 weeks, the blood examples were collected from abdominal aorta to measure the total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C), and analyzed the AI in each group.

RESULTSAfter the treatment, TC, TG, HDL-C, LDL-C and AI in each acupuncture group were all lower than those in the model group (P<0.05, P<0.01). Compared with single acupoint group and the Quchi+Zhongwan group, the content of TC in the three acupoints group was lower (P<0.01). The differences of content of TG among each acupuncture group were not significant (all P>0.05). Compared with the rest 6 acupuncture groups, the content of HDL-C and AI in the three acupoints group were significantly different (all P<0.05). The content of LDL-C in the three acupoints group was decreased as compared with the Quchi group and the Zhong-wan group.

CONCLUSIONThe electroacupuncture at "Quchi" (LI 11), "Zhongwan" (CV 12) and "Fenglong" (ST 40) has more advantages on regulating the content of HDL-C and LDL-C as well as improving AI in hyperlipemia rats, and it has superior effects on blood lipid metabolism.

Acupuncture Points ; Animals ; Electroacupuncture ; Humans ; Hyperlipidemias ; blood ; therapy ; Lipids ; blood ; Male ; Rats ; Rats, Sprague-Dawley

Antigens, CD20 ; metabolism ; CD5 Antigens ; metabolism ; Colonic Neoplasms ; complications ; metabolism ; pathology ; surgery ; Cyclin D1 ; metabolism ; Diagnosis, Differential ; Female ; Humans ; Ileal Diseases ; complications ; pathology ; surgery ; Ileocecal Valve ; Intestinal Neoplasms ; complications ; metabolism ; pathology ; surgery ; Intestinal Polyps ; complications ; metabolism ; pathology ; surgery ; Intussusception ; complications ; pathology ; surgery ; Leukemia, Lymphocytic, Chronic, B-Cell ; metabolism ; pathology ; Lymphoma, Mantle-Cell ; complications ; metabolism ; pathology ; surgery ; Middle Aged

Peroxisome proliferator-activated receptors (PPARs) are nuclear transcriptional factors closely related to glucose and lipid metabolism, insulin sensitivity. Activation of PPARs targets treated type 2 diabetes, obesity, hypertension and other metabolic diseases by insulin resistance. Recently, a variety of active ingredients of traditional Chinese medicines (TCMs) have been proved to activate PPARs targets for improving insulin resistance, which has attracted widespread attention at home and abroad. In this paper, we reviewed the pathological mechanisms between insulin resistance and PPARs, and summarized the active ingredients of TCMs improved insulin resistance based on PPARs targets. This paper may provide some theoretical guidance for the development of new drugs and TCMs.
Animals ; Drugs, Chinese Herbal ; pharmacology ; Humans ; Insulin Resistance ; Metabolic Diseases ; drug therapy ; genetics ; metabolism ; Peroxisome Proliferator-Activated Receptors ; antagonists & inhibitors ; genetics ; metabolism

Objective To retrospectively analyze and conclude the characteristics of imaging appearances of solid psedopapillary tumor of pancreas.Methods Among 7 cases with pathologically proved solid psedopapillary tumor of pancreas,6 cases underwent CT examinations of upper abdomen preoperatively,and the rest One had MRI examination.The mean age of these 7 cases(all female)was 30.7 years(range,14—44 years).Results The tumors were usually quite large in the largest diameter ranged from 2.8 to 15.9cm(mean largest diameter,7.9 cm);Tumors were all well demarcated,and 5 of them were of capsule on CT or MR imaging.All tumors were well-encapsulated on pathologic specimens, except for the capsule of 1 tumor was partially invaded;In 6 cases underwent CT examination,scattered, punctate and linear calcification were noted in the capsule of 2 tumors and the rim of another one;Except for 1 tumor was almost solid,the other 6 tumors contained both solid and cystic components;Scattered sheets of high attenuation shown in the cystic or solid parts on CT imaging in several cases and the high signal intensity on T_1-weighted MR imaging signified the possibility of bleeding in tumors,which then was testified by pathologic evaluation.Conclusion The solid psedopapillary tumor of pancreas has comparatively characteristic clinical and imaging features.