PURPOSE: Atopic dermatitis is a chronic, inflammatory skin disease characterized by intense pruritus and an immunologic profile consistent with allergic disease. It is associated with increased eosinophil and IgE level and decreased INF-gamma production. We describe the result of a treatment with INF-gammaand assess the clinical, immunologic, and laboratory data of 12 patients with atopic dermatitis. METHODS: Twelve patients were treated for 12 weeks with 2x106 units/m2 INF-gamma by subcutaneous injection. General hematologic tests were done, and total eosinophil counts, eosinophil fractions, neutrophil fractions, and IgE levels were measured before the treatment, 2 weeks after the treatment, 12 weeks after the treatment serially. We also followed up the patients for 12 weeks after discontinuing INF-gammatherapy. RESULTS: All patients showed clinically significant improvement after 12 weeks of the systemic INF-gammatherapy. There was no clinical aggravation during the therapy period and the follow-up 4 weeks without the therapy. But the recurrence rate in the 12 weeks after discontinuing the therapy was about 40%. Eosinophil counts and eosinophil fractions were significantly decreased after the therapy. And, eosinophil counts and eosinophil fractions were increased in clinically aggravated patients during the 12 weeks of off-therapy. CONCLUSION: We conclude that INF-gammais an effective therapy in atopic dermatitis without significant side effects. The eosinophil counts and eosinophil fractions were decreased during the INF-gamma therapy, and increased in clinically aggravated patients after the off-therapy. There was no aggravation during the therapy. But 5 patients were clinically aggravated during the 12 weeks of off-therapy. Further studies for a long-term maintenance therapy and its side effect might be needed in chronic atopic dermatitis.
Dermatitis, Atopic* ; Eosinophils ; Follow-Up Studies ; Hematologic Tests ; Humans ; Immunoglobulin E ; Injections, Subcutaneous ; Interferon-gamma* ; Neutrophils ; Pruritus ; Recurrence ; Skin Diseases

The final degrees of education for the third and fourth authors were mutually misplaced.

Acquired Immunodeficiency Syndrome ; Dental Clinics ; HIV ; Humans ; Mass Screening ; Sensitivity and Specificity

Bandages ; Blood Platelets ; Bone Regeneration ; Collagen ; Cytokines ; Fibrin ; Hemostasis ; Imidazoles ; Intercellular Signaling Peptides and Proteins ; Nitro Compounds ; Osteoblasts ; Platelet-Rich Plasma ; Regeneration ; Skin ; Surgery, Oral ; Tendons ; Transplants ; Wound Healing

Dental Implants ; Humans ; Mentors

INTRODUCTION: Guided bone regeneration (GBR) is a common procedure for the treatment of bone defects and bone augmentation. The non-resorbable barriers are well-documented barriers for GBR because of their stability and malleability. However, few GBR studies have focused on the different types of non-resorbable barriers. Therefore, this study examined the clinical results of different non-resorbable barriers for GBR; expanded polytetrafluoroethylene (e-PTFE) (TR-Gore Tex, Flagstaff, AZ, USA), and high-density polytetrafluoroethylene (d-PTFE) (Cytoplast membrane, Oraltronics, Bremen, Germany). MATERIALS AND METHODS: The analysis was performed on patients treated with GBR and implant placement from January 2007 to October 2007 in the department of the Seoul National University Bundang Hospital. The patients were divided into two groups based on the type of non-resorbable barrier used, and the amount of bone regeneration, marginal bone resorption after prosthetics, implant survival rate and surgical complication in both groups were evaluated. RESULTS: The implants in both groups showed high survival rates, and the implant-supported prostheses functioned stably during the follow-up period. During the second surgery of the implant, all horizontal defects were filled with new bone, and there was no significant difference in the amount of vertical bone defect. CONCLUSION: In bone defect areas, GBR with non-resorbable barriers can produce favorable results with adequate postoperative management. There was no significant difference in bone regeneration between e-PTFE and d-PTFE.
Bone Regeneration ; Bone Resorption ; Follow-Up Studies ; Humans ; Membranes ; Polytetrafluoroethylene ; Prostheses and Implants ; Survival Rate

Humans ; Maxillary Sinus ; Prognosis ; Survival Rate ; Transplantation, Heterologous ; Transplantation, Homologous ; Transplants

Airway Obstruction ; Arteries ; Cellulose, Oxidized ; Hemorrhage ; Hemostasis ; Humans ; Male ; Mandible ; Postoperative Hemorrhage

We experienced a case of anterior mediastinal teratoma in 26 month old boy with 2 month history of cough and dyspnea. The diagnosis was easily established by chest CAT which revealed calcific densities, while plane radiographs of chest revealed no evidence of calcification. Operation was done with good result and remained in good condition thereafter. A brief review of the related literature was made on this subject.
Anemia ; Animals ; Cats ; Child, Preschool ; Cough ; Diagnosis ; Dyspnea ; Hemangioma ; Humans ; Kasabach-Merritt Syndrome* ; Male ; Teratoma ; Thorax ; Thrombocytopenia

We experienced a case of anterior mediastinal teratoma in 26 month old boy with 2 month history of cough and dyspnea. The diagnosis was easily established by chest CAT which revealed calcific densities, while plane radiographs of chest revealed no evidence of calcification. Operation was done with good result and remained in good condition thereafter. A brief of the related literature was made on this subject.
Animals ; Cats ; Child, Preschool ; Cough ; Diagnosis ; Dyspnea ; Humans ; Male ; Teratoma* ; Thorax