PURPOSE: To assess the role of blood vessels in the formation of peritumoral abnormal signal intensity which exaggerates the size of malignant tumor on MR images. MATERIALS AND METHODS: We performed MR-microangiographic-pathologic correlation using implanted VX-2 carcinoma in 16 rabbit thighs 1-28 days after tumor implantation. The shape and distribution of abnormal vessels were analyzed on microangiography and on histologic examination in correlation with peritumoral abnormal signal intensity on MR images. RESULTS: Dilated peritumoral blood vessels gave rise to irregular, tortuous tumor vessels penetrated into the tumor. With the tumor growth, hypervascular tumor vessels in peritumoral area and central avascular areas were increased. These hypervascular areas on microangiography were corresponded with abnormal signal intensity on MR images. CONCLUSION: Hypervascularity could be a cause of peritumoral abnormal signal intensity which exaggerates the size of experimentally induced malignant musculoskeletal tumors on MR images.
Blood Vessels* ; Thigh

No abstract available.
Female ; Pregnancy ; Pregnancy, Ectopic*

We retrospectively analysed plain radiographs and MR imaging of 16 conventional osteosarcoma cases(8 children, 8 adults) which underwent amputations or limb salvage operations. Pathologic correlation was performed with gross and microscopic sections to evaluate 1) whether the open epiphyseal plate can function as a barrier against transphyseal spread of osteosarcoma and 2) the diagnostic value of MR imaging for the detection of the detection of the epiphyseal involvement of osteosarcoma. In children with open epiphyseal plates, conventional radiographs suggested transphyseal tumor growth in one of eight cases(12.5% and MR imaging in seven cases(87.5%). Pathologic examination confirmed epiphyseal involvement in six of seven cases noted with MR imaging(75%). On the the other hand, in adult patients with closed epiphyseal plates, conventional radiographs showed transphyseal tumor growth in six of eight cases(75%), while MR imaging and pathologic exam demonstrated tumor invasion in all cases(100%). We conclude that open epiphyseal plate does not function as and effective barrier against tumor extension, and MR imaging is an excellent method in detecting the extent of transphyseal tumor growth.
Adult ; Amputation ; Child ; Growth Plate ; Hand ; Humans ; Limb Salvage ; Magnetic Resonance Imaging* ; Methods ; Osteosarcoma* ; Retrospective Studies

No abstract available.
Animals ; Edema ; Endometrium* ; Female ; Mice* ; Uterus

OBJECTIVE: To evaluate the clinical profiles and outcomes of patients with placental abruption and the effect of hypertensive disorders on perinatal death. METHODS: It was a retrospective study over 9 years from 1 January 1995 to 31 December 2003. We reviewed the data of women (N=104) presenting placental abruption among 10,940 women who were delivered at this hospital. RESULTS: The incidence of placental abruption was 0.95% or one in 104 deliveries. Only 47.6% of these could be diagnosed before delivery. The most common symptom was vaginal bleeding (71.1%) and intrauterine fetal death had already occurred in 26.9%. Perinatal mortality rate was 32.6% including still birth (26.9%) and neonatal death (5.7%). There was no maternal death. 28.8% of placental abruption were associated with preeclampsia and other hypertensive disorders but in most cases (68.3%), the contributing factors could not be found. When the hypertensive disorders were associated, perinatal mortality rate was 33%, which was not significantly different when compared with perinatal mortality (32%) without hypertensive disorder (p>0.05). But the neonates from the hypertensive women were more growthly impaired than those from normotensive women (p<0.05). CONCLUSION: Hypertensive disorders was an important factor in women with placental abruption but in most cases the contributing factors could not be found. The hypertensive disorders did not aggravate the perinatal mortality but increased the rate of intrauterine growth retardation in placental abruption.
Abruptio Placentae* ; Female ; Fetal Death ; Fetal Growth Retardation ; Humans ; Incidence ; Infant, Newborn ; Maternal Death ; Parturition ; Perinatal Mortality ; Pre-Eclampsia ; Pregnancy* ; Retrospective Studies ; Uterine Hemorrhage

Endometriosis is a common gynecological entity and characterized by the presence of endometrial glands and stroma outside the normal location in the uterine cavity. Endometriosis has been reported mostly in the pelvic cavity but anywhere in the body such as umbilicus, appendix, bladder, cervix, pleural cavity, lung, rectum, vagina, vulva and round ligaments. The abdominal wall is one of the most common sites of extrapelvic endometriosis and usually develops in association with a prior surgical scar. However, endometriosis involving the scarless abdomen is rare. We experienced an unusual presentation of a woman with abdominal wall endometriosis in the absence of previous surgery associated with recurrent pneumothorax in menstrual cycle. We report this case with brief review of the literature.
Abdomen ; Abdominal Wall* ; Appendix ; Cervix Uteri ; Cicatrix ; Endometriosis* ; Female ; Humans ; Lung ; Menstrual Cycle ; Pleural Cavity ; Pneumothorax ; Rectum ; Round Ligament of Uterus ; Umbilicus ; Urinary Bladder ; Vagina ; Vulva

No abstract available.
Lymphohistiocytosis, Hemophagocytic*

Neonatal lupus (NL) is a passively acquired autoimmune disease that occurs in infants born from asymptomatic mothers having anti-SSA or anti-SSB antibody. Infants with NL may show symptoms of systemic lupus erythematosus, including skin rash, congenital heart block, hepatic dysfunction, and hematological abnormalities. Mothers of the infants are asymptomatic or diagnosed with autoimmune diseases. When infants born to asymptomatic mothers who have never been diagnosed with the diseases show symptoms of NL, they may be mistaken for having infections. We report an NL case of a 47-day-old girl who presented to the emergency department with fever and skin rash.

Purpose: We evaluated the incidence and characteristics of Clostridioides difficile infection (CDI) in Korean children. Methods: Medical records of patients aged 2–18 years and diagnosed with CDI at a tertiary hospital between 2009 and 2018 were analyzed. The patients were classified into three CDI groups: community-acquired (CA), community onset-health care facility-associated (COHCFA), and healthcare facility onset (HO). Results: The incidence of CDI increased from 1.00 to 10.01 cases per 10,000 admissions from 2009 to 2018 (P<0.001). As compared to the CA group, the HO group had a higher frequency of operation and malignancy as predisposing factors (40.4% vs. 0.0%, P=0.001; and 27.7% vs. 0.0%, P=0.027, respectively), frequency and number of previous antibiotic use (97.9% vs. 31.3%, P<0.001; and 2 vs. 0, P<0.001, respectively), and median postdiagnosis hospital stay (13 vs. 5 days, P=0.008). The CO-HCFA group had a lower median age and higher frequency of malignancy than the CA group (5 vs. 13 years, P=0.012; and 30.8% vs.0.0%, P=0.030, respectively). As compared to the HO group, the CA group had a higher frequency of abdominal pain and hematochezia (56.3% vs. 10.6%, P=0.001; and 50.0% vs. 10.6%, P=0.002, respectively), inflammatory bowel disease (68.8% vs. 2.1%, P=0.001), and intravenous metronidazole treatment (37.5% vs. 2.1%,P=0.001). Conclusions With the increasing incidence of pediatric CDI, awareness regarding its epidemiology and clinical characteristics is important to manage nosocomial infections.

Tinea faciei is a rare dermatophyte infection of the face that most often appears as a facial rash, followed by patches of small and raised bumps. Since it is uncommon in children and has similar rash patterns with various skin diseases, it is likely to be misdiagnosed as herpes simplex infection, contact dermatitis, disc-shaped lupus erythematosus, acne, and atopic dermatitis. In this case, siblings aged 3 and 4 were hospitalized due to skin rashes that occurred after traveling to Vietnam, and were administered antiviral drugs and systemic steroids under suspicion of herpes simplex infection with atopic dermatitis. Despite administration of these drugs, skin lesions did not show improvement. Serum beta-Dglucan assays were elevated in both patients, and after approximately 2 weeks, Trichophyton interdigitale was cultured in the older sister's skin fungal culture test. Both patients recovered after local and systemic antifungal therapy, without relapse or side effects. Skin lesions on the face, which do not respond to the existing treatment in children, should be checked for the possibility of tinea faciei through repeated fungal tests, and the beta-D-glucan assay can be a useful tool in diagnosing tinea faciei.