BACKGROUND: Epithelial tumor cells with a CD44(+)/CD24(-/low) immunoprofile may have the ability to cause breast cancer. We studied these cells and their clinicopathological significance. METHODS: The clinicopathologic findings of 100 invasive ductal carcinoma (IDC) cases and 45 ductal carcinoma in situ (DCIS) cases were reviewed. CD44(+)/CD24(-/low) tumor cells were identified by immunohistochemistry, and their clinicopathological implications in IDC and DCIS were analyzed. RESULTS: IDC with a high prevalence of CD44(+)/CD24(-/low) tumor cells was significantly associated with larger mass, higher grade, estrogen receptor (ER) negativity, and tumor cells with a higher frequency of metastasis. The proportion of CD44(+)/CD24(-/low) tumor cells in IDC, and its DCIS components was not significantly different, whereas the proportion of CD44(+)/CD24(-/low) tumor cells was higher in DCIS than in the DCIS component of IDC (p < 0.001). CONCLUSIONS: IDC with a high prevalence of CD44(+)/CD24(-/low) tumor cells might correlate with aggressive features, such as ER and higher grades. Moreover, the proportion of CD44(+)/CD24(-/low) tumor cells in the DCIS components of IDC and DCIS might harbor different biology, which may lead to differences in cancer progression and early carcinogenesis.
Antigens, CD24 ; Antigens, CD44 ; Biology ; Breast ; Breast Neoplasms ; Carcinoma, Ductal ; Carcinoma, Intraductal, Noninfiltrating ; Estrogens ; Immunohistochemistry ; Neoplasm Metastasis ; Neoplastic Stem Cells ; Prevalence

No abstract available.
Fingers* ; Warts*

No abstract available.
Cyclosporine* ; Eczema* ; Hand* ; Retrospective Studies* ; Treatment Outcome*

No abstract available.
Carcinoma, Basal Cell*

To determine the actual axial length of the pseudophakic eye, we mea-sured the axial length using ultrasound before and after cataract surgery in 157 eyes of 97 patient.The measured axial length of the pseudophakic eye with silicone or acrylic intraocular lens was longer than the axial length measured before operation.There was linear correlation between axial length measured before and after operation in cases of PMMA, silicone, or acrylic intraocular lens.The axial length corrected with ultrasonic velocity and central thickness of the intraocular lens was approximate to the mea-sure before operaion.So, we concluded that axial length is not actually elongated after operation and the exact axial length may be obtained by correcting the measured axial length of the pseudophakic eye using ultra-sonic velocity and central thickness of the intraocular lens.
Cataract ; Lenses, Intraocular ; Polymethyl Methacrylate ; Silicones ; Ultrasonics ; Ultrasonography

Nedocromil sodium is an anti-inflammatory medication for the treatment of mild to moderate asthma. The most common side effect of the nedocromil sodium is an unpleasant and bitter taste. However it is rare, less than 3%, to stop the treatment because of this side effect. Other side effects includes cough, headache, throat irritation and nausea which are reported as mild and transient. A 7-year-old female had a severe headache and dizziness during the treatment of asthma with nedocromil sodium. The symptoms subsided after nedocromil sodium was replaced by budesonide. We experienced a case of a severe headache and dizziness due to nedocomil sodium that lead to withdraw of the nedocromil sodium.
Asthma ; Budesonide ; Child ; Cough ; Dizziness* ; Female ; Headache* ; Humans ; Nausea ; Nedocromil* ; Pharynx ; Sodium

PURPOSE: Patient education is an important part of asthma management. This study was designed to evaluate the role of education program for asthmatic children and their parents. In the western countries, the effectiveness of patient education on improving self-management of asthma has been well documented. However, data from Korean population is lacking. METHODS: We performed the study to evaluate the efficacy of a hospital based education program aimed at improving self-management skills and reducing morbidity. Twenty patient and their parents attending Korea University Ansan Hospital allergy clinic were enrolled in the study. They were instructed 4 times of 10-15 minutes session with every 3 month interval on the pathophysiology of asthma, treatment and the appropriate use of medication including proper inhaler technique and the self-management of their diseases. The instructions were reinforced by three more education session at subsequent outpatient clinic attendance. RESULT: After twelve months, morbidity was assessed by the numbers of hospitalization, emergency department attendance and outpatient clinic attendance, use of oral steroids and steroid inhalation and impairment of quality of life. The efficacy of the education was demonstrated by significant reduction in the number of hospitalization(P<0.005), emergency department visit(P<0.005), outpatient clinic visit(P<0.05) and reduction of oral steroid use(P<0.001). There were also reduction of outpatient department attendance and improvement in steroid inhalation and quality of life. CONCLUSION: The result of this study suggest that a proper patient education is essential in reduction of asthma morbidity and improving in quality of life.
Ambulatory Care Facilities ; Asthma* ; Child ; Education* ; Emergency Service, Hospital ; Gyeonggi-do ; Hospitalization ; Humans ; Hypersensitivity ; Inhalation ; Korea ; Nebulizers and Vaporizers ; Outpatients ; Parents* ; Patient Education as Topic ; Quality of Life ; Self Care ; Steroids

No abstract available.
Hemorrhage*

No abstract available.
Humans ; Lichen Planus* ; Lichens*

No abstract available.
Immunoglobulin A* ; Immunoglobulins*