1.DNA Profiling via Short Tandem Repeat Analysis by Using Serum Samples.
Ji Hyun LEE ; Hye Young LEE ; Sohee CHO ; Joo Youn CHO ; In Jin JANG ; Soong Deok LEE
Korean Journal of Legal Medicine 2013;37(4):220-223
Serum is free of cellular components. Because DNA is located in the nuclei or mitochondria of cells, serum could be assumed DNA free. Few previously published case reports to date have used serum for DNA typing. Here, we report on human genotyping via short tandem repeat (STR) analysis using serum as a sample, and discuss problems involved in the process.
DNA Fingerprinting*
;
DNA*
;
Humans
;
Microsatellite Repeats*
;
Mitochondria
2.The Effect of Platelet-Rich Plasma on Allograft Transplantation after Curettage in Benign Bone Tumor.
Jae Do KIM ; Ji Youn KIM ; Su Jin JANG ; So Hak CHUNG ; Gu Hee JUNG
The Journal of the Korean Bone and Joint Tumor Society 2010;16(1):8-13
PURPOSE: This study was performed to evaluate the efficiency of Platelet-rich plasma (PRP) for acceleration of bone healing process on allograft transplantation after curettage in benign bone tumor. MATERIALS AND METHODS: From December 2007 to February 2009, twenty-one patients who had benign bone tumor and underwent allograft transplantation after curettage were evaluated. Mean follow-up period was 14.6 months (range, 12-26 months). We compared with 13 cases of PRP group and 8 cases of non-PRP group in terms of size of lesion, bone resorption, amount of applied PRP and complications. The mean age at surgery was 23.6 years (range, 4-73 years). The most common diagnosis was simple bone cyst (7) followed by enchondroma (4), giant cell tumor (3), undifferentiated benign bone tumor (3) and so on. RESULTS: The mean size of lesion was 33.5 cm3 (range, 2.3-181.9 cm3) (29.4 cm3 in PRP group and 40.2 cm3 in non-PRP group). The mean volume of injected PRP was 7.4 cc (range, 3-12 cc). Bone union started at 3.0 months (range, 1.5-5.8 months) in PRP group and 5.3 months (range, 4-8 months) in non-PRP group. Three cases for each group were excluded due to recurrence and pathologic fracture. One patient had febrile episode 3 weeks later after surgery which subsided with antibiotics. CONCLUSION: The PRP could accelerate bone union in allograft transplantation after curettage of benign bone tumor. Furthermore, we expect that PRP can accelerate bone union in fracture or non-union.
Acceleration
;
Anti-Bacterial Agents
;
Bone Cysts
;
Bone Resorption
;
Chondroma
;
Curettage
;
Follow-Up Studies
;
Fractures, Spontaneous
;
Giant Cell Tumors
;
Humans
;
Platelet-Rich Plasma
;
Recurrence
;
Transplantation, Homologous
;
Transplants
3.The Impact of Delayed Diagnosis of Soft Tissue Sarcomas of the Foot and Ankle
Ji Youn KIM ; Ji Hoon JANG ; So Hak CHUNG
The Journal of the Korean Orthopaedic Association 2023;58(1):18-26
Purpose:
Differential diagnosis between benign and malignant tumors is critical for appropriate treatment. Patients with soft tissue sarcomas of the foot and ankle are often diagnosed late, and it can be predicted their prognosis will be poor. This study was aimed to investigate whether the delayed diagnosis of soft tissue sarcoma of the foot and ankle affects the oncological results and prognoses.
Materials and Methods:
We retrospectively reviewed the data from our tumor database and included all patients who had undergone a first wide excision of primary soft tissue sarcoma of the foot and ankle. Wide excision had been performed at a single regional musculoskeletal oncology center, and the patients had been followed up for more than 1 year. Between January 2007 to January 2021, we reviewed 26 patients with soft tissue sarcomas of the foot and ankle. Statistical analyses were performed by dividing the time of diagnosis based on 6 months, 1 year, 2 years, and 5 years or more. The primary endpoints of the study were overall, local recurrence-free, and metastasis-free survival rates. Actuarial survival was estimated using the Kaplan–Meier method and Cox regression analysis. The log-rank test was used to determine whether there was a significant difference between the survival curves according to the time of diagnosis.
Results:
Six, eight, and ten patients died, had distant metastasis, and developed local recurrence during the study period, respectively. The 5-year overall survival, 5-year metastasis-free survival, and 5-year local recurrence-free survival rates of the entire patient group were 80.1%, 73.0%, and 56.7%, respectively. The 5-year overall survival rate was higher in patients diagnosed earlier when the duration until diagnosis was 1 and 5 years than in those diagnosed later. A statistically insignificant difference was observed in local recurrence and distant metastasis during each period according to the diagnostic delay.
Conclusion
Delayed diagnosis in patients with soft tissue sarcoma of the foot and ankle has no influence on the oncological prognosis. Therefore, even if the self-observation period is long in the above patients, it is necessary to actively engage in treatment.
4.Actinomycotic Brain Abscess Developed 10 Years after Head Trauma.
Ki Yong NA ; Ji Hye JANG ; Ji Youn SUNG ; Youn Wha KIM ; Yong Koo PARK
Korean Journal of Pathology 2013;47(1):82-85
No abstract available.
Brain
;
Brain Abscess
;
Craniocerebral Trauma
;
Head
5.Study on the Usage of Acne Patches in Patients with Acne.
Hye Jung JUNG ; Dong Hyuk JANG ; Jae In LEE ; Joo Youn BAE ; Ji Young AHN ; Mi Youn PARK
Korean Journal of Dermatology 2018;56(9):539-542
BACKGROUND: Patients with acne are at risk of using various over-the-counter drugs (OTCs). In addition, several OTCs are introduced in pharmacies in Korea. However, only few drugs are supported by well-established data. Among the treatments, acne patches are easy to purchase and use. Thus, they are widely used by patients. OBJECTIVE: This study aimed to investigate the patient's perception and usage of acne patches. METHODS: A questionnaire survey was conducted on 80 patients with acne who visited the outpatient department of the National Medical Center for 2 months. RESULTS: A total of 42 (52.5%) patients answered that they had used acne patches, and 38 (47.5%) patients stated that they had never used patches. Moreover, 27 (64.29%) patients responded that they used the patches on inflammatory lesions. Moreover, several patients were using acne patches after pricking themselves. There was only one response to confirm the ingredient when purchasing acne patch. Moreover, 14 (33.33%) participants responded that they noted side effects after using acne patches. Overall, the satisfaction score for the use of acne patches was 5.05. CONCLUSION: Patients often use acne patches because they can be easily purchased and used. However, they do not know how to properly choose and use the product that fits their skin. Therefore, doctors must educate patients on how to properly select and use the products.
Acne Vulgaris*
;
Bandages
;
Colloids
;
Humans
;
Korea
;
Nonprescription Drugs
;
Outpatients
;
Pharmacies
;
Skin
6.Cystic Lymphangioma Involving the Mesentery and the Retroperitoneum: A Case Report.
Dong Hun KIM ; Joo Nam BYUN ; Ji Youn JANG
Journal of the Korean Radiological Society 2005;52(5):347-350
Cystic lymphangioma is uncommon angiomatous tumor that mainly occurs in the neck. Less than 1% of these tumors affect the mesentery, retroperitoneum and greater omentum. In particular, the cystic lymphangioma involving the mesentery and the retroperitoneum is a rare lesion. We report here on an uncommon case of cystic lymphangioma that presented as a multilocular mass involving the mesentery and the retroperitoneum, and we also present a brief review of the relevant literature.
Lymphangioma
;
Lymphangioma, Cystic*
;
Mesentery*
;
Neck
;
Omentum
7.A Case of Nedocromil Sodium Withdrawal Due to Headache and Dizziness.
Jang Hun LEE ; Jee Youn LIM ; Ji Tae CHOUNG
Pediatric Allergy and Respiratory Disease 2001;11(3):260-264
Nedocromil sodium is an anti-inflammatory medication for the treatment of mild to moderate asthma. The most common side effect of the nedocromil sodium is an unpleasant and bitter taste. However it is rare, less than 3%, to stop the treatment because of this side effect. Other side effects includes cough, headache, throat irritation and nausea which are reported as mild and transient. A 7-year-old female had a severe headache and dizziness during the treatment of asthma with nedocromil sodium. The symptoms subsided after nedocromil sodium was replaced by budesonide. We experienced a case of a severe headache and dizziness due to nedocomil sodium that lead to withdraw of the nedocromil sodium.
Asthma
;
Budesonide
;
Child
;
Cough
;
Dizziness*
;
Female
;
Headache*
;
Humans
;
Nausea
;
Nedocromil*
;
Pharynx
;
Sodium
8.Relationship among the Myelography, MRI and EMG in Young Patients with Low Back Pain or Radiating Pain.
Ji Youn JANG ; Dong Hun KIM ; Young Jae PARK
Journal of the Korean Radiological Society 2006;54(6):525-530
PURPOSE: We wanted to evaluate the relationship among the myelography, magnetic resonance imaging (MRI), and electromyography (EMG) findings in young patients with low back pain, and we wanted to assess the significance of the spinal geometric measurements as well as type of disc herniation seen on MRI. MATERIALS AND METHODS: Forty-four young men with lower back pain were included, and they were all clinically suspected of suffering with lumbar disc herniation. All of them underwent myelography, MRI and EMG. We measured spinal geometry including the anteroposterior diameters of the central canal and thecal sac, the interlaminar distance, the width of the lateral recess and the thickness of the ligamentum flavum, and we evaluated for root deviation as well as disc herniation on the MRIs. We compared the types of disc herniation on MRI with the myelography and EMG findings. Also, we investigated the correlation of the spinal geometric measurements on MRI with the EMG and myelography findings. RESULTS: The types of disc herniation on MRI were not significantly related to the myelography (p = 0.298) and EMG findings (p = 0.372). The EMG findings were not related to either the myelography findings (p = 0.435) or the spinal geometric measurements (p > 0.05) on MRI. Nerve root compression that was noted on myelography was related to the thecal sac AP diameter (p = 0.016) and the width of the lateral recess (p = 0.011). There were no correlations between myelography and the findings of root deviation on MRI (p=0.052). CONCLUSION: MRI can play an excellent diagnostic role for young patients with radiculopathy or lower back pain. It could increase the diagnostic accuracy if it is used in conjunction with myelography and EMG. The narrowing of thecal sac AP diameter and the width of lateral recess rather than the type of disc herniation on MRI were well correlated with the myelography and EMG findings.
Electromyography
;
Humans
;
Ligamentum Flavum
;
Low Back Pain*
;
Magnetic Resonance Imaging*
;
Male
;
Myelography*
;
Radiculopathy
;
Spine
9.Ultrasonographic Findings of Weber-Christian Disease of the Breast: A Case Report.
Ji Youn JANG ; Yun Woo CHANG ; Dong Wha LEE
Journal of the Korean Radiological Society 2005;52(4):285-287
Weber-Christian disease is a rare inflammatory disease of subcutaneous fat necrosis that may or may not involve systemic disease. We report the results of a breast sonograph of a case diagnosed as a form of an acute lobular panniculitis affecting the breasts and upper limbs.
Breast*
;
Necrosis
;
Panniculitis
;
Panniculitis, Nodular Nonsuppurative*
;
Subcutaneous Fat
;
Ultrasonography
;
Upper Extremity
10.Subcutaneous Dermatofibrosarcoma Protuberans on the Breast.
Ji Youn PARK ; Yong Hyun JANG ; You Chan KIM
Korean Journal of Dermatology 2011;49(11):1025-1027
Dermatofibrosarcoma protuberans (DFSP) is a dermal spindle cell neoplasm of intermediate malignancy. It typically forms a brown indurated plaque on which firm nodules subsequently arise, sometimes with ulceration. Atypical DFSP presentations are not unusual, including atrophic, pedunculated, morphea-like and angioma-like forms. However, subcutaneous variant of DFSP that may either arise without dermal involvement or with minimal dermal involvement is very rare. A 36-year-old man presented with a palpable nodule without surface change around the right nipple. Microscopically, the neoplasm was composed of spindle cells with monomorphic storiform arrangement. The superficial part of the neoplasm was located in the subcutaneous tissue. Immunohistochemical staining showed strong cytoplasmic positivity for CD34, but not for factor XIIIa. Dermatologists should pay careful attention to these unusual variant of DFSP, which can be confused with other soft tissue tumors.
Adult
;
Breast
;
Cytoplasm
;
Dermatofibrosarcoma
;
Factor XIIIa
;
Humans
;
Nipples
;
Subcutaneous Tissue
;
Ulcer