No abstract available.
Child ; Histiocytoma, Benign Fibrous ; Humans

Objective: This study aimed to retrospectively analyze the prevalence of orthodontic problems and the proportion of patients who underwent orthodontic diagnosis among children aged 6 (n = 300), 7 (n = 400), and 8 (n = 400) years who had undergone panoramic radiography. Methods: Children were divided into five groups according to their chief complaint and consultation: conservative dentistry, oral and maxillofacial surgery, orthodontics, periodontics, and prosthodontics). Chief complaints investigated included first molar eruption, lack of space for incisor eruption, frequency of eruption problems, lack of space, impaction, supernumerary teeth (SNT), missing teeth, and ectropion eruption.The number of patients whose chief complaint was not related to orthodontics but had dental problems requiring orthodontic treatment was counted. The proportion of patients with orthodontic problems who received an orthodontic diagnosis was also examined. Results: Dental trauma and SNT were the most frequent chief complaints among the children. The proportion of patients with orthodontic problems increased with age. However, the orthodontic diagnosis rates based on panoramic radiographs among children aged 6, 7, 8 years were only 1.5% (6 years) and 23% (7 and 8 years). Conclusions Accurate information should be provided to patient caregivers to correct misconceptions regarding the appropriateness of delaying orthodontic examination until permanent dentition is established.

OBJECTIVE: The measurement of tumor-associated antigen as tumor makers in the serum is useful for early diagnosis, differential diagnosis, and the determination of remission after therapy in cases of malignancy. A tumor-associated antigen is not always present in all the cells forming the tumor and also be detected in other tumors or normal organs. Tissue polypeptide antigen (TPA) is a single polypeptide chain without carbohydrate. TPA has immunosuppresive properties in patients with cancer. The aim of this study was to evaluate the clinical usefulness of the cytokeratin tumor marker TPA in early diagnosis of patients with the gynecologic cancer. METHODS: In this study, the levels of TPA were measured in the serum of 61 patients with benign gynecologic tumors, 24 patients with malignant gynecologic neoplasms, and 38 healthy nonpregnant females. Serum TPA level was measured by a "sandwitch technique based" radioimmunoassay. RESULTS: As a result, serum TPA level was 30.4+/-7.6 U/L in control group, 32.6+/-9.4 U/L in benign gynecologic tumor group, 39.1+/-9.8 U/L in malignant gynecologic neoplasm. Serum TPA level was 56.6+/-7.0 U/L in ovarian cancer group. CONCLUSION: Serum levels of TPA was increased in the ovarian cancer group, but it does not seem to be a useful tumor maker for non-ovarian cancer. It would seem that measurement of TPA is useful for early diagnosis of ovarian cancer.
Diagnosis, Differential ; Early Diagnosis ; Female ; Genital Neoplasms, Female ; Humans ; Keratins ; Ovarian Neoplasms ; Radioimmunoassay ; Tissue Polypeptide Antigen*

No abstract available.
Herpes Zoster* ; Lupus Erythematosus, Cutaneous*

Aplasia cutis congenita (ACC) is an uncommon condition which is characterized by congenital, localized or widespread absence of skin or scar formation. Lesions can be multiple and may occur on any body surface, although they are mostly seen on the scalp as a solitary lesion. ACC is most often a benign isolated defect; but it can be associated with other physical anomalies or malformation syndromes. Adams-Oliver syndrome is a distinct subtype in which distal limb reduction is found in association with a solitary scalp defect. There is no single underlying cause of ACC; it may reflect a disruption of intrauterine skin development. A 25 day-old boy was referred to our clinic with a thick hemorrhagic crust, and a surrounding hairless atrophic scar on the midline over the skull vertex. He also had hypoplasia of the left 2nd to 5th toes since birth. The rest of the physical examination as well as an ultrasound examination of the brain were normal. Herein we report a rare case of ACC of the scalp accompanied by distal limb hypoplasia, Adamson-Oliver syndrome.
Brain ; Cicatrix ; Ectodermal Dysplasia ; Extremities ; Limb Deformities, Congenital ; Parturition ; Physical Examination ; Scalp ; Scalp Dermatoses ; Skin ; Skull ; Toes

PURPOSE: This study aimed to compare the accuracy (trueness and precision) of interim crowns fabricated using DLP (digital light processing) according to postcuring time. MATERIALS AND METHODS: A virtual stone study die of the upper right first molar was created using a dental laboratory scanner. After designing interim crowns on the virtual study die and saving them as Standard Triangulated Language files, 30 interim crowns were fabricated using a DLP-type 3D printer. Additively manufactured interim crowns were post-cured using three different time conditions-10-minute post-curing interim crown (10-MPCI), 20-minute postcuring interim crown (20-MPCI), and 30-minute post-curing interim crown (30-MPCI) (n = 10 per group). The scan data of the external and intaglio surfaces were overlapped with reference crown data, and trueness was measured using the best-fit alignment method. In the external and intaglio surface groups (n = 45 per group), precision was measured using a combination formula exclusive to scan data (10 C2). Significant differences in accuracy (trueness and precision) data were analyzed using the Kruskal-Wallis H test, and post hoc analysis was performed using the Mann-Whitney U test with Bonferroni correction (α=.05). RESULTS: In the 10-MPCI, 20-MPCI, and 30-MPCI groups, there was a statistically significant difference in the accuracy of the external and intaglio surfaces (P <.05). On the external and intaglio surfaces, the root mean square (RMS) values of trueness and precision were the lowest in the 10-MPCI group. CONCLUSION Interim crowns with 10-minute post-curing showed high accuracy.

PURPOSE: This study aimed to compare the accuracy (trueness and precision) of interim crowns fabricated using DLP (digital light processing) according to postcuring time. MATERIALS AND METHODS: A virtual stone study die of the upper right first molar was created using a dental laboratory scanner. After designing interim crowns on the virtual study die and saving them as Standard Triangulated Language files, 30 interim crowns were fabricated using a DLP-type 3D printer. Additively manufactured interim crowns were post-cured using three different time conditions-10-minute post-curing interim crown (10-MPCI), 20-minute postcuring interim crown (20-MPCI), and 30-minute post-curing interim crown (30-MPCI) (n = 10 per group). The scan data of the external and intaglio surfaces were overlapped with reference crown data, and trueness was measured using the best-fit alignment method. In the external and intaglio surface groups (n = 45 per group), precision was measured using a combination formula exclusive to scan data (10 C2). Significant differences in accuracy (trueness and precision) data were analyzed using the Kruskal-Wallis H test, and post hoc analysis was performed using the Mann-Whitney U test with Bonferroni correction (α=.05). RESULTS: In the 10-MPCI, 20-MPCI, and 30-MPCI groups, there was a statistically significant difference in the accuracy of the external and intaglio surfaces (P <.05). On the external and intaglio surfaces, the root mean square (RMS) values of trueness and precision were the lowest in the 10-MPCI group. CONCLUSION Interim crowns with 10-minute post-curing showed high accuracy.

We investigated whether the combination of phytochemicals and acetic acid in the form of fruit vinegar provides an additive effect on changes of mRNA levels related to fatty acid oxidation in human hepatocyte (HepG2). Among the seven fruit vinegars (Rubuscoreanus, Opuntia, blueberry, cherry, red ginseng, mulberry, and pomegranate) studied, treatment of HepG2 with pomegranate vinegar (PV) at concentrations containing 1 mM acetic acid showed the highest in vitro potentiating effect on the mRNA expression levels of peroxisome proliferator-activated receptor alpha, carnitinepalmitoyl transferase-1, and acyl-CoA oxidase compared to the control group (P < 0.05). Reversed-phase liquid chromatography in combination with quadrupole time-of-flight mass spectrometry analysis revealed four potential compounds (punicalagin B, ellagic acid, and two unidentified compounds) responsible for altered gene expression in HepG2 cells treated with PV as compared with the others. Further investigations are warranted to determine if drinking PV beverages may help to maintain a healthy body weight in overweight subjects.
Acetic Acid ; Acyl-CoA Oxidase ; Beverages ; Blueberry Plant ; Body Weight ; Chromatography, Reverse-Phase ; Drinking ; Ellagic Acid ; Fruit ; Gene Expression ; Hep G2 Cells ; Hepatocytes ; Humans ; Mass Spectrometry ; Morus ; Opuntia ; Overweight ; Panax ; PPAR alpha ; Prunus ; Punicaceae ; RNA, Messenger

Superficial epithelioma with sebaceous differentiation (SESD) is a rare benign neoplasm that shows unique histologic features despite of the non-specific clinical findings. It is histopathologically characterized by a superficial multilobular plate-like proliferation of basaloid cells with clusters of sebocytes, and the plate-like proliferation has numerous broad attachments to the overlying epidermis. We report here on a case of multiple SESDs that presented on the trunk and extremities of 59-year-old woman.
Carcinoma ; Epidermis ; Extremities ; Female ; Humans ; Middle Aged

BACKGROUND: Chronic obstructive pulmonary disease is characterized by emphysema, chronic bronchitis, and small airway remodeling. The alveolar destruction associated with emphysema cannot be repaired by current clinical practices. Stem cell therapy has been successfully used in animal models of cigarette smoke- and elastase-induced emphysema. However, the optimal dose of mesenchymal stem cells (MSCs) for the most effective therapy has not yet been determined. It is vital to determine the optimal dose of MSCs for clinical application in emphysema cases. METHODS: In the present study, we evaluated the therapeutic effects of various doses of MSCs on elastase-induced emphysema in mice. When 3 different doses of MSCs were intravenously injected into mice treated with elastase, only 5x10(4) MSCs showed a significant effect on the emphysematous mouse lung. We also identified action mechanisms of MSCs based on apoptosis, lung regeneration, and protease/antiprotease imbalance. RESULTS: The MSCs were not related with caspase-3/7 dependent apoptosis. But activity of matrix metalloproteinase 9 increased by emphysematous lung was decreased by intravenously injected MSCs. Vascular endothelial growth factor were also increased in lung from MSC injected mice, as compared to un-injected mice. CONCLUSION: This is the first study on the optimal dose of MSCs as a therapeutic candidate. This data may provide important basic data for determining dosage in clinical application of MSCs in emphysema patients.
Airway Remodeling ; Animals ; Apoptosis ; Bronchitis, Chronic ; Emphysema ; Humans ; Lung ; Matrix Metalloproteinase 9 ; Mesenchymal Stromal Cells* ; Methods ; Mice ; Models, Animal ; Pancreatic Elastase* ; Pulmonary Disease, Chronic Obstructive ; Regeneration ; Stem Cells ; Tobacco Products ; Vascular Endothelial Growth Factor A