No abstract available.
Child ; Histiocytoma, Benign Fibrous ; Humans

Objective: This study aimed to retrospectively analyze the prevalence of orthodontic problems and the proportion of patients who underwent orthodontic diagnosis among children aged 6 (n = 300), 7 (n = 400), and 8 (n = 400) years who had undergone panoramic radiography. Methods: Children were divided into five groups according to their chief complaint and consultation: conservative dentistry, oral and maxillofacial surgery, orthodontics, periodontics, and prosthodontics). Chief complaints investigated included first molar eruption, lack of space for incisor eruption, frequency of eruption problems, lack of space, impaction, supernumerary teeth (SNT), missing teeth, and ectropion eruption.The number of patients whose chief complaint was not related to orthodontics but had dental problems requiring orthodontic treatment was counted. The proportion of patients with orthodontic problems who received an orthodontic diagnosis was also examined. Results: Dental trauma and SNT were the most frequent chief complaints among the children. The proportion of patients with orthodontic problems increased with age. However, the orthodontic diagnosis rates based on panoramic radiographs among children aged 6, 7, 8 years were only 1.5% (6 years) and 23% (7 and 8 years). Conclusions Accurate information should be provided to patient caregivers to correct misconceptions regarding the appropriateness of delaying orthodontic examination until permanent dentition is established.

OBJECTIVE: The measurement of tumor-associated antigen as tumor makers in the serum is useful for early diagnosis, differential diagnosis, and the determination of remission after therapy in cases of malignancy. A tumor-associated antigen is not always present in all the cells forming the tumor and also be detected in other tumors or normal organs. Tissue polypeptide antigen (TPA) is a single polypeptide chain without carbohydrate. TPA has immunosuppresive properties in patients with cancer. The aim of this study was to evaluate the clinical usefulness of the cytokeratin tumor marker TPA in early diagnosis of patients with the gynecologic cancer. METHODS: In this study, the levels of TPA were measured in the serum of 61 patients with benign gynecologic tumors, 24 patients with malignant gynecologic neoplasms, and 38 healthy nonpregnant females. Serum TPA level was measured by a "sandwitch technique based" radioimmunoassay. RESULTS: As a result, serum TPA level was 30.4+/-7.6 U/L in control group, 32.6+/-9.4 U/L in benign gynecologic tumor group, 39.1+/-9.8 U/L in malignant gynecologic neoplasm. Serum TPA level was 56.6+/-7.0 U/L in ovarian cancer group. CONCLUSION: Serum levels of TPA was increased in the ovarian cancer group, but it does not seem to be a useful tumor maker for non-ovarian cancer. It would seem that measurement of TPA is useful for early diagnosis of ovarian cancer.
Diagnosis, Differential ; Early Diagnosis ; Female ; Genital Neoplasms, Female ; Humans ; Keratins ; Ovarian Neoplasms ; Radioimmunoassay ; Tissue Polypeptide Antigen*

No abstract available.
Herpes Zoster* ; Lupus Erythematosus, Cutaneous*

Aplasia cutis congenita (ACC) is an uncommon condition which is characterized by congenital, localized or widespread absence of skin or scar formation. Lesions can be multiple and may occur on any body surface, although they are mostly seen on the scalp as a solitary lesion. ACC is most often a benign isolated defect; but it can be associated with other physical anomalies or malformation syndromes. Adams-Oliver syndrome is a distinct subtype in which distal limb reduction is found in association with a solitary scalp defect. There is no single underlying cause of ACC; it may reflect a disruption of intrauterine skin development. A 25 day-old boy was referred to our clinic with a thick hemorrhagic crust, and a surrounding hairless atrophic scar on the midline over the skull vertex. He also had hypoplasia of the left 2nd to 5th toes since birth. The rest of the physical examination as well as an ultrasound examination of the brain were normal. Herein we report a rare case of ACC of the scalp accompanied by distal limb hypoplasia, Adamson-Oliver syndrome.
Brain ; Cicatrix ; Ectodermal Dysplasia ; Extremities ; Limb Deformities, Congenital ; Parturition ; Physical Examination ; Scalp ; Scalp Dermatoses ; Skin ; Skull ; Toes

PURPOSE: This study aimed to compare the accuracy (trueness and precision) of interim crowns fabricated using DLP (digital light processing) according to postcuring time. MATERIALS AND METHODS: A virtual stone study die of the upper right first molar was created using a dental laboratory scanner. After designing interim crowns on the virtual study die and saving them as Standard Triangulated Language files, 30 interim crowns were fabricated using a DLP-type 3D printer. Additively manufactured interim crowns were post-cured using three different time conditions-10-minute post-curing interim crown (10-MPCI), 20-minute postcuring interim crown (20-MPCI), and 30-minute post-curing interim crown (30-MPCI) (n = 10 per group). The scan data of the external and intaglio surfaces were overlapped with reference crown data, and trueness was measured using the best-fit alignment method. In the external and intaglio surface groups (n = 45 per group), precision was measured using a combination formula exclusive to scan data (10 C2). Significant differences in accuracy (trueness and precision) data were analyzed using the Kruskal-Wallis H test, and post hoc analysis was performed using the Mann-Whitney U test with Bonferroni correction (α=.05). RESULTS: In the 10-MPCI, 20-MPCI, and 30-MPCI groups, there was a statistically significant difference in the accuracy of the external and intaglio surfaces (P <.05). On the external and intaglio surfaces, the root mean square (RMS) values of trueness and precision were the lowest in the 10-MPCI group. CONCLUSION Interim crowns with 10-minute post-curing showed high accuracy.

PURPOSE: This study aimed to compare the accuracy (trueness and precision) of interim crowns fabricated using DLP (digital light processing) according to postcuring time. MATERIALS AND METHODS: A virtual stone study die of the upper right first molar was created using a dental laboratory scanner. After designing interim crowns on the virtual study die and saving them as Standard Triangulated Language files, 30 interim crowns were fabricated using a DLP-type 3D printer. Additively manufactured interim crowns were post-cured using three different time conditions-10-minute post-curing interim crown (10-MPCI), 20-minute postcuring interim crown (20-MPCI), and 30-minute post-curing interim crown (30-MPCI) (n = 10 per group). The scan data of the external and intaglio surfaces were overlapped with reference crown data, and trueness was measured using the best-fit alignment method. In the external and intaglio surface groups (n = 45 per group), precision was measured using a combination formula exclusive to scan data (10 C2). Significant differences in accuracy (trueness and precision) data were analyzed using the Kruskal-Wallis H test, and post hoc analysis was performed using the Mann-Whitney U test with Bonferroni correction (α=.05). RESULTS: In the 10-MPCI, 20-MPCI, and 30-MPCI groups, there was a statistically significant difference in the accuracy of the external and intaglio surfaces (P <.05). On the external and intaglio surfaces, the root mean square (RMS) values of trueness and precision were the lowest in the 10-MPCI group. CONCLUSION Interim crowns with 10-minute post-curing showed high accuracy.

BACKGROUND: The pathogenesis of melasma has not yet been clearly identified. Recently, it was reported that dermal fibroblasts played an important role in the epidermal pigmentary disorders. OBJECTIVES: To investigate the role of fibroblast-derived cytokines, hepatocyte growth factor (HGF), stem cell factor (SCF), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1alpha in the development of melasma. METHOD: Using immunohistochemistry, we measured the levels of cytokines produced by fibroblasts derived from lesional skin, compared with perilesional normal skin in 50 melasma patients. RESULTS: The expression of HGF and SCF was found to be significantly increased in the lesional dermis compared to perilesional normal skin. However, there was no significant difference in the expression of TNF-alpha and IL-1alpha in melasma skin. CONCLUSION: These results may indicate that the dermal fibroblast-derived cytokines, HGF and SCF play an important role in the mechanism of hyperpigmentation in melasma.
Cytokines* ; Dermis ; Fibroblasts ; Hepatocyte Growth Factor ; Humans ; Hyperpigmentation ; Immunohistochemistry ; Interleukins ; Melanosis* ; Skin ; Stem Cell Factor ; Tumor Necrosis Factor-alpha

BACKGROUND: Chromium is one of the most common metal allergens that cause allergic contact dermatitis. European regulation of chromium (VI) content in cement was first implemented in 2005, and regulation of chromium in leather in 2015. OBJECTIVE: This clinical study was performed to obtain basic data on subjects with allergic contact dermatitis due to chromium in Korea. We investigated the clinical characteristics of patients with chromium allergy among subjects with contact dermatitis who underwent patch tests. METHODS: Patch test data from June 1998 to January 2014 were retrospectively analyzed (n=975; men=290, women=685). Patients who showed positive reactions to potassium dichromate (chromium [+] group; n=58) and who showed positive reactions to other allergens except potassium dichromate (others [+] group; n=497) were identified and the characteristics of both groups were compared. Patients who only reacted to chromium (only chromium group; n=17) were identified, and their clinical characteristics were investigated. The prevalence of chromium allergy was analyzed in each 4-year period to study the changes over time. RESULTS: The sensitization rate of potassium dichromate was 5.9% (n=58) and women comprised 72.4% (n=42) of the chromium (+) group. Hands and feet were more frequently affected in the chromium (+) group (p=0.002 and 0.019, respectively). Occupational dermatitis was significantly less common in the chromium (+) group. Chromium allergy was the most prevalent in patients in their 50s (8.4%). The only chromium group had significantly more number of patients aged 40 years or older (p=0.004). The prevalence of chromium allergy was 13.5% during 1998~2002, but decreased to 5.4% during 2010~2014. CONCLUSION: The characteristics of patients with chromium allergy suggests that chromium exposure in daily activities, including leather exposure, is more relevant than occupational exposure for most patients. The prevalence of chromium allergy has been decreasing in Korea, which may be an effect of voluntary regulation of chromium content in cement by manufacturers.
Allergens ; Chromium* ; Dermatitis, Allergic Contact ; Dermatitis, Contact ; Dermatitis, Occupational ; Female ; Foot ; Hand ; Humans ; Hypersensitivity* ; Korea* ; Occupational Exposure ; Patch Tests ; Potassium Dichromate ; Prevalence ; Retrospective Studies

Fexofenadine (Allegra(R) 180) is a second-generation antihistamine. It is widely used as anti-allergic drug, which suppresses various allergic reactions mediated by histamines. A few cases of H1-antihistamine-induced urticaria have been reported. Herein, we report a rare case of fexofenadine-induced urticaria which was confirmed by a prick test, oral provocation test, and flow cytometry assisted-basophil activation test.
Basophil Degranulation Test ; Flow Cytometry ; Hypersensitivity ; Terfenadine ; Urticaria