1.Molecular Analysis of Oculocutaneous Albinism Patients in Korea.
Ji Hwan HWANG ; Sang Woong YOUN ; Jong Seong AHN ; Kyu Han KIM ; Kyoung Chan PARK
Annals of Dermatology 1997;9(3):182-187
BACKGROUND: Oculocutaneous albinism (OCA) is a genetic disorder of the melanin pigment system in which melanin synthesis is reduced or absent in the skin, hair, and eyes. OCA is classified into two major types, and tyrosinase-related OCA can be produced by mutations of the structural gene for tyrosinase enzyme (TYR gene). OBJECTIVE: The purpose of this study was to analyze the segregation of mutant alleles of the TYR gene in tyrosinase-negative and tyrosinase-positive Korean OCA patients and families. METHODS: We amplified exon I, II, and III of the TYR gene of Korean OCA patients and their families by polymerase chain reactions (PCR), and analyzed the mutations by restriction fragment length polymorphism (RFLP) analysis in exon I and single-strand conformation polymorphism (SSCP) analyses in exon II and exon III. RESULTS: Two tyrosinase-negative cases showed mutations in exon I. Four tyrosinase-nega-tive cases and one tyrosinase-positive case showed mutations in exon II, and one tyrosinase-neg- ative case showed mutations in exon III. In summary, we found three kinds of mutation in four tyrosinase-negative OCA patients and one tyrsinase-positive OCA patient. CONCLUSIONS: RFLP and SSCP analysis can provide a basis for a rapid and sensitive screening system to detect TYR gene mutations of Korean OCA patients and their families.
Albinism, Oculocutaneous*
;
Alleles
;
Exons
;
Hair
;
Humans
;
Korea*
;
Mass Screening
;
Melanins
;
Monophenol Monooxygenase
;
Polymerase Chain Reaction
;
Polymorphism, Restriction Fragment Length
;
Polymorphism, Single-Stranded Conformational
;
Skin
2.Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression.
Kanghee LEE ; Ji Won HAN ; Ki Woong KIM
Psychiatry Investigation 2017;14(5):708-711
Differentiating early Alzheimer's disease (AD) from depression with cognitive impairment is challenging in the elderly. To develop a model for differentiating these two conditions using electroencephalography (EEG), we enrolled 11 patients with early probable AD and 11 age- and cognitive function-matched patients with major depressive disorder (MDD) and compared the EEG relative powers of 9 scalp regions. Compared to the MDD group, the AD group had a higher global theta relative power (p=0.021). In the MDD group, beta relative power was higher in the mid-central region than in the left or right central regions (p<0.01). The prediction model that included global theta relative power and regional beta index was able to discriminate AD from MDD (AUC=0.893, p=0.002). A combination of global theta relative power and intra-individual regional differences in beta may differentiate early AD from MDD with cognitive impairment.
Aged
;
Alzheimer Disease*
;
Cognition Disorders
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Depression*
;
Depressive Disorder, Major
;
Diagnosis, Differential
;
Electroencephalography*
;
Humans
;
Scalp
3.Range of Eye Movement in a Normal Population and Its Relationship to Age.
Journal of the Korean Ophthalmological Society 2017;58(6):698-705
PURPOSE: The purpose of this study is to measure the range of normal eye movement and to evaluate the effect of age on the range of ocular movement in a normal population. METHODS: We conducted a prospective observational study of 85 subjects aged between 5 and 91 years. Photographs were taken of the cardinal position, and these images were analyzed using an image analysis software (Adobe Photoshop 6.0, Adobe, San Jose, CA, USA). To measure the range of eye movement, the preprocessed images were analyzed using the Image J program. The range of movement of the eyeball was quantitatively measured using corneal limbal analysis. Specifically, the ranges of ocular movement according to adduction, abduction, elevation, and depression were measured. RESULTS: The normal movement ranges were 44.4 ± 6.9° in adduction, 44.8 ± 5.5° in abduction, 27.7 ± 7.6° in elevation, and 46.7 ± 8.4° in depression. Adduction, abduction, and elevation were negatively correlated with age (R² = 0.220, R² = 0.126, and R² = 0.304, respectively, all p < 0.001). However, there was no significant correlation between age and depression (R² = 0.030, p = 0.113). CONCLUSIONS: For all ages, the range of normal ocular movement in the horizontal direction was symmetric, while the range of ocular movement in elevation was smaller than that of depression. As age increased, the range of ocular movement decreased in all directions except depression, but depression did not decrease with age. When assessing eye movement, it is necessary to consider the range of ocular movements relative to both the movement direction and changes in the ocular movement range according to age.
Aging
;
Depression
;
Eye Movements*
;
Observational Study
;
Prospective Studies
4.Risk Factors that Affects Progression of Type 2 Retinopathy of Prematurity
Journal of the Korean Ophthalmological Society 2019;60(10):953-958
PURPOSE: To identify risk factors that affect the development of type 2 retinopathy of prematurity (ROP) and progression to type 1 or threshold ROP requiring treatment. METHODS: The medical records of premature infants born with a birth weight ≤1,500 g or a gestational age ≤32 weeks were retrospectively reviewed. Potential risk factors were divided into systemic and ophthalmic factors and analyzed by univariate and multivariate logistic regression analyses. RESULTS: Three hundred and twenty-four eyes met the screening criteria. Among them, 41 eyes (12.65%) progressed to type 2 ROP and 21 eyes (6.48%) received treatment after progression to type 1 or threshold ROP. The systemic risk factor associated with progression from type 2 ROP was periventricular leukomalacia and the ophthalmic factor was the existence of nasal ROP at the time of diagnosis of type 2 ROP. CONCLUSIONS: Careful examination was needed when type 2 ROP with periventricular leukomalacia or nasal ROP developed because there was a high probability of progression and treatment.
Birth Weight
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Diagnosis
;
Gestational Age
;
Humans
;
Infant, Newborn
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Infant, Premature
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Leukomalacia, Periventricular
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Logistic Models
;
Mass Screening
;
Medical Records
;
Retinopathy of Prematurity
;
Retrospective Studies
;
Risk Factors
5.Prevalence and Trends of Dementia in Korea: A Systematic Review and Meta-Analysis.
You Joung KIM ; Ji Won HAN ; Yoon Seop SO ; Ji Young SEO ; Ka Young KIM ; Ki Woong KIM
Journal of Korean Medical Science 2014;29(7):903-912
Through a systematic review and meta-analysis of epidemiological studies on dementia, we assessed the prevalence of dementia and its subtypes-Alzheimer' disease (AD) and vascular dementia (VaD)-in Korea. We searched for epidemiological studies on dementia published in 1990-2013 using PubMed, Scopus, EMBASE, KoreaMed, KISS, and RiCH. Dementia prevalence in elderly patients (aged> or =65 yr) was 9.2% (95% confidence interval [CI], 8.2%-10.4%) from 11 studies, which was higher than those from Western and other Asian countries. AD was the most prevalent dementia type, with a prevalence of 5.7% (95% CI, 5.0%-6.4%) from 10 studies compared with 2.1% (95% CI, 1.6%-2.7%) for VaD from 9 studies. The age-specific prevalence of dementia approximately doubled with each 5.8-yr increase of age. Although a significant increasing trend of dementia prevalence was not observed, it increased slightly from 7.3% to 8.7% after 2005; AD prevalence increased after 1995 and VaD prevalence decreased after the early 2000s. The AD/VaD ratio increased from 1.96 in the early 1990s to 4.13 in the 2010s, similar to the worldwide ratio. Owing to this high prevalence in the aging population, dementia will impose significant economic burdens to Korean society.
Age Factors
;
Alzheimer Disease/epidemiology
;
Asian Continental Ancestry Group
;
Databases, Factual
;
Dementia/*epidemiology
;
Dementia, Vascular/epidemiology
;
Humans
;
Prevalence
;
Quality Assurance, Health Care
;
Republic of Korea
6.A Case of Gastric Cavernous Hemangioma Diagnosed by Endoscopic Submucosal Dissection.
Mun Chul KIM ; Shang Hoon HAN ; Mi Young JANG ; Seol Bong YOO ; Back Jin SUNG ; Wang Guk OH ; Ji Woong KIM ; Jin Woong CHO
The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2013;13(3):198-201
Gastric cavernous hemangioma is a relatively rare benign gastric disease. Gastric hemangiomas are most commonly encountered in adulthood, although they can occur in any age group. While surgical resection is the curative treatment, endoscopic resection can be performed for treatment of selected cases. The patient was a 53-year-old male who was referred for evaluation of incidentally detected gastric subepithelial tumor with dense vascularity and oozing on the apex of the lesion. An EUS revealed a homogenously hypoechoic mass confined to the submucosal layer that showed no continuity with adjacent vessels, and there was no regional lymphadenopathy. Endoscopic submucosal dissection was successfully performed with en bloc resection. The final diagnosis was benign cavernous hemangioma of the stomach.
Hemangioma
;
Hemangioma, Cavernous
;
Humans
;
Male
;
Middle Aged
;
Stomach
;
Stomach Diseases
7.A Clinical Analysis of Abdominal Stab Injuries.
Jae Woong HAN ; Byung Chun KIM ; Jae Pil JUNG ; Ji Woong CHO ; Bong Hwa CHUNG ; Kyung Suk CHUNG ; Koo Hyun KANG
Journal of the Korean Society of Traumatology 2006;19(2):143-149
PURPOSE: This study was done to evaluate the incidence, type of injury, medical consequences, mortality, and prognostic factors associated with stab wounds in patients who visited Kangnam Sacred Heart Hospital, Hallym University, Seoul, Korea. METHODS: A retrospective analysis of the clinical data of 40 patients with abdominal stab wounds who visited Kangnam Sacred Heart Hospital, Hallym University, Seoul, Korea from January 1, 2000 to December 31, 2004. RESULTS: 1) The most prevalent age group was patients in their the twenties to fourties (77.5% of all patients), and average age of the patients was 39.3 years. The male-to-female ratio was 2.07:1. 2) The external site of stab wounds was most commonly the periumbilcal area of the abdomen (14 cases, 33.3%). 3) The most commonly injured organs were the liver and the stomach (10 cases each, 16.9%). 4) Operations were performed on all 40 patients, with 9 (22.5%) negative operation findings. 5) Death occurred in 5 cases (12.5%). 6) The trauma indices of the death group were TRISS 51.9%, RTS 3.6 points, and APACHE II 23.0 points. 7) The average transfusion amount of the death group was 13.8 pints CONCLUSION: These data suggest that the transfusion amount and the trauma index of abdominal stab injuries may be statistically significant factors for predicting mortality.
Abdomen
;
APACHE
;
Heart
;
Humans
;
Incidence
;
Korea
;
Liver
;
Mortality
;
Retrospective Studies
;
Seoul
;
Stomach
;
Wounds, Stab
8.A Clinical Analysis of Abdominal Stab Injuries.
Jae Woong HAN ; Byung Chun KIM ; Jae Pil JUNG ; Ji Woong CHO ; Bong Hwa CHUNG ; Kyung Suk CHUNG ; Koo Hyun KANG
Journal of the Korean Society of Traumatology 2006;19(2):143-149
PURPOSE: This study was done to evaluate the incidence, type of injury, medical consequences, mortality, and prognostic factors associated with stab wounds in patients who visited Kangnam Sacred Heart Hospital, Hallym University, Seoul, Korea. METHODS: A retrospective analysis of the clinical data of 40 patients with abdominal stab wounds who visited Kangnam Sacred Heart Hospital, Hallym University, Seoul, Korea from January 1, 2000 to December 31, 2004. RESULTS: 1) The most prevalent age group was patients in their the twenties to fourties (77.5% of all patients), and average age of the patients was 39.3 years. The male-to-female ratio was 2.07:1. 2) The external site of stab wounds was most commonly the periumbilcal area of the abdomen (14 cases, 33.3%). 3) The most commonly injured organs were the liver and the stomach (10 cases each, 16.9%). 4) Operations were performed on all 40 patients, with 9 (22.5%) negative operation findings. 5) Death occurred in 5 cases (12.5%). 6) The trauma indices of the death group were TRISS 51.9%, RTS 3.6 points, and APACHE II 23.0 points. 7) The average transfusion amount of the death group was 13.8 pints CONCLUSION: These data suggest that the transfusion amount and the trauma index of abdominal stab injuries may be statistically significant factors for predicting mortality.
Abdomen
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APACHE
;
Heart
;
Humans
;
Incidence
;
Korea
;
Liver
;
Mortality
;
Retrospective Studies
;
Seoul
;
Stomach
;
Wounds, Stab
9.A Case of Esophageal Stricture Due to Metastatic Breast Cancer Diagnosed by Using Endoscopic Ultrasound Guided Fine Needle Biopsy.
Shang Hoon HAN ; Min A YANG ; Jae Un LEE ; Moon Sik PARK ; Young Jae LEE ; Ji Woong KIM ; Myoung Jin JU ; Jin Woong CHO
The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2015;15(2):136-140
Metastatic cancer to the esophagus is rare and the breasts are the most common primary tumors that metastasize to the esophagus. Since metastatic breast cancer is located in the submucosal layer, diagnosis by general forceps biopsy is difficult. Hence, various techniques including endoscopic ultrasound guided fine needle aspiration, endoscopic ultrasound guided fine needle biopsy, unroofing technique, and submucosal tunneling method are used for diagnosis. Moreover, the patient's medical history should be inspected carefully and previous histological findings of cancer should also be evaluated. Herein, the authors report a case of metastatic breast cancer along with literature reviews. Endoscopy was performed in patient who had undergone breast cancer surgery 13 years previously. Histological examination from a midesophageal stricture was normal. Endoscopic ultrasound was performed and uneven hypoechoic masses were found in the third layer of the esophageal wall. The esophageal stricture was finally diagnosed as metastatic breast cancer by endoscopic ultrasound-guided fine needle biopsy.
Biopsy
;
Biopsy, Fine-Needle*
;
Breast
;
Breast Neoplasms*
;
Constriction, Pathologic
;
Diagnosis
;
Endoscopic Ultrasound-Guided Fine Needle Aspiration
;
Endoscopy
;
Endosonography
;
Esophageal Stenosis*
;
Esophagus
;
Humans
;
Neoplasm Metastasis
;
Surgical Instruments
;
Ultrasonography*
10.The Effect of Corneal Biomechanical Factors on Ocular Pulse Amplitude in Normal Subjects.
Han Jo KWON ; Ji Woong LEE ; Jong Hun SHIN
Journal of the Korean Ophthalmological Society 2015;56(8):1248-1255
PURPOSE: To investigate the influence of corneal biomechanical factors on ocular pulse amplitude measured using dynamic contour tonometry in normal subjects. METHODS: The study population consisted of normal subjects who visited the outpatient clinic from January, 2014 to July, 2014. Ocular pulse amplitude was measured using dynamic contour tonometry and corneal hysteresis (CH) and corneal resistance factor (CRF) were measured using an ocular response analyzer. We applied univariate and multivariate linear regressions to investigate the relationship between ocular pulse amplitude and corneal biomechanical factors and other ocular factors. RESULTS: Fifty eyes of 50 patients (average age 52.8 +/- 17.2 years) were examined. The average ocular pulse amplitude was 2.90 +/- 1.04 mm Hg and the CH and CRF were 10.44 +/- 1.96 mm Hg and 11.03 +/- 2.21 mm Hg, respectively. In univariate linear regression, factors influencing ocular pulse amplitude were ocular pressure based on CRF (beta = 0.280, p = 0.049), Goldmann applanation tonometry (beta = 0.293, p = 0.039), and spherical equivalent (beta = 0.283, p = 0.047), while in multivariate linear regression the only factor influencing ocular pulse amplitude was CRF (beta = 0.686, p = 0.042). CONCLUSIONS: A positive correlation between ocular pulse amplitude reflecting ocular perfusion pressure and CRF reflecting corneal elasticity was observed. Correlations between the 2 factors will be an important aspect in future studies regarding the influences of corneal biomechanical factors on ocular perfusion pressure in glaucoma patients.
Ambulatory Care Facilities
;
Elasticity
;
Glaucoma
;
Humans
;
Linear Models
;
Manometry
;
Perfusion