Adult ; Coal Mining ; Humans ; Male ; Pneumoconiosis ; classification ; diagnostic imaging ; Radiography ; Reference Standards

OBJECTIVE:To investigate therapeutic efficacy and recurrence rate of vaginal administration of lactobacillus com-bined with chlorquinaldol-promestriene for senile patients with atrophic vaginitis. METHODS:150 senile patients with atrophic vag-initis were selected and divided into group A,B,C according to random number table,with 50 cases in each group. Group A was given Lactobacillus vaginal capsules,2 capsules,qd (at bedtime);group B given Chlorquinaldol-promestriene vaginal tablets,1 tablet,qd(at bedtime);group C given Chlorquinaldol-promestriene vaginal tablets,1 tablet,qd(at bedtime),and Lactobacillus vaginal capsules,2 capsules,qd,next morning,implanting into vagina. 3 groups received treatment for 18 d. Clinical efficacy, vaginal health score,vaginal symptom score and vaginal pH value were observed in 3 groups,and the occurrence of ADR and re-currence rate during follow-up period (12 months) were recorded. RESULTS:The total effective rate of group C was 94.00%, which was significantly higher than group A(72.00%)and B(74.00%),with statistical significance(P<0.05). Before treatment, there was no statistical significance in vaginal health score,vaginal symptom score and vaginal pH value among 3 groups (P>0.05). After treatment,vaginal health score of 3 groups were increased significantly,while vaginal symptom score and vaginal pH value were decreased significantly;and the improvement of above indexes in group C were significantly better than in group A and B,with statistical significance(P<0.05). No obvious ADR was found in 3 groups during treatment. The recurrence rate of group C during follow-up period(4.00%)was significantly lower than that of group A(18.00%)and group B(20.00%),with statistical significance(P<0.05). CONCLUSIONS:Vaginal administration of lactobacillus combined with chlorquinaldol-promestriene for se-nile patients with atrophic vaginitis can effectively relieve clinical symptoms and signs,improve vaginal cleanliness,regulate the lo-cal pH value and reduce the risk of recurrence,with good safety.

Objective To observe the effect of T cell subset in the children patients with community acquired pneumonia. Methods A total of 36 patients with community acquired pneumonia were enrolled and they were divided into 2 groups according to pathogen, bacterial infection group, and non-bacterial infection group. And in another way they were divided into severe cases group and non-severe cases group. Indexes of T lymphocyte subset CD3+, CD4+, CD8+, CD19+and activity of natural killer (NK) cell were detected in all patients by flow cytometry and compared. Results The levels of CD3+, CD4 +, CD8 +, CD19 + and NK cell had no significant difference between bacterial infection group and non-bacterial infection group (P>0.05). The levels of CD3+, CD4+and CD19+had no significant difference between severe cases group and non-severe cases group (P>0.05). But the level of CD8+ in severe cases group was significantly higher than that in non-severe cases group:(28.4 ± 7.8)%vs. (14.4 ± 3.5)%, P<0.01. The level of NK cell in severe cases group was significantly lower than that in non-severe cases group: (7.3 ± 2.1)%vs. (16.6 ± 5.4)%, P<0.01. Conclusions The children patients with community acquired pneumonia patients may develop into severe pneumonia with high percent of CD8+or low activity of NK cell. So they should be given immune intervention as soon as possible.

Objective To observe the treatment of continuous passive motion ( CPM) on lower motor function in pa-tients with stroke.Methods 60 patients were evenly randomized into control group and treatment group .The control group received conventional rehabilitation treatment , while the treatment group received conventional rehabilitation and CPM therapy .They were assessed with modified Ashworth scale ( MAS) ,Fugl-Meyer assessment ( FMA) ( lower limb,hip,knee and ankle) and 10-meter walking time.Results After treatment,the scores of MAS,FMA and 10-meter walking time were both improved when compared with those before treatment (P<0.05),and between the two groups ,the scores of MAS , FMA and 10-meter walking time were much better in the treatment group with signifi-cant difference ( P<0.05 ) .Conclusion CPM can alleviate muscle spasms ,and enhance the muscle group coordi-nation on foot .Furthermore,CPM can contribute to the balance and lower limb motor function , and strengthen gait of patients with stroke .

OBJECTIVE:To analyze the factors in the causation of cefradine-induced hematuria.METHODS:The material in CHINESE BIBLIOGRAPHIC DATA BASE OF BIOLOGY & MEDICINE(from 1980 to February 2001)and PHARMACEUTICAL ABSTRACTS(1990～2000)was reviewed and the data were analysed on patients'age and sex,route of drug administration,beginning of hematuria,prognosis and time of recovery.RESULTS:18 reports on cefradine-induced hematuria(108 cases) were found,which indicated that hematuria was mainly associated with renal hypoplasia in childhood and intravenous administration of cefradine.CONCLUSION:Intravenous administration of cefradine in children should be very careful.

OBJECTIVE:To explore the clinical significance of water-soluble vitamins for injection in supportive care of postoperative tumor patients undergoing chemotherapy.METHODS:Water-soluble vitamins for injection was given to64post operative patients with gastrointestinal malignancy in treatment group for3days before chemotherapy and for7days after chemotherapy;adenosine triphosphate,coenzyme a and kalium chloratum were given to60patients in control group for the same period.Nutritional and oral mucosa condition,hemoglobin and hepatic function were observed before and after chemotherapy.RESULTS:Appetite increased in71.8%patients in treatment group,none was observed in control group(P

Objective To study the clinical application of trigemino-cervical reflex(TCR)in migraine without aura(MWOA)and chronic tension-type headache(CTTH).Methods The TCR was recorded using surface electromyographic recordings bilaterally from the sternocleidomastoid muscle after stimulation of infraorbital branch of the trigeminal nerve.The reflex was investigated in 25 patients with unilateral MWOA,25 patients with CTTH and 36 healthy subjects.The patients were outpatients who visited Fujian provincial institution hospitals from January 2009 to February 2010.Results Compared with the healthy subjects,the bilateral peak latency of P19/N31(PLP19 and PLN31)was significantly shortened in the subjects with MWOA(left and fight side were(19.49 ± 1.95)ms and(19.81 ± 1.79)ms respectively)or CTTH(left:(19.56 ±2.02)ms,and right:(19.16 ± 1.67)ms),t values were between 2.027 and 3.654,all P ＜ 0.05.The values of PLP19 and PLN31 between the patients with MWOA and with CTTH were not significantly different.Conclusions The peak latency of P19/N31 was shortened in the subjects with MWOA or CTTH,suggesting that the trigeminal and brainstem may participate in the pathophysiology of MWOA and CTTH.There was no significant difference in PLP19 and PLN31 between the patients with MWOA and CTTH,indicating similar abnormalities in the endogenous pain control mechanisms in both migraine and

Evidence suggests that translocation of gut bacteria or their toxins is a major contributor to gut-derived sepsis and multisystem organ failure in critically ill patients.This review reevaluates the data from studies in animal models and humans on bacterial translocation.The new insights in mechanisms of bacterial translocation pathogenesis and its clinical relevance will help clinicians to make correct strategies to enhance gut function.

Objective: To evaluate the effect and clinical significance of early enteral nutrition in postoperative patients with malignant obstructive jaundice. Methods: Thirty patients with malignant obstructive jaundice were randomized into postoperative early enteral nutrition (EN) group and parenteral nutrition (PN) group. Results: The body weight and level of prealbumin, albumin, transferrin decreased significantly after operation in both group, and there was no significant difference between two groups. Nitrogen balance was positive in the EN group, but it was negative in the PN group. EN had less influence on hepatic enzymes than PN. The economic consumption in EN group was less than that in PN group. Conclusions: Compared with PN, early EN support can ameliorate malnutrition state in postoperative patients with malignant obstructive jaundice more safely, effectively and economically.

The authors,in this paper,has briefly looked back the developmental history of human parasitology,which,as an independent discipline,was established in late 19th century and early 20th century.In the process,it underwent an early height of development,then met with setback and relative decline.Since 70s-80s of last century,the introduction and application of new theory of modern biology,especially advanced biotechniques to parasitology has led to a striking development in many fields of the discipline,leading to deeper understanding of parasite-host interplay as well as providing new ideals and tools for disease control.The authors also stressed that nowadays the discipline is still relatively isolated from the mainstream of modern biologic research and is still neglected by scientific community and medical education in the world,though it still is one of the major problems in public health,particularly in developing world including China.To argue the currently neglected situation of parasitology,especially in medical education,the authors emphasized the continuing requirements for the discipline and reflected on the developmental strategy of parasitology to meet the coming challenges and opportunities for further development.