No abstract available.
Female ; Hydronephrosis* ; Ovarian Cysts*

OBJECTIVES: A healthcare decision-making support model and rule management system is proposed based on a personalized rule-based intelligent concept, to effectively manage chronic diseases. METHODS: A Web service was built using a standard message transfer protocol for interoperability of personal health records among healthcare institutions. An intelligent decision service is provided that analyzes data using a service-oriented healthcare rule inference function and machine-learning platform; the rules are extensively compiled by physicians through a developmental user interface that enables knowledge base construction, modification, and integration. Further, screening results are visualized for the self-intuitive understanding of personal health status by patients. RESULTS: A recommendation message is output through the Web service by receiving patient information from the hospital information recording system and object attribute values as input factors. The proposed system can verify patient behavior by acting as an intellectualized backbone of chronic diseases management; further, it supports self-management and scheduling of screening. CONCLUSIONS: Chronic patients can continuously receive active recommendations related to their healthcare through the rule management system, and they can model the system by acting as decision makers in diseases management; secondary diseases can be prevented and health management can be performed by reference to patient-specific lifestyle guidelines.
Chronic Disease* ; Decision Support Systems, Clinical ; Delivery of Health Care* ; Expert Systems ; Health Records, Personal ; Humans ; Knowledge Bases ; Life Style ; Mass Screening ; Self Care

No abstract available.
Hepacivirus ; Hepatitis C* ; Hepatitis*

The study of antiviral pathways to reveal methods for the effective response and clearance of virus is closely related to understanding interferon (IFN) signaling and its downstream target genes, IFN-stimulated genes. One of the key antiviral factors induced by IFNs, 2'-5' oligoadenylate synthase (OAS), is a well-known molecule that regulates the early phase of viral infection by degrading viral RNA in combination with RNase L, resulting in the inhibition of viral replication. In this review, we describe OAS family proteins from a different point of view from that of previous reviews. We discuss not only RNase L-dependent (canonical) and -independent (noncanonical) pathways but also the possibility of the OAS family members as biomarkers for various diseases and clues to non-immunological functions based on recent studies. In particular, we focus on OASL, a member of the OAS family that is relatively less well understood than the other members. We will explain its anti- and pro-viral dual roles as well as the diseases related to single-nucleotide polymorphisms in the corresponding gene.
2',5'-Oligoadenylate Synthetase/*genetics/*metabolism ; Animals ; Biomarkers ; *Disease Susceptibility ; Endoribonucleases/metabolism ; Genetic Predisposition to Disease ; Humans ; Multigene Family ; Polymorphism, Single Nucleotide ; Signal Transduction

OBJECTIVE: Endometriosis is a very common gynecological condition in which tissue similar to endometrium proliferates at sites outside the uterine cavity. Although it generally remain a benign condition, malignant transformation has been documented, and it is commonly found in association with endometrioid subtype ovarian carcinoma. In order to identify the genomic change in those areas possibly involved in the pathogenesis of endometriosis, we performed LOH analysis. METHODS: Twenty seven cases of endometriosis were analyzed for the detection of LOH using 5 microsatellite markers. LOH analysis was performed by PCR, capillary electrophoresis and gene scan analysis using DNA from sections of tumor and normal tissue pairs. RESULTS: Twenty two of 27 (81.5%) cases demonstrated LOH at one or more loci. The frequency of LOH was 37.0% (D18S69), 25.9% (D22S274), 14.8% (D22S283), 7.4% (D6S286), 7.4% (D13S160). CONCLUSION: The frequencies of LOH was increased in higher stage of endometriosis. Most notable findings were found at chromosome 18 and 22 loci (D18S69, D22S274). These region might involve the some candidate genes closely related with the pathogenesis of endometriosis.
Chromosomes, Human, Pair 18 ; DNA ; Electrophoresis, Capillary ; Endometriosis* ; Endometrium ; Female ; Loss of Heterozygosity* ; Microsatellite Repeats ; Polymerase Chain Reaction

No abstract available.
Brain* ; Meningitis* ; Tuberculoma*

Purpose: The purpose of this study is to evaluate Ti-base abutment’s three different heights and three different cement types on the pull-off force of zirconia-based restorations. Materials and Methods: A total of 90 fixture lab analogs were embedded in auto polymerizing resin bloack. 90 Ti-base abutments heights of 3 mm, 5 mm, 7 mm were scanned and zirconia restoration were prepared from scanned files. Zirconia restoration were cemented with three different types of cements (temporary, semi-permanent, permanent) following manufacturer’s instructions. All 90 specimens were placed and tested in a universal testingmachine for pull-out testing. Retention was measured by recording the force at load drop. Statistical analysis was performedusing Kruskal-Wallis test for detecting whether there are any statistical significance along cement types or abutment heights.After that, Mann-Whitney test was used for figuring out differences regarding abutment height and the comparison between 3cements. Results: Temp bond showed significantly lower pull-off force compared to Fujicem regardless of any abutment height.However, there were significant differences between Cem-implant and Fujicem in abutment height of 3 mm and 7 mm, but there was no significant difference in 5 mm. Temp bond and Cem-implant had significant differences only in abutment height of 5 mm. Conclusion Although Ti-base abutment height did not influenced zirconia restorations’ retentiveness, cement types showed significant differences.

Purpose: The purpose of this study is to evaluate Ti-base abutment’s three different heights and three different cement types on the pull-off force of zirconia-based restorations. Materials and Methods: A total of 90 fixture lab analogs were embedded in auto polymerizing resin bloack. 90 Ti-base abutments heights of 3 mm, 5 mm, 7 mm were scanned and zirconia restoration were prepared from scanned files. Zirconia restoration were cemented with three different types of cements (temporary, semi-permanent, permanent) following manufacturer’s instructions. All 90 specimens were placed and tested in a universal testingmachine for pull-out testing. Retention was measured by recording the force at load drop. Statistical analysis was performedusing Kruskal-Wallis test for detecting whether there are any statistical significance along cement types or abutment heights.After that, Mann-Whitney test was used for figuring out differences regarding abutment height and the comparison between 3cements. Results: Temp bond showed significantly lower pull-off force compared to Fujicem regardless of any abutment height.However, there were significant differences between Cem-implant and Fujicem in abutment height of 3 mm and 7 mm, but there was no significant difference in 5 mm. Temp bond and Cem-implant had significant differences only in abutment height of 5 mm. Conclusion Although Ti-base abutment height did not influenced zirconia restorations’ retentiveness, cement types showed significant differences.

Purpose: The purpose of this study is to evaluate Ti-base abutment’s three different heights and three different cement types on the pull-off force of zirconia-based restorations. Materials and Methods: A total of 90 fixture lab analogs were embedded in auto polymerizing resin bloack. 90 Ti-base abutments heights of 3 mm, 5 mm, 7 mm were scanned and zirconia restoration were prepared from scanned files. Zirconia restoration were cemented with three different types of cements (temporary, semi-permanent, permanent) following manufacturer’s instructions. All 90 specimens were placed and tested in a universal testingmachine for pull-out testing. Retention was measured by recording the force at load drop. Statistical analysis was performedusing Kruskal-Wallis test for detecting whether there are any statistical significance along cement types or abutment heights.After that, Mann-Whitney test was used for figuring out differences regarding abutment height and the comparison between 3cements. Results: Temp bond showed significantly lower pull-off force compared to Fujicem regardless of any abutment height.However, there were significant differences between Cem-implant and Fujicem in abutment height of 3 mm and 7 mm, but there was no significant difference in 5 mm. Temp bond and Cem-implant had significant differences only in abutment height of 5 mm. Conclusion Although Ti-base abutment height did not influenced zirconia restorations’ retentiveness, cement types showed significant differences.

Genetic alterations have been recognized as an important event in the carcinogenesis of gastric cancer (GC). We conducted high resolution bacterial artificial chromosome array-comparative genomic hybridization, to elucidate in more detail the genomic alterations, and to establish a pattern of DNA copy number changes with distinct clinical variables in GC. Our results showed some correlations between novel amplified or deleted regions and clinical status. Copy-number gains were frequently detected at 1p, 5p, 7q, 8q, 11p, 16p, 20p and 20q, and losses at 1p, 2q, 4q, 5q, 7q, 9p, 14q, and 18q. Losses at 4q23, 9p23, 14q31.1, or 18q21.1 as well as a gain at 20q12 were correlated with tumor-node-metastasis tumor stage. Losses at 9p23 or 14q31.1 were associated with lymph node status. Metastasis was determined to be related to losses at 4q23 or 4q28.2, as well as losses at 4q15.2, 4q21.21, 4q 28.2, or 14q31.1, with differentiation. One of the notable aspects of this study was that the losses at 4q or 14q could be employed in the evaluation of the metastatic status of GC. Our results should provide a potential resource for the molecular cytogenetic events in GC, and should also provide clues in the hunt for genes associated with GC.
Stomach Neoplasms/genetics/*pathology ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Receptors, Thyrotropin/genetics ; Nucleic Acid Hybridization/*methods ; Neoplasm Staging ; Middle Aged ; Male ; MafB Transcription Factor/genetics ; Lymphatic Metastasis/genetics ; Humans ; Genome, Human/genetics ; Gene Expression Regulation, Neoplastic ; Female ; Chromosomes, Human, Pair 20/genetics ; Chromosomes, Human, Pair 14/genetics ; *Chromosome Aberrations ; Aged, 80 and over ; Aged ; Adult