The primary transitional cell carcinoma in nasal cavity is clinically manifested by progessively increasing nasal decongestion,bloody and purulent secretion intermittent appear ,headaches,hearing loss.The macroscopic character showed that a medium gray red ground tissue .The tumor cells were arranged in nested ,pa-pillary by microscopy,the nucleus was round or oval shape ,the tumor cells was infiltrating growth,basophilia or bright.Immunhistochenmical showed that P63,CK5/6,CK18,UroplakinIII,CerbB -2,CEA were positive,Ki67 positive index was about S -100,Cga,Syn,Calponinare all tested negative .Nasal primary transitional cell carcino-ma is uncommon clinically ,and it is easy to misdiagnosed .Its diagnosis and differential diagnosis mainly depends on pathological histoloy and immunohistochenmical examination .

Hypopharyngeal cancer is considered to be one of the head and neck tumor with poor progno -sis.The clinical curative effect of different treatments for hypopharyngeal cancer is also different .Surgery and ra-diotherapy of comprehensive treatment are the main treatments of hypopharyngeal cancer .Chemotherapy and bio-logical therapy also plays an important role on hypopharyngeal cancer .In this paper,we summarize the clinical curative effect of different treatments for hypopharyngeal cancer .

Despite recent advances in surgical techniques and radiotherapy and chemotherapy ,the prog-nosis of laryngeal carcinoma is still poor ,especially patients with in the stage ⅢandⅣ.Hence,there needs a no-vel therapy to improve the treatment of laryngeal carcinoma .Molecular targeted therapy represents an exciting field in the treatment of cancer .This review focuses on the relationship between the laryngeal carcinoma and some promising targets,including EGFR,VEGF,COX-2,mTOR,Nm23-H1 and iNOS,and related inhibitors in la-ryngeal carcinoma research .

Objective To observe the clinical efficacy of stuck-needle pulling needling method in treating typeⅠgastroptosis.Method Fifty patients with typeⅠgastroptosis were randomized into a treatment group and a control group, 25cases each. The control group was intervened by ordinary acupuncture, and the treatment group was intervened by stuck-needle pulling needling at Zhongwan (CV12) in addition to the treatment given to the control group. Result The total effective rate was 96.0% in the treatment group versus 80.0% in the control group, and the total effective rate of the treatment group was significantly superior to that of the control group (P<0.01); the markedly effective rate was 88.0% in the treatment group versus 40.0% in the control group, and the markedly effective rate of the treatment group was higher than that of the control group; the treatment and control groups both showed significant efficacies in mitigating the gastroptosis symptoms (P<0.01).ConclusionStuck-needle pulling needling method can effectively manage the symptoms of typeⅠgastroptosis.

Objective To assess the effect of inhalation of 20ppm nitric oxide(NO) on gas exchange and hemodynamics in acute lung injury induced by surfactant depletion in piglet.Methods Sixteen female piglets weighing 25-30 kg were induced with thiopental and pancuronium and maintained with continuous infusion of thiopental,fentanyl and pancuronium. The animals were tracheotomized and mechanically ventilated with oxygen(FiO 2=1.0). Femoral artery was cannulated for arterial blood sampling and blood gas analysis.Pulmonary catheter was inserted through the femoral vein for measurement of CVP, mean pulmonary artery pressure(MPAP), PCWP, cardiac output (CO) and sampling of mixed venous blood. Acute lung injury was induced by lung lavage after the method described by Lachmann until PaO 2 was lower than 100mm Hg(PaO 2/FiO 2

Objective To analyze the clinical practice of the diagnosis and treatment of four patients with myeloproliferative diseases (MPD) and review the relative literatures. Methods The progress of diagnosing and treating one polycythemia vera patient, two essential thrombocythemia patients and one primary myelofibrosis patient were introduced. Results Interferon alone, interferon combined with hydroxyurea and HLA matched sible allogeneic hematopoietic stem cell transplantation were carried out separately, the satisfying outcomes were shown. Conclusion Detection of genetic mutation of JAK2 V617F has markedly facilitated the approach to clinical diagnosis of MPD. The therapeutic aim for patients with polycythemia vera and essential thrombocythemia is preventing the occurrence thromboembolic events, while for some high-risk primary myelofibrosis patient, allogeneic stem cell transplantation should be considered.

OBJECTIVE To discuss and focus on the hospital infection management in the secondary care and over level hospitals,and the effective control of nosocomial infection.METHODS For the problems and hidden drisks,were targeted to take a scientific and effective prevention and control measures to strengthen the management of the details.RESULTS By changing the concept of process-oriented monitoring,training and scientific management the nosocomial infection effectively controlled.CONCLUSIONS Only the standardized management and operations,security checks and routine testing can be a real focus on hospital infection management.

Objective: To analyze the epidemiological status of overweight and obesity in various student groups and the prevalence changes in recent 15 years, in order to take effective preventive measures against obesity. Methods: Students aged 7 through 22 years participated in the 1985 and 2000 National Surveys on Students Constitution and Health were used as subjects. The newly established BMI screening criteria for overweight and obesity, to analyze the prevalence among various populations. Results: In 2000, the prevalence rates of obesity were 4.37%,1.46%,2.32% and 0.92%,and that of overweight were 10.38%,4.34%,5.94% and 3.67% for the urban boys, rural boys,urban girls and rural girls, respectively, which were all significantly increased in multiple times as compared with those in 1985. However, significant differences could be found among various areas. The prevalence rates of obesity in several metropolitans have reached 9.63% for males and 4.50% for females, and those of overweight have reached 15.29% for males and 8.77% for females, respectively. Most of the other areas are still staying at the early prevalence stage. The prevalence of obesity in the Western China is generally low, and actually no prevalence of obesity is found in the rural female population. Conclusion: It’s an urgent task to act on a series of comprehensive measures to prevent and cure the obesity of youth in China’s developed areas from now on. However, corresponding effective measures of obesity prevention are also needed in other areas of this country.

Induced pluripotent stem cells(iPS)are derived from the differentiated somatic cells that regain the differentiation capabilities by the direct nuclear reprogramming with the exogenous factors.The methods for iPS induction evolved from transcription factors to RNA binding proteins,small molecules,and extracellular signals with the efforts in improving biosafty.The cellular and epigenetic characterization for iPS generation is a progressive and time-dependent process,which is tightly associated with the cellular differentiation status.However,epigenetics of iPS is not same as the embryonic stem cells.In combination with gene therapy and cellular transplantation therapy,the achievements of iPS had been applied in animal disease model treatment.

The anti-tumor activity of fermentation and the ethanol extraction of ten Polyprous fungi against human lung cancer cell NCI-H460 were determined by MTr method,the effect of medium and time for cultivation on the anti-tumor activity were studied.The results showed that the fermentation liquid of Onnia tomentosa and Ceizene unicolon and the mycelium ethanol extract of Formitopsis pinicola had obvious an- ti-tumor activity,the tumor inhibiting ratio of mycelium ethanol extract of Formitopsis pinicola cultivated in Potato-woodehipping medium was 88.87% at the concentration for 500?g/mL,and the inhibiting ratio had little change when Formitopsis pinicola cultivated in different medi- um and for different days.