No abstract available.
Child* ; Humans ; Lung*

PURPOSE: This study was performed to identify relationships among stress, hardiness, and the level of self-care in kidney transplant patients and use the results of this study as baseline data for developing self-care promotion programs. METHOD: Subjects were 41 patients who undergone a kidney transplantation surgery at least one month before and were receiving regular follow-up care via OPD. Four researchers interviewed each subjects by filling out questionnaires. RESULTS: The mean score of the level of stress was 2.32(SD=0.54) on a 4 point scale and the mean score of hardiness was 4.68(SD=0.62) on a 6 point scale. The mean score of self-care among the subjects was 3.83(SD=0.55). There was statistically a significant positive relationship between self-care and hardiness(r=0.42). Especially, relationships between self-care and commitment (r=.51) and control(r=.36) as the sub- dimensions of hardiness were significant. The item suggested as most stressful was economic burden and the item suggested as least stressful was sexual activity. CONCLUSION: Although transplant patients have various stressors, the positive self-care activities of the patients could be increased if the commitment and control were enhanced by proper intervention programs.
Follow-Up Studies ; Humans ; Kidney Transplantation ; Kidney* ; Self Care* ; Sexual Behavior ; Surveys and Questionnaires

PURPOSE: The purpose of the study was to identify differences in physiological.psychological.environmental.behavioral characteristics between obese and control children participating in a health camp and to identify the factors related to childhood obesity. METHODS: Two hundred eighty seven children aged 6 to 12 years were recruited from a health camp for elementary students in D city, Korea. Data collection was done on November 28 and 29, 2009. Anthropometric measurements, blood tests, and self-report surveys were conducted. Chi-square test, independent t-test, ANCOVA, and multiple logistic regression were performed using PASW statistics 18.0. RESULTS: Obese children had adverse conditions for both physiological and psychological characteristics. In terms of environmental and behavioral characteristics, high maternal BMI and more than two hours of TV watching were significantly associated with high risk of childhood obesity (OR=1.11, 95% CI=1.02-1.21; OR=2.05, 95% CI=1.23-3.41). CONCLUSION: Through a multi-factorial approach, the current study identified the differences between obese and control children participating in a health camp and risk factors of childhood obesity. These findings provide preliminary data and perspectives on intervention research for prevention and management of childhood obesity.
Aged ; Child ; Community Health Nursing ; Data Collection ; Hematologic Tests ; Humans ; Korea ; Logistic Models ; Obesity ; Risk Factors ; Child Health

BACKGROUND: Women undergoing general anesthesia for breast mass excision have a high risk for postoperative nausea and vomiting (PONV). We therefore evaluated the efficacy of ramosetron versus granisetron for preventing PONV. METHODS: One hundred twenty women scheduled for breast mass excision received, in a randomized allocated, double-blind manner, an intravenous placebo (P group), granisetron 40microgram/kg (G group) or ramosetron 6 microgram/kg (R group) at the end of surgery. Emetic episode and side effects were assessed. RESULTS: The incidence and severity of nausea in G and R group was less than P group (P<0.05) during the first 24 hrs. The incidence of vomiting in R group was less than P group (P<0.05) during the first 6 hrs. However there was no significant difference in the incidence of PONV between G and R group. CONCLUSIONS: Our results showed that both granisetron and ramosetron significantly decreased the occurrence of PONV compared to placebo. However, any different efficacy for preventing PONV was not revealed between granisetron and ramosetron.
Anesthesia, General* ; Breast* ; Female ; Granisetron* ; Humans ; Incidence ; Nausea ; Postoperative Nausea and Vomiting* ; Vomiting

BACKGROUND: In addition to the analgesic selection and method of administration, how medical and nursing staff perceives postoperative pain and opioid analgesia is important for the effective pain control. Therefore, we have studied about these perceptions of our medical and nursing staff. METHODS: Eighty five surgeons and seventy eight registered nurses working in the surgical wards within this hospital were surveyed by means of questionnaires to identify the attitudes to postoperative pain and knowledge about opioid analgesia. RESULTS: Seventy-nine percent of doctors and 61% of nurses attempted to relieve pain as much as possible. However, 47% of the nurses felt that analgesia was under-prescribed. The reasons given to administer analgesics inadequately by the doctors and nurses were side effects such as emesis, respiratory depression, and the fear of drug addiction. Regarding respiratory depression, 47% of doctors and 60% of nurses felt it occurred after i.m. injection of opioids postoperatively. Concerning the possibility of addiction after the patients were given 50~100 mg demerol i.m. every four hours for one week after major surgery; 37% of doctors and 83% of nurses thought that drug addiction may develop. CONCLUSIONS: Our medical and nursing staff personnel were afraid of respiratory depression as well as a fear of addiction when they administered opioids. This situation is likely to be a significant factor in under-prescribing. It may be necessary for them to have a special education program about pain relief and opioid analgesia after surgery.
Analgesia ; Analgesics ; Analgesics, Opioid* ; Education, Special ; Humans ; Meperidine ; Nursing Staff* ; Nursing* ; Pain, Postoperative* ; Surveys and Questionnaires ; Respiratory Insufficiency ; Substance-Related Disorders ; Vomiting

A possible role of hepatocyte nuclear factor 1 (HNF1) or HNF3, a predominant trans-acting factors of hepatic or pancreatic beta-cells, was examined on the tissue specific interdependent expression of glucokinase (GK) in liver, H4IIE, HepG2, HIT-T15 and MIN6 cell line. The tissues or cell lines known to express GK showed abundant levels of HNF1 and HNF3 mRNA as observed in liver, H4IIE, HepG2, HIT-T15 and MIN6 cells, whereas they were not detected in brain, heart, NIH 3T3, HeLa cells. The promoter of glucokinase contains several HNF3 consensus sequences and are well conserved in human, mouse and rat. Transfection of the glucokinase promotor linked with luciferase reporter to liver or pancreatic beta cell lines showed high interacting activities with HNF1 and HNF3, whereas minimal activities were detected in the cells expressing very low levels of HNFs. The binding of HNF1 or HNF3 to the GK promoter genes was confirmed by electrophoretic mobility shift assay (EMSA). From these data, we propose that the expression of HNF1 and/or HNF3 may, in part, contribute to the tissue specific expression of GK.
3T3 Cells ; Animal ; Blotting, Northern ; Cell Line ; Cell Nucleus/metabolism ; Cells, Cultured ; DNA-Binding Proteins/genetics/*physiology ; Genes, Reporter ; Glucokinase/*biosynthesis/*genetics ; Hela Cells ; Human ; Liver/metabolism ; Luciferase/metabolism ; Mice ; Models, Genetic ; Nuclear Proteins/genetics/*physiology ; Plasmids/metabolism ; Promoter Regions (Genetics) ; Protein Binding ; Rats ; Support, Non-U.S. Gov't ; Tissue Distribution ; Transcription Factors/genetics/*physiology ; Transcription, Genetic ; Transfection

Anti-coccidial effects of the fruits of Tribulus terrestris (Tribuli fructus) ethanol extract (TTE) were studied with animal experiment following per oral administration with Eimeria (E.) tenella. This experiment was performed on the 3-day-old chicks (n=30). The animals were divided with 3 groups; TFE 15mg per animal+infected (n=10), TTE untreated+infected (n=10) and non-infected control (n=10). Animals were administrated with or without TTE during 1 week, and then inoculated with E. tenella. The anti-coccidial activity were evaluated with oocysts shedding numbers in stools, body weights changes and food intake changes. The TTE-inoclated animals revealed significantly decreased stool oocysts numbers (P < 0.05) when compared to the TTE untreated animals. Also, TTE-treated animals showed more increased body weight gains (P < 0.05) than the TTE untreated animals. These results demonstrate that TTE produce anticoccidial activities against E. tenella. TTE could be a promising treatment for the coccidiosis.
Administration, Oral ; Animal Experimentation ; Animals ; Body Weight ; Coccidiosis ; Eating ; Eimeria tenella* ; Eimeria* ; Ethanol* ; Fruit* ; Oocysts ; Polytetrafluoroethylene ; Tribulus*

Background: We compared the effects of palonosetron with ondansetron for preventing postoperative nausea and vomiting (PONV) during the first 24 h after surgery in women receiving intravenous patient-controlled analgesia (IV-PCA) with fentanyl for pain control. Methods: In this prospective, randomized, double-blinded study, 204 healthy patients who were undergoing elective surgery with general anesthesia were enrolled. In the palonosetron group (n = 102), 0.075 mg bolus was given intravenously (i.v.) 30 min before the end of surgery and 8 ml saline was added to the IV-PCA. In the ondansetron group (n = 102), 8 mg bolus i.v. was given 30 min before the end of surgery and 16 mg of ondansetron was added to the IV-PCA. The incidence of PONV, severity of nausea, and use of rescue anti-emetics were evaluated 6 and 24 h after the operation. Results: The incidences of nausea (55.6%) and vomiting (14.1%) in the palonosetron group did not differ from those (58.3 and 19.8%) in the ondansetron group during the first 24 h after surgery (P > 0.05). No significant differences were observed in the severity of nausea and use of rescue anti-emetics between the two groups (P > 0.05). Conclusions The effects of palonosetron in preventing PONV were not different from those of ondansetron during the first 24 h postoperatively in women receiving IV-PCA with fentanyl.

Gastric cancer associated with pregnancy is extremely rare and the information on this particular subject is limited. Gastrointestinal symptoms such as abdominal pain, nausea, vomiting and loss of appetite are common during pregnancy but also can be the only symptoms in stomach cancer until the late stage. Clinicians' reluctance to pursue diagnostic studies appears to be a major contributing factor of delayed diagnosis and poor outcome. A 33-year-old-women at 30 weeks gestation with advanced gastric cancer died sixteen days after emergency cesarean delivery. We report this case to alert clinicians to this rare possibility.
Abdominal Pain ; Appetite ; Delayed Diagnosis ; Emergencies ; Female ; Humans ; Nausea ; Pregnancy ; Pregnancy Trimester, Third* ; Stomach Neoplasms* ; Vomiting

BACKGROUND: Chronic Myelogenous Leukemia (CML) is the first proven disease in which gene abnormality, t(9;22)(q34;q11) can cause the disease to occur in humans. Recently, targeted therapy with STI571 (GleevecTM), signal transduction inhibitor for BCR-ABL kinase was developed and can induce cytogenetic remission in patients with CML. Hypermetaphase-FISH (HMF)/Interphase-FISH (I-FISH, Fluorescence in situ hybridization) aiming specific chromosomal abnormalities are unambiguous quantitative molecular genetic methods for individual Philadelphia (Ph1) chromosome positive cells. We evaluated the change of Ph1 chromosome in CML patients during STI571 therapy using HMF/I- FISH. METHODS: Twenty one patients with CML were treated with STI571 which was provided from Norvatis pharmaceutical company as Expanded Access Program for Compassionate Use from May 2001 at the doses of 200-600 mg/day orally. Median age of this cohort was 37 years old and median follow up duration was 113 days (48~165 days). HMF or I-FISH using bone marrow or peripheral blood were performed on the sample at baseline, day 14, day 28 and then monthly. RESULTS: Complete cytogenetic responses which were assessed by HMF/I-FISH counting several hundreds cells were found in 8 of 21 patients. Among them, 4 of 10 chronic phase, 2 of 2 accelerate phase and 2 of 8 blastic crisis patients achieved cytogenetic complete response. One patient with blastic crisis was relapsed after achieving cytogenetic complete response. Grade III-IV thrombocytopenia and neutropenia were noticed in 8 and in 7 patients respectively, but there were no major bleeding episodes nor neutropenic fever. CONCLUSION: BCR-ABL tyrosine kinase inhibitor, STI571 was tolerable for patients with CML. The majority of patients achieved hematologic remission and 8 out of 21 patients achieved complete cytogenetic response regardless of their disease stage. Cytogenetic response of Ph1 chromosome can be quantified accurately with HMF/I-FISH.
Adult ; Bone Marrow ; Chromosome Aberrations ; Cohort Studies ; Compassionate Use Trials ; Cytogenetics ; Fever ; Fluorescence ; Follow-Up Studies ; Fusion Proteins, bcr-abl ; Hemorrhage ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive* ; Molecular Biology ; Neutropenia ; Philadelphia Chromosome* ; Phosphotransferases ; Signal Transduction ; Thrombocytopenia ; Imatinib Mesylate