1.The Clinical Significance of SCC, CEA and TPA as Tumor Markers in Cervical Cancer.
Chang Soo PARK ; Ho Sun CHOI ; Ji Soo BYUN
Korean Journal of Gynecologic Oncology and Colposcopy 1994;5(4):1-8
The clinical role of tumor markers to detect the extent of tumor invasion and recurrence in cervical cancer has been debated. To evaluate the chncal significance of SCC, CEA and TPA as tumor markers in cervical, we studied 744 patients weith cervieal cancer from June 1990 to Mey 1994. The cut-off val ues of SCC, CEA and TPA were 1.5 ng/ml, 4.5 ng/mi and 110 U/I respectively. Followings were the results. 1. The serum concentration and positive rates of SCC before therapy(567 cases) were 3,0+/-7.0ng/ml(40.4%) for stage I,8.7+/-13.9 ng/ml(71.6%) for stage II, 10.8+/-14.7 ng/ml(85.7%) for stage III, 23.9+/-24.3 ng/ml(94.7%) for stage IV, and 13.4+/-19.1 ng/ml(75.0%) for recurrent cancer. It was increased with advancing clinical stage(p<0.01). 2. The seum levels and positive rate of CEA before therapy(627cases) were 3.4+/-4.3 ng/ml (18%) for stage I, 7.1+/-12.3 ng/ml(37.2%) for stage II, 8.4+/-9.6 ng/ml(57.9%) for stage III, 15.4+/-22.2 ng/ml(52.6%) for stage IV, and 10.3+/-16.2 ng/ml(46.4%) for recurrent cancer. It was increased with advancing clinical stage from stage Ito stage III(p<0.01). 3. The serum concentration and positiceive rate of TFA before therapy(301cases) were 51.7+/-53.8 U/l(9.5%) for stage I, 105.3+/-108.8 U/l(32.3%) for stage II, 186.3%+/-159.8 U/l(50%) for stage III, 191.3+/-l06.2 U/I(63.6%) for stage IV, and 135.4+/-117.0 U/l(46.4%) for recurrent cancer. It was increased with advencing clinical stage(p<0.01). 4. In 64 patients{24.2%) with lymph node invasion of 265 patients treated by operation, the mean serum levels of SCC, CEA and TPA were higher than lymph node negative group(p<0.05). 5. The serum levels of SCCand CKA after therepy were 82.8% in sensitivity. 94.3% in specificity, 67.9% in positive predictive value, 97.4% in negative predictive value.
Humans
;
Lymph Nodes
;
Recurrence
;
Sensitivity and Specificity
;
Biomarkers, Tumor*
;
Uterine Cervical Neoplasms*
3.Perinatal Prognosis of Single Umbilical Artery.
Yoon Ha KIM ; Tae Bok SONG ; Ji Soo BYUN ; Young Youn CHOI ; Ji Young LEE
Korean Journal of Perinatology 1999;10(2):155-160
OBJECTIVE: To evaluate the perinatal prognosis of fetuses with a single umbilical artery. METHODS: From 1992 to 1998, nineteen cases with single umbilical artery(SUA) was observed in 8,704 deliveries at Chonnam University Hospital. RESULTS: Out of nineteen fetuses, thirteen fetuses with single umbilical artery were detected by antenatal ultrasonographic examination and six fetuses were detected after birth. The male to female ratio was 0.9: 1. Congenital malformations were observed in 8 babies(42.1%) and included leg deformity, esophageal atresia, imperforated anus, ventriculomegaly, meningocele, hydronephrosis, ventricular septal defect, joint contracture, cleft lip and palate, toe anomaly, imperforated anus, kyphosis, no urethra and testis, clubfoot, patent ductus arteriosus and rnild mitral regurgitation. Among 10 cases of karyotyping analysis three cases were diagnosed as trisomy 18. Fourteen fetuses(77.8%) showed growth restriction at delivery. Antenatal obstetric complications were hydramnios(n = 3), oligohydramnios(n =2), and severe preeclampsia(n = 3). CONCLUSION: Careful ultrasonographic evaluation for the identification of a SUA is necessary because of its frequent association with congenital anomaly, growth restriction and cytogenetic abnormality.
Anal Canal
;
Chromosome Aberrations
;
Cleft Lip
;
Clubfoot
;
Congenital Abnormalities
;
Contracture
;
Ductus Arteriosus, Patent
;
Esophageal Atresia
;
Female
;
Fetus
;
Heart Septal Defects, Ventricular
;
Humans
;
Hydronephrosis
;
Jeollanam-do
;
Joints
;
Karyotyping
;
Kyphosis
;
Leg
;
Male
;
Meningocele
;
Mitral Valve Insufficiency
;
Palate
;
Parturition
;
Prognosis*
;
Single Umbilical Artery*
;
Testis
;
Toes
;
Trisomy
;
Urethra
4.Clinical Study on Intrauterine Fetal Growth Restriction.
Soo HAN ; Yoon Ha KIM ; Jin JEONG ; Kyung Min LEE ; Tae Bok SONG ; Ji Soo BYUN
Korean Journal of Perinatology 1997;8(4):385-391
This study was undertaken at the department of Obstetrics and Gynecology, Chonnam University Medical School, to investigate the association between some of the risk factor and the incidence of intrauterine fetal growth restriction(IUGR). The studied population was selected from patients who admitted at Chonnam University Hospital during January, 1992 through May, 1997, with following criteria, Korean, singletone pregnancy with live birth and known gestational weeks with 28 or more. And then, the risk factors were analyzed in terms of maternal factor, placental factor, and fetal factor. The following results were obtained. 1) The incidence of IUGR was 6.1%. 2) The incidence of IUGR was higher at young aged mother and nullipara. 3) Only 39.1% of etiologic factors for IUGR was found to have known causes. According to the risk factors for IUGR, hypertensive disorder during pregnancy, anemia, cardiac disease, leukemia, and pulmonary tuberculosis were associated with increased incidence of IUGR. 4) The relative risk of IUGR was much higher in neonates born with congenital anomalies. 5) According to the placental causes of IUGR, placenta previa and placenta abruption showed some association with IUGR.
Anemia
;
Fetal Development*
;
Fetal Growth Retardation
;
Gynecology
;
Heart Diseases
;
Humans
;
Incidence
;
Infant, Newborn
;
Jeollanam-do
;
Leukemia
;
Live Birth
;
Mothers
;
Obstetrics
;
Placenta
;
Placenta Previa
;
Pregnancy
;
Risk Factors
;
Schools, Medical
;
Tuberculosis, Pulmonary
5.A case of prenatal ultrasonographic diagnosis of Roberts syndrome.
Yong Hoon CHO ; Young Don YOON ; Tae Bok SONG ; Ji Soo BYUN ; Young Youn CHOI
Korean Journal of Perinatology 1992;3(1):88-94
No abstract available.
Diagnosis*
6.Topographic distribution of the carcinoma in situ of the uterine cervix.
Young Ran CHUNG ; Jang Soon CHANG ; Ho Sun CHOI ; Ji Soo BYUN
Korean Journal of Obstetrics and Gynecology 1993;36(7):1178-1183
No abstract available.
Carcinoma in Situ*
;
Cervix Uteri*
;
Female
7.A case of pregnancy complicated by ruptured endometrioma.
Young Don YOON ; Hye Won CHUNG ; Tae Bok SONG ; Sang Woo JUHNG ; Ji Soo BYUN
Korean Journal of Perinatology 1993;4(3):428-432
No abstract available.
Endometriosis*
;
Female
;
Pregnancy*
8.A Case of Nongestational Ovarian Choriocarcinoma.
Jae Hyung NA ; Hyun Woo SHIN ; Ho Sun CHOI ; Ji Soo BYUN
Korean Journal of Gynecologic Oncology and Colposcopy 1994;5(3):54-58
Pure ovarian choriocarcinoma of germ cell origin is exceedingly rare neoplasm, and even the presence of choriocarcinomatous elements admixed with other neoplastic germ cell elements is rare. In the most cases, the tumor is admixed with other neoplastic germ cell elemeats, and their presence is diagnostic of noagsatational choriocarcinoma, except for the remote of the tumor being a geatational choriocarcinoma metasttic to an ovarian germ cell tumor. We have experienced a case of nongestational ovarian choriocarcinoma in 10 year dld woman. So we report this case with a brief review of its literatures.
Choriocarcinoma*
;
Female
;
Germ Cells
;
Humans
;
Neoplasms, Germ Cell and Embryonal
;
Pregnancy
9.Protein/creatinine ratio in random urine specimens for quantitation of proteinuria in preeclampsia.
Kyeong Seok JANG ; Sang Yook LEE ; Young Don YOON ; Tae Bok SONG ; Ji Soo BYUN
Korean Journal of Obstetrics and Gynecology 1993;36(7):2147-2151
No abstract available.
Pre-Eclampsia*
;
Proteinuria*
10.A clinical study on the delivery after previous cesarean section.
Hyun Ju KIM ; Young Don YOON ; Tae Bok SONG ; Ji Soo BYUN
Korean Journal of Obstetrics and Gynecology 1993;36(7):2140-2146
No abstract available.
Cesarean Section*
;
Female
;
Pregnancy