1.The Effects of Occlusion Therapy in Patients With Anisometropic Amblyopia Aged 8 Years and Older.
Seong Jae KIM ; Yeon Jeong PARK ; Ji Myoung YOO
Journal of the Korean Ophthalmological Society 2010;51(1):70-75
PURPOSE: To compare the effects of full-time and part-time occlusion therapy in patients who had been diagnosed with anisometropic amblyopia after age eight and have begun treatment. METHODS: We included patients eight years old or older who had been diagnosed with anisometropic amblyopia. They were treated with full-time or part-time occlusion therapy and followed up for at least six months. Treatment was considered successful when visual acuity was increased by two lines or more. RESULTS: There were 26 total patients. There were 14 part-time and 12 full-time occlusion therapy patients in the respective groups. Visual acuity for the amblyopic eyes was significantly improved while the non-amblyopic eyes did not show any significant differences after the treatment. The changes in the visual acuity were significantly larger for the full-time treatment group compared to the part-time treatment group. The full-time occlusion group showed a significant difference in visual acuity of the amblyopic eyes after treatment. Lower visual acuity of an amblyopic eye at the first visit led to a greater improvement in visual acuity after the treatment. CONCLUSIONS: With good compliance, occlusion therapy for anisometropic amblyopia can be successful even if it is initiated after eight years of age.
Aged
;
Amblyopia
;
Compliance
;
Eye
;
Humans
;
Visual Acuity
2.A Case of Concurrent Papillary Thyroid Carcinoma in Familial Medullary Thyroid Microcarcinoma with a Germline C634W Mutation.
Ji Hye KIM ; Ji Hyun PARK ; Tae Sun PARK ; Hong Sun BAEK ; Myoung Ja CHUNG ; Ki Hwan HONG
Endocrinology and Metabolism 2010;25(4):354-359
The origins of medullary carcinoma (MTC) and papillary carcinoma (PTC) of the thyroid are embryologically different. Tumors showing concurrent medullary and papillary features are rare and they represent less than 1% of all thyroid malignancies. Hereditary MTC is an autosomal dominantly inherited disease which is genetically determined as part of the MEN 2A, MEN 2B, or variants of MEN 2A such as familial MTC. Germline mutations of the RET gene are the underlying cause of the majority of cases of hereditary medullary carcinomas. The pathogenesis of concurrent PTC with familial MTC has rarely been known. Genetic analysis of the RET oncogene has so far provided conflicting results. Here we describe a family whose sibling was affected by both PTC & MTC, and the family carried a germ-line point mutation in the RET extracellular domain that converted cysteine 634 into tryptophan (C634W).
Carcinoma
;
Carcinoma, Medullary
;
Carcinoma, Papillary
;
Cysteine
;
Factor IX
;
Germ-Line Mutation
;
Humans
;
Multiple Endocrine Neoplasia Type 2a
;
Multiple Endocrine Neoplasia Type 2b
;
Oncogenes
;
Point Mutation
;
Siblings
;
Thyroid Gland
;
Thyroid Neoplasms
;
Tryptophan
3.Association of Polymorphisms of the TNF-alpha and TGF-beta1 Genes with Renal Allograft Dysfunction.
Ji Young PARK ; Myoung Hee PARK ; Hye Jin PARK ; Jongwon HA ; Sang Joon KIM ; Curie AHN
The Journal of the Korean Society for Transplantation 2002;16(1):38-46
PURPOSE: Tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta1 have been shown to play important roles in allograft rejection of various organs. This study was performed to evaluate the association of TNF-alpha and TGF-beta1 genes and renal allograft dysfunction. METHODS: Five TNF-alpha ( 1,031 T/C, 863 C/A, 857 C/T, 308 G/A, 238 G/A) and two TGF-beta1 (codon 10 T/C, codon 25 G/C) single nucleotide polymorphism (SNP) sites were studied using PCR-SSCP and PCR-RFLP methods in 100 controls and 165 patients underwent renal transplantation. For the TGF-beta1 gene, we also studied the polymorphism of donors. RESULTS: The allele frequencies of each SNP sites in controls were not different from those of patients. The phenotype frequency of TNF-alpha high producer type, 308 A was significantly higher in the patients with recurrent acute rejection episodes (REs) compared with patients with no or one RE (38.5% vs. 9.2%, P=0.007). The frequency of TGF-beta1 low producer genotype, codon 10 CC was also significantly higher in the patients with recurrent REs (53.8% vs. 22.4%, P=0.029). Analysis of chronic renal allograft dysfunction (CRAD) revealed that the TGF-beta1 high producer type, codon 10 T allele in donors was associated with CRAD (66.7% vs. 48.2%, P=0.043). This association was significant only among patients with recurrent REs. Occurrence of CRAD was not influenced by TGF-beta1 polymorphisms in the patients. CONCLUSION: These results would be useful for predicting high risk group for acute rejection or CRAD in renal transplantation and might be useful for implying individualized immunosuppressive therapy.
Alleles
;
Allografts*
;
Codon
;
Gene Frequency
;
Genotype
;
Humans
;
Kidney Transplantation
;
Phenotype
;
Polymorphism, Single Nucleotide
;
Tissue Donors
;
Transforming Growth Factor beta1*
;
Transforming Growth Factors
;
Tumor Necrosis Factor-alpha*
4.Thin Glomerular Basement Membrane Disease with Herlyn-Werner-Wunderlich Syndrome: Uterus Didelphys, Blind Hemivagina and Ipsilateral Renal Agenesis.
Myoung Soo KIM ; Yong Jun PARK ; Young Jun PARK ; Noh Hyuck PARK ; Ji Sun SONG ; Pyung Kil KIM
Journal of the Korean Society of Pediatric Nephrology 2007;11(2):299-305
Herlyn-Werner-Wunderlich syndrome(HWWs) is a rare variant of Mullerian ductal anomalies characterized by the presence of a hemivaginal septum, a didelphic uterus, and ipsilateral renal agenesis. It usually presents after menarche with progressive pelvic pain, and palpable mass due to hemihematocolpos. If a cystic mass is detected behind the urinary bladder in children, in association with the absence of a kidney, the diagnosis of uterus didelphys with imperforate vagina and hydrocolpos should be considered. When renal agenesis is found in asymptomatic children, the small size and the tubular shape of the uterus makes it almost impossible to evaluate uterine anomalies, so follow-up should be performed until the end of puberty. Appropriate preoperative diagnosis and treatment will prevent unnecessary procedures and offer relief of symptoms. We report one case of didelphic uterus with blind hemivagina and ipsilateral renal agenesis with biopsy-proven thin glomerular basement membrane disease which is not related to the above syndrome.
Adolescent
;
Child
;
Diagnosis
;
Female
;
Follow-Up Studies
;
Glomerular Basement Membrane*
;
Humans
;
Hydrocolpos
;
Kidney
;
Menarche
;
Pelvic Pain
;
Puberty
;
Unnecessary Procedures
;
Urinary Bladder
;
Uterus*
;
Vagina
5.Pathologic Findings Affecting the Diagnostic Accuracy in Determining the Depth of Invasion of Gastric Cancer by Endoscopic Ultrasonography (EUS).
Jae Bock CHUNG ; Sang Bae CHUN ; Si Young SONG ; Young Myoung MOON ; Jin Kyung KANG ; In Suh PARK ; Myung Wook KIM ; Ji Young HAN ; Chan Il PARK
Korean Journal of Gastrointestinal Endoscopy 1993;13(3):545-549
Endoscopic ultrasonography(EUS) has been used in assessing the depth of cancer invasion of the stomach. However, there are pathologic findings coexisting cancers which are unable to be detected by EUS resulting in mis-staging preoperatively. To find out the causes of mis-staging in determining the depth of cancer invasion, we analysed the pathologic findings of mis-staged cases of gastric cancer by EUS. (continue...)
Endosonography*
;
Stomach
;
Stomach Neoplasms*
6.In vivo verification of regional hyperthermia in the liver.
Jae Myoung NOH ; Hye Young KIM ; Hee Chul PARK ; So Hyang LEE ; Young Sun KIM ; Saet Byul HONG ; Ji Hyun PARK ; Sang Hoon JUNG ; Youngyih HAN
Radiation Oncology Journal 2014;32(4):256-261
PURPOSE: We performed invasive thermometry to verify the elevation of local temperature in the liver during hyperthermia. MATERIALS AND METHODS: Three 40-kg pigs were used for the experiments. Under general anesthesia with ultrasonography guidance, two glass fiber-optic sensors were placed in the liver, and one was placed in the peritoneal cavity in front of the liver. Another sensor was placed on the skin surface to assess superficial cooling. Six sessions of hyperthermia were delivered using the Celsius TCS electro-hyperthermia system. The energy delivered was increased from 240 kJ to 507 kJ during the 60-minute sessions. The inter-session cooling periods were at least 30 minutes. The temperature was recorded every 5 minutes by the four sensors during hyperthermia, and the increased temperatures recorded during the consecutive sessions were analyzed. RESULTS: As the animals were anesthetized, the baseline temperature at the start of each session decreased by 1.3degrees C to 2.8degrees C (median, 2.1degrees C). The mean increases in temperature measured by the intrahepatic sensors were 2.42degrees C (95% confidence interval [CI], 1.70-3.13) and 2.67degrees C (95% CI, 2.05-3.28) during the fifth and sixth sessions, respectively. The corresponding values for the intraperitoneal sensor were 2.10degrees C (95% CI, 0.71-3.49) and 2.87degrees C (1.13-4.43), respectively. Conversely, the skin temperature was not increased but rather decreased according to application of the cooling system. CONCLUSION: We observed mean 2.67degrees C and 2.87degrees C increases in temperature at the liver and peritoneal cavity, respectively, during hyperthermia. In vivo real-time thermometry is useful for directly measuring internal temperature during hyperthermia.
Anesthesia, General
;
Animals
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Fever*
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Glass
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Liver*
;
Peritoneal Cavity
;
Skin
;
Skin Temperature
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Swine
;
Thermometry
;
Ultrasonography
7.Expression of Cortactin and Focal Adhesion Kinase in Colorectal Adenocarcinoma: Correlation with Clinicopathologic Parameters and Their Prognostic Implication.
Yo Na KIM ; Ji Eun CHOI ; Jun Sang BAE ; Kyu Yun JANG ; Myoung Ja CHUNG ; Woo Sung MOON ; Myoung Jae KANG ; Dong Geun LEE ; Ho Sung PARK
Korean Journal of Pathology 2012;46(5):454-462
BACKGROUND: Cortactin and focal adhesion kinase (FAK) are two important components among actin cross-linking proteins that play a central role in cell migration. METHODS: The aims of this study were to evaluate the expression of cortactin and FAK in normal colorectal mucosa and colorectal adenocarcinoma (CRC) using tissue microarray of 2 mm cores to correlate their expression with other clinicopathological factors and, investigate their prognostic significance. RESULTS: Twenty (9%) and 24 cases (11%) of normal colorectal mucosa were immunoreactive for cortactin and FAK. In addition, 184 (84%) and 133 cases (61%) of CRCs were immunoreactive for cortactin and FAK, respectively. Cortactin expression was associated with histologic differentiation and FAK expression. Cortactin, but not FAK expression was also correlated with poor overall and relapse-free survival and served well as an independent prognostic factor for poor survival. CONCLUSIONS: Cortactin expression, in association with FAK expression, may plays an important role in tumor progression. Furthermore, it may also be a satisfactory biomarker to predict tumor progression and survival in CRC patients.
Actins
;
Adenocarcinoma
;
Calcium Hydroxide
;
Colorectal Neoplasms
;
Cortactin
;
Focal Adhesion Protein-Tyrosine Kinases
;
Focal Adhesions
;
Humans
;
Immunohistochemistry
;
Mucous Membrane
;
Proteins
;
Zinc Oxide
8.Acute Hemodynamic Effects of Sublingual Captopril in Regurgitant Valvular Heart Disease.
Ji Dong SUNG ; Song Hoe KOO ; Ha Jin LIM ; Myoung Yoong LEE ; Hyo Soo KIM ; Dae Won SOHN ; Byoung Hee OH ; Myoung Mook LEE ; Young Bae PARK ; Yoon Sik CHOI ; Jung Don SEO ; Young Woo LEE
Korean Circulation Journal 1993;23(5):669-675
BACKGROUND: Many Studies regarding hemodynamic changes by various vasodilators, such as nitroprusside, nifedipine, and hydralazine have been reported, however little data are available upon acute hemodynamic change due to captopril, an angiotensin converting enzyme inhibitor especially in chronic regurgitant valvular heart disease. Therefore the aim of this study is to evaluate the acute hemodynamic effects of sublingual captopril in patients with regurgitant valvular heart diseases. METHODS: Among the 9 patients enrolled in this study, 5 patients mitral regurgitation, 2 had aortic regurgitation, and 2 had both. Five had patients were male and 4 were female. Before, 15 minutes and 30 minutes after administration of 25mg of captopril via sublingual route, forward cardiac output was measured three times using Swan-Ganz catheter. Right and left cardiac catheterization were also done at each phase and measurement of pulmonary capillary wedge pressures, pulmonary artery pressures, right atrial pressures, aortic pressures, left ventricular pressures were done. RESULTS: 1) Heart rate, pulmonary capillary wedge pressures, cardiac output and cardiac indices left ventricular end-diastolic pressure, diastolic and mean aortic pressures, and diastolic pulmonary artery pressure showed no significant change after administration of sublingual captopril. 2) Systolic aortic pressure decreased significantly from basal value(130+/-35) to 15 minute value(126+/-39). 3) Systemic vascular resistance at 15 minute showed significant reduction as compared with basal value(from 1743+/-551 to 1642+/-491). Pulmonary vascular resistance at 30 minutes(254+/-193) was significantly lower than basal value(282+/-229). CONCLUSIONS: Reductions of systemic and pulmonary vascular resistance occurred relatively rapidly, however, acute effects on cardiac output and pulmonary capillary wedge pressures were not evident. Clinical implication of sublingual captopril in patients with regurgitant valvular heart diseases is worth evaluationg by more extensive hemodynamic studies.
Aortic Valve Insufficiency
;
Arterial Pressure
;
Arteries
;
Atrial Pressure
;
Blood Pressure
;
Capillaries
;
Captopril*
;
Cardiac Catheterization
;
Cardiac Catheters
;
Cardiac Output
;
Catheters
;
Female
;
Heart Rate
;
Heart Valve Diseases*
;
Hemodynamics*
;
Humans
;
Hydralazine
;
Male
;
Mitral Valve Insufficiency
;
Nifedipine
;
Nitroprusside
;
Peptidyl-Dipeptidase A
;
Pulmonary Artery
;
Pulmonary Wedge Pressure
;
Vascular Resistance
;
Vasodilator Agents
;
Ventricular Pressure
9.Comparison of Icare Rebound Tonometer with Goldmann Applanation Tonometry.
Kook LEE ; Ji Young LEE ; Jung Il MOON ; Myoung Hee PARK
Journal of the Korean Ophthalmological Society 2013;54(2):296-302
PURPOSE: To compare Icare rebound tonometer (IRT) and Goldmann applanation tonometer (GAT) and investigate the clinical usefulness of IRT. METHODS: In a retrospective study of 131 eyes with glaucoma and glaucoma suspect, intraocular pressure (IOP) was measured with IRT and GAT. The correlation between IRT and GAT and the influence of refractive error (spherical equivalent; SE) and central corneal thickness (CCT) were analyzed. RESULTS: A distinct correlation between IRT and GAT was found. IOP measured with GAT was 2.23 +/- 3.16 mm Hg higher than with IRT (p < 0.001). As CCT increased, IOP was measured higher with both GAT and IRT. IOP in myopic eyes (SE > or = -5 diopter) was measured relatively lower than in hyperopic eyes (SE < -5 diopter) with GAT (+1.50 +/- 0.68 mm Hg) and IRT (+1.88 +/- 0.75 mm Hg). CONCLUSIONS: IRT showed strong correlation with GAT, but IOP measured approximately 2 mm Hg lower. The IOP tends to measure lower at low CCT and in myopic eyes.
Eye
;
Glaucoma
;
Intraocular Pressure
;
Iron-Dextran Complex
;
Manometry
;
Peptides
;
Refractive Errors
;
Retrospective Studies
10.Immunohistochemical Staining of Insulin-like Growth Factor-1 in Human Lung Cancer cells of NSCLC and SCLC.
Ji Hyun PARK ; Myoung Jae KANG ; Heung Bum LEE ; Yong Chul LEE ; Yang Keun RHEE
Tuberculosis and Respiratory Diseases 2000;48(3):324-330
OBJECTIVE: Lung cancer arises after a series of morphological changes, which take several years to progress from normal epithelium to invasive cancer. Multiple molecular changes and growth factors factor production have been documented in lung cancers, both small cell and non-small cell types. Insulin-like growth factors(IGFs) are important mitogenic and anabolic peptides, both in vivo and in vitro, and are thought to be significant autocrine-paracrine factors involved in normal and malignant cell proliferation. In this study, we have investigated (delete) the degree of expression of IGF-1 on the immunohistochemical staining in human non-small cell lung cancer(NSCLC) cells and small cell lung cancer (SCLC) cells were investigated. METHODS: Immunohistochemical staining for IGF-1 was performed in 15 cases of small cell carcinoma, 15 cases of squamous cell carcinoma, 15 cases of adenocarcinoma, and 12 cases of bronchoalveolar carcinoma. RESULTS: The NSCLC cells showed significantly increased expression The expression of IGF-1 on the immunohistochemical staining significantly increased in NSCLC cells than in SCLC cells. CONCLUSION: These results suggest that IGF-1 are expressed the expression of IGF-1 in human lung cancer cells(.), and the (The) immunohistochemical staining of IGF-1 in lung cancer cell lines may help in differentiation of may assist in the differentiation of NSCLC and SCLC.
Adenocarcinoma
;
Carcinoma, Small Cell
;
Carcinoma, Squamous Cell
;
Cell Line
;
Cell Proliferation
;
Epithelium
;
Humans*
;
Insulin-Like Growth Factor I
;
Intercellular Signaling Peptides and Proteins
;
Lung Neoplasms*
;
Lung*
;
Peptides
;
Small Cell Lung Carcinoma