Drug-induced tubulointerstitial nephritis is one cause of acute kidney injury. Although traditional remedies have been widely used in South Korea, Dioscorea quinqueloba-induced tubulointerstitial nephritis has not been reported in the general population. A 72-year-old male patient was transferred to our hospital with pulmonary edema, oliguria, decreased mentality, severe generalized edema after taking D. quinqueloba 25 days ago. His initial lab findings showed a blood urea nitrogen level of 43.4 mg/dL, a creatinine level of 5.3 mg/dL. Urinalysis revealed SG (1.015), blood (many), protein (++) and WBC (0-3/HPF). Kidney biopsy demonstrated severe mononuclear cell infiltration into the renal interstitium with mild tubular atrophy. Aggressive renal replacement therapy and supportive care resulted in gradual restoration of his renal function. This case implies that D. quinqueloba may be one cause that induces tubulointerstitial nephritis in some patients.
Acute Kidney Injury ; Aged ; Atrophy ; Biopsy ; Blood Urea Nitrogen ; Creatinine ; Dioscorea* ; Edema ; Humans ; Kidney ; Korea ; Male ; Nephritis, Interstitial* ; Oliguria ; Pulmonary Edema ; Renal Replacement Therapy ; Urinalysis

Drug-induced interstitial nephritis is one cause of acute kidney injury. Although traditional remedies have been widely used in South Korea, Corni fructus-induced interstitial nephritis has not been reported in the general population. A 65-year-old female patient was admitted with sudden onset of gross hematuria after ingesting Corni fructus tea for 2 weeks. Her initial lab findings showed a blood urea nitrogen level of 35.1 mg/dL, creatinine level of 1.7 mg/dL, albumin level of 4.5 g/dL, and hemoglobin level of 10.3 g/dL. Urinalysis revealed SG (1.025), blood (many), protein (+), and WBC (0-3/HPF). Her 24-hour total protein level was 1,120 mg/day. No specific abnormalities were found on serum and urine protein electrophoresis. Kidney biopsy demonstrated severe mononuclear cell infiltration into the renal interstitium with mild tubular atrophy and pericapsular fibrosis. Immediate withdrawal of Corni fructus, appropriate education, and conservative management resulted in gradual restoration of her renal function. This case implies that Corni fructus may be a causative allergen that induces acute interstitial nephritis in some patients.
Acute Kidney Injury ; Aged ; Atrophy ; Biopsy ; Blood ; Blood Urea Nitrogen ; Cornus ; Creatinine ; Education ; Electrophoresis ; Female ; Fibrosis ; Hematuria ; Hemoglobins ; Humans ; Kidney ; Nephritis, Interstitial* ; Pyridines ; Republic of Korea ; Tea ; Thiazoles ; Urinalysis ; Urine

Drug-induced interstitial nephritis is one cause of acute kidney injury. Although traditional remedies have been widely used in South Korea, Corni fructus-induced interstitial nephritis has not been reported in the general population. A 65-year-old female patient was admitted with sudden onset of gross hematuria after ingesting Corni fructus tea for 2 weeks. Her initial lab findings showed a blood urea nitrogen level of 35.1 mg/dL, creatinine level of 1.7 mg/dL, albumin level of 4.5 g/dL, and hemoglobin level of 10.3 g/dL. Urinalysis revealed SG (1.025), blood (many), protein (+), and WBC (0-3/HPF). Her 24-hour total protein level was 1,120 mg/day. No specific abnormalities were found on serum and urine protein electrophoresis. Kidney biopsy demonstrated severe mononuclear cell infiltration into the renal interstitium with mild tubular atrophy and pericapsular fibrosis. Immediate withdrawal of Corni fructus, appropriate education, and conservative management resulted in gradual restoration of her renal function. This case implies that Corni fructus may be a causative allergen that induces acute interstitial nephritis in some patients.
Acute Kidney Injury ; Aged ; Atrophy ; Biopsy ; Blood ; Blood Urea Nitrogen ; Cornus ; Creatinine ; Education ; Electrophoresis ; Female ; Fibrosis ; Hematuria ; Hemoglobins ; Humans ; Kidney ; Nephritis, Interstitial* ; Pyridines ; Republic of Korea ; Tea ; Thiazoles ; Urinalysis ; Urine

No abstract available.
Eczema* ; Scrotum ; Syphilis*

Chronic bronchiolitis is a condition associated with cigarette smoking, and later associated with pulmonary parenchymal alteration and progressive deterioration of lung function. Early respiratory bronchiolitis was produced in Sprague-Dawley rats by indirect inhalation of cigarette smoke daily in a smoke exposure chamber designed by authors for 1 month. Experimental group A (n=5) was sacrificed after having smoked 30 cigarettes, group B (n=5) after 80 cigarette, and group C (n=7) after 140 cigarettes, respectively. Examination of morphologic changes in the lungs was done on light microscope, transmission and scanning electron microscopes. Light microscopically, increase in number of goblet cells in the bronchial mucosa, brown-pigmented macrophages in the alveoli, multifocal alveolar collapse adjacent to the bronchioles, dilatation of alveolar ducts and alveolar spaces were observed. Transmission electron microscopically, irregularly shaped Clara cells, alveolar wall collapse, and focally type I epithelial cell injury were seen. Scanning electron microscopically, scattered alveolar collapse, irregular dilatation of alveolar ducts, alveolar spaces and interalveolar pores (pores of Kohn) were seen. The terminal and respiratory bronchioles showed morphological alteration of Clara cells, but no evidence of cellular bronchiolitis or bronchiolar obstruction. We conclude that sidestream smoke induces an early respiratory bronchiolitis including aggregates of brown pigmented macrophages and varying degrees of structural alteration of adjacent pulmonary parenchyma.
Bronchioles ; Bronchiolitis ; Dilatation ; Epithelial Cells ; Goblet Cells ; Inhalation ; Lung ; Macrophages ; Mucous Membrane ; Rats, Sprague-Dawley ; Smoke* ; Smoking ; Tobacco Products*

Several therapeutic methods, expectant management, endourology and ESWL can be used in the treatment of ureteral calculi. In a retrospective analysis during a 3-year period, 96 patients showed spontaneous passage of stones. 164 patients treated with endourologic procedures and 168 who underwent ESWL with a Wolf Piezolith 2300 were analysed as to the success rate in stone removal, complication rate, anesthesia and hospitalization. The mean stone size was 5mm in the expectant management group and 6mm in both endourology and ESWL groups. 11mm was the mean size in the surgical group. Complete removal of all stone fragments was achieved in 52.5% of the expectant managed patients. The overall success rate were comparable with modalities which were 94.5% in endourology and 91.4% in ESWL and 100% in ureterolithotomy. The group treated endourologically had a better success rate but no significant difference to ESWL group. On the other hand, the group treated with ESWL had a shorter hospitalization, lower complication rate, no need for anesthesia. These observations showed that in situ ESWL provides a optimal first line therapy for distal ureteral calculi larger than 5mm, while ureteroscopy is better reserved as a salvage procedure should ESWL fail. Expectant management is more efficient for distal ureteral calculi less than 5mm.
Anesthesia ; Hand ; Hospitalization ; Humans ; Retrospective Studies ; Ureter* ; Ureteral Calculi ; Ureteroscopy ; Wolves

BACKGROUND: Defects in TGF-beta receptors have been found in a variety of malignant cells, we therefore investigated whether these defects could be also demonstrated in leukemic cells. In addition, we analyzed the relation between TGF-beta receptor expression and responsiveness to TGF-beta-induced growth inhibitory effects. METHODS: Eleven human leukemic cell lines and two normal cell lines were recruited for the study. To evaluate the expression of TGF-beta receptor type I (RI) and type II (RII), Western blotting analysis was conducted utilizing two kinds of primary antibodies against both RI and RII. Band strength was quantitated with densitometry. Moreover, specific peptides against primary antibodies were employed for competitive inhibition assay. Responsiveness to TGF-beta1 was assessed by [3H] thymidine uptake. RESULTS: Bands of same molecular size were demonstrated by two different primary antibodies. Peptides against RI or RII antibodies successfully blocked the emergence of RI or RII message, respectively, verifying that former bands represented specific RI or RII. Relative RI levels in leukemic cells except HL-60 compared with CCL-64, normal lung epithelial cells, were in the range of 0.48~1.14. In contrast, relative RII levels, although variable between individual cells, were less than 0.25 in all the leukemic cells. Percents [3H]thymidine uptake of leukemic cells at 10 ng/mL of TGF-beta1 compared with untreated control were widely distributed in the range of 7.7~62.9%. Positive correlation between RII levels and TGF-beta responsiveness was observed (P=0.025). CONCLUSION: Defective RI expression seems to be rare, however, defective RII expression appears to be rather common in leukemic cells. Positive correlation between RII levels and TGF-beta responsiveness suggests role of defective RII expression in the acquisition of resistance to TGF-beta in leukemic cells.
Antibodies ; Blotting, Western ; Cell Line* ; Densitometry ; Epithelial Cells ; Humans ; Lung ; Peptides ; Receptors, Transforming Growth Factor beta ; Thymidine ; Transforming Growth Factor beta ; Transforming Growth Factor beta1

Papillary renal cell carcinoma is a histological variant that may be cystic in appearance. This variety has been termed cystadenocarcinoma to distinguish it from a renal cell carcinoma that has been rendered cystic through necrosis and hemorrhage. Because a greater proportion presented as stage I lesion, papillary renal cell carcinoma has been reported to have a better prognosis than renal cell carcinoma in general. We report a case of cystadenocarcinoma of the kidney that was confirmed by surgical exploration.
Carcinoma, Renal Cell ; Cystadenocarcinoma* ; Hemorrhage ; Kidney* ; Necrosis ; Prognosis

Much has been tried to avoid the toxicity and increase the quality of local anesthesia during epidural anesthesia. One idea is that a mixture of local anesthetics would give better result than separate in jections. This study was undertaken to compare the use of lidocaine alone in contrast to a lidoca-ine-tetracaine mixture. Thirty three cases of epidural anesthesia were performed at Dae-Jeon Eul Ji Hospital from Jan. to Nov. 1985. The results were as follow; 1) There was no difference in the time of onset of anesthesia between the single k Mixt-ure groups. 2) The duration of anesthesia from the mixture was longer than lidocaine by itself. 3) Muscle relaxation from the mixture was superior to lidocaine alone. 4) Toxicity of the mixture was no more than lidocaine alone. 5) In all the groups, pressure drop in diastole was more than that of systole. The heart rate was normal or slightly increased. In conclusion, the use of the lidocaine-tetracaine mixture was better than lidocaine alone for epidural anesthesia.
Anesthesia ; Anesthesia, Epidural* ; Anesthesia, Local ; Anesthetics, Local ; Diastole ; Heart Rate ; Lidocaine ; Muscle Relaxation ; Systole

The occurrence of double primary tumors in an individual patient was first described by Billroth approximately 100 years ago. The genitourinary organs appear to be at greater risk for double primary tumors, because the urological system is at higher risk for primary tumors( prostate and bladder ). Multifocal involvement is a well-known feature of transitional cell carcinoma. But the coexistence of two separate primary urothelial carcinomas occurring simultaneously is extremely unusual. We report on a 25-year-old man who had synchronous double primary tumors : squamous cell carcinoma of the bladder and transitional cell carcinoma of the ureter.
Adult ; Carcinoma, Squamous Cell* ; Carcinoma, Transitional Cell* ; Humans ; Prostate ; Ureter* ; Urinary Bladder*