Primary systemic amyloidosis is a progressive disease that is frequently fatal. Nephrotic syndrome is present in almost one-third, congestive heart failure in one-quarter, and peripheral neuropathy in one-sixth of patients at the time of diagnosis. If heart or renal failure are presented, survival rate is poor. We experienced a case of a 66 year-old female patient who had complained lower leg edema and paresthesia of extremities for about 5 months. The laboratory findings were consistent with nephrotic syndrome, but the lower leg edema was non-pitting and the cause of paresthesia was unknown. We performed kidney and nerve biopsy and confirmed a case of primary systemic amyloidosis. In this case, presence of postural hypotension, probable cardiac involvement and relatively long spikes along the outside of the glomerular capillary loops on methenamine silver stain is suggestive of poor prognosis. We can predict chronic renal failure and congestive heart failure in the course of this case. We report a case of primary systemic amyloidosis predominantly presenting nephrotic syndrome and peripheral neuropathy with review of related literatures.
Aged ; Amyloidosis* ; Biopsy ; Capillaries ; Diagnosis ; Edema ; Extremities ; Female ; Heart ; Heart Failure ; Humans ; Hypotension, Orthostatic ; Kidney ; Kidney Failure, Chronic ; Leg ; Methenamine ; Nephrotic Syndrome* ; Paresthesia ; Peripheral Nervous System Diseases* ; Prognosis ; Renal Insufficiency ; Survival Rate

Acute uric acid nephropathy is a kind of acute renal failure and results from uric acid crystal deposition within the collecting ducts and the distal tubules due to rapid increase of serum uric acid concentration. Hyperuricemia can be, in the relation to the underlying physiology, clas sified into the three categories. i.e., increased urate pro duction, decreased uric acid excretion, or a combination of the two. It is most commonly presented in the lympho proliferative or myeloproliferative disorders after effective cytolytic chemotherapy in the form of tumor lysis syn drome. But we have recently experienced a case of a 73 year-old female patient with acute lymphoblastic leuke mia whose first presentation was acute uric acid nephrop athy, spontaneously developed without chemotherapy and so report it with review of related literatures.
Acute Kidney Injury ; Aged ; Drug Therapy ; Female ; Humans ; Hyperuricemia ; Myeloproliferative Disorders ; Physiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma* ; Uric Acid*