1.A Case of Cutaneous Larva Migrans Improved by Oral Ivermectin
Hee Seong YOON ; Si Hyub LEE ; Seung Dohn YEOM ; Jeonghyun SHIN ; Gwang Seong CHOI ; Ji Won BYUN
Korean Journal of Dermatology 2018;56(1):70-72
No abstract available.
Ivermectin
;
Larva Migrans
2.Polyphenols in peanut shells and their antioxidant activity: optimal extraction conditions and the evaluation of antiobesity effects
Da Hye GAM ; Ji Woo HONG ; Suh Hee YEOM ; Jin Woo KIM
Journal of Nutrition and Health 2021;54(1):116-128
Purpose:
The extraction conditions for bioactive components from peanut shells, which is a byproduct of peanut processing, were optimized to enhance the total phenolic content (TPC, Y1 ), total flavonoid content (TFC, Y2 ), and 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (RSA, Y3). In addition, this study evaluated the anti-obesity effect of peanut shell extract.
Methods:
Optimization of ultrasonic‐assisted extraction (UAE) was performed using a response surface methodology. The independent variables applied for extraction were time (X1 : 5.0–55.0), temperature (X2 : 26.0–94.0), and ethanol concentration (X3 : 0.0%–99.5%). Quadratic regression models were derived based on the results of 17 experimental sets, and an analysis of the variance was performed to verify its accuracy and precision of the regression equations.
Results:
When evaluating the effects of independent variables on responses using statistically-based optimization, the independent variable with the most significant effect on the TPC, TFC, and RSA was the ethanol concentration (p = 0.0008). The optimal extraction conditions to satisfy all three responses were 35.8 minutes, 82.7°C, and 96.0% ethanol. Under these conditions, the inhibitory activities of α-glucosidase and pancreatic lipase by the extract were 86.4% and 78.5%, respectively.
Conclusion
In this study, UAE showed superior extraction efficiency compared to conventional hot-water extraction in the extraction of polyphenols and bioactive materials. In addition, α-glucosidase and pancreatic lipase inhibitory effects were identified, suggesting that peanut shells can be used as effective antioxidants and anti-obesity agents in functional foods and medicines.
3.Prevalence of human parechovirus and enterovirus in cerebrospinal fluid samples in children in Jinju, Korea.
Ji Hyun SEO ; Jung Sook YEOM ; Hee Shang YOUN ; Tae Hee HAN ; Ju Young CHUNG
Korean Journal of Pediatrics 2015;58(3):102-107
PURPOSE: Human parechovirus (HPeV) and enterovirus (EV) are causative agents of a sepsis-like illness in neonates and of infections of the central nervous system in young children. The objectives of this study were to assess the prevalence of HPeV3 and EV infection in young children with a sepsis-like illness or with meningitis in Jinju, Korea. METHODS: Cerebrospinal fluid (CSF) samples were collected from 267 patients (age range, 1 day to 5 years) and assessed for HPeV and EV by performing reverse transcription polymerase chain reaction assay. Amplification products of the VP3/VP1 region of HPeV and of the VP1 region of EV were sequenced to identify the virus type. RESULTS: HPeV and EV were detected in 3.4% and 7.5% of the total CSF samples assessed, respectively. The age distribution of EV-positive patients (median age, 1.4 months) had a significantly broader range than that of HPeV-positive patients (median age, 7.8 months). The peak seasons for HPeV and EV infection were spring and summer, respectively. The clinical symptoms for HPeV and EV infection were similar, and fever was the most common symptom. Pleocytosis was detected in 22.2% of HPeV-positive patients and 35.5% of EV-positive patients. The VP3/VP1 gene sequence of the nine Korean strains clustered most closely with the Japanese strain (AB759202). CONCLUSION: The data indicate that HPeV infection is predominant in young infants (<6 months) and that meningitis without pleocytosis was caused by both HPeV and EV infection in children.
Age Distribution
;
Asian Continental Ancestry Group
;
Central Nervous System
;
Cerebrospinal Fluid*
;
Child*
;
Enterovirus*
;
Fever
;
Gyeongsangnam-do
;
Humans
;
Infant
;
Infant, Newborn
;
Korea
;
Leukocytosis
;
Meningitis
;
Parechovirus*
;
Polymerase Chain Reaction
;
Prevalence*
;
Reverse Transcription
;
Seasons
4.An Atypical Erythromelalgia on the Chest.
Si Hyub LEE ; Hee Seong YOON ; Seung Dohn YEOM ; Ji Won BYUN ; Gwang Seong CHOI ; Jeonghyun SHIN
Annals of Dermatology 2018;30(6):733-735
No abstract available.
Erythromelalgia*
;
Thorax*
5.Two Cases of Herpes Zoster Following Varicella Vaccination in Immunocompetent Young Children:One Case Caused by Vaccine-Strain
Da-Eun KIM ; Hae Ji KANG ; Myung-Guk HAN ; Hye-young YEOM ; Sung Hee CHANG
Pediatric Infection & Vaccine 2022;29(2):110-117
Herpes zoster (HZ) has been reported in immunocompetent children who received the varicella vaccine. In vaccinated children, HZ can be caused by vaccine-strain or by wild-type varicella-zoster virus (VZV). Like wild-type VZV, varicella vaccine virus can establish latency and reactivate as HZ. We report two cases of HZ in otherwise healthy 16- and 14-month-old boys who received varicella vaccine at 12 months of age. They presented with a vesicular rash on their upper extremities three to four months after varicella vaccination. In one case, a swab was obtained by abrading skin vesicles and VZV was detected in skin specimens by polymerase chain reaction. The VZV open-reading frame 62 was sequenced and single nucleotide polymorphism analysis confirmed that the virus from skin specimen was vaccinestrain. This is the first HZ case following varicella vaccination confirmed to be caused by vaccine-strain VZV in the immunocompetent children in Korea. Pediatricians should be aware of the potential for varicella vaccine virus reactivation in vaccinated young children.
6.The Clinical Usefulness of a Repeat Urine Culture 48 Hours after Antimicrobial treatment in Anatomically Normal and Abnormal Urinary Tract Infection.
Kyung Hee PARK ; Jung Suk YEOM ; Ji Suk PARK ; Eun Sil PARK ; Ji Hyun SEO ; Jae Young LIM ; Chan Hoo PARK ; Hee Shang YOUN
Journal of the Korean Society of Pediatric Nephrology 2009;13(1):49-55
PURPOSE: We aimed to compare the frequency of positive repeat urine cultures 48 hours after antimicrobial treatment between anatomically normal and abnormal urinary tract Infection (UTI) groups to determine the potential clinical usefulness of the tests. METHODS: We reviewed medical records of 930 patients under age 14, who had been admitted for UTI at Gyeongsang National University Hospital from January 1, 1998 to August 1, 2008. The eligible patients were divided into two groups the anatomically normal UTI group and the anatomically abnormal UTI group. Statistical analyses were performed with variables consisting of the sex ratio, age distribution and the frequency of positive repeat urine cultures of each group. RESULTS: The sex ratio of the anatomically normal UTI group was M:F=1.9:1, whereas that of the anatomically abnormal UTI group was M:F=3.5:1 (P=0.019). For age distribution, it was found that the mean age of the anatomically normal UTI group was 0.82+/-1.83 years, whereas that of the anatomically abnormal UTI group was 1.18+/-2.57 years (P=0.113). The frequency of positive repeat urine cultures in the anatomically normal UTI group was 3/279 (1.1%), whereas that of the anatomically abnormal UTI group was 1/90 (1.1%) (P=0.675). CONCLUSION: We conclude that performing a repeat urine culture is not justified in terms of clinical usefulness, and it is unreasonable to use the results as an index of therapeutic success. A follow-up urine culture is unnecessary in patients with both the anatomically normal and abnormal UTI group.
Age Distribution
;
Follow-Up Studies
;
Humans
;
Hydronephrosis
;
Medical Records
;
Sex Ratio
;
Urinary Tract
;
Urinary Tract Infections
;
Vesico-Ureteral Reflux
7.Initial Orthostatic Hypotension is Possibly Associated with Autonomic Dysfunction when Diagnosed with a Tilt Table Test.
Jae Young CHO ; Hong Seop YEOM ; Jung Sook YEOM ; Ji Sook PARK ; Ji Hyun SEO ; Eu Sil PARK ; Jae Young LIM ; Chan Hoo PARK ; Hyang Ok WOO ; Hee Shang YOUN ; Ki Jong PARK
Journal of the Korean Child Neurology Society 2012;20(4):201-208
PURPOSE: Initial orthostatic hypotension is typically associated with active standing and normal autonomic function. Some adolescents in the present study displayed initial orthostatic hypotension during passive tilting, and we hypothesized that this condition was due to abnormal autonomic function. METHODS: The present study compared autonomic functioning in two groups of adolescents: patients with a diagnosis of initial orthostatic hypotension according to the tilt table test and patients with typical symptoms of initial orthostatic hypotension but normal tilt table test results. RESULTS: Significantly higher total composite autonomic severity scores and considerably higher adrenergic index were noted in the tilt table tested group. CONCLUSION: Initial orthostatic hypotension is possibly associated with autonomic dysfunction, especially abnormal vasoconstrictive ability, in individuals diagnosed with a tilt table test. Clinicians should take note of autonomic function when performing diagnoses of initial orthostatic hypotension using the tilt table test.
Adolescent
;
Humans
;
Hypotension, Orthostatic
;
Tilt-Table Test
8.Clinical Significance of Antibodies Against Platelet HLA Class I in Children with Idiopathic Thrombocytopenic Purpura.
Hong Jun LEE ; Jung Sook YEOM ; Ji Sook PARK ; Eun Sil PARK ; Ji Hyun SEO ; Jae Young LIM ; Chan Hoo PARK ; Hyang Ok WOO ; Hee Shang YOUN
Korean Journal of Blood Transfusion 2013;24(3):233-240
BACKGROUND: A previous history of transfusion has been known to be associated with production of anti-HLA class I antibodies. However, platelet glycoproteins are the main target of idiopathic thrombocytopenic purpura (ITP). The mechanism of antibody production is known to differ significantly between glycoproteins and anti-HLA class I. The aim of this study was to evaluate the clinical significance of anti-HLA class I antibodies in childhood ITP. METHODS: Enrollment for the normal control group targeted 48 people who visited Gyeongsang National University Hospital from 1990 to 2010, and 48 young children with ITP. Anti-glycoproteins and anti-HLA class I antibodies were tested using the Modified Antigen Capture Enzyme-linked immunosorbent assay (MACE) kit. RESULTS: The positive rate of anti-HLA antibodies was significantly different [36/39 (92.3%) vs 29/46 (63%)] [ITP group vs normal control group] (P=0.002). The mean positive S/C ratio of anti-HLA antibodies was also significantly different (3.55 vs 1.51) [ITP group vs normal control group] (P=0.0000). The positive rate of anti-HLA did not differ significantly between the transfused group and the non-transfused group [12/12 (100%) vs 24/27 (88%)] [transfused ITP vs non-transfused ITP]. The mean positive S/C ratio of anti-HLA antibodies did not differ significantly between the transfused ITP group and the non-transfused ITP group (4.30 vs 3.25) [transfused ITP vs non-transfused ITP]. Consecutive testing showed that positive rate and positive S/C ratio of anti-HLA antibodies did not change significantly between sampling times in both groups [transfused ITP vs non-transfused ITP] (P=1.00 and P=0.15). CONCLUSION: Anti-HLA class I antibodies may be involved in childhood ITP. Transfusion did not affect the course of childhood ITP.
Antibodies*
;
Antibody Formation
;
Blood Platelets*
;
Child*
;
Enzyme-Linked Immunosorbent Assay
;
Glycoproteins
;
Humans
;
Platelet Membrane Glycoproteins
;
Purpura, Thrombocytopenic, Idiopathic*
9.Denys-Drash syndrome, Septated Vagina And Low Level Of Anti-mullerian Hormone In male neonate.
Hong Jun LEE ; Jung Sook YEOM ; Ji Sook PARK ; Eun Sil PARK ; Ji Hyun SEO ; Jae Young LIM ; Chan Hoo PARK ; Hyang Ok WOO ; Hee Shang YOUN
Annals of Pediatric Endocrinology & Metabolism 2014;19(2):100-103
There is a wide variety of genital abnormalities observed in patients with Denys-Drash syndrome (DDS). WT1 is thought to influence the genes related to genital development and mutations in this gene have been associated with DDS. DDS should be considered in the differential diagnosis of newborns with genital anomalies. In contrast to other conditions with 46,XY disorders of sex development, individuals with DDS often have duplicated genital organs (a double vagina, cervix or uterus). A double uterus has not yet been reported with 1390G>A (Arg464 Asn) mutation. However, duplicated genitals have been reported with other genetic mutations in patients with DDS. The duplicated genitals in DDS may be associated with low anti-Mullerian hormone (AMH) secretion. Measurement of the AMH levels may add to our understanding of variations in genital development and their abnormalities in disorders such as DDS. In conclusion, this is first case of low level of AMH and double uterus in 1390G>A (Arg464 Asn) mutations of DDS male.
46, XY Disorders of Sex Development
;
Anti-Mullerian Hormone*
;
Cervix Uteri
;
Denys-Drash Syndrome*
;
Diagnosis, Differential
;
Female
;
Genitalia
;
Humans
;
Infant, Newborn*
;
Male
;
Uterus
;
Vagina*
10.A Case of Idiopathic Congenital Neonatal Cholestasis in a Patient with Down Syndrome.
Tae Eon HUH ; Hyun Jeong DO ; Ji Sook PARK ; Jung Sook YEOM ; Eun Sil PARK ; Ji Hyun SEO ; Jae Young LIM ; Chan Hoo PARK ; Hyang Ok WOO ; Hee Shang YOUN
Pediatric Gastroenterology, Hepatology & Nutrition 2012;15(2):117-121
Down syndrome is a rare cause of neonatal cholestasis. Neonatal cholestasis in a patient with Down syndrome is usually associated with severe liver diseases, such as neonatal hemochromatosis, myeloproliferative disorder and intrahepatic bile duct paucity. We experienced a case of idiopathic neonatal cholestasis in a patient with Down syndrome, which resolved spontaneously.
Bile Ducts, Intrahepatic
;
Cholestasis
;
Down Syndrome
;
Hemochromatosis
;
Humans
;
Infant, Newborn
;
Liver Diseases
;
Myeloproliferative Disorders