No abstract available.

No abstract available.
Eczema, Dyshidrotic* ; Guillain-Barre Syndrome* ; Immunization, Passive* ; Immunoglobulins*

No abstract available.
Adult ; Angiography ; Balloon Occlusion ; Capsule Endoscopy ; Gastrointestinal Hemorrhage/*complications/therapy ; Humans ; Jejunal Diseases/*diagnosis/etiology ; Jejunum/*blood supply ; Male ; Recurrence ; Tomography, X-Ray Computed ; Varicose Veins/*diagnosis/etiology

This paper represents the versatility of buccinator myomucosal flap for intraoral and orbital reconstruction of mild to moderate defect and we introduce recontructive methods are introduced along with our clinical experience. Buccal artery from internal maxillary artery is the main arterial pedicle, and buccal branch from facial artery also can supply blood for the buccinator muscle. The abundant blood flow from interconnected pedicles supports the reliable circulation of the buccal mucosa. So we could reconstruct the eye socket using reversed island buccinator myomucosal flap based on the angular vessel. The motor innervation of the buccinator muscle comes from the facial nerve. The buccinator muscle is considered to be a part of the sphincteric muscular system involving the functions of sucking, whistling, propelling food during mastication and voiding the buccal cavity. From 1990 to 1999, the flap was utilized in 8 patients to reconstruct the small to moderate intraoral defect and 1 patient for orbital mucosal defect. All flaps survived completely. There has been no flap necrosis and fistula. The results have been functionally and esthetically satisfactory. It is very reliable and safe flap with a minimal morbidity of donor site. It doesn't require microsurgical technique. Rapid healing may be achieved with its mucosal nature. We conclude that buccinator myomucosal flap can be widely used with a lot of advantages for intraoral and orbital defect because of its many advantages.
Arteries ; Facial Nerve ; Fistula ; Humans ; Mastication ; Maxillary Artery ; Mouth Mucosa ; Mouth* ; Necrosis ; Orbit* ; Singing ; Tissue Donors

An ipsilateral supraclavicular lymph node recurrence of breast cancer after surgery has been considered a predecessor to distant metastases. There still is a debate as to whether breast carcinoma patients with the isolated supraclavicular lymph node recurrence should be considered to have disseminated disease or if aggressive treatment, with curative intent, is justified. We report two cases of an isolated ipsilateral supraclavicular lymph node recurrence following modified radical mastectomy, and multimodality treatments with modified radical neck dissection, systemic chemotherapy and involved field radiotherapy. These patients have lived without locoregional recurrence or distant metastases for 3 and 2 years, respectively. Conclusively, we recommend aggressive combined multimodality treatments, including surgery, such as modified radical neck dissection or complete excision of the involved lymph nodes, systemic chemotherapy, and involved field radiotherapy, in patients with isolated supraclavicular lymph node recurrence, but with no other evidence of distant metastases.
Breast Neoplasms ; Drug Therapy ; Humans ; Lymph Nodes ; Mastectomy, Modified Radical ; Neck Dissection ; Neoplasm Metastasis ; Radiotherapy ; Recurrence

Cryptotanshinone is known for its inhibitory activity against tumorigenesis in various human cancer cells. However, exact mechanisms underlying the anticancer effects of cryptotanshinone are not fully elucidated. Here, we propose a plausible molecular mechanism, wherein cryptotanshinone represses rapamycin-sensitive mTORC1/S6K1 mediated cancer cell growth and cell transformation. We investigated the various effects of cryptotanshinone on the mTORC1/S6K1 axis, which is associated with the regulation of cell growth in response to nutritional and growth factor signals. We found that cryptotanshinone specifically inhibited the mTORC1-mediated phosphorylation of S6K1, which consequently suppressed the clonogenicity of SK-Hep1 cells and the neoplastic transformation of JB6 Cl41 cells induced by insulin-like growth factor-1. Finally, we observed that cryptotanshinone prevented S6K1 from binding to the Raptor/mTOR complex, rather than regulating mTOR and its upstream pathway. Overall, our findings provide a novel mechanism underlying anti-cancer effects cryptotanshinone targeting mTORC1 signaling, contributing to the development of anticancer agents involving metabolic cancer treatment.

Cryptotanshinone is known for its inhibitory activity against tumorigenesis in various human cancer cells. However, exact mechanisms underlying the anticancer effects of cryptotanshinone are not fully elucidated. Here, we propose a plausible molecular mechanism, wherein cryptotanshinone represses rapamycin-sensitive mTORC1/S6K1 mediated cancer cell growth and cell transformation. We investigated the various effects of cryptotanshinone on the mTORC1/S6K1 axis, which is associated with the regulation of cell growth in response to nutritional and growth factor signals. We found that cryptotanshinone specifically inhibited the mTORC1-mediated phosphorylation of S6K1, which consequently suppressed the clonogenicity of SK-Hep1 cells and the neoplastic transformation of JB6 Cl41 cells induced by insulin-like growth factor-1. Finally, we observed that cryptotanshinone prevented S6K1 from binding to the Raptor/mTOR complex, rather than regulating mTOR and its upstream pathway. Overall, our findings provide a novel mechanism underlying anti-cancer effects cryptotanshinone targeting mTORC1 signaling, contributing to the development of anticancer agents involving metabolic cancer treatment.

BACKGROUND: A few studies have revealed increased levels of certain cytokines in patients with ischemic stroke. Cytokine changes have not been studied in patients with transient ischemic attack(TIA). The purpose of this study was to evaluate the temporal profile of the inflammatory response in patients with vertebrobasilar insufficiency (VBI) and to compare the inflammatory response between TIA and infarction through analyzing serum interleukin(IL)-6 and IL-10. METHODS: We serially measured the serum levels of IL-6 and IL-10 in 14 patients with VBI, 12 patients with vertebrobasilar territoy infarction, and 21 patients with lacunar infarction at the timing of admission, at 1 day after symptom onset, and at 5 day after symptom onset. Cytokines were measured by sandwich ELISA method. RESULTS: The IL-6 level obtained at day 1 was significantly elevated compared with the normal control group in patients with TIA (p<0.05). The IL-6 level at day 1 was the highest in patients with VBI. The level of IL-10 in patients with VBI was significantly higher than normal group at all time points(p<0.05). The IL-10 level at the timing of admission was the highest in patients with VBI. But the serum levels of IL-6 and IL-10 between VBI and vertebrobasilar territory and lacunar infarction groups did not show any differences. CONCLUSION: These findings show that pro- and anti-inflammatory cytokines in serum are elevated in patients with TIA. These results suggest that cytokine cascade occurs in TIA.
Cytokines ; Enzyme-Linked Immunosorbent Assay ; Humans ; Infarction ; Interleukin-10* ; Interleukin-6* ; Stroke ; Stroke, Lacunar ; Vertebrobasilar Insufficiency*

BACKGROUND: A few studies have revealed increased levels of certain cytokines in patients with ischemic stroke. Cytokine changes have not been studied in patients with transient ischemic attack(TIA). The purpose of this study was to evaluate the temporal profile of the inflammatory response in patients with vertebrobasilar insufficiency (VBI) and to compare the inflammatory response between TIA and infarction through analyzing serum interleukin(IL)-6 and IL-10. METHODS: We serially measured the serum levels of IL-6 and IL-10 in 14 patients with VBI, 12 patients with vertebrobasilar territoy infarction, and 21 patients with lacunar infarction at the timing of admission, at 1 day after symptom onset, and at 5 day after symptom onset. Cytokines were measured by sandwich ELISA method. RESULTS: The IL-6 level obtained at day 1 was significantly elevated compared with the normal control group in patients with TIA (p<0.05). The IL-6 level at day 1 was the highest in patients with VBI. The level of IL-10 in patients with VBI was significantly higher than normal group at all time points(p<0.05). The IL-10 level at the timing of admission was the highest in patients with VBI. But the serum levels of IL-6 and IL-10 between VBI and vertebrobasilar territory and lacunar infarction groups did not show any differences. CONCLUSION: These findings show that pro- and anti-inflammatory cytokines in serum are elevated in patients with TIA. These results suggest that cytokine cascade occurs in TIA.
Cytokines ; Enzyme-Linked Immunosorbent Assay ; Humans ; Infarction ; Interleukin-10* ; Interleukin-6* ; Stroke ; Stroke, Lacunar ; Vertebrobasilar Insufficiency*

Adult-onset metachromatic leukodystrophy (MLD) is very rare with a combination of cognitive and behavioral symptoms and peripheral polyneuropathy. A 47-year-old man was admitted due to memory impairment, gait disturbance, dysarthria and personality changes for a period of 3 years. The arylsulfatase A level in his leukocytes was decreased. A brain MRI showed bilateral symmetrical demyelination but nerve conduction velocities (NCV) were normal. We report a very rare case of adult-onset MLD with normal NCV.
Behavioral Symptoms ; Brain ; Cerebroside-Sulfatase ; Demyelinating Diseases ; Dysarthria ; Gait ; Humans ; Leukocytes ; Leukodystrophy, Metachromatic* ; Magnetic Resonance Imaging ; Memory ; Middle Aged ; Neural Conduction* ; Polyneuropathies