In the information age, teaching methods are undergoing tremendous changes, and the traditional teaching methods are difficult to draw students′ attention. As the core course of stomatology, oral histopathology is an important foundation for oral students. Along with the rapid development of medical science, it is imperative to deepen the reform of teaching. This article discussed the diversified teaching methods conducted in oral histopathology course in Zhejiang University School of Stomatology in the past 10 years with the core teaching theory of “learning before teaching” including the exploration design course, case based learning, journal club, etc. Diversified teaching methods activated students′ subjective initiative, which laid a foundation for the next stage of clinical study, and provided a guiding framework for the future teaching reforms.