The close similarity of acrokeratosis verruciformis(AKV) to the acral lesions of Dariers disease is well known. However, the exact relationship between the two disorders has not been satisfactorily resolved. A case of Dariers disease associated with guttate leukoderma and AKV is presented. The patient was a 17-year-old male who had dark cursted papules on the neck and lower abdomen, flat-topped keratotic papules on the dorsal surface of hoth hands, and white macules disseminated on the trunk and lower extremities of 7 years duration. The histopathologic examination of the lesion on the lower abdomen revealed parakeratotic plugs, corps ronds, and suprabasal clefts. The lesion on the dorsum of the hand showed compact hyperkeratosis, acanthosis, and papillomatosis with the pattern of church spires. The leukodermic lesion revealed decreased melanin content in the epidermal cells.
Male ; Humans

No abstract available.

The formation of spontaneous rosettes between human lymphocytes and sheep erythro ytes under suitable conditions is a constant feature of T-lymphocytes. Recently. It has been demonstrated in the mouse, rat, guinea pig and in man that a certain proportion of peripheral blood lymphocytes has the property to bind autolognus erythrocytes in vitro. These lymphocytes are called auiologous rosette forming cells(ARFC). Although there are several reports on human ARFC. the results are not in accordance. The present study was undertaken to demonstrate the autologous rosette forming property of human peripheral blood lymphocytes, and to enumerate the percentage of ARFC in different sex and age guoups. Fifty healthy persons entered this study between Martch and September. 1980. at the Department of Dermatolgy, Seoul National Universty Hospital. The method of quantitation of AREC was s sight modification of that of Lambermont et al(1977). The results were as follows.
Male ; Humans ; Mice ; Animals

Progressive cribriform and zosteriform hyperpigmentaion (PCZP) is a pigmentary disorder of the skin which was first described by Rower et al in 1978. The disorder is characterized clinically by uniformalyptan cribriform macular pigmentation in a zosteriform distibution and histopathologically by absence of nevus cells and increased melanin in the basal cells. The authors have experienced a case of PCZP in 21 year old Korean man which we believe is the first documented case in Korea. The patient noted light brown macules on his left inguinal area at the age of 17 which has gradually extended to become cribriform macular pigmentation in a zosteriform distribution. Histopathologic examination of the lesion showed an increase in basal melanin pigmentation. No nevus cells were present.
Humans ; Hyperpigmentation* ; Korea ; Melanins ; Nevus ; Pigmentation ; Skin ; Young Adult

The accurate diagnosis of spine trauma is essential to its proper management, since therapeutic decisionsdepend on radiography and clinical data. Failure to recognize significant injury to the spine can lead to severeneurological deficit in the previously neulogically intact patient. The developmemt of CT has open a new demensionin evaluation of spinal column. In our experience CT not only offer the accurate and thorough evaluation of spinalinjury, but does so in a rapid and more efficient manner when compared with conventional radiolgraphy. CT hasbecome the diagnostic procedure of choice when screening plain film and clinical examination indecate that acomprehensive radiographic evaluation is necessary. Eighteen patients with thoracic and lumber spinal fracturewere studied with CT. Four had multiple level injuries. The resuls are summerized as follow; 1. Among the 18patients, 4 had multiple level injuries and other 14 patients had single spinal injury. 2. 8 patients (11 spines)had simple compression fracture and 12 patients (13 spines) had burst fracture of vertebral body. 3. 15 spinesamong the 24 involved spines are located at T12 and L1 level. 4. Spineal canal narrowing and bony fragment in thecanal are defiend only 7 of 13 spines (53.8%) of burst fracture in conventional radiography. However CT showed inall spines of burst fracture. 5. Spinal posterior element involvement is suggested only one of 12 spines of burstfracture, but correctly interpretated by CT in 7 spines(11 anatomical position).
Diagnosis ; Fractures, Compression ; Humans ; Mass Screening ; Radiography ; Spinal Fractures ; Spinal Injuries ; Spine

Conventional radiology of the pancreas are too often unsatisfactory. It is well known that the whole body CTis very useful in identifying retroperitoneal pathology. The authors intended to present normal pancreaticmorphology and data for preparation of basis for interpretation o abnormalities. We results were as follows; 1.There were 36 male and 24 female patients, and their ages ranged fro 7 to 78 years. 2. 1) The organs adjacentpancreas were stomach, inferior vena cava, duodenum, caudate lobe of the liver left kidney, left adrenal gland,superior mesenteric vessels, spleen. 2) In 19 patients, pancreatic tail at the level of left kidney in thetransverse plane, it was either ventral in 13(68%), ventromedial in 2(19%), ventrolateral in 4(21%) to leftkidney, in the other ventral in 13(68%), ventromedial in 2(19%), ventrolateral in 4(21%) ot left kidney, in theother 41 patients, it was cranial to the upper pole of left kidney, ventral in 15(61%), ventromedial in 1(2%),ventrolateral in 15(37%). 3) Pancreatic tail was cranial to the pancreatic body, 3cm cranial in 2(4%), 2-3cm in5(8%), 1-2cm in 6(10%), less than 1cm in 11(18%). In the other, caudal in 3(5%). 3. Pancreatic shape was uniformtapering form in 37(62%), lobulated form in 23(38%). 4. Pancreatic orientation was horizontal in 13(22%), vertical56(76%), S-shaped in 1(2%). 5. Pancreatic margin was smooth in 22(37%), lobulated in 38(63%). 6. In most patients,pancrease was uniform in density. 7. Pancreatic size was 0.5+-0.1 in measurement ratio of the head in 48(80%),0.4+-0.1 of the body in 49(88%), 0.5+-0.1 of the tail in 47(78%).
Clothing ; Duodenum ; Female ; Head ; Humans ; Kidney ; Liver ; Male ; Pancreas ; Pathology ; Spleen ; Stomach ; Tail ; Vena Cava, Inferior

OBJECTIVES: This study was designed to investigate the effect of antipsychotic drugs (chlorpromazine, haloperidol and clozapine) on the cerebral hemodynamics including the changes in regional cerebral blood flow(rCBF) and the pill arteriolar diameter of male Sprague-Dawley rats. METHODS: The changes in rCBF were determined by laser-Doppler flowmetry, and the changes in diameter of pill arteriole were measured through a closed cranial window. RESULTS: Clozapine(0.1~10 microgram/kg, i.v. or 0.03~3 micrometer caused an increase in rCBF in association with a vasodilation of pill arteriole in a dose-dependent miner, whereas chlorpromazine and haloperidol(5~500 microgram/kg, i.v., or respectively) were without effect on rCBF. Clozapine-induced increases in rCBF were significantly blocked by topical pretrfatment with NMDA receptor blockers(MgCl(2), MK-801, ketamine and D(-)-2-amino-5-phosphonopentanoic acid). Constitutive nitric oxide synthase inhibitors (N(G)-nitro-L-arginine, 7-nitroindazole and diphenyleneiodonium) markedly inhibited the clozapine-induced increases in rCBF. However, aminoguanidine, an inducible nitric oxide synthase inhibitor did not affect the clozapine-induced increases in rCBF. Inhibitors of soluble guanylyl cyclase(methylene blue and 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one) significantly attenuated the clozapine-induced increases in rCBF. CONCLUSION: These results suggest that typical antipsychotic drugs are without effect on rCBF, but atypical antipsychotir drug clozapine exerts an increase in rCBF with pial arteriolar dilation via mediation of NMDA receptor stimulation, and thereby, leading to activation of neuronal and endothelial nitric oxide synthases and increase in cyclic GMP formation.
Animals ; Antipsychotic Agents* ; Arterioles ; Chlorpromazine ; Clozapine ; Cyclic GMP ; Dizocilpine Maleate ; Haloperidol ; Hemodynamics* ; Humans ; Ketamine ; Laser-Doppler Flowmetry ; Male ; N-Methylaspartate ; Negotiating ; Neurons ; Nitric Oxide ; Nitric Oxide Synthase ; Nitric Oxide Synthase Type II ; Rats* ; Rats, Sprague-Dawley ; Vasodilation

BACKGROUND: Suction auto epidermal graft for the treatment of stable vitiligo has become popular clinically. In general, depigmented epidermis is removed by liquid nitrogen freezing for preparation of the recipient site. There have been some problems with the nitrogen freezing method, uneven repigmentation, appearance of Koebner's phenomenon on normal colored skin around the graft site, scar formation on recipients sites. In our view these resulted in unwanted damage to the dermis and epidermal and skin appendageal melanocytes of normal skin by freezing. OBJECTIVE: To introduce a method to remove the depigmented epidermis of recipient site with minimal unwanted damage to melanocytes and dermal tissue. METHODS: Using Ellman surgitron, irradiation equipment of 3.8MHz frequency the depigmented epidermis was removed with a blade electrode under rated electric power around 10 watts depending on the thickness of the epidermis. Operating mode was fully filtered current for minimal charring and destruction of tissue through pure micro-smooth cutting. RESULTS: In the case of removal of the epidermis with Ellman surgitron, oozing and inflammation decreased markedly compared with those applied with liquid nitrogen. And it was confirmed histopathologically that there was no significant unwanted destruction of healthy tissue. Moreover, the electrode of Ellman surgitron is designed to be apt to trace the margin of depigmented lesion. And Ellman surgitron features a continuously linear intensity setting for precise, predictable control to minimize tissue destruction and charring. So we were able to remove the epidermis of the shallow lesion looking like a pseudopod and of the thinnest part of the body like eyelid also. And we grafted normal epidermis successfully on the depigmented lesion. CONCLUSION: The removal of depigmented epidermis by radio-frequency gave satisfactory results in the suction auto epidermal graft by overcoming the defects shown as depigmented epidermis which were removed by liquid nitrogen freezing. And this method made patients comfortable because of less pain, a one day operation procedure and good results.
Cicatrix ; Dermis ; Electrodes ; Epidermis* ; Eyelids ; Freezing ; Humans ; Inflammation ; Melanocytes ; Nitrogen ; Skin ; Suction* ; Transplants* ; Trout ; Vitiligo

No Abstract Available.
Pterygium*

It has been proposed that action spectrum in polymorphous light eruption lies predominantly in the sunburn range, but reaches through the long-wave ultraviolet (UV) into visible part of the spectrum. We examined the efficacy of UUB, UVA and visible light in reproducing skin lesions, and found that the UVA was most suitable in provoking the typical skin lesions in our 3 cases with polymorphous light eruption, Plewig and his associates reproduced the clinical lesions with megadoses of UVA,(60J/cm2); in our experiment, 5 to 10 J/cm2 was sufficient. The reason for this discrepancy is not clear but the method of phototest, light source and energy, the different susceptibility in different races and other factors may influence the phototest results.