The deoxyribonucleic acid content was determined in 50 cases of renal cell carcinoma by means of flow cytometric analysis of paraffin-embedded specimens. Of these, 22 cases (44%) were diploid and 28 cases (56% ) were aneuploid. The incidence of aneuploid pattern according to histological grade was 38% in high grade and 75% in low grade with statistical difference. The ploidy status did not correlate with tumor stage, tumor cell type or presence of microvascular invasion. Of 22 cases in which two separate specimens were analyzed from each primary tumor. intratumoral heterogeneity of ploidy status was observed in 9 cases(41%). Of 13 cases in which specimens from both primary tumor and regional metastatic lesions were analyzed, intertumoral heterogeneity was observed in 8 cases(62%). A close correlation between tumor stage and prognosis was observed. The prognostic difference according to histological grade. tumor cell type or presence ol microvascular invasion was statistically unacceptable. The 5-year survival rate according to ploidy status was 77% in diploid tumors and 47% in aneuploid tumors with statistical significance, but no significant difference in overall survival was observed. Among the patients without metastasis of renal cell carcinoma. those with diploid tumors had better prognoses in comparison to those with aneuploid tumors. Conclusively, DNA content in renal cell carcinoma analyzed by FCM had shown the coexistence of intratumoral and intertumoral heterogeneities and is considered to be an important prognostic stratifier in renal cell carcinoma without metastasis.
Aneuploidy ; Carcinoma, Renal Cell* ; Diploidy ; DNA* ; Flow Cytometry ; Humans ; Incidence ; Neoplasm Metastasis ; Ploidies ; Population Characteristics ; Prognosis ; Survival Rate

It has been suggested that the fish oil can reduce atherogenesis in humans and animals, and that peroxidation of lipoproteins may be a major factor causing atherosclerotic lesions. We tested these posibilities in rabbits fed an atherogenic diet by comparing the effect of a eicosapentaenoic acid(EPA: a major component of fish oil)supplement and a butyrated hydroxyanisole(BHA: antioxidant)diet supplement. Tweenty-eight young male New Zealand White rabbits were used in this study. The animals were divided by control, cholesterol fed only, cholesterol + EPA, and cholesterol + BHA groups. The experimental course lasted 12 weeks and animals were sacrificed periodically(2, 5, 8, 12weeks)for quantitative studies of aortic atherosclerosis using light and electron microscopy. Plasma cholesterol levels were determined and lipopreteins were separated periodically. The cholesterol fed only group showed an increased serum cholseterol level and atherosclerotic lesions from 5 weeks of experiments. The EPA supplement resulted in similiar serum cholesterol levels with cholesterol fed only group, but greater lesion than cholesterol fed only group. The BHA supplement resulted in higher serum cholesterol levels except VLDL-cholesterol than EPA supplement group. However, the atherosclerotic lesion was not increased. Our studies support the theory that oxidative modification of lipoproteins is important for the atherogenesis and antioxidant may have a protective effect. However, it failed to show antiatherogenesis effect of fish oil.
Male ; Humans ; Rabbits ; Animals

No abstract available.
Colon* ; Colonic Neoplasms*

PURPOSE: This study was performed to evaluate the contribution of appendiceal computed tomography (CT) in the more accurate diagnosis of acute appendicitis and decrease in the rate of negative appendectomies. METHODS: Between May and August 2005, 146 patients with right lower quadrant (RLQ) abdominal pain and tenderness were diagnosed using appendiceal CT. The appendiceal CT scans were performed with contrast media in the abdominal and pelvic areas. 7 mm slice scans were taken both before and after the contrast media injection, with a time delay. The control group was comprised of 99 patients, who were also checked by abdominal CT or ultrasonography, between December 2004 and April 2005, with the data analyzed retrospectively. RESULTS: In the study group, 85 of the 146 cases were diagnosed with acute appendicitis on appendiceal CT, and had undergone an appendectomy, including 42 men (mean age 39.9 yr) and 43 women (mean age 44.6 yr). The sensitivity and specificity of appendiceal CT in acute appendicitis were 95.3 and 98.4%, respectively. There were 4 (4.7%) negative appendectomy cases; 2 in men and 2 in women. The control group conprised of 47 men and 52 women. There were 13 (13.1%) negative appendectomy cases; 4 in men and 9 in women. CONCLUSION: The routine use of appendiceal CT, in patients with RLQ abdominal pain and tenderness, resulted in a significant decrease in the negative appendectomy rate.
Abdominal Pain ; Appendectomy ; Appendicitis* ; Contrast Media ; Diagnosis ; Female ; Humans ; Male ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed ; Ultrasonography

OBJECTIVE: The rupture of an aneurysm during operation is an event that can be considered grave. The authors present the retrospective analysis of 10 cases of intraoperative rupture in 145 consecutive aneurysm procedure. METHODS: Of 10 cases of intraoperative rupture, two cases were ruptured at predissection period, six cases during dissection and two cases during clip application. RESULTS: The causes of intraoperative aneurysm rupture in our 10 cases were forceful and blunt dissection(4 cases), excessive brain retraction(2 cases), poor exposure of aneurysm neck(1 case), poor clip application(1 case), excessive removal of aneurysmal intracerebral hematoma(1 case), unknown(1 case that was ruptured during anesthesia or craniotomy). Methods of management of nine intraoperative rupture except one of rupture during craniotomy were temporary clipping to the parent artery(3 cases), tentative aneurysm clipping(2 cases), temponade with cottonid and suction(2 cases), and induced hypotension(2 cases). The final outcome of 10 cases of intraoperative aneurysmal rupture was good in 5, fair in 1, poor in 1 and dead in 2 cases. Especially cases that were ruptured during predissection period and case that were managed with induced hypotension were poor result. CONCLUSION: The use of meticulous microsurgical technique with sharp dissection around the aneurysm, a systematic contingency plan for dealing with sudden hemorrhage and the judicious use of temporary clips should serve to minimize the adverse effect of intraoperative rupture on overall management morbidity and mortality.
Anesthesia ; Aneurysm* ; Brain ; Craniotomy ; Hemorrhage ; Humans ; Hypotension ; Mortality ; Parents ; Retrospective Studies ; Rupture*

No abstract available.
Neurilemmoma*

OBJECTIVE: Suprasellar meningioma have in general been difficult lesions to treat because of their vicinity to the optic apparatus and major vessels, and high vascularity. This study was performed to analyze clinical outcome of patients with histopathologically identified suprasellar meningioma. METHOD: Between 1989 and 1998, 37 patients(30 women, 7 men: average 47.5years) with histopathologically identified meningiomas originating from the suprasellar region underwent surgical tumor removal in our institution. The medical records and clinical data of these patients are retrospectively analyzed. RESULT: The tumor size ranged from 2.1cm to 6.5cm(average 5.1cm) in diameter. The tumors have been approached basically through the pterional and bifrontal routes. Skull base technique was also applied in large or complicated cases. Total resection rates and overall outcome including visual function was better in patients with tumor of less then 3cm. A considerable increase of mortality, morbidity and failure of visual improvement were seen in case of the tumors size of 3cm or more. CONCLUSION: Early diagnosis and treatment were important factors in the successful management of these suprasellar meningioma. In large complicated cases encasing major vessels or invading cavernous sinus or anterior skull base, surgeons need to operate with extreme caution and piecemeal removal of the tumor without injuring optic apparatus and major vessels utilizing skull base technique.
Cavernous Sinus ; Early Diagnosis ; Female ; Humans ; Male ; Medical Records ; Meningioma* ; Mortality ; Retrospective Studies ; Skull Base

Anterior basal meningiomas, which belong the olfactory groove and suprasellar meningioma account for 12 to 22% of all intracranial meningioma. Anterior cranial base meningioma are difficult to operate on because of their proximity to the important neurovascular structure. The authors report 25 cases of large meningiomas of the anterior. cranial base operated on during recent 5-year period. The tumor ranged from 3cm to 6.5cm in diameter. Fifteen tumors were located in the suprasellae(included tuberculum sellae, planum sphenoidale, diaphragma sellae,and anterior clinoid process), ten on olfactory groove. The mean age of 19 female and 6 male patient was 55years. The main clinical symptom were visual disturbance, anosmia, headache, and psychotic syndrome. Tumors were approached in 11 cases by pterional, in 9 cases by bifrontal, in 3 cases by transbasal, in 2 case by orbitozygomatic infratemporal and in 1 case by combined approach with tranabasal and orbitozygomatic infratemporal. Total tumor removal was performed in 80% of cases. Postoperative complication include accentuated psychotic syndrome in two cases, worsening of visual function in two, major vessel injury in one, infection in one, CSF rhinorrhea in one, and oculomotor palse in one. Postoperative death was in four(16%). Results at follow up of the 21 survivours were good in 17(68%), fair in 4(16%). Selection criteria for operative approach is discussed with review of pertinent literature.
Female ; Follow-Up Studies ; Headache ; Humans ; Male ; Meningioma* ; Olfaction Disorders ; Patient Selection ; Postoperative Complications ; Skull Base ; Temazepam

Malignant fibrous histiocytoma is a pleomorphic sarcoma in adults, which occurs principally as a mass on an extremity or in the abdominal cavity or retroperitoneum. It typically involved deep fascia or skeletal muscle and only rarely was confined to the subcutis without fascial involvement. Malignant fibrous histiocytomas developed in the intraabdominal organs are very rare and only few cases have been reported until now. Here, we report a case of malignant fibrous histiocytomar developed in the stomach of a 46-year old male who showed clinical and histologic features of malignant fibrous histiocytoma without any identified etiologic factors. The patient was treated successfully with surgery, and has had no recurrence since, during the ensuring one and a half yars.
Abdominal Cavity ; Adult ; Extremities ; Fascia ; Histiocytoma, Malignant Fibrous* ; Humans ; Male ; Middle Aged ; Muscle, Skeletal ; Recurrence ; Sarcoma ; Stomach*

This study was conducted to investigate the mothers' nutritional knowledge on weaning of 101 infants (8 for 4 mo, 44 for 5 mo, 45 for 6 mo, 4 for 7 mo) at a public health center of Incheon. Informations on the mothers' nutritional knowledge were obtained by questionnaires. In this survey 41.6% of infants were breast-feeding, 43.6% of them were bottle-feeding, and 14.9% of them were mixed feeding right after birth. The rate of breast-feeding right after birth was significantly higher in mothers of high school graduate than mothers of college/university graduate (p < 0.05). The infants of mothers graduated high school began to be weaned significantly earlier than the infants of mothers graduated college/university (p < 0.05). 95.1% of infants (n = 101) began to be weaned 4 to 6 months. 83.1% of infants were fed home-made weaning foods. 66.7% of infants were fed rice gruel, 18.5% of them were fruit juice, 6.2% of them were mixed grain, and 4.9% of them were commercially prepared weaning foods as their first supplementary foods. As main supplementary foods, 32.8% of infants were fed vegetable, 30.5% of them were rice gruel, and 27.7% of them were fruit juice. Mothers' nutritional knowledge related to weaning was significantly higher among mothers of college/university graduate than mothers of high school graduate (p < 0.05). 86.1% of mothers disagreed with the questionnaire in which breast-fed infants aged over 4 months needed to be fed iron sufficient food. For the improvement of nutritional status especially iron nutritional status of infants, nutritional education for mothers with weaning aged infants has to be increased and related programs have to be operated effectively.
Edible Grain ; Education ; Fruit ; Humans ; Incheon ; Infant* ; Iron ; Mothers ; Nutritional Status ; Parturition ; Public Health ; Vegetables ; Weaning*