1.Percutaneous alcohol sclerotherapy for symptomatic congenital cysts.
Chong Soo KIM ; Gyung Ho CHUNG ; Sang Young LEE ; Jeung Min LEE ; Myung Hee SON ; Ho Young SONG ; Ki Chul CHOI
Journal of the Korean Radiological Society 1992;28(1):29-35
Twenty patients with symptomatic congenital cysts in the liver, kidney, thyroid, and lower neck underwent, ultrasound guided percutaneous aspiration through a drainage catheter with temporary instillation of 95% ethanol into the cyst. Our procedure was based on the method as described by Bean and Rodan(16) in 1985. Additionaly, two othe steps were odded to prevent the dilutional effect of residual cyst fluid. One was the preliminary washing of the cyst with alcohol. The other was to treat with 30% replacement of alcohol every 10 minutes during the treatment secession. Minot complications of transient temperature elevation and hziness occurred, butj no major complications were encountered. After the alcohol treatment follow up examinations were performed with computed tomography or ultrasonography at 6 weeks. 6 months. 9 months and 15 months. Although there was diminished size, recurrence was noted in 6 of twenty patients(30%) at 6 weeks and one of twenty patients(5%) at 6 months. There was no recurrence at 9 months and 15 months. The results indicated that percutaneous aspiration and alcohol sclerotherapy are safe and effective therapy for symptomatic congenital cysts.
Catheters
;
Cyst Fluid
;
Drainage
;
Ethanol
;
Follow-Up Studies
;
Humans
;
Kidney
;
Liver
;
Methods
;
Neck
;
Recurrence
;
Sclerotherapy*
;
Thyroid Gland
;
Ultrasonography
2.Echocardiographic Indices Associated with Left Ventricular End-Diastolic Pressure.
Young Keun ON ; Myung Koo KIM ; Ho Seuk JEUNG ; Min Su HYUN ; Sung Koo KIM ; Young Joo KWON
Korean Circulation Journal 2002;32(10):872-877
BACKGROUND AND OBJECTIVES: It has been suggested that the indices based on tissue doppler and color M-mode echocardiography reflect the left ventricular end-diastolic pressure. These include the early diastolic transmitral velocity (E) to early myocardial velocity ratio measured by tissue doppler (E') and the E to the wave propagation velocity (Vp) ratio measured from color M-mode images. However, these indices have not been well validated in congestive heart failure patients. SUBJECTS AND METHODS:Thirty one congestive heart failure patients who underwent simultaneous cardiac catheterization and echocardiography, and had normal sinus rhythm were enrolled in this study. The left ventricular end-diastolic pressure obtained from the left heart catheterization was compared with the diastolic indices using pulsed doppler, tissue doppler and color M-mode echocardiography. RESULTS: The left ventricular end-diastolic pressure (LVEDP) ranged from 3.3 to 23 mmHg. Some parameters showed a significant correlation with the LVEDP. The propagation velocity showed a significant correlation with the LVEDP (r=0.382, p=0.034), and the E to propagation velocity ratio (E/Vp) showed a good correlation with the LVEDP(r=0.408, p=0.023). In addition, the E to early diastolic velocity of the mitral annulus (E') ratio had an insignificant correlation with the LVEDP(r=0.322, p=0.078). Among the patients with ischemic congestive heart failure, the E to the propagation velocity ratio (E/Vp) showed a marginal correlation with the LVEDP (r=0.461, p=0.047). CONCLUSION: In patients with congestive heart failure, the Vp and E/Vp showed a good correlation with the LVEDP. In the subgroup of patients with ischemic congestive heart failure, only the E/Vp showed a significant correlation with the LVEDP.
Blood Flow Velocity
;
Cardiac Catheterization
;
Cardiac Catheters
;
Echocardiography*
;
Heart Failure
;
Humans
;
Mitral Valve
;
Ventricular Pressure
3.Agenesis of the right lobe of liver.
Jeung Min LEE ; Chong Soo KIM ; Soo Hyun CHUNG ; Myung Hee SOHN ; Gyung Ho CHUNG ; Young Min HAN ; Ki Chul CHOI ; Baik Hwan CHO
Journal of the Korean Radiological Society 1993;29(4):805-808
Agenesis of the right lobe of the liver is a rare anomaly which may be associated with stone diseases, portal hypertension, and other congenital anomalies. The radiological differential diagnosis includes lobar atrophy due to cirrhosis or hilar cholangiocarcinoma. We present a case of agenesis of the right lobe of the liver with characteristic clinical and radiological findings.
Atrophy
;
Diagnosis, Differential
;
Fibrosis
;
Hypertension, Portal
;
Klatskin Tumor
;
Liver*
4.Agenesis of the right lobe of liver.
Jeung Min LEE ; Chong Soo KIM ; Soo Hyun CHUNG ; Myung Hee SOHN ; Gyung Ho CHUNG ; Young Min HAN ; Ki Chul CHOI ; Baik Hwan CHO
Journal of the Korean Radiological Society 1993;29(4):805-808
Agenesis of the right lobe of the liver is a rare anomaly which may be associated with stone diseases, portal hypertension, and other congenital anomalies. The radiological differential diagnosis includes lobar atrophy due to cirrhosis or hilar cholangiocarcinoma. We present a case of agenesis of the right lobe of the liver with characteristic clinical and radiological findings.
Atrophy
;
Diagnosis, Differential
;
Fibrosis
;
Hypertension, Portal
;
Klatskin Tumor
;
Liver*
5.Quality Characteristics of Care Food (Jelly) Prepared with Wild Carrot (Daucus carota L.) Juice.
Hee Sun KANG ; Min Ju KIM ; Jeong Ok RHO ; Hyong Il CHOI ; Myung Ryun HAN ; Jeung Ho MYUNG ; Ae Jung KIM
Journal of the Korean Dietetic Association 2017;23(4):337-349
This study evaluated the quality characteristics of jelly prepared with different levels (0%, 5%, 10%, 15%, 20%, and 25%) of wild carrot (WC, Daucus carota L.) juice as a care food for the elderly. The lightness, redness, yellowness, and delta (Δ) values of the jelly (Control, WCJ5, WCJ10, WCJ15, WCJ20, and WCJ25) decreased with increasing amounts of wild carrot juice added. The mechanical properties, such as hardness, springiness, chewiness, and gumminess, of the jelly were decreased with increasing amounts of wild carrot juice added. The total polyphenol and total flavonoid contents of the jelly increased with increasing amounts of wild carrot juice added. The DPPH radical scavenging activity (IC50) also increased with increasing amounts of wild carrot juice added. The α-glucosidase inhibitory effects of wild carrot (WC) and WCJ25 were 71% and 54.4%, respectively, compared to the positive control (acarbose). The lipase inhibitory effects of WC and WCJ25 were 44.2% and 14.4%, respectively, compared to the positive control group (orlistat). On the other hand, the sensory evaluation score was the best at WCJ20, which contained 20% wild carrot juice. In conclusion, WCJ20 or WCJ25 is expected to be a care food for the elderly with respect to texture as well as the antioxidant and enzymatic activity (α-glucosidase inhibitory and lipase inhibitory activities).
Aged
;
Daucus carota*
;
Hand
;
Hardness
;
Humans
;
Lipase
6.Role of Glycogen Synthase Kinase-3 in Motor Neuronal Cell Death Mechanism of in Vitro Familial ALS Model (G94A, A4V mutant motoneuron).
Seong Ho KOH ; Juhan KIM ; Myung Ho KIM ; Hyun Jeung YU ; Manho KIM ; Hun Jung KIM ; Kwang Woo LEE ; Seung H KIM
Journal of the Korean Neurological Association 2005;23(2):249-256
BACKGROUND: G93A or A4V mutations in the human Cu/Zn- superoxide dismutase gene (hSOD1) cause familial amyotrophic lateral sclerosis (fALS). However, it has not yet clearly understood how these bring about fALS. We investigated the effects of the G93A or A4V mutations in hSOD1 on the phosphatydilinositol-3-kinase (PI3K)/Akt and glycogen synthase kinase-3 (GSK-3) pathway, and effects of GSK-3 inhibitor on the G93A- or A4V-mutant cells. METHODS: To evaluate those effects, VSC4.1 motoneuron cells were transfected with G93A- or A4V-mutant types of hSOD1 (G93A and A4V cells, respectively) with/without GSK-3 inhibitor were compared with them transfected with wild type (wild cells) in cell viability and intracellular signals, including PI3K/Akt, GSK-3, and caspase-3, 24 hours after neuronal differentiation. RESULTS: Compared with wild cells, MTT assay revealed a greatly reduced viability in G93A and A4V cells without GSK-3 inhibitor. However, treatment with GSK-3 inhibitor increased the viability of G93A and A4V cells. Western blotting showed that PI3K and pAkt were decreased, and GSK-3 and caspase-3 were increased in G93A and A4V cells, and that GSK-3 inhibitor treatment reduced caspase-3 but did not affected PI3K, Akt and GSK-3. CONCLUSIONS: These results suggest that the G93A or A4V mutations induce inhibition of PI3K/Akt and activation of GSK-3 and caspase-3 resulting the vulnerability to oxidative stress, and that GSK-3 mediated cell death mechanism is important in G93A and A4V cell death.
Amyotrophic Lateral Sclerosis
;
Blotting, Western
;
Caspase 3
;
Cell Death*
;
Cell Survival
;
Glycogen Synthase Kinase 3
;
Glycogen Synthase*
;
Glycogen*
;
Humans
;
Motor Neurons*
;
Neurons
;
Oxidative Stress
;
Superoxide Dismutase
7.Effect of Poly (ADP-ribose) Polymerase Inhibitor Against the Ischemia/Reperfusion Injury in Ischemic Stroke Model.
Seong Ho KOH ; Seung Hyun KIM ; Chi Won SONG ; Hyugsung KWON ; Yong Soon KIM ; Sunjung KIM ; Younjoo PARK ; Ki Sok KIM ; Hyun Jeung YU ; Juhan KIM ; Myung Ho KIM ; Hai Kwan JUNG
Journal of the Korean Neurological Association 2003;21(6):634-641
BACKGROUND: Nuclear enzyme poly (ADP-ribose) polymerase (PARP) activated by DNA damage participates in DNA repair. However, overactivation of PARP could be an important pathogenic mechanism of ischemic cell death. We investigated the protective effect of an inhibitor of PARP, 3-aminobenzamide (3-AB), against ischemia/reperfusion injury in ischemic stroke model. METHODS: Occlusion of left middle cerebral artery (MCA) was done by intraluminal filament technique in 24 rats weighing from 315 g to 358 g, and reperfusion was done at 2 hours after occlusion. To evaluate the effect of PARP inhibitor in ischemic stroke, 3-AB was administered to 12 rats (3-AB group) 10 minutes before artificial occlusion of left MCA. Infarct area was confirmed by using 2, 3, 5-triphenyltetrazolium chloride stain. The immunoreactivities of poly (ADP-ribose) reflecting activity of enzyme PARP and activated caspase-3 were compared in infarct, peri-infarct and normal zones in 3-AB group and 12 controls. RESULTS: The volume of infarction was decreased about 34% in 3-AB group compared with controls. In 3-AB group, immunoreactivities of PAR were significantly reduced in ischemic regions, especially peri-infarct zone, but those of activated caspase-3 were significantly increased in same region. CONCLUSIONS: These results suggest that treatment of PARP inhibitor can reduce the infarct volume by converting necrotic cell death into apoptosis. PARP inhibition can be another potential neuroprotective strategy in ischemic stroke.
Animals
;
Apoptosis
;
Caspase 3
;
Cell Death
;
DNA Damage
;
DNA Repair
;
Infarction
;
Middle Cerebral Artery
;
Rats
;
Reperfusion
;
Stroke*
8.Incidence of coronary anomaly in coronary angiography.
Ju Sung KIM ; Myung Su KIM ; Ho Seuk JEUNG ; Eun Sang RYOO ; Min Su HYUN ; Sung Gu KIM ; Young Joo KWON
Korean Journal of Medicine 2001;60(5):448-455
BACKGROUND: Coronary anomalies are found incidentally, in which anatomy is altered but physiology is normal; that is, coronary blood flow is normal. However, certain anomalies are associated with myocardial ischemia or infarction, heart failure, and sudden death. METHODS: From February 1988 to February 2000, 3534 cases have been catheterized, among them we experienced 28 cases of coronary anomalies. The incidence of coronary anonalies and clinical characteristic were evaluated. RESULTS: The incidence of coronary anomalies was 0.79% and in 28 cases of coronary anomalies, 5 cases of anomalous origin from the aorta (0.14%), 2 cases of coronary artery aneurysm (0.16%) and 21 cases of coronary arteriovenous fistula (CAVF,0.59%) were found. In 5 cases of anomalous origin from the aorta, 4 cases showed that right coronary artery originated from left coronary sinus of Valsalva, 1 case showed that left circumflex coronary artery originated from right coronary sinus of Valsalva. All of coronary artery aneurysm were found in right coronary artery. In 21 cases of CAVF, 28 sites of fistula were found and 14 sites originated from right coronary artery (50%), 6 sites from left circumflex coronary altery (21.5%), 6 sites from left anterior-descending coronary artery, 2 sites from left main coronary artery (7%). 13 sites of CAVF drained into pulmonary artery (46%), 10 sites into right atrium (36%), 5 sites into right ventricle (18%). In 7 cases which had double CAVF, 4 cases were originated from bilateral coronary artery, 3 cases were originated from single coronary artery. In 10 cases CAVF without other cardiac lesion, 4 cases confirmed ischemic heart disease. CONCLUSION: In our study, CAVF is most common coronary anomaly and without other cardiac disease CAVF may develope ischemic cardiac disease.
Aneurysm
;
Aorta
;
Arteriovenous Fistula
;
Catheters
;
Coronary Aneurysm
;
Coronary Angiography*
;
Coronary Sinus
;
Coronary Vessel Anomalies
;
Coronary Vessels
;
Death, Sudden
;
Fistula
;
Heart Atria
;
Heart Diseases
;
Heart Failure
;
Heart Ventricles
;
Incidence*
;
Infarction
;
Myocardial Ischemia
;
Physiology
;
Pulmonary Artery
9.Incidence of coronary anomaly in coronary angiography.
Ju Sung KIM ; Myung Su KIM ; Ho Seuk JEUNG ; Eun Sang RYOO ; Min Su HYUN ; Sung Gu KIM ; Young Joo KWON
Korean Journal of Medicine 2001;60(5):448-455
BACKGROUND: Coronary anomalies are found incidentally, in which anatomy is altered but physiology is normal; that is, coronary blood flow is normal. However, certain anomalies are associated with myocardial ischemia or infarction, heart failure, and sudden death. METHODS: From February 1988 to February 2000, 3534 cases have been catheterized, among them we experienced 28 cases of coronary anomalies. The incidence of coronary anonalies and clinical characteristic were evaluated. RESULTS: The incidence of coronary anomalies was 0.79% and in 28 cases of coronary anomalies, 5 cases of anomalous origin from the aorta (0.14%), 2 cases of coronary artery aneurysm (0.16%) and 21 cases of coronary arteriovenous fistula (CAVF,0.59%) were found. In 5 cases of anomalous origin from the aorta, 4 cases showed that right coronary artery originated from left coronary sinus of Valsalva, 1 case showed that left circumflex coronary artery originated from right coronary sinus of Valsalva. All of coronary artery aneurysm were found in right coronary artery. In 21 cases of CAVF, 28 sites of fistula were found and 14 sites originated from right coronary artery (50%), 6 sites from left circumflex coronary altery (21.5%), 6 sites from left anterior-descending coronary artery, 2 sites from left main coronary artery (7%). 13 sites of CAVF drained into pulmonary artery (46%), 10 sites into right atrium (36%), 5 sites into right ventricle (18%). In 7 cases which had double CAVF, 4 cases were originated from bilateral coronary artery, 3 cases were originated from single coronary artery. In 10 cases CAVF without other cardiac lesion, 4 cases confirmed ischemic heart disease. CONCLUSION: In our study, CAVF is most common coronary anomaly and without other cardiac disease CAVF may develope ischemic cardiac disease.
Aneurysm
;
Aorta
;
Arteriovenous Fistula
;
Catheters
;
Coronary Aneurysm
;
Coronary Angiography*
;
Coronary Sinus
;
Coronary Vessel Anomalies
;
Coronary Vessels
;
Death, Sudden
;
Fistula
;
Heart Atria
;
Heart Diseases
;
Heart Failure
;
Heart Ventricles
;
Incidence*
;
Infarction
;
Myocardial Ischemia
;
Physiology
;
Pulmonary Artery
10.Activation of NLRP3 Inflammasome by Palmitic Acid in Human Sebocytes
Yu-Ra JUNG ; Jung-Min SHIN ; Chang-Hyeon KIM ; Sooil KIM ; Chang-Deok KIM ; Young-Joon SEO ; Jeung-Hoon LEE ; Myung IM ; Young LEE ; Young Ho LEE
Annals of Dermatology 2021;33(6):541-548
Background:
Sebocytes are the main cells involved in the pathogenesis of acne by producing lipids and inflammatory cytokines. Although palmitic acid (PA) has been suggested to induce an inflammatory reaction, its effect on sebocytes remains to be elucidated.
Objective:
In the present study, we investigated whether PA promotes inflammasome-mediated inflammation of sebocytes both in vivo and in vitro.
Methods:
We intradermally injected PA into the mice ears. And, we treated cultured human sebocytes with PA. Inflammasome-mediated inflammation was verified by immunohistochemistry, Western blot and ELISA.
Results:
PA-treated mice developed an inflammatory response associated with increased interleukin (IL)-1β expression in the sebaceous glands. When PA was added to cultured human sebocytes, caspase-1 activation and IL-1β secretion were significantly enhanced. In addition, NLRP3 knockdown attenuated IL-1β production by sebocytes stimulated with PA. PA-mediated inflammasome activation required reactive oxygen species.
Conclusion
These findings indicate that PA activates the NLRP3 inflammasome before induction of an inflammatory response in sebocytes. Thus, PA may play a role in the inflammation of acne