1.Echinococcus granulosus Protoscolex DM9 Protein Shows High Potential for Serodiagnosis of Alveolar Echinococcosis
Jeong-Geun KIM ; Xiumin HAN ; Yoon KONG
The Korean Journal of Parasitology 2022;60(1):25-34
Alveolar echinococcosis (AE) caused by infection with E. multilocularis metacestode, represents one of the most fatal helminthic diseases. AE is principally manifested with infiltrative, proliferating hepatic mass, resembling primary hepatocellular carcinoma. Sometimes metastatic lesions are found in nearby or remote tissue. AE diagnosis largely depends on imaging studies, but atypical findings of imaging features frequently require differential diagnosis from other hepatic lesions. Serological tests may provide further evidence, while obtaining reliable AE materials is not easy. In this study, alternative antigens, specific to AE were identified by analyzing E. granulosus protoscolex proteins. An immunoblot analysis of E. granulosus protoscolex showed that a group of low-molecular-weight proteins in the range from 14 kDa to 16 kDa exhibited a sensitive and specific immune response to AE patient sera. Partial purification and proteomic analysis indicated that this protein group contained myosin, tubulin polymerization promoting protein, fatty-acid binding protein, uncharacterized DM9, heat shock protein 90 cochaperone tebp P-23, and antigen S. When the serological applicability of recombinant forms of these proteins was assessed using enzyme-linked immunosorbent assay, DM9 protein (rEgDM9) showed 90.1% sensitivity (73/81 sera tested) and 94.5% specificity (172/181 sera tested), respectively. rEgDM9 showed weak cross-reactions with patient sera from the transitional and chronic stages of cystic echinococcosis (3 to 5 stages). rEgDM9 would serve as a useful alternative antigen for serodiagnosis of both early- and advanced-stage AE cases.
2.Gastrofiberscopic findings and helicobacter pylori gastritis in children with recurrent abdominal pain.
Jeong Kee SEO ; Je Geun CHI ; Eui Chong KIM
Journal of the Korean Pediatric Society 1992;35(12):1646-1656
No abstract available.
Abdominal Pain*
;
Child*
;
Gastritis*
;
Helicobacter pylori*
;
Helicobacter*
;
Humans
3.Placental Site Trophoblastic Tumor(PSTT) with Vaginal Metastasis: A case report.
Yee Jeong KIM ; Kyu Rae KIM ; Soon Hee JEONG ; Ho Geun KIM ; Jang Yeon KWON
Korean Journal of Pathology 1991;25(6):570-575
PSTT has been established as a separate entity distinct from choriocarcinoma since 1983, because of its different morphological features, biologic behavior and response to chemotherapy. Most cases of PSTT have indolent clinical courses, but there have been several reports showing malignant behavior resulted in death of the patient. We report a case of PSTT showing vaginal metastatis. In biopsy specimen, it was difficult to make differential diagnosis from squamous cell carcinoma of uterine cervix due to uniform and mononuclear cytologic characteristics. Immunohistochemical stains for hPL and hCG were not typical for either PSTT or choriocarcinoma. We suggest that poorly differentiated PSTT may synthesize the lesser amount of hPL than typical PSTT and it may behave more aggressively.
Diagnosis, Differential
;
Biopsy
4.Associations between Self-Efficacy, Social Capital and Self-Rated Health Status in Healthy Individuals.
Bo Kyoung KIM ; Jin Hyang LEE ; Jang Rak KIM ; Baek Geun JEONG ; Ki Soo PARK
Korean Journal of Health Promotion 2011;11(3):144-153
BACKGROUND: Discrepancies exist in the existing researches regarding the association between social capital and self-efficacy, and most of these researches have been done in developed countries. The aims of this study were to assess the independent association between individual social capital and self-efficacy and to assess the associations between individual social capital, self-efficacy and self-rated health. METHODS: Data were obtained from the Gyeongnam health survey (6,500 persons) conducted in 2008. A self-administered questionnaire was additionally administered to gather information on demographic variables, health behaviors, chronic diseases, self-efficacy, social capital, and self-rated health status. Total study population was 3,843 as those with chronic diseases were excluded. RESULTS: In males, trust was positively associated with confidence and preference to task difficulty, and participation was negatively associated with confidence and positively associated with regulation and preference to task difficulty. In females, trust was positively associated with confidence and preference to task difficulty and negatively associated with regulation. Participation was positively associated with preference to task difficulty. In males, the odds for self-rated health status was better for persons with confidence (95% confidence interval, CI 1.088-1.705), trust (95% CI 1.172-1.821) and participation (95% CI 1.268-2.117). In females, the odds for self-rated health status was better for those with confidence (95% CI 1.250-1.803), preference of task difficulty (95% CI 1.019-1.683) and participation (95% CI 1.024-1.555). CONCLUSIONS: High social capital measured at an individual level may promote self-efficacy and health status.
Chronic Disease
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Developed Countries
;
Female
;
Health Behavior
;
Health Surveys
;
Humans
;
Male
;
Self Efficacy
;
Surveys and Questionnaires
5.Types of perception toward non-face-to-face clinical practice among nursing students
Geun Myun KIM ; Soo Jung CHANG ; Jeong Ah KIM
Journal of Korean Academic Society of Nursing Education 2023;29(3):247-262
Purpose:
This study aimed to identify the types of perception toward non-face-to-face clinical practice and to characterize the types of students who experienced online clinical practice during the coronavirus disease 2019 (COVID-19) pandemic.
Methods:
Q-methodology was used in this study, and 270 Q populations were formed based on in-depth interviews with 10 nursing students who had experienced non-face-to-face clinical practice, as well as related literature. Interviews were performed from August 1 to 31, 2022. A total of 42 Q samples were extracted, and Q sorting was performed on 33 nursing students who had experienced non-face-to-face clinical practice. A Q factor analysis was performed using the PC-QUANL program.
Results:
The nursing students’ perceptions of non-face-to-face clinical practice were classified into the following five types: “future professional competency-focused type,” “realistic convenience priority type,” “task burden awareness type,” “negative critic type,” and “limited experience dissatisfaction type.”
Conclusion
This study revealed non-face-to-face clinical practice’s positive and negative aspects in nursing education. Moreover, it identified the aspects of clinical practice that cannot be replaced by non-face-to-face clinical practice and the elements of non-face-to-face practice that can complement clinical practice. These findings can be used as fundamental data to establish a stable and efficient system for improving the quality of clinical practice in the post-COVID-19 era and to implement effective non-face-to-face clinical practice according to student types.
6.Mitral Atresia Associated with Corrected Transposition of Great Arteries.
Dong Heon YOON ; Jeong Wook SEO ; Je Geun CHI ; Yong Soo YOON ; Jeong Yeon CHOI ; Yong Jin KIM ; In Won KIM
Korean Journal of Pathology 1988;22(3):295-300
A case of congenital absence of right atriovntricular (A-V) connection of heart is reported. Patient was 81 day old male infant with chief complaints of dyspnea and irritability. Clinical evaluation revealed increased pulmonary vascularity on chest x-ray, absence of right A-V connection, regurgitation of left A-V valve, right-sided ventricular hypoplasia and L-TGA. Clinical assessment of the case was tricupsid atresia with LTGA and mitral regurgitation. Pulmonary artery banlding and artial septectomy was performed. Parenteral alimentation through the femoral veins resulted in obstruction of IVC and subsequent multiorgan failure. The autopsy findings of the heart were corrected transposition of great arteries with associated anomallies of right-sided mitral atresia, Ebstein's malformation of left-sided tricuspid valve, ventricular septal defect, muscular hypertrophy of right-sided left ventricle with luminal obliteration. Long segment of IVC was completely occluded due to occlusive thrombi with fungal infection. Bilateral kidneys were infarcted and azygos vein was markedly engorged. Microscopic examination revealed candidal colonization in the inferior vena cava and septic embolzation in brain.
Infant
;
Male
;
Female
;
Humans
7.Mitral Atresia Associated with Corrected Transposition of Great Arteries.
Dong Heon YOON ; Jeong Wook SEO ; Je Geun CHI ; Yong Soo YOON ; Jeong Yeon CHOI ; Yong Jin KIM ; In Won KIM
Korean Journal of Pathology 1988;22(3):295-300
A case of congenital absence of right atriovntricular (A-V) connection of heart is reported. Patient was 81 day old male infant with chief complaints of dyspnea and irritability. Clinical evaluation revealed increased pulmonary vascularity on chest x-ray, absence of right A-V connection, regurgitation of left A-V valve, right-sided ventricular hypoplasia and L-TGA. Clinical assessment of the case was tricupsid atresia with LTGA and mitral regurgitation. Pulmonary artery banlding and artial septectomy was performed. Parenteral alimentation through the femoral veins resulted in obstruction of IVC and subsequent multiorgan failure. The autopsy findings of the heart were corrected transposition of great arteries with associated anomallies of right-sided mitral atresia, Ebstein's malformation of left-sided tricuspid valve, ventricular septal defect, muscular hypertrophy of right-sided left ventricle with luminal obliteration. Long segment of IVC was completely occluded due to occlusive thrombi with fungal infection. Bilateral kidneys were infarcted and azygos vein was markedly engorged. Microscopic examination revealed candidal colonization in the inferior vena cava and septic embolzation in brain.
Infant
;
Male
;
Female
;
Humans
8.Serum Interleukin-2, Soluble Interleukin-2 Receptors and Neopterin Concentrations in Guillain-Barre Syndrome.
Jeong Geun LIM ; Young Choon PARK ; Jung Chul KIM
Journal of the Korean Neurological Association 1994;12(2):279-288
Guillain-Barre syndrome (GBS) is an autoimmune disease with an acute evolution of inflammatory demyelinating polyradiculoneuropathy. Although the precise immune mechanisms and involved antigens are uncertain, both humoral and cellular immune mechanisms are thought to be involved. Interactions between the various compartments of the immune system are governed by cytokines. Laboratory investigations have shown that immune activation can be quantified by measurement of cytokines and soluble immune activation products in serum. Interleukin-2(IL-2) is probably the best characterized among the many cytokines and soluble interleukin-2 receptor (sIL-2R) and neopterin are major immune activation products. In order to observe activities of cellular immunity of GBS, we measured serum concentrations of IL-2, sIL-2R and neopterin in 28 patients with GBS and in 22 healthy controls. Serial serum samples were drawn 2 to 25 days after motor onset of the disease, 2 to 3 days after treatment with plasmapheresis and 43-300days of follow-up. The occurences of IL-2 positive serum samples were 41.7%, 23.8% and 18.2% in each time in GBS but none in healthy controls. Initial serum sIL-2R and neopterin level were elevated in 21% and 17% of patients with GBS compared with healthy controls. After plasmapheresis, both serum sIL-2R and neopterin level were significantly elevated in GBS compared with initial serum samples and healthy controls. Thus, T-cell and macrophage activation may play a role in the pathogenesis of GBS. However, further study is needed to evaluate the effect of plasmapheresis and clinical severity on the serum concentration of IL-2, sIL-2R and neopterin in GBS.
Autoimmune Diseases
;
Cytokines
;
Follow-Up Studies
;
Guillain-Barre Syndrome*
;
Humans
;
Immune System
;
Immunity, Cellular
;
Interleukin-2*
;
Macrophage Activation
;
Neopterin*
;
Plasmapheresis
;
Polyradiculoneuropathy
;
Receptors, Interleukin-2*
;
T-Lymphocytes
9.Prenatal imaging of thanatophoric dysplasia: a case report.
Jeong Geun YI ; Mie Young KIM ; Kyung Joo PARK ; Chun Hwan HAN ; Joo Hyuk LEE
Journal of the Korean Radiological Society 1993;29(6):1337-1340
Thanatophoric dysplasia is the most common lethal congenital chondrodysplasia with characteristic features of narrow thorax, short rib, severe platyspondyly, short bowed limbs and skull deformity, etc. It is not a hereditary disorder and there is usually no family history of dysplasia. We experienced a case of thanatophoric dysplasia at 38 weeks of gestation with antenatal sonographic and abdominal radiographic findings of small thorax, short bowed extremities with surrounding thickened soft tissues and marked platyspondyly. Soon atter delivery, the baby died and post-mortem radiographs showed the characteristic findings of thanatophoric dysplasia.
Congenital Abnormalities
;
Extremities
;
Humans
;
Pregnancy
;
Ribs
;
Skull
;
Thanatophoric Dysplasia*
;
Thorax
;
Ultrasonography
10.An Assessment of Functional Status of the Elderly in an Institution.
Jong Han PARK ; Jeong Geun LIM ; Dong Won KIM
Journal of the Korean Neurological Association 1994;12(4):647-651
It is supposed in Korea that institutional care for the elderly would increase while their home care would decrease. Assessment of the functional status is of much importance for effective caregiving for the institutionalized people. The functional status was evaluated in 89 elderly residents of an institution in Taegu, using the Korean version of the mini-mental state examination, the Blessed Dementia Rating Scale, the Barthel Activities of Daily Living, and the Motoricity Index. Vision and hearing were also examined. Based on scores of the Korean version of mini-mental state examination, 45% were found to have definite cognitive impairment and further 25% to have questionable cognitive impairment. About 35% of the subjects possibly had mild or more severe dementia on the Blessed Dementia Rating Scale. Fifty-seven percent had impairment in activities of daily living, and 66% had impairment in motor power. Sixteen percent and 20% had poor vision and hearing difficulty, respectively, to the degree of impairment in daily activities. These findings indicate that more than half of elderly people in institutional care may need either partial or total help from others.
Activities of Daily Living
;
Aged*
;
Daegu
;
Dementia
;
Hearing
;
Home Care Services
;
Humans
;
Korea