1.Evaluation of Severity of Childhood Pancreatitis with Multiple Factor Scoring Systems.
Journal of the Korean Pediatric Society 1995;38(12):1653-1663
No abstract available.
Pancreatitis*
2.Esophageal varix in children: endoscopic evaluation and clinical characteristics.
Soon Young KIM ; Jeong Kee SEO
Journal of the Korean Pediatric Society 1993;36(12):1691-1700
Fifty five children with endoscopically proven esophageal varices from Jul. 1987 to Dec. 1992 were analyzed for endoscopic and clinical characteristics. The results were as follows: 1) According to etiological classification of portal hypertension in 55 cases, 35 cases showed intrahepatic causes 964%) and 20 cases had extrahepatic causes (36%). The most common clinical manifestation on admission was hematemesis (42%) and abdominal mass (36%). 2) Portal vein thrombosis was the most common cause of portal hypertension. Patients with portal vein thrombosis showed more frequent bleeding than with intrahepatic portal hypertension. Most of them had the first bleeding episode before 7 years old of age. Progression of portal hypertension in portal vein thrombosis was more rapid and bleeding episode was earlier than that in most of intrahepatic causes of the portal hypertension. 3) Twenty patients showed gastritis (10 cases), duodenitis (4 cases), gastric ulcer (4 cases) and esophagitis (2 cases) besides varix on the endoscopic examination. In 4 cases, the cause of upper GI bleeding was found as duodenal ulcer (3 cases) or hemorrhagic errosive gastritis (1 case) with no variceal bleeding. 4) Among 36 cases with variceal bleeding, 20 cases had predisposing factors for bleeding such as medication for URI including Aspirin. 5) More than one episode of bleeding were noted in 36 cases (65%) of the patients with varix. Thirty-one cases were treated conservatively with success. The remaining 5 cases with severe bleeding were managed with IV pitressin, SB-tube insertion and emergency shunt operation. High mortality rate (40%) was found in these patients group. In conclusion, in patients with clinically suspected portal hypertension, regular endoscopic examination might be recommended for the earlier recognition and effective prevention of variceal bleeding. for bleeding varices, in addition to conservative management, active treatment such as pitressin, SB-tube, sclerotherapy, endoscopic variceal ligation and emergency shunt operation should be considered with the emergency endoscopy which can identify bleeding focus and predict the chance of rebleeding.
Aspirin
;
Causality
;
Child*
;
Classification
;
Duodenal Ulcer
;
Duodenitis
;
Emergencies
;
Endoscopy
;
Esophageal and Gastric Varices*
;
Esophagitis
;
Gastritis
;
Hematemesis
;
Hemorrhage
;
Humans
;
Hypertension, Portal
;
Ligation
;
Mortality
;
Sclerotherapy
;
Stomach Ulcer
;
Varicose Veins
;
Vasopressins
;
Venous Thrombosis
3.Cholelithiasis in Childhood.
Soon Young KIM ; Jeong Kee SEO
Journal of the Korean Pediatric Society 1994;37(1):70-77
Nineteen children found to have gallstones at Seoul National University of Children's Hospital from Jun. 1982 to Jun. 1992 were reviewed. The results were as follows: 1) The mean age was 10 years, with 9 boys and 10girls. Most of the cases(63%) were over 10 years of age. 2) Clinical manifestations were abdominal pain(14 cases), nausea and/or vomiting (5 cases), fever (2 cases), jaundice (2 cases) and fatty food intolerance (1 case). Five cases were asymptomatic. Of 14 cases with abdominal pain, only 5 cases showed typical biliary colic which suggests cholelithiasis. 3) Associated conditions in cholelithiasis were Wilson disease (5 cases), congenital hereditary spherocytosis (2 cases), choledochal cyst (2 cases), total parenteral nutrition following ileal resection (1 case). And the other conditions which had association with cholelithiasis are not certain, and they were nephrotic syndrome, histiocytic cytophathic panniculitis, meningococcal meningitis, portal vein thrombosis and cardiac cirrhosis. The remaining 4 cases showed no associated conditions or diseases. 4) Eleven of 19 patients with cholelithiasis (58%) showed cholecystitis. 5) Cholecystectomy was performed in 4 cases with frequently recurred abdominal pain or associated diseases which needed operative correction. Symptoms completely subsided after operation. In conclusion, cholelithiasis in children has a variety of associated conditions and nonspecific abdominal symptoms were nore common than classic biliary colic. Although cholelithiasis in pediatric population are uncommon problems, the possibility of gallstones should be considered in the evaluation of abdominal pain in children with associated conditions.
Abdominal Pain
;
Child
;
Cholecystectomy
;
Cholecystitis
;
Choledochal Cyst
;
Cholelithiasis*
;
Colic
;
Fever
;
Fibrosis
;
Gallstones
;
Hepatolenticular Degeneration
;
Humans
;
Jaundice
;
Meningitis, Meningococcal
;
Nausea
;
Nephrotic Syndrome
;
Panniculitis
;
Parenteral Nutrition, Total
;
Seoul
;
Venous Thrombosis
;
Vomiting
4.The Abeominal Tuberculosis in Children.
Young Sik KIM ; Jeong Hun HA ; Jeong Kee SEO
Journal of the Korean Pediatric Society 1988;31(12):1594-1602
No abstract available.
Child*
;
Humans
;
Tuberculosis*
5.A Clinical Study of Reye`s Syndrome.
Young Seo PARK ; Hwan Jong LEE ; Sang Pok SUK ; Jeong Kee SEO ; Kwang Wook KO
Journal of the Korean Pediatric Society 1984;27(11):1088-1096
No abstract available.
6.Balloon Cell Malignant Melanoma: A case report.
Ji Young SEO ; Soon Young KIM ; Jeong Hee KANG ; Young Ok KIM ; Bang HUR
Korean Journal of Pathology 1999;33(7):537-539
Balloon cell malignant melanoma (BCMM) is a rare histologic variant of malignant melanoma, which is composed either predominantly or entirely of large clear or foamy cells. The incidence of balloon cell malignant melanoma is about 0.15% of all cutaneous malignant melanomas. Recently, we experienced a case of cutaneous balloon cell malignant melanoma in the right lower abdomen with right inguinal and both axillary lymph node metastasis in a 56-year-old man. The cutaneous lesion was 4.5 3.5 cm in size, a well-demarcated black nodular mass, involving abdominal skin and subcutaneous tissue. The tumor was histologically composed of two types of tumor cells: predominant clear cell and focal, pigmented spindle cell. The nodal lesion was composed entirely of clear cells. Both clear and spindle cells showed positive reaction for S-100 protein and HMB-45 on immunohistochemistry.
Abdomen
;
Humans
;
Immunohistochemistry
;
Incidence
;
Lymph Nodes
;
Melanoma*
;
Middle Aged
;
Neoplasm Metastasis
;
S100 Proteins
;
Skin
;
Subcutaneous Tissue
7.Two Cases of Thin Basement Membrane Nephropathy presented with Minimal Change Nephrotic Syndrome.
Young Mee SEO ; Jae Gul CHUNG ; En Sil YU ; Jin Yeong JEONG ; Young Seo PARK
Journal of the Korean Pediatric Society 2000;43(7):978-982
Thin basement membrane nephropathy(TBMN) is defined histologically as follows: 1) By light rnicroscopy only minor abnormalities are detected in the glomeruli at most minor mesangial widening. 2) By electron microscopy, diffuse thinning of glomerular basement rnembrane is demonstrated. 3) By immunofluorescence, absence of immunoglobulins and complement components is demonstrated. 4) Alport's syndrome and systemic diseases that may affect the glomerular structure have been excluded. TBMN presented frequently with recurrent or persistent microscopic hematuria. Massive proteinuria such as in nephrotic syndrome rarely occurs in TBMN. We reported two cases of TBMN presented with typical minimal change nephrotic syndrome.
Basement Membrane*
;
Complement System Proteins
;
Fluorescent Antibody Technique
;
Hematuria
;
Immunoglobulins
;
Microscopy, Electron
;
Nephritis, Hereditary
;
Nephrosis, Lipoid*
;
Nephrotic Syndrome
;
Proteinuria
8.Image Standardization and Determination of Gray Level Threshold in the Assessment of the Myocardial Fibrosis by the Computerized Image Analysis.
Nam Young LEE ; Young Sik PARK ; Jin Haeng CHUNG ; Jeong Wook SEO
Korean Journal of Pathology 1998;32(7):494-503
The computerized image analysis is a useful tool for the quantitative assessment of histopathologic findings. In contrast to the usual microscopic examination by pathologists, the computerization should be accompanied with the standardization process of the image. We developed an algorithm to standardize images and to determine the optimal gray level threshold, using a myocardial fibrosis model. Sirius red staining was more convenient for the image analysis than Masson's trichrome staining because of a better contrast with the surrounding structures. To get an optimal measurement, light intensity was standardized at each of the fibrosis, myocardium and background. In this study, the most promising method to determine the degree of fibrosis was that of revising the background without tissue to a gray level of 200, obtaining a green component of the color image, revising the myocardial fiber to 163, and defining a partial ratio as fibrosis index when the gray level threshold was 120. These threshold levels and parameters were determined after drawing the binarization index curves according to the change of the gray level threshold and by the morphological examination of the actual binarization figures overlaid to the original color image. Through these processes we could get a consistent result on the myocardial fibrosis and we expect a similar principle applies when we analyze color images in the histopathologic quantitation by computerized image analysis.
Fibrosis*
;
Myocardium
9.Expression of Involucrin and Filaggrin in Various Skin Disorders: Immunohistochemical Study.
Seung Chul LEE ; Jee Bum LEE ; Jae Jeong SEO ; Jin Young PARK ; Young Ho WON
Korean Journal of Dermatology 1999;37(6):708-714
BACKGROUND: The cornified cell envelope (CE) is a unique structure found in the terminal differentiation of the skin. The precursor proteins of the CE are composed of many candidate structural proteins, among which invalucrin and filaggrin are important ones to participate in the complicated process of forming, the complex structure. OBJECTIVE: The purpose of this study was to evaluate the usefulness of expression of involucrin and filaggrin as markers of terminal differentiation in various skin disorders including tumors. METHODS: Immunohistochemical studies were performed in the formalin-fixed, paraffin-embedded skin samples of non-tumors (41 cases) and tumors (43 cases).
Skin*
10.Syndrome of Inappropriate Secretion of Antidiuretic Hormone(SIADH) in Acute Respiratory Diseases.
Young Jee KIM ; Young Yull KOH ; Jeong Kee SEO ; Hung Ko MOON
Journal of the Korean Pediatric Society 1987;30(9):1021-1028
No abstract available.