1.Nocardia Pneumonia.
Korean Journal of Medicine 2003;64(3):328-329
No abstract available.
Nocardia*
;
Pneumonia*
2.Stem Cell ; New Paradigm in the Era of Genomic Medicine.
Woong Yang PARK ; Jeong Sun SEO
Journal of the Korean Medical Association 2002;45(6):711-718
Human stem cells have been isolated from embryos as well as diverse somatic tissues. Much efforts have been made to apply those stem cells for therapeutic purpose. Molecular dissection of "stemness" and differentiation process will provide us a clue to further understanding of stem cell biology. The fate of stem cell is determined in part by internal regulation mediated by transcriptional control. A set of genes related to specific functions might be expressed and suppressed upon external or internal signaling. Therefore, it is necessary to identify the complete gene expression profile that defines the stem cell. Moreover, we should verify the potential of therapeutic stem cells regarding differentiation, specific function, tumorigenecity, and toxicity rigorously before the clinical application. At present we have only limited information on "stemness" and differentiation into specific lineages. In the genome era, we can draw a molecular portrait on these functional and morphologic changes along the differentiation, trans-differentiation as well as de-differentiation using the DNA chip technology. We need to accumulate database for gene expression at various steps of stem cell differentiation, which will enhance our knowledge for research on and medical application of stem cell.
Biology
;
Embryonic Structures
;
Gene Expression
;
Gene Expression Profiling
;
Genome
;
Genomics
;
Humans
;
Oligonucleotide Array Sequence Analysis
;
Stem Cells*
;
Transcriptome
3.Clinical Analysis about the Injuries of Tendons , Vessels and Nerves in the Wrist
Jeong Gyu PARK ; Suk Woong YOON ; Yong Ju KIM
The Journal of the Korean Orthopaedic Association 1987;22(4):941-946
The wrist joint is exposed to trauma easily which is a small portion of human body. Because there are many structures(tendons, vessels and nerves) in the wrist, it is necessary to examine carefully and treat properly when it is damaged. We have treated 230 cases of soft tissue injuries around the wrist and the result can be summarized as follows; 1. Among the 230 cases, the male ratio was 85% and the highest incidence was in the third decade. 2. Right side injuries were more than left and flexor surface injuries were more than extensor surface. 3, The main cause of injury was glass, 149 cases(64.8%) and the next on was knife, 37 cases(16%). 4. Injuries in the night were more than daytime. 5. Injuries in the summer were more than winter.
Glass
;
Human Body
;
Humans
;
Incidence
;
Male
;
Soft Tissue Injuries
;
Tendons
;
Wrist Joint
;
Wrist
4.The Association between Unexplained Second-Trimester Human Chorionic Gonadotropin Elevations and Pregnancy Outcome.
Jae Woong HWANG ; Seong Un JEONG ; Jeong Wook SEO ; Yun Seok YANG ; Jun Sook PARK
Korean Journal of Obstetrics and Gynecology 1998;41(11):2790-2794
We conducted this cohort analytic study to determine whether women with unexplained elevations of maternal serum hCG at 15-18 weeks' gestation are at increased risk for pregnancy complications and adverse perinatal outcomes. The inclusion criteria were a singleton gestation, a confirmed gestational age, and an hCG level greater than 2.0 multiples of the median (MoM). The exclusion criteria were fetal anomalies, an abnormal karyotype, molar pregnancy, and an MSAFP level greater than 2.5 multiples of the median (MoM). A group of randomly selected women with hCG levels under 2.0 MoM served as controls. Patients with elevated levels of hCG had a significantly higher risk for PIH (17.9% versus 4.5%; P <.05) and preterm delivery (17.9% versus 3.5%; P<, 05) than control. But no significant differences were observed in the incidence of intrauterine growth restriction and low birth weight and in the newborn weight. We suggested that pregnancies with unexplained elevated hCG levels should be regarded as high-risk pregnancies. And these patients require careful monitoring with adequate obstetric management.
Abnormal Karyotype
;
Chorionic Gonadotropin*
;
Cohort Studies
;
Female
;
Gestational Age
;
Humans*
;
Hydatidiform Mole
;
Incidence
;
Infant, Low Birth Weight
;
Infant, Newborn
;
Pregnancy
;
Pregnancy Complications
;
Pregnancy Outcome*
;
Pregnancy*
;
Pregnancy, High-Risk
5.A Retrospective Study Investigating Risks of Acute Respiratory Distress Syndrome and Mortality Following Human Metapneumovirus Infection in Hospitalized Adults.
Hyunjung HWANG ; Yujin KIM ; Jeong Woong PARK ; Sung Hwan JEONG ; Sun Young KYUNG
Korean Journal of Critical Care Medicine 2017;32(2):182-189
BACKGROUND: Human metapneumovirus (hMPV) is a relatively recently identified respiratory virus that induces respiratory symptoms similar to those of respiratory syncytial virus infection in children. The characteristics of hMPV-infected adults are unclear because few cases have been reported. METHODS: We conducted a retrospective review of hospitalized adult patients with a positive multiplex real-time polymerase chain reaction assay result from 2012 to 2016 at a single tertiary referral hospital in South Korea. We analyzed clinical characteristics of the enrolled patients and divided patients into an acute respiratory distress syndrome (ARDS) group and a non-ARDS group. RESULTS: In total, 110 adults were reviewed in this study. Their mean age was 61.4 years, and the majority (n = 105, 95.5%) had comorbidities or were immunocompromised. Most of the patients had pneumonia on chest X-ray (n = 88, 93.6%), 22 (20.0%) had ARDS, and 12 (10.9%) expired during hospitalization. The mortality rate for patients with ARDS was higher than that of the other patients (36.4% vs. 5.7%, P = 0.001). The risk factor for hMPV-associated ARDS was heart failure (odds ratio, 5.24; P = 0.044) and laboratory values were increased blood urea nitrogen and increased C-reactive protein. The acquisition site of infection was divided into community vs. nosocomial; 43 patients (39.1%) had a nosocomial infection. The risk factors for nosocomial infection were an immunocompromised state, malignancy and immunosuppressive treatment. CONCLUSIONS: These data suggest that hMPV is one of the important respiratory pathogens important respiratory pathogen that causes pneumonia/ARDS in elderly, immunocompromised individuals and that it may be transmitted via the nosocomial route.
Adult*
;
Aged
;
Blood Urea Nitrogen
;
C-Reactive Protein
;
Child
;
Comorbidity
;
Cross Infection
;
Heart Failure
;
Hospitalization
;
Humans*
;
Korea
;
Metapneumovirus*
;
Mortality*
;
Pneumonia
;
Real-Time Polymerase Chain Reaction
;
Respiratory Distress Syndrome, Adult*
;
Respiratory Syncytial Viruses
;
Retrospective Studies*
;
Risk Factors
;
Tertiary Care Centers
;
Thorax
6.No title available in English.
Jung Soo PARK ; Woong Yoon JEONG ; Jong Ho YOON ; Jong Joo JEONG ; Eun Kyung KIM
Korean Journal of Endocrine Surgery 2003;3(1):69-73
No abstract available.
7.Identifying barriers to Papanicolaou smear screening in Korean women: Korean National Health and Nutrition Examination Survey 2005.
Su Jeong PARK ; Woong Sub PARK
Journal of Gynecologic Oncology 2010;21(2):81-86
OBJECTIVE: This study was conducted to provide a nationwide analysis on barriers to cervical cancer screening in Korea. METHODS: Data used for this study was obtained in a survey called Korean National Health and Nutrition Examination Survey (KNHANES) 2005, which collected data from 2,590 Korean women aged older than 21 years who had not had a hysterectomy and were eligible for Papanicolaou (Pap) smears. Multivariate analysis was adopted to control each demographic factor and unhealthy behavior variable. Demographic factors included age, education, income, job and region; health-related behavior factors were defined as current smoking, obesity, hormone replacement therapy and disability. RESULTS: The study found that cervical cancer screening rate was significantly positively associated with income (odds ratio [OR], 1.002; 95% confidence interval [CI], 1.001 to 1.002), with education (OR, 1.324; 95% CI, 1.030 to 1.703), with job (OR, 1.420; 95% CI, 1.030 to 1.957), and with hormone replacement therapy (OR, 3.732; 95% CI, 2.354 to 5.916). Meanwhile, the age (OR, 0.977; 95% CI, 0.968 to 0.985), disability (OR, 0.358; 95% CI, 0.143 to 0.894) and smoking (OR, 0.447; 95% CI, 0.280 to 0.715) were significantly negatively associated with one's chances to take cervical cytology. CONCLUSION: In order to increase the rates of Korean women taking Pap test, cervical cancer screening programs will have to pay special attention to the elderly, low-income group, smokers, and the disabled.
Aged
;
Demography
;
Female
;
Hormone Replacement Therapy
;
Humans
;
Hysterectomy
;
Korea
;
Mass Screening
;
Multivariate Analysis
;
Nutrition Surveys
;
Obesity
;
Smoke
;
Smoking
;
Uterine Cervical Neoplasms
;
Vaginal Smears
8.Reconstructive Arthrodesis using a Non-living Fibular Graft with an Attached Periosteal Sleeve for Osteosarcoma of the Distal Tibia: A Case Report.
Jong Woong PARK ; Jong Hoon PARK ; Soon Hyuck LEE ; Woong Kyo JEONG ; Si Young PARK
The Journal of the Korean Orthopaedic Association 2008;43(6):813-817
According to previous reports, ankle arthrodesis is regarded as the best reconstructive procedure after limb salvage surgery for osteosarcoma of the distal tibia. Of the many arthrodesis options, vascularized fibular graft (VFG) is widely accepted as the most successful method. However, reconstruction using VFG is not always possible, because VFG is a complicated surgical procedure and is associated with high rates of morbidity at donor sites. The authors devised a novel reconstructive surgical procedure that exploits the osteogenic potential of the periosteum. A 10-year-old female patient with osteosarcoma of the distal tibia underwent limb salvage surgery and the ipsilateral distal fibula and periosteal sleeve were transported to the defect for ankle arthrodesis. The transported fibula and periosteal new bone formation acted as a dual strut bone graft providing better stronger stability than fibula alone transfer. The authors believe the proposed procedure is an easier alternative to the surgically demanding VFG method.
Animals
;
Ankle
;
Arthrodesis
;
Child
;
Durapatite
;
Female
;
Fibula
;
Humans
;
Limb Salvage
;
Osteogenesis
;
Osteosarcoma
;
Periosteum
;
Reconstructive Surgical Procedures
;
Tibia
;
Tissue Donors
;
Transplants
9.Multidetector-row CT Angiography of Hepatic Artery: Comparison with Conventional Angiography.
Jin Woong KIM ; Yong Yeon JEONG ; Woong YOON ; Jae Kyu KIM ; Jin Gyoon PARK ; Jeong Jin SEO ; Heoung Keun KANG
Journal of the Korean Radiological Society 2003;48(3):241-247
PURPOSE: To determine the usefulness of three-dimensional CT angiography using multidetector-row CT (MDCT) for delineating the arterial anatomy of the liver. MATERIALS AND METHODS: Hepatic arterial three-dimensional CT angiography was performed using MDCT (Lightspeed Qx/I; GE Medical Systems, Milwaukee, Wis., U.S.A.) in 45 patients with HCC undergoing conventional angiography for transcatheter hepatic arterial chemoembolization. The scanning parameters during the early arterial phase were 2.5 mm slice thickness, 7.5 mm rotation of table speed, and a pitch of 3. Images were obtained by one radiologist using maximum intensity projection from axial CT images obtained during the early arterial phase. Two radiologists blinded to the findings of conventional angiography independently evaluated the hepatic arterial anatomy and the quality of the images obtained. RESULTS: Compared with conventional angiography, reader A correctly evaluated the hepatic arterial anatomy depicted at three-dimensional CT angiography. Reader B's evaluation was correct in 40 of 45 patients. Interobserver agreement was good (kappa value, 0.73), and both readers assessed the quality of three-dimensional CT angiography as excellent. CONCLUSION: Three-dimensional CT angiography using MDCT was accurate for delineating the arterial anatomy of the liver, and interobserver agreement was good. The modality may provide, prior to conventional angiography, valuable information regarding a patient's hepatic arterial anatomy.
Angiography*
;
Hepatic Artery*
;
Humans
;
Liver
10.Effects of short-term pravastatin therapy in patients with hyperlipidemia.
Jeong Woong PARK ; Kyu Hyung RYU ; Chong Yoon LIM ; Young Bahk KOH ; Yung LEE
Korean Circulation Journal 1993;23(1):136-141
BACKGROUND: Pravastatin, HMG-CoA reductase inhibitor, has been known to be the most effective drug in patients with hypercholesterolemia. We studied the effectiveness and side effects of this drug. METHODS: We studied twenty four patients(8 males, 16 females), with pravastatin 5mg bid for 8 weeks, whose fasting serum total cholesterol levels were higher than 240mg/dl on the first visit. Lipid profiles were checked at 2 weeks interval for 8 weeks and compared with baseline level individually. RESULTS: Among lipid profiles, pravastatin significantly decreased the total cholesterol from 282.8mg/dL to 224.5mg/dL(reduction rate, 21%), the LDL cholesterol from 197.2mg/dL to 143.8mg/dL(27%), the total cholesterol/HDL cholesterol ratio from 6.2 to 4.6(25%), and the LDL cholesterol/HDL cholesterol ratio from 4.1 to 2.7 (34%). These changes were statistically significant(p<0.05). Triglyceride and HDL cholesterol showed no significant changes compared to baseline levels during treatment. The clinical and laboratory findings after treatment did not show serious abnormalities except two patients who dropped out due to side effect such as constipation and skin eruption. CONCLUSION: Results from the present study show that short-term pravastatin therapy seems to be effective and safe in patients with hypercholesterolemia.
Cholesterol
;
Cholesterol, HDL
;
Cholesterol, LDL
;
Constipation
;
Fasting
;
Humans
;
Hypercholesterolemia
;
Hyperlipidemias*
;
Male
;
Oxidoreductases
;
Pravastatin*
;
Skin
;
Triglycerides