1.Electronic Commerce and e-Marketplace.
Journal of the Korean Medical Association 2000;43(11):1076-1085
No abstract available.
Commerce*
2.A case of bilateral polycystic kidney: prenatal ultrasonographic diagnosis.
Korean Journal of Obstetrics and Gynecology 1991;34(11):1625-1629
No abstract available.
Diagnosis*
;
Polycystic Kidney Diseases*
3.A Study on Developing Computer Models of Neuropsychiatric Diseases.
Journal of the Korean Society of Biological Psychiatry 1999;6(1):12-20
In order to understand the pathogenesis and progression of some synaptic loss related neuropsychiatric diseases. We attempted to develop a computer model in this study. We made a simple autoassociative memory network remembering numbers, transformed it into a disease model by pruning synapses, and measured its memory performance as a function of synaptic deletion. Decline in performance was measured as amount of synaptic loss increases and its mode of declines is sudden or gradual according to the mode of synaptic pruning. The developed computer model demonstrated how synaptic loss could cause memory impairment through a series of computer simulations, and suggested a new way of research in neuropsychiatry.
Computer Simulation*
;
Dementia
;
Memory
;
Neuropsychiatry
;
Schizophrenia
;
Synapses
4.Intrauterine Infection as a Cause of the Neonatal Pulmonary Injury and Bronchopulmonary Dysplasia.
Jin Haeng CHUNG ; Jeong Wook SEO
Korean Journal of Pathology 2000;34(6):431-436
The pathogenetic role of intrauterine infection to the neonatal pulmonary injury and bronchopulmonary dysplasia was assessed by studying the interleukin-6 (IL-6) level in the umbilical cord blood and the early morphologic changes of the neonatal lung. Patients were grouped into bronchopulmonary dysplasia (4 cases), chorioamnionitis without chronic lung injury (4 cases), and 6 cases without morphologic evidence of chronic lung injury or placental inflammation. IL-6 level of umbilical cord blood was higher in babies with bronchopulmonary dysplasia (17.7 pg/ml) compared to those with chorioamnionitis (4.7 pg/ml) or those with morphologically normal lung and placenta (6.2 pg/ml). Morphologic parameters of neonatal pulmonary injury were hyaline membrane, terminal bronchiole inflammation, terminal bronchiole regeneration, alveolar collapse and fibroblastic proliferation. Bronchiolar regeneration was the most peculiar feature seen in the lung with bronchopulmonary dysplasia. Alveolar collapse and interstitial fibroblastic reaction were commonly seen in bronchopulmonary dysplasia. The postnatal age at death was higher in those with bronchopulmonary dysplasia, although the occurrence of the morphologic changes was related with the chronicity of those lesions. These findings suggest that intrauterine infection is an aggravating factor for the neonatal pulmonary injury and bronchopulmonary dysplasia, although the early stage of the lung injury is not a definitive indicator for the progressive pulmonary damage leading to the bronchopulmonary dysplasia.
Bronchioles
;
Bronchopulmonary Dysplasia*
;
Chorioamnionitis
;
Cytokines
;
Female
;
Fetal Blood
;
Fibroblasts
;
Humans
;
Hyalin
;
Hyaline Membrane Disease
;
Infant, Newborn
;
Inflammation
;
Interleukin-6
;
Lung
;
Lung Injury*
;
Membranes
;
Placenta
;
Pregnancy
;
Regeneration
5.A case of metastatic neuroblastoma to brain.
Sang Wook CHOI ; Mee Jeong LEE
Journal of the Korean Pediatric Society 1991;34(5):715-719
No abstract available.
Brain*
;
Neuroblastoma*
6.Morphological Observation on the Prenatal Development of the Human Heart (I): Study on the Early Cardiac Development using Human and Chick Embryos.
Korean Journal of Pathology 1989;23(2):187-197
Normal embryonic development of human heart is studied with special emphasis to the formation of atrioventricular and ventriculoarterial connections and their significance in congenital heart disease. Twenty nine human embryos and 8 chick embryos are used in this study. Human embryos are analyzed by reconstruction of serial section slides and chick embryos are microdissected and examined by scanning electron microscopy. In the early cardiac development (Streeter horizon 12), bulbo-ventricular fold divided two ventricles first. The atrioventricular canal is incompletely divided and the canal was in contact neither with septum primum nor with ventricular septal crest. Infundibular and truncal septa were not seen. The division of A-V canal was observed during the stages 14-15. Septation of truncus arteriosus (Streeter horizon 15-17) was followed by septation of bulbus cordis (Streeter horizon 16-17). The shortening of mitral-aortic distance and downward left shift of aortic valve occured after the trunco-infundibular septation and finally the secondary interventricular formen closed at the end of seventh week (Streeter horizon 20-21).
Humans
;
Chick Embryo
;
Animals
7.Computerization of Surgical Pathology Reporting and Data Storage by Automatic Coding System using Personal Computer.
Woo Ho KIM ; Jeong Wook SEO ; Yong Il KIM
Korean Journal of Pathology 1989;23(4):410-415
The authors developed a computer program for use in report printing as well as data storage and retrieval system at the surgical pathology and its efficacy was evaluated at the Department of Pathology, Seoul National University Hospital. This program used IBM PC XT and was written in DBASE III plus language. The main features of the program included an automatic coding and decoding of the diagnosis, automatic searching of the previous biopsy during gross dictation, powerful word processing function and flexibility of the program. The data storage was carried out during the typewriting of the report, so that the typist's workload became markedly reduced. Two kinds of data files wer stored in the hard disk ; the temporary file contained full informations and the permanent file contained the core data only. Searching of a specific case was performed by pathology accession number, chart number, patient's name or by SNOMED code within a second. All the cases were arranged by copied to the diskette during the daily service automatically, with which data were easily restored in case of hard disk failure. The advantages of this program using a persosnal computer were discussed with comparison to those of larger computer system. Based on the experience of 8 months usage in Seoul National University, we assume that this program gives a sufficient solution to the surgical pathology service of many institutes where a large computer system with well designed software is not available yet.
Biopsy
8.A Case of Ki - 1 Lymphoma.
Yun Jeong LEE ; Chun Wook PARK ; Cheol Heon LEE
Korean Journal of Dermatology 1994;32(2):327-331
Ki-1 antigen was found by a monoclonal antibody, made against a Hidgkin' disease-derived cell line (L428) that reacted with Reed-Sternberg cells in Hodgkins disease and a few lymphocytes around lymphoid follicle. In 1985, Stein et al identified a large cell anaplastic lymphoma showing a distinctive pleomorphic appearance, sinus growth pattern, and reactivity to Ki-l. We report a case of Ki-1 positive large cell anaplastic lymphoma, which was presenting as a elevated plaque on the skin of popliteal fossa in a 69-year-old female.
Aged
;
Antigens, CD30
;
Cell Line
;
Female
;
Hodgkin Disease
;
Humans
;
Lymphocytes
;
Lymphoma*
;
Reed-Sternberg Cells
;
Skin
9.A case of lateral medullary syndrome presenting as sensory -motor stroke.
Jeong Wook PARK ; Joung Ho RHA ; Beum Saeng KIM
Journal of the Korean Neurological Association 1997;15(1):200-203
Lateral medullary syndrome is famous for its unique symptom complex such as crossed sensory change or Homer syndrome, and thus hardly can be misdiagnosed. Though this syndrome has been reported to be able to accompany ipsilateral motor weakness, the sensory change of extremities is known to be almost always contralateral to the lesion. We recently experienced one case presented with weakness and dysmetria on the right associated with ipsilateral sensory change. But few days later, he showed additional neurologic signs compatible with right lateral medullary syndrome. Brain MRI showed rostro-caudally elongated lesion extending from right lateral medulla to the upper cervical cord. Here we suggest the probable neuroanatomical substrate for this symptom and clinico-radiologic relationship with previous literature.
Brain
;
Cerebellar Ataxia
;
Extremities
;
Lateral Medullary Syndrome*
;
Magnetic Resonance Imaging
;
Neurologic Manifestations
;
Stroke*
10.The Role of Cell Proliferation and Apoptosis in the Cardiac Development.
Eo Jin KIM ; Hyo Soo KIM ; Jeong Wook SEO
Korean Journal of Pathology 1998;32(12):1049-1057
The functional and morphologic cardiac developments are determined by the morphogenesis, growth and remodeling of the heart resulted from the cell proliferation and apoptosis. We studied the distribution of the proliferation and apoptotic activity of myocardial cells according to the developmental stages in embryos of C57bl/6 mice. Serial histologic sections were stained with PCNA and TUNEL method and were analyzed with image analyzer (BMI, Seoul). The ventricular myocardium of an embryonic heart could be divided into trabecular, inner compact and outer compact layers. Proliferation indices at layers of the left ventricular myocardium on embryonal days (ED) 13, 14, 16, 17 and 18 were 19.9%/47.4%/60.4%, 16.1%/45.8%/60.3%, 24.6%/45.6%/38.1%, 23.3%/17.7%/18.3% and 31.2%/28.0%/19.4% (trabecular/ inner compact/ outer compact) and the right ventricle, 11.0%/34.4%/60.5%, 23.0%/44.0%/69.0%, 29.2%/42.9%/35.1%, 30.4%/30.5%/22.3% and 32.4%/28.4%/16.3%. The apoptotic indices of the left ventricle/VIF were 0.23%/3.66% on ED 13-14, 0.42%/1.31% on ED 16 and 0.05%/0.60% on ED 17-18. The results show that the proliferation of the myocytes was maximal at the outer compact layer on ED 13 and 14 but lowest on ED 17 and 18. This decrease was more pronounced at the left ventricle. The innermost trabecular layer showed a constant proliferation activity of 11.0-32.4%. The presence of spatiotemporal differences in the cell proliferation reveals regional regulation in the developmental timing of cardiac development. Functional maturation is considered to be responsible for the change of proliferation activity. The apoptosis was most frequent and intense in the VIF and crux throughout the periods of each embryonal day where as rarely seen in the ventricular myocardium, especially in the trabecular layer of myocardium. These findings suggest that the apoptosis plays the role in the development of atrioventricular, ventriculoarterial septation and valve formation. Our results also reveal that the participation of apoptosis in formation of the trabeculation can be denied.
Animals
;
Apoptosis*
;
Cell Proliferation*
;
Embryonic Structures
;
Heart
;
Heart Ventricles
;
In Situ Nick-End Labeling
;
Mice
;
Morphogenesis
;
Muscle Cells
;
Myocardium
;
Proliferating Cell Nuclear Antigen