With a short survey of the indications for operative treatment of lumbar disc herniations the operative techniques for conventional classical posterior approach were described. Description of the “micro”-approach with a help of an operating microscope, treatment of recurrence and the procedure in cases with a narrow spinal canal, an enlarged facet joint, a narrowed intervertebral foramen and a lateral recess syndrome was additionally given. Short subchapters dealed with anesthesia, operative position, postoperative treatment and complications along with review of literatures.
Anesthesia ; Recurrence ; Spinal Canal ; Zygapophyseal Joint

No abstract available.
Pyloric Stenosis, Hypertrophic*

Osteoarthritic changes in experimental animals has been induced by several different methods. In order to study the changes of the articular cartilage induced by injuries of ligaments and/or meniscus of the knee joints, the author performed the experimental study that section of the medial collateral and anterior cruciate ligaments (group I) and section of the medial collateral and anterior cruciate ligaments combined with excision of the medial meniscus (group II) in twenty adult rabbit's knees caused instability. Histological changes of the articular cartilage were observed up to four months. The results were as follows: 1. The changes of the articular cartilage were gradually advanced depend on the time lapse after experimental procedures, in group I and ll. 2. The changes of the articular cartilage could be noticed from eighth week after experimental procedures in group I and from fourth week in group II, and more severe at sixteenth in group I and at twelfth week in group II. 3. The changes of the articular cartilage in group ll were appeared earlier and more severe than in group l. 4. The changes of the articular cartilage in the medial side of the knee joint were noticed more severe than in the lateral side.
Adult ; Animals ; Anterior Cruciate Ligament ; Cartilage, Articular ; Humans ; Knee Joint ; Knee ; Ligaments ; Menisci, Tibial ; Rabbits

Acute increased intracranial pressure in rabbits caused by inflation of an extradural balloon was associated with a sequential alteration in vital signs. As the balloon was inflated with small increments of saline, the intracranial pressure rose. The first few increments were not usually associated with a sustained rise in intracranial pressure. As the intracranial pressure was raised with additional increments, the vital signs altered in the following order. As the first increments were added, the respiratory rate decreased. Further inflation of the balloon was associated with a definite reduction of the pulse rate and marked slowing of the respiration. As the respirations became slower, with the increasing intracranial pressure their amplitude increased. At this stage, later than the onset of respiratory change, further increment was sufficient to give a sudden parallel rise of the intracranial and arterial pressures. With this parallel rise of pressures the respiration became short and shallow associated with periods of apnea. Pulse rate usually increased as the arterial pressure rose. A transient sudden rise of venous blood pressure was observed when the arterial pressure rose suddenly parallel to rise of intracranial pressure. If the balloon was not deflated the arterial pressure declined, the pulse rate decreased significantly and periods of apnea occurred. Thereafter the intracranial and systemic arterial pressures gradually declined along with a reduction of the pulse rate. Respiration ceased and finally the heart stopped.
Apnea ; Arterial Pressure ; Brain* ; Heart ; Heart Rate ; Inflation, Economic ; Intracranial Pressure* ; Rabbits ; Respiration ; Respiratory Rate ; Venous Pressure ; Vital Signs

With the purpose of avoiding the usual complications of systemic hypothermia and particularly those secondary to the lower tolerance of temperature of the cardiac neuromuscular elements as compared with tissue of the central nervous system, extravascular local cooling of the brain in cat was designed for the experiment. The experimental technique was deviced to cool the brain with cold liquid(2-3 degrees C) of physiological saline perfused or irrigated onto and with the salineice(-7 degrees C) rested on the surface of the brain. Thermocouples were introduced and placed at different depths of each 0.3cm in the brain, then the brain temperatures were measured at each depth before and during cooling every 10 minutes. Average temperature of brain surface before cooling was 35.7+/-1.7 degrees C and mean of it recorded from surface to 1.5cm depth in the brain was 36.7+/-1.1 degrees C in 20 cats. During cooling temperatures was effectively and markedly droped at extent of 0.6cm thick in the subcortical tissue, and at 20 minutes, cooling the maximal drop of temperature was recorded. During cooling with saline solution, average temperature of normal brain surface was 22.3+/-41 degrees C and mean of it recorded at different depths in brain was 28.7+/-2.5 degrees C. During cooling with saline ice, average temperature of normal brain surface was 12.2+/-2.6 degrees C, and mean of it recorded at different depths in brain was 22.0+/-1.3 degrees C. Temperature in the areas of brain injured by contusion or compression was relatively lower than in the normal brain. Temperature lowering in the injured brain during the cooling was more evident and marked in its degree than that in normal brain. Gross neurological examination failed to demonstrate any impairment of voluntary motor function after the cooling of brain for 50 minutes.
Animals ; Brain* ; Cats* ; Central Nervous System ; Contusions ; Hypothermia ; Ice ; Neurologic Examination ; Sodium Chloride

Numerous experimental and clinical studies of brain metabolism have reported since last 10 years, and many authors have concentrated their efforts on the metabolism of gas, glucose, electrolytes and enzymes. Glutamic acid that is utilized in the brain is one of the most important metabolites and plays very important role in the brain to detoxify the ammonia which is toxic to the nervous tissue even with minute amount. Authors have attempted to measure the level of ammonia in the diseased brain tissue of rabbits as the first step believing that there may be some derangement in the process of production or detoxication of the ammonia in the brain. The experiments were carried out on adult rabbits weighing between 1.5 and 2.2kg. The specimens were grouped into 3:contrast group of normal rabbits compression group of animals with expanding laminaria in the intracranial epidural space and ischemic group of animals with bilateral liation of common carotid arteries. Although we could'nt find any helpful references to the study of the ammonia measurement in the rabbit's brain and were facing a little difficulty to conclude whether the result of this experiment is significant or not, it was the fact that there was a strong tendency of increase in the ammonia level at an acute stage of brain compression and ischemia and then, as the time elapsed, the decreasing, level of ammonia near the contrast group was studied. Therefore, as a second step further research on the substances which relate to the ammonia metabolism has to be done in the above mentioned experimental media.
Adult ; Ammonia* ; Animals ; Brain* ; Carotid Artery, Common ; Electrolytes ; Epidural Space ; Glucose ; Glutamic Acid ; Humans ; Ischemia* ; Laminaria ; Metabolism ; Rabbits

A study has been made of efferent single fibers in the cat whose axon is projected to the cardiac branches of the right vagus. The main objective of this experiment was to replicate some of the mechanisms involving vagal efferent discharges and to observe the effect of somatic stimulation, pain and coldness, on the discharges. Electrical activities of a single of a single fiber were recorded on the central segments of small cut strands separated from the right cervical vagus under the pentobarbital sodium anesthesia. The fiber was considered to be cardio-inhibitory in function because of the activity in inverse effect on the heart rate in almost all conditions. Pain and cold stimulation of skin reflexly excited these fibers, as did stimulation of baroreceptor in the carotid sinus. Response to the somatic stimulation applied on the skin, by the increase of impulse frequency, amplitude, discharge duration and pulse rate of electrical discharges were observed. The auther observed that efferent fibers in the cutaneous nerve excited the cardiac efferent vagal fibers in response to reflex stimulation.
Anesthesia ; Animals ; Axons ; Carotid Sinus ; Cats ; Heart Rate ; Nerve Fibers, Myelinated ; Pentobarbital ; Pressoreceptors ; Reflex ; Skin

It has been postulated that central nervous system disorders characterized by convulsive seizures are caused by alterations in one or more cerebral metabolism especially in cellular energy metabolism, electrolyte metabolism and glutamate metabolism. In the present study, alterations in cerebral energy metabolism, cellular electrolyte metabolism and glutamate metabolism were studied to investigate biochemical nature of cerebral disturbances in rats injected intraperitoneally with massive doses of penicillin. Also carried out were in vitro experiments by which direct effects of penicillin on concentrations of high energy compounds and Na+, K+-ATPase activity in the brains were determined. Intraperitoneal injections of pencillin G sodium(1,000,000 I.U. per kg body weight) to rats twice daily for 3 to 5 days resulted in significant decreases in cerebral concentrations of ATP, phosphocreatine and lactate, suggesting that penicillin induces cerebral dysfunctions by inhibiting energy production. While cerebral Na+, K+-ATPase activity and brain K+ content were significantly decreased in rats with penicllin-induced cerebral dysfunctions, brain Na+ and water contents were significantly increased. Observations that, in rats with penicillin-induced cerebral dysfunctions, the fall in high-energy phosphate contents in the brain took place as rapidly as the cation shifts indicate that alterations in both energy metabolism and electrolyte metabolism in the brain may be responsible for cerebral dysfunctions induced by penicillin. These assumptions were further supported by the findings that Na+, K+-ATPase activity and high-energy phosphate contents in the isolated cerebral hemispheres were profoundly affected by the addition of penicillin to the medium in which in vitro experiment was carried out. While the activity of glutamine synthetase in the brain was increased in rats exhibiting cerebral dysfunctions induced by penicillin, the activity of glutamine dehydrogenase was significantly decreased. Significance of changes in activities of these two brain enzymes in penicillin-induced cerebral dysfunctions was not immediately understood. It may be possible, however, that penicillin may influence glutamate contents in the brain directly orindirectly through the alteration of these two brain enzyme activities so as to modify the cerebral functions.
Adenosine Triphosphate ; Animals ; Brain ; Central Nervous System Diseases ; Cerebrum ; Energy Metabolism ; Glutamate-Ammonia Ligase ; Glutamic Acid ; Glutamine ; Injections, Intraperitoneal ; Lactic Acid ; Metabolism ; Oxidoreductases ; Penicillins* ; Phosphocreatine ; Rats ; Seizures

In the treatment of the intracranial gliomas surgical intervention is recommended as the standard procedure which should be performed in all cases when the tumor is accessible. While surgery will not bring about a cure and clearly, radiation therapy and chemotherapy have made a significant impact of long-term survival in the treatment of the malignant gliomas, nevertheless surgery still remains the single most effective method for achieving a rapid reduction of tumor burden reducing increased intracranial pressure and provides a tissue diagnosis. Following surgery, the other antitumor programs have the best chance of achieving a significant increment of tumor cell kill, therefore, surgery has a distinct role to play in the multidisciplinable approach to the treatment of these highly aggressive malignant tumors. It is very unlikely that future advances will obviate the necessity for conventional surgery in the treatment of benign gliomas. The surgical management of gliomas with major emphasis on malignant ones is presented including the pathophysiology, radiological diagnosis, aim of surgery, surgical procedure and some different possibility of surgical treatment. Prospective future development of surgical treatment of brain tumor is also considered.
Brain Neoplasms ; Diagnosis ; Drug Therapy ; Glioma* ; Intracranial Pressure ; Tumor Burden

Impact injuries to the surgically exposed dura overlying the lumbar cord at L2 were produced in cats. Cytochrome oxidase activities in frozen-dried sample of spinal cord gray matter were measured and analyzed as a step in the investingation of the possible effects of spinal cord trauma on mitochondria. As conservative index of mitochondria damage in gray matter resulting from inactivation on cytochrome oxidase activity, electron microscopic studies of mitochondrial ultrastructural changes in traumatized gray matter were performed. The effects of Naloxone on the alteration of the cytochrome oxidase activities and ultrastructures of the mitochondria in the gray matter were studied. A drop in cytochrome oxidase activities to approximately 50% of normal value was found as early as 15 minutes post-trauma, which greatest decrease at 1/2 hour and 1 hour post-trauma. Ultrastructural changes of the mitochondria continued to proceed with the lapse of time after the injury. Mitochondriae were slightly enlarged with decreased number of cristae at 15 minutes post-trauma. Enlargement of the mitochondria with disintegration of cristae and electron-lucent area in the matrices were observed at 1 hour and 4 hour post-trauma. As relatively less change to the mitochondrial ultrastructures was observed in the Naloxone-treated group than in the non-treated group, the results of this study suggest that Naloxone confers beneficial effects in enhancing the cytochrome-oxidase activity and preserving the mitochondrial ultrastructures from injury.
Animals ; Cats ; Cytochromes* ; Electron Transport Complex IV* ; Mitochondria ; Naloxone* ; Reference Values ; Spinal Cord Injuries* ; Spinal Cord*