1.The Proximal and Distal Interphalangeal Flexion Dysfunction, Opposition Palm Ratio and Thumb Index Ratio in the Korean Adults.
Ki Un JANG ; Yeong Uck JANG ; Hyun Jae YOO ; Kwang Ik JEONG ; Do Hoon KIM ; Dong Sik PARK
Journal of the Korean Academy of Rehabilitation Medicine 2001;25(6):1023-1030
OBJECTIVE: The purpose of this study was to evaluate the incidence of inability to flex proximal interphalangeal (PIP) and distal interphalangeal (DIP) joint in normal Koreans. The opposition palm ratio and thumb index ratio was also of interest. METHOD: Randomly selected eighty nine normal Korean adults of 48 men and 41 women, with ages 20 to 79 years. The finger flexion was measured using the standard flexor digitorum superficialis (FDS) and flexor digitorum profundus (FDP) screening tests. Thumb index ratio and opposition palm ratio was also assessed additionally. RESULTS: In the sample population, 2 subjects (2.2%) were unable to bilaterally flex their fifth PIP joints independently. Four subjects (4.4%) were unable to flex one or both of their fourth or fifth DIP joints. These results show far less incidence of FDS dysfunction comparing with 52% of FDS dysfunction rate in Americans. The opposition palm ratio in men were 63.6% and in women 69.9%, indicating lower ratio in men. The thumb index ratio was not different statistically between the men and women. CONCLUSION: These data suggest that the different incidences of FDS and FDP dysfunction should be considered in interpretation. The opposition palm ratio and thumb index ratio might be useful in the hand rehabilitation.
Adult*
;
Female
;
Fingers
;
Hand
;
Humans
;
Incidence
;
Joints
;
Male
;
Mass Screening
;
Rehabilitation
;
Thumb*
2.A Case of Azoospermia Associated with Inversion of Chromosome 1.
Yoon Sung NAM ; Nam Keun KIM ; Chang Jin JEONG ; Sun Hee CHA ; Sung Un JANG ; Kwang Yul CHA
Korean Journal of Obstetrics and Gynecology 2002;45(5):851-854
Chromosomally derived sterility has long been recognized. A review of the literature of somatic chromosome investigations in infertile males has shown that 13.7% of azoospermic males and 4.6% of oligozoospermic males have an abnormal karyotype. In the first group, sex chromosome abnormalities predominate (mainly 47,XXY), whereas in the latter, autosome anomalies (i.e. Robertsonian and reciprocal translocations) are the most frequent. A similar review on meiotic studies revealed that meiotic chromosome anomalies can explain male infertility in 4.3-40.4% of patients. Recently, fluorescent in-situ hybridization studies on spermatozoa from infertile men were published; it was suggested that both X-Y pairing and pairing of the autosomes were impaired, resulting in spermatogenic disruption. It is estimated that there are 2,000 genes that regulate spermatogenesis, most of these being present on the autosomes, but there are approximately 30 genes on the Y chromosome. In general, autosomal genes that regulate spermatogenesis are concerned with regulation of metabolic processes in other cells in the body as well as in the cells of spermatogenesis, whereas Y genes are not essential for vital functions related to reproduction. To be able to provide proper counseling for those couples whose male infertility can now be treated by intracytoplasmic sperm injection, it is suggested that clinical investigations should include mitotic and meiotic studies, an analysis of the chromosome content of individual spermatozoa and a DNA analysis of blood and spermatozoa to detect partially deleted Y chromosome material. We have experienced a case of azoospermia associated with inversion of chromosome 1. So we report this case with a brief review of literatures.
Abnormal Karyotype
;
Azoospermia*
;
Chromosomes, Human, Pair 1*
;
Counseling
;
DNA
;
Family Characteristics
;
Humans
;
Infertility
;
Infertility, Male
;
Male
;
Metabolism
;
Reproduction
;
Sex Chromosome Aberrations
;
Sperm Injections, Intracytoplasmic
;
Spermatogenesis
;
Spermatozoa
;
Y Chromosome
3.Clinical study for Patients with Cervical Cancer who had undergone Radical Hysterectomy.
Seong Un JEONG ; Sung Joong CHO ; Jang Hwan KIM ; Nam Woo LEE ; Kyung Jin KIM ; Mi Hae PARK ; In Tak HWANG ; Ji Hak JUNG
Korean Journal of Obstetrics and Gynecology 1999;42(8):1671-1676
OBJECTIVE: The purpose of this study was to analyze the clinical study for patients with cervical cancer who had undergone radical hysterectomy. METHOD: The subjects of this study were one hundred and sixty two patients with cervical cancer who had undergone radical hysterectomy at Eulji Medical College Hospital, Taejon, Korea, from January 1983 to December 1992. We reviewed the medical record retrospectively and analyzed the data. RESULT: The distribution of patients by age was found in the order of 50 decade and 60 decade, 40 decade. Those by the clinical stages were as follows: Stage Ia, 12 cases(7.4%); Stage Ib, 84 cases(51.9%); Stage IIa, 39 cases(24.1%); Stage IIb 27 cases(16.7%). The results of histopathologic type were distributed as follows: squamous cell carcinoma was 91.9%, adenocarcinoma was 4.9% and adenosquamous cell carcinoma was 3.1%. The histologic subtypes of squamous cell carcinoma(149 cases) were as follows: Large cell non-keratinizing type was 75.9%, large cell keratinizing type was 14.8% and small cell type was 1.2%. The frequancy of lymph node metastasis was 22.9% in stage I and 31.8% in stage II. The overall incidence of lymph node metastasis was 26.4%. The frequency of external radiation therapy done after radical hysterectomy was 63.5% in stage I and 75.8% in stage II. The 5-year survival rate was as follows: The Ia was 100%; Stage Ib, 95.2%(4cases); Stage IIa, 87.2%(5cases); Stage IIb, 77.8%(6cases). The incidence of recurrence was 7.4% and recurrent sites were vaginal stump , rectum and pelvic wall. CONCLUSION: The highest incidence of cervix cancer in age distribution was 50 decade(30.9%) and 60 decade(30.9%). The most common clinical stage was Ib(51.9%) and most frequent pathologic type was squamous cell carcinoma(91.9%). The overall incidence of lymph node metastasis was 26.4% and The most common site of recurrence was vaginal stump. The 5-year survival rate was 100% in the stage Ia, 95.2% in the stage Ib, 87.2% in the stage IIa, 77.8% in the stage IIb.
Adenocarcinoma
;
Age Distribution
;
Carcinoma, Squamous Cell
;
Daejeon
;
Humans
;
Hysterectomy*
;
Incidence
;
Korea
;
Lymph Nodes
;
Medical Records
;
Neoplasm Metastasis
;
Rectum
;
Recurrence
;
Retrospective Studies
;
Survival Rate
;
Uterine Cervical Neoplasms*
4.Effects of Heme Oxygenase-1 Inducer and Inhibitor on Experimental Autoimmune Uveoretinitis.
Jeong Un JANG ; Sook Hee LEE ; Chang Uk CHOI ; Song Chull BAHK ; Hun Taeg CHUNG ; Yun Sik YANG
Korean Journal of Ophthalmology 2007;21(4):238-243
PURPOSE: Experimental autoimmune uveoretinitis (EAU) is an animal model of posterior uveitis and heme oxygenase-1 (HO-1) is a well-known anti-oxidant factor. However, there is no report a protective role of HO-1 on EAU in vivo. To verify that HO-1 is induced in EAU by interphotoreceptor retinoid-binding protein (IRBP), that an HO-1 inducers ameliorates the associated inflammation, and that an HO-1 inhibitor exacerbates this inflammation. METHODS: Forty four Lewis rats were given either 40 mol/kg hemin or 40 mol/kg SnPP (tin protoporphyrin IX) by intraperitoneal injection and twenty two uveitis control rats were injected with 0.5 mL of saline once daily 5-20 days after IRBP immunization inducing EAU. Three normal control rats were used for Western blotting and ELISA assay of HO-1. The clinical uveitis signs of inflammation were scored in the three groups from 0 to 4 on alternate three days. To confirm the clinical results, histological and immunohistochemical stain of HO-1 were performed on the day of peak inflammation and Western blotting and ELISA assay of HO-1 were performed on 6th, 12th and 18th day after IRBP immunization. RESULTS: Hemin, an inducer of HO-1, ameliorated the clinical signs of EAU. In contrast, SnPP-treated rats show that the severity of the clinical sign were exacerbated at the peak period of the disease. These results are roughly compatible with histological, immunoblotting, and immunohistochemical evaluations and an ELISA assay of HO-1. CONCLUSIONS: We suggest that HO-1 plays an important protective role in EAU.
Animals
;
Autoimmune Diseases/diagnosis/*drug therapy/metabolism
;
Blotting, Western
;
Disease Models, Animal
;
Enzyme Inhibitors/*administration & dosage
;
Enzyme-Linked Immunosorbent Assay
;
Heme Oxygenase-1/*biosynthesis/drug effects
;
Hemin/*administration & dosage
;
Immunohistochemistry
;
Injections, Intraperitoneal
;
Male
;
Metalloporphyrins/*administration & dosage
;
Microscopy, Acoustic
;
Protoporphyrins/*administration & dosage
;
Rats
;
Rats, Inbred Lew
;
Retinitis/diagnosis/*drug therapy/metabolism
;
Treatment Outcome
;
Uveitis, Posterior/diagnosis/*drug therapy/metabolism
5.Three cases of post-transfusion hepatitis C.
Kyung Un NO ; Ho Seong KIM ; Ji Won CHOI ; Dong Wook KIM ; Cheol Ho JANG ; Beom Su PARK ; Jeong Kee SEO ; Gyeong Hoon KANG ; Je Geun CHI
Journal of the Korean Pediatric Society 1992;35(9):1255-1262
No abstract available.
Hepacivirus
;
Hepatitis C*
;
Hepatitis*
6.The Prevalence and Ergonomic Analysis of Cumulative Trauma Disorders in the Paper Reviewing Workers.
Ki Un JANG ; Sang Wook PARK ; Kwang Ik JEONG ; Jong Tae PARK ; Dae Sung KIM ; Dong Hyun PARK ; Dong Sik PARK
Journal of the Korean Academy of Rehabilitation Medicine 2001;25(2):321-329
OBJECTIVE: To survey the prevalence of cumulative trauma disorders (CTDs) and to analyze the ergonomic factors in the paper reviewing workers. METHOD: Five hundreds and twenty subjects of paper reviewers were collected from 'National Medical Insurance Association' who had been exposed to risky working environment regarding CTDs. The subjects were first screened by occupational medicine specialists and confirmed by physiatrist. The subjects were also examined by serologic test, radiologic imaging, and electro diagnostic study. Ergonomists analyzed the job element to identify the risk factors by baseline checklist of CTDs. RESULTS: Among the workers, 51 (9.8%) of 520 were confirmed to CTDs, the prevalance of myofascial pain syndrome was 22 (43.1%), that of medial epicondylitis was 13 (25.5)%, lateral epicondylitis 8 (15.7%) and others. Pain scale of National Industrial Occupational Safety Health Institute symtoms criteria was highest in the shoulder girdle and the next was in the neck, in the wirst and fingers. The ergonomic risk score was highest 2.56 in the 'verifying' job, and the next 2.20 in 'the 2nd examination' job and 'the 1st examination' job, 1.72 in 'correcting' job. CONCLUSION: The result would be helpful for the prevention and management of CTDs in the paper reviewing workers.
Checklist
;
Cumulative Trauma Disorders*
;
Fingers
;
Human Engineering
;
Insurance
;
Myofascial Pain Syndromes
;
Neck
;
Occupational Health
;
Occupational Medicine
;
Prevalence*
;
Risk Factors
;
Serologic Tests
;
Shoulder
;
Specialization
7.The Types of Impairments in Burn Patients.
Cheong Hoon SEO ; Ki Un JANG ; Jung Kyu AHN ; Jeong In YANG ; Sik PARK
Journal of the Korean Academy of Rehabilitation Medicine 2006;30(2):179-183
OBJECTIVE: The aim of this study was to investigate the types of impairments in burn patients. METHOD: The retrospective data of 143 patients with burn injury was collected who were admitted to the burn rehabilitation department in Hangang Sacred Heart Hospital from Jan 2000 to Jul 2004. We have collected the informations on impairment of burn injury. RESULTS: Limitation of joint motion (78.6%) was the most common disability, followed by hypertrophic scar (53%), peripheral neuropathy (32.9%), and amputation (20.3%) in burn injured patients in rehabilitation management. The common sites of joint limitation were finger joint (38.1%), shoulder (35.7%), elbow (30.8%) and knee (28.0%) joint. Neuropathy by the order of frequency were median (29.7%), ulnar (22.6%) and peroneal (20.2%) nerve lesion. The most common site of amputation was transradial amputation (8.4%). CONCLUSION: Above analytic data will provide the useful information about disability of burn patients to know where we should focus on to reduce complication rate or to restore body functional level in burn patient rehabilitation.
Amputation
;
Burns*
;
Cicatrix, Hypertrophic
;
Contracture
;
Elbow
;
Finger Joint
;
Heart
;
Humans
;
Joints
;
Knee
;
Peripheral Nervous System Diseases
;
Rehabilitation
;
Retrospective Studies
;
Shoulder
8.Evaluation of Nerve Block after Phenol and Ethanol Injection.
Sung Sik KIM ; Ki Un JANG ; Jong Chul KIM ; Ju Hyung LEE ; Kwang Ik JEONG ; Dong Sik PARK
Journal of the Korean Academy of Rehabilitation Medicine 2002;26(4):470-474
OBJECTIVE :To evaluate the axonal degeneration after nerve block with phenol and ethanol injection into tibial nerve. METHOD: Tibial nerves of thirty Sprague-Dawley rats were exposed. For the developement of neuropathic pain, the method of intraneural injection was performed. Five percent phenol, 90% ethanol or normal saline were injected into the epineurial sheath of tibial nerve at each group. The mechanical and thermal allodynia were evaluated in post- injection 1, 2, 3, and 4 weeks. The mechanical allodynia was evaluated by withdrawal response to 10 stimulations with von Frey hair. Thermal allodynia was tested by withdrawal response to 5 stimulations with acetone. Motor nerve conduction study was performed in post-injection 1, 2, and 4 weeks. RESULTS: In behavioral test, the experimental group exhibited increased withdrawal response to mechanical and cold stim ulation, but there was no significant difference between two groups, phenol and ethanol groups. In motor nerve conduc tion study, compound motor action potential amplitude loss were observed in experimental group, but there was no significant difference between two groups, phenol and ethanol groups. CONCLUSION: These results suggest that axonal degeneration of ethanol is roughly similar to those of phenol block.
Acetone
;
Action Potentials
;
Animals
;
Axons
;
Ethanol*
;
Hair
;
Hyperalgesia
;
Nerve Block*
;
Neural Conduction
;
Neuralgia
;
Phenol*
;
Rats
;
Rats, Sprague-Dawley
;
Tibial Nerve
9.Relationship between Abdominal Obesity and Electrocardiographic QTc Interval Prolongation.
Jeong Woon PARK ; Ji Un JANG ; Chang Sup KIM ; Moon Chan KIM ; Tae Heum JEONG
Journal of the Korean Academy of Family Medicine 2005;26(10):604-608
BACKGROUND: Electrocardiographic QTc interval prolongation can cause serious arrhythmias such as ventricular tachycardia, ventricular fibrillation, torsade de pointes, and even sudden death. Many studies have been performed to clarify whether QTc interval prolongation is related to increasing body mass index (BMI) and abdominal obesity. However, there is no study about the relationship between abdominal obesity and QTc interval prolongation in Korea. We, therefore, studied the relationship between QTc interval prolongation and abdominal obesity among Korean adults. METHODS: The measurement of height, weight, and waist circumference, and standard 12-lead ECG was performed on 3,086 subjects at a health promotion center of a university hospital from March to April, 2003. We excluded: 37 subjects whose ECG or body measurement was not performed, 17 with a past history of cardiac disease or current cardiac medications which can influence QTc interval, 9 taking neuropsychiatric medications, 25 with abnormal serum concentration of potassium or calcium, 1 foreigner and 59 with underweight. First, we studied the correlation between BMI and waist circumference. Then, we analyzed the relationship between QTc interval prolongation and the index of obesity. RESULTS: A total of 2,938 subjects consisted of 2,411 men and 527 women. BMI and waist circumference were shown to have a significant correlation with QTc interval after age was adjusted in men (P<0.01, P<0.01). The odds ratio between QTc interval prolongation and the subjects of normal, overweight, and obesity by BMI were not significant in both men and women. In men with abdominal obesity, the odds ratio between QTc interval prolongation and abdominal obesity by waist circumference was 1.33 (0.99~1.79). CONCLUSION: In men, abdominal obesity was shown a positive correlation with QTc interval prolongation. But these results were not statistically significant.
Adult
;
Arrhythmias, Cardiac
;
Body Mass Index
;
Calcium
;
Death, Sudden
;
Electrocardiography*
;
Emigrants and Immigrants
;
Female
;
Health Promotion
;
Heart Diseases
;
Humans
;
Korea
;
Male
;
Obesity
;
Obesity, Abdominal*
;
Odds Ratio
;
Overweight
;
Potassium
;
Tachycardia, Ventricular
;
Thinness
;
Torsades de Pointes
;
Ventricular Fibrillation
;
Waist Circumference
10.Emphysematous Gastritis Worsened after Upper Endoscopy
Tae Un KIM ; Su Jin KIM ; Hwaseong RYU ; Jin Hyeok KIM ; Joo Yeon JANG ; Jeong A YEOM ; Jieun ROH ; Hee Seok JEONG ; Byung Soo PARK ; Dong Il KIM
The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2020;20(1):73-76
Emphysematous gastritis is an infectious disease in which air is formed in the gastric wall by gas-forming organisms. It is infrequently reported but can be fatal without early diagnosis and treatment. The stomach is rarely infected because of the acidity of the gastric secretions and the rich blood supply. Treatment should be aimed at covering gram-negative organisms and anaerobes using broad-spectrum intravenous antibiotics, and occasional surgical management in order to enhance survival. Risk factors are those that lead to disrupted mucosal integrity, such as corrosive injury, and those that result in an immunosuppressed condition, including diabetes mellitus, chronic kidney disease, immunosuppressive drug use, and subsequent invasion by gas-forming organisms. We experienced a case of emphysematous gastritis that worsened after endoscopy. Aeration during upper endoscopy examination can cause barotrauma to the gastric wall with impairment of the mucosal barrier, resulting in the spread of gastric wall infection to the whole body. Therefore, we report this case and provide relevant literature review to suggest that early endoscopic evaluation can lead to exacerbation of emphysematous gastritis.