No abstract available.
Embryonic Structures* ; Female ; Fertilization in Vitro* ; Pregnancy ; Pregnancy, Tubal*

No abstract available.
Actinobacillus* ; Aggregatibacter actinomycetemcomitans* ; Apoptosis* ; Humans ; Jurkat Cells*

Endothelin (ET) is a potent vasoconstrictive 21-amino acid peptide hormone released from vascular endothelium The effects of ET-1 on coronary and systemic hemodynamics in comparison with Bay K 8644, a Ca2+ agonist, were studied in halothane-anesthetized dogs. The modification of ET-1 effects by nicardipine, a voltage-dependent Ca2+ antagonist, was also investigated. Single bolus ET-1 (100 ng/ kg) and Bay K 8644 (30 ug) were administered consecutively into left circumflex coronary artery during intracoronary infusion of either 0.9% saline (0.5 ml/kg/h, n=11) or nicardipine (1 ug/kg/min, n=10). Coronary and systemic hemodynamic parameters were measured just prior to (baseline), during saline or nicardipine infusion and 1, 5, 10, 20, 30, 45, and 60 min after ET-1 injection. Also electrocardiographic changes were observed continuously. The results are as follows: 1) Both ET-1 and Ray K 8644 produced a marked and immediate reduction in coronary blood flow and an increase in coronary vascular resistance. 2) ET-1 evoked coronary vasoconstrictions were long-lasting as compared with transient actions of Bay K 8644. 3) ET-1 reduced peak systolic intramyocardial pressure (IMP), mean aortic pressure (MAP), and cardiac index (CI), in contrast Bay K 8644 increased IMP without any changes in MAP and CL 4) Nicardipine (1 ug/kg/min, i.c) produced a significant increase (2-fold) in coronary blood flow and a reduction (46%) in coronary vascular resistance, whereas other hemodynamic parameters remained unchanged. 5) Nicardipine partially attenuated coronary vascular and systemic effects of ET-1, but it completely prevented those of Bay K 8644. 6) ET-1 (100 ng/kg, i.c.) produced a significant ST segment elevation in electrocardiogram in all cases of the saline group, but in none of the nicardipine group. These findings suggest that ET-1 is a potent and long-lasting coronary vasoconstrictor and that its vasoconstrictive effect is mediated in part by promoting Ca2+ influx through a voltage-dependant Ca2+ channel since nicardipine only partially attenuated ET-1 induced cardiovascular effects.
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester ; Animals ; Arterial Pressure ; Coronary Vessels ; Dogs* ; Electrocardiography ; Endothelin-1* ; Endothelins ; Endothelium, Vascular ; Hemodynamics* ; Nicardipine* ; Vascular Resistance ; Vasoconstriction

The estimated incidence of twin pregnancy consisting of hydatidiform mole and co-existing fetus is one per 22,000-100,000 pregnancies. Most patients with hydatidiform mole and co-existing normal fetus must be cautioned about the potential for risks of malignant change and severe medical complications, such as preeclampsia, hyperthyroidism and antepartum hemorrhage, that may necessitate prompt pregnancy termination. We experienced a case of twin pregnancy with a hydatidiform mole and co-existing fetus in hypogonadotropic hypogonadismal woman who had been treated with gonadotropin for ovulation induction. A brief reviews of related literatures was done.
Female ; Fetus* ; Gonadotropins ; Hemorrhage ; Humans ; Hydatidiform Mole* ; Hyperthyroidism ; Hypogonadism ; Incidence ; Ovulation Induction ; Pre-Eclampsia ; Pregnancy ; Pregnancy, Twin*

Nail-patella syndrome is a rare autosomal dominant pleiotropic disorder characterized by dysplasia of the nails, patellar aplasia or hypoplasia, iliac horns, and dysplasia or dislocation of the elbow. We experienced a case of nail-patella syndrome. NPS is a relatively uncommon disease; however, an understanding of the typical radiologic findings is useful in establishing the diagnosis and guiding the treatment.
Animals ; Diagnosis ; Dislocations ; Elbow ; Horns ; Nail-Patella Syndrome* ; Patella

OBJECTIVES: The primary objective of this study is to compare model performance of machine learning methods with that of a previous study in which a nonlinear mixed effects model was created using NONMEM(R) for the pharmacokinetic and pharmacodynamic data for propofol. The secondary objective was to evaluate if a pharmacodynamic model describing the relationship between the dose of propofol and bispectral index (BIS) outperform that describing the relationship between a pharmacokinetic model derived-predicted concentrations of propofol and BIS. METHODS: Data were collected during a study involving the infusion of propofol into healthy volunteers. Pharmacokinetic and pharmacodynamic models were constructed using artificial neural networks (ANNs), support vector machines (SVMs), and multi-method ensembles and were compared with the nonlinear mixed effects method as implemented by NONMEM(R). Model performance was assessed by goodness-of-fit statistics, paired t-tests between predicted and observed values for each model and scatterplots. RESULTS: In pharmacokinetic analysis, ensemble I, the mean of ANN and NONMEM(R) predictions, achieved minimal error and the highest correlation coefficient. SVM produced the highest error and the lowest correlation coefficient. In pharmacodynamic analysis, ANN exhibited the best performance. An ANNModel describing the relationship between the dose of propofol and BIS was not inferior to an ANN model describing the relationship between predicted concentrations of propofol derived from an ANN pharmacokinetic model and BIS. CONCLUSIONS: In pharmacokinetic analysis, ensemble combined with ANN achieved slightly better performance than NONMEM(R). The relationship between the dose of propofol and BIS can be predicted without considering pharmacokinetics of propofol.
Machine Learning ; Propofol ; Support Vector Machine

During childhood, meningioma is an uncommon tumor, and in infants, extracranial meningioma is very rare. We report a case of primary cutaneous menigioma occurring on the scalp of a ten-month-old girl.
Female ; Humans ; Infant* ; Meningioma* ; Scalp*

Acute necrotizing encephalopathy (ANE) may be suspected when a young child presents with abrupt onset of altered mental status, seizures, or both. Definitive clinical diagnosis is based on magnetic resonance imaging (MRI) results. ANE is associated with influenza virus infections. Preliminary data suggests that up to 25% of ANE patients die, and up to 25% of ANE survivors develop substantial neurologic sequelae. Here, we describe a case of a comatose 22-month-old girl who was admitted to our hospital because of febrile illness and seizures. On day 13 of her illness, she died from ANE associated with infection from parainfluenza virus. Brain MRI results indicated diffuse bilateral symmetric signal changes in both basal ganglia, thalami, periventricular white matter, pons, and cerebral white matter, as well as generalized swelling of the brain.
Basal Ganglia ; Brain ; Child ; Coma ; Humans ; Infant ; Magnetic Resonance Imaging ; Orthomyxoviridae ; Paramyxoviridae Infections ; Pons ; Seizures ; Survivors ; Viruses

Topiramate is an antiepileptic drug effective for multiple types of seizure and is also used to prevent migraine attack. Several side effects have been reported, such as metabolic acidosis, nephrolithiasis, anorexia, weight reduction, drowsiness, glaucoma, hyperthermia, and cognitive dysfunction, whereas skin manifestationis were rarely reported. We report a case of a 12-year-old girl on medication of topiramate for 8 months due to focal epilepsy. She had fever, sore throat, burning sense in the vaginal area, and then flaccid bullae and erythematous patches proceeded to the whole bodyskin and mucosa including the conjunctiva, oral cavity, and genital areas. She was diagnosed with toxic epidermal necrolysis (TEN) and improved after the discontinuation of topiramate and with administration of high-dose intravenous steroid and immunoglobulin. We, herein, report a girl who developed severe side effects on the skin, TEN, due to topiramate.

In this paper, we describe 72-year-old female patient without evidence of malignant disease presented with significantly elevated serum carbohydrate antigen (CA) 19-9 levels by respiratory infections. She was diagnosed with respiratory infections due to Mycobacterium avium complex and Pseudomonas aeruginosa. The serum CA 19-9 levels remarkably increased (1,453-5,300 U/mL; reference range, <37 U/mL) by respiratory infection and abruptly decreased (357-534 U/mL) whenever infection was controlled by specific treatments. This case suggests that serum CA 19-9 levels may be used as a diagnostic marker to indicate new or resistant infections to previous antibiotics in chronic lung diseases without significant changes in chest X-ray findings.
Aged ; Anti-Bacterial Agents ; Female ; Humans ; Lung ; Lung Diseases ; Lung Neoplasms ; Mycobacterium avium Complex ; Pseudomonas aeruginosa ; Reference Values ; Respiratory Tract Infections ; Thorax