BACKGROUND: Many reports have shown that hormone replacement therapy(HRT) in postmenopausal women decreases lipoprotein(a)[Lp(a)]. However these had small numbers of subjects, short duration of therapy, or comparisons of only a few regimens. The influences of progesterone on Lp(a) and lipids, administered with estrogen, are controversial. METHODS: Five hundred and fifty-one postmenopausal women were divided into 4 groups : group A ; 0.625mg conjugated equine estrogen(CEE)(m=140), group B ; 0.625mg CEE plus 5mg medroxyprogesterone acetate(MPA)(m=97), group C ; 0.625mg CEE plus 10mg MPA(n=109), and group D ; 2mg estradiol valerate(E2) plus 0.5mg norgestrel(N)(n=134) and group E ; control(n=71). Lp(a) and lipids levels were measured before and 12 months after HRT. RESULTS: Estrogen replacement therapy(ERT) for 12 months lowered Lp(a) level by 37.1%. The addition of progesterone attenuated the Lp(a)-lowering effect of estrogen and decreased by 27.7%, 29.6%, and 30.3% in groups B(p<0.05), C(p<0.05), and D(p<0.0001) respectively. High density lipoprotein cholesterol(HDL-C) was increased markedly in group A(16.5%), increased moderately in groups B(10.8%) and C(11.3%), and not changed in group D. Low density lipoprotein cholesterol was decreased by 10.9%, 13.7%, 11.3%, and 17.6% in groups A, B, C, and D respectively. CONCLUSIONS: Reduction of Lp(a) with estrogen replacement therapy may be one of mechanisms for cardioprotective effect in postmenopausal women. The combined therapy of estrogen and progesterone may reveal different effects on heart due to adverse actions of progesterone on Lp(a) and HDL-C. The variations in the androgenic potency of progesterone may explaine inconsistent results on HDL-C in previous studies.
Cholesterol, LDL ; Estradiol ; Estrogen Replacement Therapy ; Estrogens ; Female ; Heart ; Hormone Replacement Therapy* ; Humans ; Lipoprotein(a)* ; Lipoproteins ; Medroxyprogesterone ; Progesterone*

A 17-year-old high School boy showed multiple, various sized, grayish or violaceous scaly verrucous plaques on the entire body including the oral mucosa, both soles and palms. We considered this is the first case that involves entire body including the oral mucosa, both soles and palms in dermatologic literatures. We reported this case and reviewed briefly literature
Adolescent ; Humans ; Lichen Planus* ; Lichens* ; Male ; Mouth Mucosa

No Abstract Available.
Adult* ; Capsulorhexis* ; Cataract* ; Follow-Up Studies* ; Humans

This study was started for the purpose of providing the basic data for continous managment of kidney transplantation patients after discharge. This study was conducted on 180 patients who received renal transplants at three hospital ( B, M. P) pusan, korea.. The data collection was done for june 1. to August 31. 2002. General characteristics, renal transplantaton characteristics. physical characteristics, the level of compliance and the degree of educational demand were done by the number and percentage. the mean. standard deviation. The level of compliance and educational demand followed by the characteristics of general and kidney transplantation were analyzed by t-test and ANOVA. The result were as fallows: 1. Man was higher than woman such as 60.0%, Mean age was 42.5 years old. Average total duration of after operation was 5.5 years. 2. Cases of systolic blood pressure over 140mmHg were 10.0%, cases of diastolic blood pressure over 90mmHg were 22.8% and obesity factor in BMI was 15.6%. The person who daily water intake amount is 5000cc was 0,6%, the case that daily urine output is below 1000cc was 8.9%. and the case that urine output is zero was 0,6%. 3. The mean score of compliance was 77.47 point. The score in medication part was highest such as 4.67 point, that in stress situation was lowest such as 3,50 point. 4. The average score of educational demand was 154.02 point. and physical state part was 4.36 points highest. activation part was 3.48 points lowest. As a role of nurse Confirmation of compliance is very important encourage to make good through regular hospital visitation. point out the noncompliance part and then increase compliance of renal transplantation patient As well there will be maintain the normal kidney function to satisfy educational demand through continous education.
Blood Pressure ; Busan ; Compliance* ; Data Collection ; Drinking ; Education ; Female ; Humans ; Kidney ; Kidney Transplantation* ; Korea ; Obesity

Hepatoid carcinoma is a rare type of malignant tumor resembling hepatocellular carcinoma that arises in extrahepatic sites.(stomach, lung, ovary, pancreas, bladder and renal pelvis). Hepatoid carcinoma of the ovary is an extremely rare ovarian tumor, first described by Ishikura and Scully in 1987. Histologically it is important to differentiate this entity from other oxyphil tumors of the ovary as it requires aggressive treatment. We have experienced a case of hepatoid carcinoma of the ovary in 69-year-old postmenopausal woman, who has been treated with operation and adjuvant Taxol - cisplatin chemotherapy. We present this case with brief review of literatures.
Aged ; Carcinoma, Hepatocellular ; Cisplatin ; Drug Therapy ; Female ; Humans ; Lung ; Ovary ; Paclitaxel ; Pancreas ; Pregnancy* ; Primary Ovarian Insufficiency* ; Urinary Bladder

OBJECTIVES: The purpose of this study was to investigate the effectiveness of a day-hospital treatment program designed to help development of children with pervasive developmental disorder (PDD) and mental retardation (MR). METHODS: Retrospective review of the charts of 32 children (28 with PDD, 4 with MR), who participated in a day-hospital treatment program of Seoul Metropolitan Eunpyeong Hospital, from October 2008 to February 2012, was conducted. Development level of each patient was evaluated according to the Psycho-Educational Profile-Revised (PEP-R), Social Maturity Scale (SMS), and Childhood Autism Rating Scale (CARS). Evaluation was done at two points, before participation and after 1 year participation. RESULTS: Children who participated in the day-hospital treatment program showed significant improvement in all categories of PEP-R, SMS, and CARS. CONCLUSION: Day-hospital treatment program is effective for helping development of children with PDD and MR.
Autistic Disorder ; Child* ; Humans ; Intellectual Disability* ; Retrospective Studies* ; Seoul

The purpose of this study was to provide a basic resource for establishment of hygienic management standards for meal delivery from the central kitchen to schools. Flow diagrams for delivery of food were analyzed, and time-temperature conditions of the food and environment were measured. Four different foods samples including Mexican salad, radish salad, stir-fried pork and vegetables, and stir-fried chicken and vegetables were collected after production and before service. Microbiological analysis was performed for aerobic plate counts (APC), Enterobacteriaceae, coliforms, E. coli, Salmonella spp., S. aureus, B. cereus, C. perfringens, and L. monocytogenes. After completion of production of cooked foods 2~3 hours were taken for the cooked foods to reach the temperature danger zone. Food temperatures at the meal service did not meet the recommended temperatures (10/57degrees C) for conventional school food service systems. The highest APC counts were observed in radish salad (5.70 log CFU/g), followed by Mexican salad (5.18 log CFU/g). Enterobacteriaceae and coliform counts were within acceptable levels of those recommended by the UK Public Health Laboratory Service. No E. coli or pathogens were found. These results provide useful information for determination of microbiological hazards in school food service systems, and suggest that time-temperature control during delivery is necessary for the safety of cooked foods.
Chickens ; Enterobacteriaceae ; Food Services ; Humans ; Meals ; Public Health ; Raphanus ; Salmonella ; Vegetables

PURPOSE: This study was carried out to suggest methods for improving school health promotion programs by investigating the daily activities and the performance level of environment management, the awareness of importance, and opinions on the revision of and knowledge about laws and regulations related to school health promotion programs. METHOD: The subjects of this study were 289 school nurses in Gyeongsangbuk-do. The survey used a questionnaire containing 90 questions developed by the present researcher. Data were collected from July 5 to July 21, 2006 and analyzed using SPSS 12.0 for Windows. RESULT: 1. Regular check-up and drinking water management got the highest score in performance level. Sexual health and drinking water management got the highest score in the awareness of importance. 2. School nurses were aware of laws and regulations related to their clients (0.93), and the revision opinion was high on the whole (3.58). 3. According to general characteristics, the more educated school nurse were (F=6.80, p=.001) and the fewer students their school had (F=4.66, p=.010), the higher their performance level in daily activities was. The shorter their career in their work was (F=4.86, p=.008), the fewer classes their school had (F=5.04, p=.007) and the fewer students their school had (F=3.83, p=.023), the higher their awareness of importance was. 4. There was not any difference in the performance level of environment management according to general characteristics. The awareness of importance was highest in school nurses with experience less then ten years (F=3.66, p=.027). 5. There was not any difference in knowledge about laws and regulations according to general characteristics. The revision opinion was high in school nurses at schools with less than 18 classrooms (F=6.04, p=.003) and less than 500 students (F=4.24, p=.015). CONCLUSION: When school nurses perform school health promotion programs actively and vigorously, the students can be healthy and national health promotion can be actualized fundamentally.
Drinking Water ; Gyeongsangbuk-do ; Health Promotion ; Humans ; Jurisprudence ; Reproductive Health ; School Health Services* ; School Nursing ; Social Control, Formal ; Surveys and Questionnaires

BACKGROUND: Pravastatin, HMG-CoA reductase inhibitor, has been known to be the most effective drug in patients with hypercholesterolemia. We studied the effectiveness and side effects of this drug. METHODS: We studied twenty four patients(8 males, 16 females), with pravastatin 5mg bid for 8 weeks, whose fasting serum total cholesterol levels were higher than 240mg/dl on the first visit. Lipid profiles were checked at 2 weeks interval for 8 weeks and compared with baseline level individually. RESULTS: Among lipid profiles, pravastatin significantly decreased the total cholesterol from 282.8mg/dL to 224.5mg/dL(reduction rate, 21%), the LDL cholesterol from 197.2mg/dL to 143.8mg/dL(27%), the total cholesterol/HDL cholesterol ratio from 6.2 to 4.6(25%), and the LDL cholesterol/HDL cholesterol ratio from 4.1 to 2.7 (34%). These changes were statistically significant(p<0.05). Triglyceride and HDL cholesterol showed no significant changes compared to baseline levels during treatment. The clinical and laboratory findings after treatment did not show serious abnormalities except two patients who dropped out due to side effect such as constipation and skin eruption. CONCLUSION: Results from the present study show that short-term pravastatin therapy seems to be effective and safe in patients with hypercholesterolemia.
Cholesterol ; Cholesterol, HDL ; Cholesterol, LDL ; Constipation ; Fasting ; Humans ; Hypercholesterolemia ; Hyperlipidemias* ; Male ; Oxidoreductases ; Pravastatin* ; Skin ; Triglycerides

PURPOSE: Bacillus Calmette-Guerin(BCG) therapy for superficial bladders carcinoma and carcinoma in situ is believed to exert its antitumor effects through immune mechanisms when BCG is instilled into the bladder, but its detail mechanisms are poorly understood. Recently, intravesical BCG instillation is known to induce nitric oxide(NO) which is revealed to be tumoricidal . This experiment was performed to determine the intravesical localization and alteration of expression of inducible nitric oxide synthase(iNOS) after BCG instillation. MATERIALS AND METHODS: Normal saline(0.85m1/kg, control group) and BCG(6mg/kg, experimental group) were instilled intravesically in fifty four female mice. After 2 hours, each mouse urinated after removal of urethral ligature, and was sacrificed at 6th, 12th, 18th hour, 1st day, 1.5th, 2th, 3th, 7th and 14th day, respectively. Immunohistochemistry was performed on paraffin embedded bladder tissue using anti-inducible NOS antibody(Transduction Labaratories, USA.). RESULTS: Inflammatory cells were infiltrated in the bladder wall in the BCG-treated group, but not in the control group. Number of inflammatory cells among BCG-treated group, was the highest in the 18th hour group and was reduced gradually with time elapse thereafter In the control group, immunoreactivity of iNOS to be positive in the all intermediate cell layer and a few basal cell layer of bladder transitional epithelium, which did not change as time passed. In the BCG-treated group, immunoreactivity of iNOS increased from 6 hours after BCG instillation, and gradually decreased from 7 days to restore to the level of the control group. However, some cells of transitional epithelium showed reduced immunoreactivity, focally. CONCLUSIONS: These results suggest that iNOS is tonically expressed in transitional epithelium of mouse bladder which is further induced by BCG instillation. Also, NOS-mediated NO production is supposed to be one of factors to induce tumoricidal erect by BCG instillation.
Animals ; Bacillus ; Carcinoma in Situ ; Epithelium ; Female ; Humans ; Immunohistochemistry ; Ligation ; Mice* ; Mycobacterium bovis* ; Nitric Oxide ; Nitric Oxide Synthase Type II* ; Paraffin ; Urinary Bladder