1.A Case of Extra-Adrenal Pheochromocytoma with Abdominal Colic and Paroxysmal Hypertension.
Jeong Seong KANG ; Soo Yeon WON ; Il Mun JEON ; Myoung Kyu JANG ; Suck Chei CHOI ; Jin Won JEONG ; Yang Kyu PARK ; Ock Kyu PARK
Korean Circulation Journal 1993;23(4):621-624
Pheochromocytomas can arise wherever chromaffin cells are found, and most of them(90%) are in one or both adrenal glands. But they may be located anywhere along the sympathetic chain and rarely in aberrant sites. One of the common extra-adrenal sites from which these tumors can arise is a collection of para-aortic and para-ganglion cells around the origin of the inferior mesenteric artery. We experienced a case of extra-adrenal pheochromocytoma located at the organ of Zukerkandl in a 21-year-old female patient with abdominal colic and paroxysmal hypertension, whose symptoms and blood pressure returned to normal after successful surgical excision of the tumor.
Adrenal Glands
;
Blood Pressure
;
Chromaffin Cells
;
Colic*
;
Female
;
Humans
;
Hypertension*
;
Mesenteric Artery, Inferior
;
Pheochromocytoma*
;
Young Adult
2.A Study to Establish Rare Blood Type Donor Registration System.
Mi Kyung LEE ; Byung Chan CHOI ; Deok Ja OH ; Ok Joo JEONG ; Mun Jeong KIM
Korean Journal of Blood Transfusion 2005;16(1):38-44
BACKGROUND: To find compatible rare bloods, the Korean Red Cross (KRC) blood center is currently testing many units randomly selected from the units in storage. Since this procedure is usually very time-consuming, it is necessary to establish a new donor management system for the rare blood types. METHODS: We evaluated 261 units of red blood cells (RBCs), which were supplied as compatible bloods to the requests of hospitals in 2003. RESULTS: A total of 14 hospitals requested 248 units of compatible RBCs for their 39 patients through 64 occasions and 261 units were supplied. The blood types of 35 patients were identified using the medical records of the hospitals. A total of 19 kinds of specific antigens were negative and, among them, 10 kinds of single specific antigens were negative and 9 kinds of multiple antigens were negative. The frequencies of the negative antigens were C+e(17.9%), E+c(10.3%) and Jka(10.3%), respectively. The number of tested blood units was 1,894 and the rate of compatibility was 13.8%. The mean age of 257 blood donors was 22.5 and, among them, 220 donors (85.6%) were multiple donors with 7.5 collections on average. CONCLUSION: We conclude that the rare blood type donor registration system is necessary and suggest the following preconditions. First, the results of compatible blood test and irregular antibody screening test for the blood donor need to be registered automatically by the blood information management system(BIMS). Second, the test system should be improved to enhance the irregular antibody detection rate. Third, establishment of a frozen-thawing system for RBCs is needed. Fourth, the donors need to be informed of the results of their rare blood type, if any, including irregular antibody. Fifth, a new organization should be established to manage the rare blood type donor registration system. Finally, well cooperation with hospitals and KRC blood center is needed to ensure the stability of blood service for rare blood type RBCs.
Blood Donors
;
Erythrocytes
;
Hematologic Tests
;
Humans
;
Information Management
;
Mass Screening
;
Medical Records
;
Red Cross
;
Tissue Donors*
3.Atypical Ischemic Cranial Nerve Palsy in a Diabetic Patient
Ju Won CHOI ; Junho MUN ; Jeong Han KONG ; Youn Joo CHOI
Journal of the Korean Ophthalmological Society 2023;64(3):266-271
Purpose:
We report an atypical case of ischemic oculomotor palsy occurring sequentially in both eyes and then improving, followed by a new abducens palsy in a diabetic patient with poor blood sugar control.Case summary: A 51-year-old woman presented with diplopia, dizziness, and pain in the right eye and was diagnosed with oculomotor palsy in the right eye. Magnetic resonance imaging of her brain was normal but glycated hemoglobin concentration was 13.4%. After 2 months, the third nerve palsy in the right eye had recovered completely but a new third nerve palsy occurred in the left eye. 1 month later, the symptoms had improved, and the patient did not return to our clinic until 18 months later, when she returned with new diplopia. This time, she was diagnosed with a sixth nerve palsy in the left eye and was observed while controlling her blood sugar. She recovered after 4 months.
Conclusions
Generally, cranial nerve palsies occur unilaterally in situations that can cause ischemia, such as diabetes, high blood pressure, and hyperlipidemia. Rarely, they occur bilaterally, or two or more cranial nerve palsies occur simultaneously. However, it is very rare that cranial nerve palsy occurs sequentially in both eyes under the same systemic blood sugar control. Diabetic patients with poor blood sugar control require long-term monitoring, considering the possibility of symptoms developing in both eyes with a time lag or other forms of ischemic cranial nerve palsy.
4.Power Doppler Ultrasound Findings of Renal Infarct after Experimental Renal Artery Occlusion: Comparison withSpiral CT.
Seung Eun JUNG ; Kyung Sub SHINN ; Hak Hee KIM ; Seok Hwan MUN ; Young Joon LEE ; Bae Young LEE ; Byung Gil CHOI ; Jae Mun LEE ; Hee Jeong LEE
Journal of the Korean Radiological Society 1999;40(2):307-315
PURPOSE: To evaluate the efficacy of power Doppler ultrasonography (PDUS) in depicting renal infarction inrabbits during experimental renal segmental arterial occlusion, and to compare the results with those of CTscanning. MATERIALS AND METHODS: In 28 rabbits weighing 2.5-4kg, the segmental renal artery was occluded throughthe left main renal artery by embolization with Ivalon (Nycomed, Paris, France). Power Doppler ultrasonography andspiral CT scanning were performed before and at 2, 5, 8, 15, and 24 hours, and 3 and 7 days after occlusion of thesegmental renal artery. The location of infarcted areas and collaterals, as seen on PDUS and CT scans, wasevaluated by two radiologists. RESULTS: In all cases, as seen on power Doppler ultrasonography, infaretedareas-when compared with normal parenchyma, clearly demonstrated wedge-shaped perfusion defects in the kidney. Thelocation of the lesion closely corresponded to the location seen during CT scanning. After renal arterialocclusion, transiently congested capsular arteries, which were named 'capsular sign', were seen in 63% ofrabbits in the two and five-hour groups. No significant cortical rim sign was demonstrated on power Dopplerultrasonography, though it was noted on spiral CT at 15 and 24 hours, and 3 and 7 days after renal arterialocclusion. CONCLUSION: Power Doppler ultrasonography was useful for the diagnosis of renal infarction. Congestedcapsular artery seen in the early stage of renal infarction might be a characteristic finding of this condition,as seen on power Doppler ultrasonography.
Animals
;
Arteries
;
Diagnosis
;
Estrogens, Conjugated (USP)
;
Infarction
;
Kidney
;
Perfusion
;
Rabbits
;
Renal Artery*
;
Tomography, Spiral Computed
;
Tomography, X-Ray Computed
;
Ultrasonography*
;
Ultrasonography, Doppler
5.Stereotactic Body Radiation Therapy for Low- to Intermediate-risk Prostate Adenocarcinoma.
Bae Kwon JEONG ; Hojin JEONG ; In Bong HA ; Hoon Sik CHOI ; Sung Chul KAM ; Jeong Seok HWA ; Jae Seog HYUN ; Ky Hyun CHUNG ; See Min CHOI ; Ki Mun KANG
Journal of Korean Medical Science 2015;30(6):710-715
The aim of the present study was to evaluate the efficacy and toxicity of stereotactic body radiation therapy (SBRT) for low- to intermediate-risk prostate adenocarcinoma. Thirty-nine patients were retrospectively reviewed. The SBRT was delivered using the CyberKnife with the fiducial tracking method combined with In-tempo imaging. The gross target volume, which included the prostate only, was delineated on the fused CT/MRI scans. The prescription dose was delivered every other day as 5 fractions of 7.5 Gy. Venous blood was obtained before and after SBRT to assess the prostate-specific antigen (PSA) level. Toxicity was evaluated using the CTCAE, v4.03. The median follow-up time was 30.0 months. The median initial PSA level was 7.7 ng/mL. PSA levels decreased in all patients treated with SBRT, and after 5 months, the median PSA was less than 2 ng/mL. The rate of overall 3-yr actuarial biochemical failure free survival was 93.9%. Acute side effects were generally comparable with those of previous studies. The PSA change and toxicity after SBRT for low- to intermediate-risk prostate adenocarcinoma indicates favorable biochemical responses and tolerable levels of toxicity. Additionally short course treatment may produce cost benefit and convenience to patients.
Adenocarcinoma/*diagnosis/*surgery
;
Aged
;
Aged, 80 and over
;
Humans
;
Male
;
Middle Aged
;
Prostatic Neoplasms/*diagnosis/*surgery
;
Radiosurgery/*methods
;
Radiotherapy Dosage
;
Radiotherapy Planning, Computer-Assisted
;
Radiotherapy, Image-Guided/*methods
;
Risk Assessment
;
Treatment Outcome
6.Classification of Microsatellite Alterations Detected in Endoscopic Biopsy Specimens of Gastric Cancers.
Young Deok CHOI ; Sang Wook CHOI ; Eun Jeong JEON ; Jeong Jo JEONG ; Ki Ouk MIN ; Kang Hoon LEE ; Sung LEE ; Mun Gan RHYU
Journal of the Korean Gastric Cancer Association 2004;4(2):109-120
PURPOSE: Individual gastric cancers demonstrate complicated genetic alterations. The PCR-based analysis of polymorphic microsatellite sequences on cancer-related chromosomes has been used to detect chromosomal loss and microsatellite instability. For the purpose of preoperative usage, we analyzed the correspondance rate of the microsatellite genotype between endoscopic biopsy and surgical specimens. MATERIALS AND METHODS: Seventy-three pairs of biopsy and surgical specimens were examined for loss of heterozygosity and microsatellite instability by using 40 microsatellite markers on eight chromosomes. Microsatellite alterations in tumor DNAs were classified into a high-risk group (baseline- level loss of heterozygosity: 1 chromosomal loss in diffuse type and high-level loss of heterozygosity: 4 or more chromosomal losses) and a low-risk group (microsatellite instability and low-level loss of heterozygosity: 2 or 3 chromosomal losses in diffuse type or 1~3 chromosomal losses in intestinal type) based on the extent of chromosomal loss and microsatellite instability. RESULTS: The chromosomal losses of the biopsy and the surgical specimens were found to be different in 21 of the 73 cases, 19 cases of which were categorized into a genotype group of similar extent. In 100 surgical specimens, the high-risk genotype group showed a high incidence of nodal involvement (19 of 23 cases: < or =5 cm; 23 of 24 cases: >5 cm) irrespective of tumor size while the incidence of nodal involvement for the low-risk genotype group depended on tumor size (5 of 26 cases: < or =5 cm; 18 of 27 cases: >5 cm). Extraserosal invasion was more frequent in large-sized tumor in both the high-risk genotype group (< or =5 cm: 12 of 23 cases; >5 cm: 23 of 24 cases) and the low-risk genotype group (< or =5 cm: 7 of 26 cases; >5 cm: 16 of 27 cases). The preoperative prediction of tumor invasion and nodal involvement based on tumor size and genotype corresponded closely to the pathologic tumor stage (ROC area>0.7). CONCLUSION: An endoscopic biopsy specimen of gastric cancer can be used to make a preoperative genetic diagnosis that accurately reflect the genotype of the corresponding surgical specimen.
Biopsy*
;
Classification*
;
Diagnosis
;
DNA
;
Genotype
;
Incidence
;
Loss of Heterozygosity
;
Microsatellite Instability
;
Microsatellite Repeats*
;
Stomach Neoplasms*
7.Micro-Structural Profiles of Trabecular Bone at the Ankle Joint.
Hyon Jeong KIM ; Tae Sun AN ; Myong Hyun BAEK ; Mun Kwon CHOI ; Ye Yeon WON
Journal of Korean Foot and Ankle Society 2004;8(2):157-160
PURPOSE: This study aimed to investigate and compare the micro-structural profiles of trabecular bone from different facets at the ankle joint. MATERIALS AND METHODS: In a fresh cadaver ankle, four cored 10 mm of diameter cylindrical specimens of trabecular bone were harvested from the distal tibia, the talar dome, the medial malleolus, and the lateral malleolus. Using a micro-computed tomography, two-dimensional and three-dimensional micro-structural indices of the trabecular bone were analyzed. RESULTS: Each specimen from the tibia, talus, medial malleolus, and the lateral malleolus showed unique micro-structural pattern. Tibia versus talus, the talus was seen a higher bone volume fraction and a wider supporting zone subchondrally whereas the tibia was seen a relatively lower bone volume fraction and a much narrower supporting zone subchondrally. Lateral malleolus versus medial malleolus, the lateral malleolus was seen the thicker but sparse trabeculae pattern whereas the medial malleolus was seen the thinner but more compact trabecular pattern. CONCLUSION: Each four locations from the different facet at the ankle joint have distinct own micro-structural patterns of the trabecular bone, suggesting different mechanical properties.
Ankle Joint*
;
Ankle*
;
Cadaver
;
Talus
;
Tibia
8.Relative Afferent Pupillary Defect in Normal Subjects in 10 to 39 Years of Age.
In Bum LEE ; Byung Hun CHOI ; Yeon Seong MUN ; Jeong Min HWANG
Journal of the Korean Ophthalmological Society 2005;46(6):1034-1036
PURPOSE: In order to investigate the incidence of relative afferent pupillary defect (RAPD) in normal adolescence and if there is any interocular difference in the case with RAPD. METHODS: Fifty-eight adolescence in 14 to 36 years of age who showed normal findings on measurement of visual acuity, intraocular pressure, slit lamp examination, and funduscopic examination except refractive errors underwent swinging flashlight test and infrared pupillography. The case with RAPD further underwent optical coherence tomography, color vision test, Humphrey visual field test, and Bryngelson test (hole-in-the-card test). RESULTS: One out of 58 cases, in whom more pronounced myopic astigmatism and lower mean deviation on Humphrey visual field test within normal limits were found, showed RAPD in the dominant right eye with swinging flashlight test and infrared pupillography. CONCLUSIONS: The incidence of RAPD in normal adolescence was 1.7%. Myopic astigmatism was higher in the eye with RAPD.
Adolescent
;
Astigmatism
;
Color Vision
;
Humans
;
Incidence
;
Intraocular Pressure
;
Pupil Disorders*
;
Refractive Errors
;
Tomography, Optical Coherence
;
Visual Acuity
;
Visual Field Tests
9.Phylogenetic Analysis of the 56-kDa Type-Specific Protein Genes of Orientia tsutsugamushi in Central Korea.
Hye Won JEONG ; Young Ki CHOI ; Yun Hee BAEK ; Mun Hyuk SEONG
Journal of Korean Medical Science 2012;27(11):1315-1319
There are several antigenic variants of Orientia tsutsugamushi. The 56-kDa type-specific antigen (TSA) is responsible for the antigenic variation. Nucleotide sequences of the 56-kDa TSA obtained from 44 eschar samples of Korean scrub typhus patients and from 40 representative strains retrieved from the GenBank database were analyzed phylogenetically. Clinical patient data were assessed based on the genotyping results. Of the 44 nucleotide sequences, 32 (72.7%) clustered with the Boryong genotype, which is the major genotype in Korea. Eleven nucleotide sequences (25%) clustered with the Kawasaki genotype, not identified in Korea until 2010. One nucleotide sequence was consistent with the Karp genotype. The clinical course of the patients infected with each genotype showed no differences. Diagnostic performance of the immunofluorescence assay (IFA) using the 56-kDa TSA from Gilliam, Karp and Boryong as test antigens were not different for the Boryong and Kawasaki genotypes. Although Boryong is still the predominant genotype, the results suggest that Kawasaki genotype is quite prevalent in Chungbuk province of Korea.
Aged
;
Bacterial Proteins/*genetics/metabolism
;
Base Sequence
;
DNA, Bacterial/analysis
;
Databases, Genetic
;
Female
;
Genotype
;
Humans
;
Male
;
Middle Aged
;
Open Reading Frames
;
Orientia tsutsugamushi/*classification/isolation & purification
;
Phylogeny
;
Republic of Korea
;
Scrub Typhus/diagnosis/metabolism/*microbiology
;
Sequence Analysis, DNA
10.Phylogenetic Analysis of the 56-kDa Type-Specific Protein Genes of Orientia tsutsugamushi in Central Korea.
Hye Won JEONG ; Young Ki CHOI ; Yun Hee BAEK ; Mun Hyuk SEONG
Journal of Korean Medical Science 2012;27(11):1315-1319
There are several antigenic variants of Orientia tsutsugamushi. The 56-kDa type-specific antigen (TSA) is responsible for the antigenic variation. Nucleotide sequences of the 56-kDa TSA obtained from 44 eschar samples of Korean scrub typhus patients and from 40 representative strains retrieved from the GenBank database were analyzed phylogenetically. Clinical patient data were assessed based on the genotyping results. Of the 44 nucleotide sequences, 32 (72.7%) clustered with the Boryong genotype, which is the major genotype in Korea. Eleven nucleotide sequences (25%) clustered with the Kawasaki genotype, not identified in Korea until 2010. One nucleotide sequence was consistent with the Karp genotype. The clinical course of the patients infected with each genotype showed no differences. Diagnostic performance of the immunofluorescence assay (IFA) using the 56-kDa TSA from Gilliam, Karp and Boryong as test antigens were not different for the Boryong and Kawasaki genotypes. Although Boryong is still the predominant genotype, the results suggest that Kawasaki genotype is quite prevalent in Chungbuk province of Korea.
Aged
;
Bacterial Proteins/*genetics/metabolism
;
Base Sequence
;
DNA, Bacterial/analysis
;
Databases, Genetic
;
Female
;
Genotype
;
Humans
;
Male
;
Middle Aged
;
Open Reading Frames
;
Orientia tsutsugamushi/*classification/isolation & purification
;
Phylogeny
;
Republic of Korea
;
Scrub Typhus/diagnosis/metabolism/*microbiology
;
Sequence Analysis, DNA